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Protein

Leucine-rich alpha-2-glycoprotein

Gene

LRG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich alpha-2-glycoprotein
Short name:
LRG
Gene namesi
Name:LRG1
Synonyms:LRG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:29480. LRG1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular region Source: UniProtKB
  • extracellular space Source: UniProtKB
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134919634.

Polymorphism and mutation databases

BioMutaiLRG1.
DMDMi23503037.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 35351 PublicationAdd
BLAST
Chaini36 – 347312Leucine-rich alpha-2-glycoproteinPRO_0000020579Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi37 – 371O-linked (GalNAc...)
Disulfide bondi43 ↔ 56
Glycosylationi79 – 791N-linked (GlcNAc...) (complex)1 Publication
Glycosylationi186 – 1861N-linked (GlcNAc...) (complex)6 Publications
Glycosylationi269 – 2691N-linked (GlcNAc...)1 Publication
Disulfide bondi303 ↔ 329
Glycosylationi325 – 3251N-linked (GlcNAc...) (complex)2 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei306 – 3061Not glycosylated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP02750.
PeptideAtlasiP02750.
PRIDEiP02750.

2D gel databases

DOSAC-COBS-2DPAGEP02750.
SWISS-2DPAGEP02750.

PTM databases

PhosphoSiteiP02750.
UniCarbKBiP02750.

Expressioni

Tissue specificityi

Plasma.

Gene expression databases

BgeeiP02750.
CleanExiHS_LRG1.
GenevisibleiP02750. HS.

Organism-specific databases

HPAiHPA001888.
HPA001889.

Interactioni

Protein-protein interaction databases

BioGridi125537. 2 interactions.
DIPiDIP-60317N.
IntActiP02750. 1 interaction.
STRINGi9606.ENSP00000302621.

Structurei

3D structure databases

ProteinModelPortaliP02750.
SMRiP02750. Positions 53-331.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati93 – 11422LRR 1Add
BLAST
Repeati117 – 13822LRR 2Add
BLAST
Repeati141 – 16222LRR 3Add
BLAST
Repeati165 – 18622LRR 4Add
BLAST
Repeati189 – 21022LRR 5Add
BLAST
Repeati213 – 23422LRR 6Add
BLAST
Repeati237 – 25822LRR 7Add
BLAST
Repeati261 – 28222LRR 8Add
BLAST
Domaini299 – 34749LRRCTAdd
BLAST

Sequence similaritiesi

Contains 8 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000234378.
HOVERGENiHBG000045.
InParanoidiP02750.
OMAiTRCAGPE.
OrthoDBiEOG79CXZM.
PhylomeDBiP02750.
TreeFamiTF351919.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02750-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSWSRQRPK SPGGIQPHVS RTLFLLLLLA ASAWGVTLSP KDCQVFRSDH
60 70 80 90 100
GSSISCQPPA EIPGYLPADT VHLAVEFFNL THLPANLLQG ASKLQELHLS
110 120 130 140 150
SNGLESLSPE FLRPVPQLRV LDLTRNALTG LPPGLFQASA TLDTLVLKEN
160 170 180 190 200
QLEVLEVSWL HGLKALGHLD LSGNRLRKLP PGLLANFTLL RTLDLGENQL
210 220 230 240 250
ETLPPDLLRG PLQLERLHLE GNKLQVLGKD LLLPQPDLRY LFLNGNKLAR
260 270 280 290 300
VAAGAFQGLR QLDMLDLSNN SLASVPEGLW ASLGQPNWDM RDGFDISGNP
310 320 330 340
WICDQNLSDL YRWLQAQKDK MFSQNDTRCA GPEAVKGQTL LAVAKSQ
Length:347
Mass (Da):38,178
Last modified:September 19, 2002 - v2
Checksum:i20C99ED50152FA9C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti64 – 641G → S.
Corresponds to variant rs7251081 [ dbSNP | Ensembl ].
VAR_050629
Natural varianti133 – 1331P → S.1 Publication
Corresponds to variant rs966384 [ dbSNP | Ensembl ].
VAR_024245

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403428 mRNA. Translation: AAK95527.1.
BC034389 mRNA. Translation: AAH34389.1.
BC070198 mRNA. Translation: AAH70198.1.
CCDSiCCDS12130.1.
PIRiA03211. NBHUA2.
RefSeqiNP_443204.1. NM_052972.2.
UniGeneiHs.655559.

