Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

C-reactive protein

Gene

CRP

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells (By similarity).By similarity

Miscellaneous

Asp-61, Arg-76, Arg-77, and Glu-81 may be involved in the calcium-dependent binding of phosphorylcholine, a property that may be important for the biological function of this protein.

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi80Calcium 1By similarity1
Metal bindingi158Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi159Calcium 1By similarity1
Metal bindingi159Calcium 2By similarity1
Metal bindingi169Calcium 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processAcute phase
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
C-reactive protein
Gene namesi
Name:CRP
Synonyms:PTX1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000002353121 – 225C-reactive protein1 PublicationAdd BLAST205

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi55 ↔ 116PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP02742

Expressioni

Tissue specificityi

Found in plasma.

Inductioni

The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli.

Interactioni

Subunit structurei

Homopentamer. Pentraxin (or pentaxin) have a discoid arrangement of 5 non-covalently bound subunits. Interacts with FCN1; may regulate monocyte activation by FCN1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000004059

Structurei

3D structure databases

ProteinModelPortaliP02742
SMRiP02742
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 225Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST202

Sequence similaritiesi

Belongs to the pentraxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J9V0 Eukaryota
ENOG410YIJN LUCA
HOGENOMiHOG000247043
HOVERGENiHBG005405
InParanoidiP02742
KOiK16143

Family and domain databases

CDDicd00152 PTX, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR030476 Pentaxin_CS
IPR001759 Pentraxin-related
PfamiView protein in Pfam
PF00354 Pentaxin, 1 hit
PRINTSiPR00895 PENTAXIN
SMARTiView protein in SMART
SM00159 PTX, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00289 PTX_1, 1 hit
PS51828 PTX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02742-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKLLWCFLT LVSFSNMSDQ AGMHKKAFVF PKESDNSYVS LNAQLKKPLK
60 70 80 90 100
AFTVCLYFYT DLSMTRGYSI FSYATRRQFN EILLFWSKDI GYSFSVGGDE
110 120 130 140 150
IIFKVSDIPV DPTHLCASWE SSTGIAELWV DGKPMVRKSL KKGYILGPEA
160 170 180 190 200
SIILGQDQDS FGGSFEKQQS LVGDIGNVNM WDYALSPEEI NTIYAGGTFS
210 220
PNVLDWRELT YQVRGEVHVK PQLWP
Length:225
Mass (Da):25,493
Last modified:January 1, 1988 - v1
Checksum:iC6D634FDE844438F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10T → I in AAA31206 (PubMed:3007506).Curated1
Sequence conflicti46K → T AA sequence (PubMed:6754715).Curated1
Sequence conflicti50K → L AA sequence (PubMed:6754715).Curated1
Sequence conflicti76R → K in AAA75404 (PubMed:3026463).Curated1
Sequence conflicti84 – 88LFWSK → FFVKE AA sequence (PubMed:6754715).Curated5
Sequence conflicti91G → V AA sequence (PubMed:6754715).Curated1
Sequence conflicti93 – 101Missing AA sequence (PubMed:6754715).Curated9
Sequence conflicti108I → V in AAA31206 (PubMed:3007506).Curated1
Sequence conflicti167K → W AA sequence (PubMed:6754715).Curated1
Sequence conflicti177N → D AA sequence (PubMed:6754715).Curated1
Sequence conflicti193I → V in AAA31206 (PubMed:3007506).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti62L → K. 1
Natural varianti89D → V. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14538 Genomic DNA Translation: AAA75403.1
L47237 mRNA Translation: AAA75404.1
M13497 mRNA Translation: AAA31206.1
PIRiA25605 CJRB
RefSeqiNP_001075734.1, NM_001082265.1
UniGeneiOcu.1848

Genome annotation databases

GeneIDi100009091
KEGGiocu:100009091

Similar proteinsi

Entry informationi

Entry nameiCRP_RABIT
AccessioniPrimary (citable) accession number: P02742
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 1, 1988
Last modified: May 23, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health