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P02742 (CRP_RABIT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-reactive protein
Gene names
Name:CRP
Synonyms:PTX1
OrganismOryctolagus cuniculus (Rabbit) [Reference proteome]
Taxonomic identifier9986 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus

Protein attributes

Sequence length225 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells By similarity.

Cofactor

Binds 2 calcium ions per subunit By similarity.

Subunit structure

Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits By similarity.

Subcellular location

Secreted.

Tissue specificity

Found in plasma.

Induction

The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli.

Miscellaneous

Asp-61, Arg-76, Arg-77, and Glu-81 may be involved in the calcium-dependent binding of phosphorylcholine, a property that may be important for the biological function of this protein.

Sequence similarities

Belongs to the pentaxin family.

Contains 1 pentaxin domain.

Ontologies

Keywords
   Biological processAcute phase
   Cellular componentSecreted
   DomainSignal
   LigandCalcium
Metal-binding
   PTMDisulfide bond
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processacute-phase response

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Ref.3
Chain21 – 225205C-reactive protein Ref.3
PRO_0000023531

Regions

Domain21 – 225205Pentaxin

Sites

Metal binding801Calcium 1 By similarity
Metal binding1581Calcium 1; via carbonyl oxygen By similarity
Metal binding1591Calcium 1 By similarity
Metal binding1591Calcium 2 By similarity
Metal binding1691Calcium 2 By similarity

Amino acid modifications

Disulfide bond55 ↔ 116 Ref.3

Natural variations

Natural variant621L → K.
Natural variant891D → V.

Experimental info

Sequence conflict101T → I in AAA31206. Ref.2
Sequence conflict461K → T AA sequence Ref.3
Sequence conflict501K → L AA sequence Ref.3
Sequence conflict761R → K in AAA75404. Ref.1
Sequence conflict84 – 885LFWSK → FFVKE AA sequence Ref.3
Sequence conflict911G → V AA sequence Ref.3
Sequence conflict93 – 1019Missing AA sequence Ref.3
Sequence conflict1081I → V in AAA31206. Ref.2
Sequence conflict1671K → W AA sequence Ref.3
Sequence conflict1771N → D AA sequence Ref.3
Sequence conflict1931I → V in AAA31206. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P02742 [UniParc].

Last modified January 1, 1988. Version 1.
Checksum: C6D634FDE844438F

FASTA22525,493
        10         20         30         40         50         60 
MEKLLWCFLT LVSFSNMSDQ AGMHKKAFVF PKESDNSYVS LNAQLKKPLK AFTVCLYFYT 

        70         80         90        100        110        120 
DLSMTRGYSI FSYATRRQFN EILLFWSKDI GYSFSVGGDE IIFKVSDIPV DPTHLCASWE 

       130        140        150        160        170        180 
SSTGIAELWV DGKPMVRKSL KKGYILGPEA SIILGQDQDS FGGSFEKQQS LVGDIGNVNM 

       190        200        210        220 
WDYALSPEEI NTIYAGGTFS PNVLDWRELT YQVRGEVHVK PQLWP 

« Hide

References

[1]"Cloning and characterization of the gene for rabbit C-reactive protein."
Hu S.-I., Miller S.M., Samols D.
Biochemistry 25:7834-7839(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: New Zealand white.
Tissue: Liver.
[2]"Rabbit C-reactive protein. Biosynthesis and characterization of cDNA clones."
Syin C., Gotschlich E.C., Liu T.-Y.
J. Biol. Chem. 261:5473-5479(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Primary structure of rabbit C-reactive protein."
Wang C.-M., Nguyen N.Y., Yonaha K., Robey F., Liu T.-Y.
J. Biol. Chem. 257:13610-13615(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 21-225.
+Additional computationally mapped references.

Web resources

Protein Spotlight

No more Christmas pudding? - Issue 30 of January 2003

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M14538 Genomic DNA. Translation: AAA75403.1.
L47237 mRNA. Translation: AAA75404.1.
M13497 mRNA. Translation: AAA31206.1.
PIRCJRB. A25605.
RefSeqNP_001075734.1. NM_001082265.1.
UniGeneOcu.1848.

3D structure databases

ProteinModelPortalP02742.
SMRP02742. Positions 20-225.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9986.ENSOCUP00000004059.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100009091.

Organism-specific databases

CTD1401.

Phylogenomic databases

eggNOGNOG113288.
HOGENOMHOG000247043.
HOVERGENHBG005405.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001759. Pentaxin.
[Graphical view]
PfamPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSPR00895. PENTAXIN.
SMARTSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS00289. PENTAXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCRP_RABIT
AccessionPrimary (citable) accession number: P02742
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 1, 1988
Last modified: February 19, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries