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P02742

- CRP_RABIT

UniProt

P02742 - CRP_RABIT

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Protein

C-reactive protein

Gene

CRP

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells (By similarity).By similarity

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi80 – 801Calcium 1By similarity
Metal bindingi158 – 1581Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi159 – 1591Calcium 1By similarity
Metal bindingi159 – 1591Calcium 2By similarity
Metal bindingi169 – 1691Calcium 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. acute-phase response Source: UniProtKB-KW
  2. regulation of interleukin-8 secretion Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Acute phase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
C-reactive protein
Gene namesi
Name:CRP
Synonyms:PTX1
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
ProteomesiUP000001811: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 20201 PublicationAdd
BLAST
Chaini21 – 225205C-reactive protein1 PublicationPRO_0000023531Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi55 ↔ 1161 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Found in plasma.

Inductioni

The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli.

Interactioni

Subunit structurei

Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits. Interacts with FCN1; may regulate monocyte activation by FCN1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000004059.

Structurei

3D structure databases

ProteinModelPortaliP02742.
SMRiP02742. Positions 20-225.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 225205PentaxinAdd
BLAST

Sequence similaritiesi

Belongs to the pentaxin family.Curated
Contains 1 pentaxin domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG113288.
HOGENOMiHOG000247043.
HOVERGENiHBG005405.
InParanoidiP02742.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001759. Pentaxin.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00289. PENTAXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02742-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKLLWCFLT LVSFSNMSDQ AGMHKKAFVF PKESDNSYVS LNAQLKKPLK
60 70 80 90 100
AFTVCLYFYT DLSMTRGYSI FSYATRRQFN EILLFWSKDI GYSFSVGGDE
110 120 130 140 150
IIFKVSDIPV DPTHLCASWE SSTGIAELWV DGKPMVRKSL KKGYILGPEA
160 170 180 190 200
SIILGQDQDS FGGSFEKQQS LVGDIGNVNM WDYALSPEEI NTIYAGGTFS
210 220
PNVLDWRELT YQVRGEVHVK PQLWP
Length:225
Mass (Da):25,493
Last modified:January 1, 1988 - v1
Checksum:iC6D634FDE844438F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 101T → I in AAA31206. (PubMed:3007506)Curated
Sequence conflicti46 – 461K → T AA sequence (PubMed:6754715)Curated
Sequence conflicti50 – 501K → L AA sequence (PubMed:6754715)Curated
Sequence conflicti76 – 761R → K in AAA75404. (PubMed:3026463)Curated
Sequence conflicti84 – 885LFWSK → FFVKE AA sequence (PubMed:6754715)Curated
Sequence conflicti91 – 911G → V AA sequence (PubMed:6754715)Curated
Sequence conflicti93 – 1019Missing AA sequence (PubMed:6754715)Curated
Sequence conflicti108 – 1081I → V in AAA31206. (PubMed:3007506)Curated
Sequence conflicti167 – 1671K → W AA sequence (PubMed:6754715)Curated
Sequence conflicti177 – 1771N → D AA sequence (PubMed:6754715)Curated
Sequence conflicti193 – 1931I → V in AAA31206. (PubMed:3007506)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti62 – 621L → K.
Natural varianti89 – 891D → V.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14538 Genomic DNA. Translation: AAA75403.1.
L47237 mRNA. Translation: AAA75404.1.
M13497 mRNA. Translation: AAA31206.1.
PIRiA25605. CJRB.
RefSeqiNP_001075734.1. NM_001082265.1.
UniGeneiOcu.1848.

Genome annotation databases

GeneIDi100009091.

Cross-referencesi

Web resourcesi

Protein Spotlight

No more Christmas pudding? - Issue 30 of January 2003

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14538 Genomic DNA. Translation: AAA75403.1 .
L47237 mRNA. Translation: AAA75404.1 .
M13497 mRNA. Translation: AAA31206.1 .
PIRi A25605. CJRB.
RefSeqi NP_001075734.1. NM_001082265.1.
UniGenei Ocu.1848.

3D structure databases

ProteinModelPortali P02742.
SMRi P02742. Positions 20-225.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9986.ENSOCUP00000004059.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100009091.

Organism-specific databases

CTDi 1401.

Phylogenomic databases

eggNOGi NOG113288.
HOGENOMi HOG000247043.
HOVERGENi HBG005405.
InParanoidi P02742.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR013320. ConA-like_dom.
IPR001759. Pentaxin.
[Graphical view ]
Pfami PF00354. Pentaxin. 1 hit.
[Graphical view ]
PRINTSi PR00895. PENTAXIN.
SMARTi SM00159. PTX. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS00289. PENTAXIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and characterization of the gene for rabbit C-reactive protein."
    Hu S.-I., Miller S.M., Samols D.
    Biochemistry 25:7834-7839(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: New Zealand white.
    Tissue: Liver.
  2. "Rabbit C-reactive protein. Biosynthesis and characterization of cDNA clones."
    Syin C., Gotschlich E.C., Liu T.-Y.
    J. Biol. Chem. 261:5473-5479(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Primary structure of rabbit C-reactive protein."
    Wang C.-M., Nguyen N.Y., Yonaha K., Robey F., Liu T.-Y.
    J. Biol. Chem. 257:13610-13615(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 21-225.

Entry informationi

Entry nameiCRP_RABIT
AccessioniPrimary (citable) accession number: P02742
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 1, 1988
Last modified: November 26, 2014
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Asp-61, Arg-76, Arg-77, and Glu-81 may be involved in the calcium-dependent binding of phosphorylcholine, a property that may be important for the biological function of this protein.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3