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Protein

Leucine-rich alpha-2-glycoprotein

Gene

LRG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171236-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich alpha-2-glycoprotein
Short name:
LRG
Gene namesi
Name:LRG1
Synonyms:LRG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:29480. LRG1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular region Source: UniProtKB
  • extracellular space Source: UniProtKB
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi116844.
OpenTargetsiENSG00000171236.
PharmGKBiPA134919634.

Polymorphism and mutation databases

BioMutaiLRG1.
DMDMi23503037.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 351 PublicationAdd BLAST35
ChainiPRO_000002057936 – 347Leucine-rich alpha-2-glycoproteinAdd BLAST312

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi37O-linked (GalNAc...)1
Disulfide bondi43 ↔ 56
Glycosylationi79N-linked (GlcNAc...) (complex)1 Publication1
Glycosylationi186N-linked (GlcNAc...) (complex)6 Publications1
Glycosylationi269N-linked (GlcNAc...)1 Publication1
Disulfide bondi303 ↔ 329
Glycosylationi325N-linked (GlcNAc...) (complex)2 Publications1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei306Not glycosylated1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP02750.
PeptideAtlasiP02750.
PRIDEiP02750.

2D gel databases

DOSAC-COBS-2DPAGEP02750.
SWISS-2DPAGEP02750.

PTM databases

PhosphoSitePlusiP02750.
UniCarbKBiP02750.

Expressioni

Tissue specificityi

Plasma.

Gene expression databases

BgeeiENSG00000171236.
CleanExiHS_LRG1.
GenevisibleiP02750. HS.

Organism-specific databases

HPAiHPA001888.
HPA001889.

Interactioni

Protein-protein interaction databases

BioGridi125537. 2 interactors.
DIPiDIP-60317N.
IntActiP02750. 1 interactor.
STRINGi9606.ENSP00000302621.

Structurei

3D structure databases

ProteinModelPortaliP02750.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati93 – 114LRR 1Add BLAST22
Repeati117 – 138LRR 2Add BLAST22
Repeati141 – 162LRR 3Add BLAST22
Repeati165 – 186LRR 4Add BLAST22
Repeati189 – 210LRR 5Add BLAST22
Repeati213 – 234LRR 6Add BLAST22
Repeati237 – 258LRR 7Add BLAST22
Repeati261 – 282LRR 8Add BLAST22
Domaini299 – 347LRRCTAdd BLAST49

Sequence similaritiesi

Contains 8 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000234378.
HOVERGENiHBG000045.
InParanoidiP02750.
OMAiDTRCAGP.
OrthoDBiEOG091G0RZG.
PhylomeDBiP02750.
TreeFamiTF351919.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02750-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSWSRQRPK SPGGIQPHVS RTLFLLLLLA ASAWGVTLSP KDCQVFRSDH
60 70 80 90 100
GSSISCQPPA EIPGYLPADT VHLAVEFFNL THLPANLLQG ASKLQELHLS
110 120 130 140 150
SNGLESLSPE FLRPVPQLRV LDLTRNALTG LPPGLFQASA TLDTLVLKEN
160 170 180 190 200
QLEVLEVSWL HGLKALGHLD LSGNRLRKLP PGLLANFTLL RTLDLGENQL
210 220 230 240 250
ETLPPDLLRG PLQLERLHLE GNKLQVLGKD LLLPQPDLRY LFLNGNKLAR
260 270 280 290 300
VAAGAFQGLR QLDMLDLSNN SLASVPEGLW ASLGQPNWDM RDGFDISGNP
310 320 330 340
WICDQNLSDL YRWLQAQKDK MFSQNDTRCA GPEAVKGQTL LAVAKSQ
Length:347
Mass (Da):38,178
Last modified:September 19, 2002 - v2
Checksum:i20C99ED50152FA9C
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05062964G → S.Corresponds to variant rs7251081dbSNPEnsembl.1
Natural variantiVAR_024245133P → S.1 PublicationCorresponds to variant rs966384dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403428 mRNA. Translation: AAK95527.1.
BC034389 mRNA. Translation: AAH34389.1.
BC070198 mRNA. Translation: AAH70198.1.
CCDSiCCDS12130.1.
PIRiA03211. NBHUA2.
RefSeqiNP_443204.1. NM_052972.2.
UniGeneiHs.655559.

Genome annotation databases

EnsembliENST00000306390; ENSP00000302621; ENSG00000171236.
GeneIDi116844.
KEGGihsa:116844.
UCSCiuc002mau.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF403428 mRNA. Translation: AAK95527.1.
BC034389 mRNA. Translation: AAH34389.1.
BC070198 mRNA. Translation: AAH70198.1.
CCDSiCCDS12130.1.
PIRiA03211. NBHUA2.
RefSeqiNP_443204.1. NM_052972.2.
UniGeneiHs.655559.

3D structure databases

ProteinModelPortaliP02750.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125537. 2 interactors.
DIPiDIP-60317N.
IntActiP02750. 1 interactor.
STRINGi9606.ENSP00000302621.

PTM databases

PhosphoSitePlusiP02750.
UniCarbKBiP02750.

Polymorphism and mutation databases

BioMutaiLRG1.
DMDMi23503037.

2D gel databases

DOSAC-COBS-2DPAGEP02750.
SWISS-2DPAGEP02750.

Proteomic databases

PaxDbiP02750.
PeptideAtlasiP02750.
PRIDEiP02750.

Protocols and materials databases

DNASUi116844.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306390; ENSP00000302621; ENSG00000171236.
GeneIDi116844.
KEGGihsa:116844.
UCSCiuc002mau.4. human.

Organism-specific databases

CTDi116844.
DisGeNETi116844.
GeneCardsiLRG1.
HGNCiHGNC:29480. LRG1.
HPAiHPA001888.
HPA001889.
MIMi611289. gene.
neXtProtiNX_P02750.
OpenTargetsiENSG00000171236.
PharmGKBiPA134919634.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000234378.
HOVERGENiHBG000045.
InParanoidiP02750.
OMAiDTRCAGP.
OrthoDBiEOG091G0RZG.
PhylomeDBiP02750.
TreeFamiTF351919.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171236-MONOMER.
ReactomeiR-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

GeneWikiiLRG1.
GenomeRNAii116844.
PROiP02750.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171236.
CleanExiHS_LRG1.
GenevisibleiP02750. HS.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiA2GL_HUMAN
AccessioniPrimary (citable) accession number: P02750
Secondary accession number(s): Q8N4F5, Q96QZ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: September 19, 2002
Last modified: November 30, 2016
This is version 157 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.