Genome annotation databases

EnsembliENST00000306390; ENSP00000302621; ENSG00000171236.
GeneIDi116844.
KEGGihsa:116844.
UCSCiuc002mau.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403428 mRNA. Translation: AAK95527.1.
BC034389 mRNA. Translation: AAH34389.1.
BC070198 mRNA. Translation: AAH70198.1.
CCDSiCCDS12130.1.
PIRiA03211. NBHUA2.
RefSeqiNP_443204.1. NM_052972.2.
UniGeneiHs.655559.

3D structure databases

ProteinModelPortaliP02750.
SMRiP02750. Positions 53-331.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125537. 2 interactions.
DIPiDIP-60317N.
IntActiP02750. 1 interaction.
STRINGi9606.ENSP00000302621.

PTM databases

PhosphoSiteiP02750.
UniCarbKBiP02750.

Polymorphism and mutation databases

BioMutaiLRG1.
DMDMi23503037.

2D gel databases

DOSAC-COBS-2DPAGEP02750.
SWISS-2DPAGEP02750.

Proteomic databases

PaxDbiP02750.
PeptideAtlasiP02750.
PRIDEiP02750.

Protocols and materials databases

DNASUi116844.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306390; ENSP00000302621; ENSG00000171236.
GeneIDi116844.
KEGGihsa:116844.
UCSCiuc002mau.4. human.

Organism-specific databases

CTDi116844.
GeneCardsiLRG1.
HGNCiHGNC:29480. LRG1.
HPAiHPA001888.
HPA001889.
MIMi611289. gene.
neXtProtiNX_P02750.
PharmGKBiPA134919634.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000234378.
HOVERGENiHBG000045.
InParanoidiP02750.
OMAiTRCAGPE.
OrthoDBiEOG79CXZM.
PhylomeDBiP02750.
TreeFamiTF351919.

Miscellaneous databases

GeneWikiiLRG1.
GenomeRNAii116844.
NextBioi80020.
PROiP02750.
SOURCEiSearch...

Gene expression databases

BgeeiP02750.
CleanExiHS_LRG1.
GenevisibleiP02750. HS.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 8 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization and expression analysis of leucine-rich alpha2-glycoprotein, a novel marker of granulocytic differentiation."
    O'Donnell L.C., Druhan L.J., Avalos B.R.
    J. Leukoc. Biol. 72:478-485(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-133.
    Tissue: Colon, Kidney and Lung.
  3. "Periodicity of leucine and tandem repetition of a 24-amino acid segment in the primary structure of leucine-rich alpha 2-glycoprotein of human serum."
    Takahashi N., Takahashi Y., Putnam F.W.
    Proc. Natl. Acad. Sci. U.S.A. 82:1906-1910(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 36-347.
  4. "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
    Bunkenborg J., Pilch B.J., Podtelejnikov A.V., Wisniewski J.R.
    Proteomics 4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-186.
    Tissue: Plasma.
  5. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-186; ASN-269 AND ASN-325.
    Tissue: Plasma.
  6. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
    Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.
    J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-186.
    Tissue: Saliva.
  7. "Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry."
    Picariello G., Ferranti P., Mamone G., Roepstorff P., Addeo F.
    Proteomics 8:3833-3847(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-186.
    Tissue: Milk.
  8. Cited for: GLYCOSYLATION AT ASN-186 AND ASN-325.
  9. "Enrichment of glycopeptides for glycan structure and attachment site identification."
    Nilsson J., Rueetschi U., Halim A., Hesse C., Carlsohn E., Brinkmalm G., Larson G.
    Nat. Methods 6:809-811(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-79 AND ASN-186, STRUCTURE OF CARBOHYDRATES.
    Tissue: Cerebrospinal fluid.
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiA2GL_HUMAN
AccessioniPrimary (citable) accession number: P02750
Secondary accession number(s): Q8N4F5, Q96QZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: September 19, 2002
Last modified: May 11, 2016
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.