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Protein

C-reactive protein

Gene

CRP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

Miscellaneous

This protein owes its name to its ability precipitate pneumococcal C-polysaccharide in the presence of calcium.

Cofactori

Ca2+Note: Binds 2 calcium ions per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi78Calcium 1PROSITE-ProRule annotation1
Metal bindingi79Calcium 1PROSITE-ProRule annotation1
Metal bindingi156Calcium 1PROSITE-ProRule annotation1
Metal bindingi156Calcium 2PROSITE-ProRule annotation1
Metal bindingi157Calcium 1; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi158Calcium 1PROSITE-ProRule annotation1
Metal bindingi158Calcium 2PROSITE-ProRule annotation1
Metal bindingi168Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

  • calcium ion binding Source: BHF-UCL
  • choline binding Source: BHF-UCL
  • complement component C1q binding Source: BHF-UCL
  • low-density lipoprotein particle binding Source: BHF-UCL
  • low-density lipoprotein particle receptor binding Source: AgBase

GO - Biological processi

  • acute-phase response Source: BHF-UCL
  • defense response to Gram-positive bacterium Source: BHF-UCL
  • inflammatory response Source: ProtInc
  • negative regulation of blood vessel diameter Source: AgBase
  • negative regulation of lipid storage Source: BHF-UCL
  • negative regulation of macrophage derived foam cell differentiation Source: BHF-UCL
  • opsonization Source: BHF-UCL
  • positive regulation of gene expression Source: AgBase
  • positive regulation of superoxide anion generation Source: AgBase
  • regulation of interleukin-8 secretion Source: UniProtKB

Keywordsi

Biological processAcute phase
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-173623. Classical antibody-mediated complement activation.
SIGNORiP02741.

Names & Taxonomyi

Protein namesi
Recommended name:
C-reactive protein
Cleaved into the following chain:
Gene namesi
Name:CRP
Synonyms:PTX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:2367. CRP.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular region Source: UniProtKB
  • extracellular space Source: BHF-UCL

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1401.
OpenTargetsiENSG00000132693.
PharmGKBiPA120.

Chemistry databases

DrugBankiDB05744. CRx-139.

Polymorphism and mutation databases

BioMutaiCRP.
DMDMi117486.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
ChainiPRO_000002352619 – 224C-reactive proteinAdd BLAST206
ChainiPRO_000002352719 – 223C-reactive protein(1-205)Add BLAST205

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19Pyrrolidone carboxylic acid1 Publication1
Disulfide bondi54 ↔ 115PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP02741.
PeptideAtlasiP02741.
PRIDEiP02741.

2D gel databases

DOSAC-COBS-2DPAGEiP02741.
SWISS-2DPAGEiP02741.

PTM databases

iPTMnetiP02741.
PhosphoSitePlusiP02741.

Expressioni

Tissue specificityi

Found in plasma.

Inductioni

The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli. It is induced by IL1/interleukin-1 and IL6/interleukin-6.

Gene expression databases

BgeeiENSG00000132693.
CleanExiHS_CRP.
ExpressionAtlasiP02741. baseline and differential.
GenevisibleiP02741. HS.

Organism-specific databases

HPAiCAB005036.
HPA027367.
HPA027396.

Interactioni

Subunit structurei

Homopentamer. Pentraxin (or pentaxin) have a discoid arrangement of 5 non-covalently bound subunits. Interacts with FCN1; may regulate monocyte activation by FCN1.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • complement component C1q binding Source: BHF-UCL
  • low-density lipoprotein particle receptor binding Source: AgBase

Protein-protein interaction databases

BioGridi107791. 50 interactors.
DIPiDIP-39125N.
IntActiP02741. 11 interactors.
MINTiMINT-1206167.
STRINGi9606.ENSP00000255030.

Structurei

Secondary structure

1224
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi25 – 29Combined sources5
Beta strandi37 – 40Combined sources4
Beta strandi48 – 60Combined sources13
Helixi61 – 63Combined sources3
Beta strandi67 – 74Combined sources8
Beta strandi77 – 86Combined sources10
Turni87 – 89Combined sources3
Beta strandi90 – 95Combined sources6
Beta strandi98 – 103Combined sources6
Beta strandi112 – 119Combined sources8
Turni120 – 122Combined sources3
Beta strandi124 – 129Combined sources6
Beta strandi132 – 138Combined sources7
Beta strandi150 – 155Combined sources6
Helixi166 – 168Combined sources3
Beta strandi172 – 182Combined sources11
Helixi186 – 194Combined sources9
Beta strandi201 – 203Combined sources3
Helixi205 – 207Combined sources3
Beta strandi210 – 215Combined sources6
Beta strandi217 – 220Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B09X-ray2.50A/B/C/D/E19-224[»]
1CRVmodel-A/B/C/D/E19-224[»]
1GNHX-ray3.00A/B/C/D/E/F/G/H/I/J19-224[»]
1LJ7X-ray3.15A/B/C/D/E/F/G/H/I/J19-224[»]
3L2YX-ray2.70A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T19-224[»]
3PVNX-ray1.98A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T19-224[»]
3PVOX-ray3.00A/B/C/D/E/F/G/H/I/J/K/L/M/N/O/P/Q/R/S/T19-224[»]
ProteinModelPortaliP02741.
SMRiP02741.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02741.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 224Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST202

Sequence similaritiesi

Belongs to the pentraxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J9V0. Eukaryota.
ENOG410YIJN. LUCA.
GeneTreeiENSGT00760000119128.
HOGENOMiHOG000247043.
HOVERGENiHBG005405.
InParanoidiP02741.
KOiK16143.
OMAiNEILIFW.
OrthoDBiEOG091G0H6X.
PhylomeDBiP02741.
TreeFamiTF330208.

Family and domain databases

CDDicd00152. PTX. 1 hit.
InterProiView protein in InterPro
IPR013320. ConA-like_dom.
IPR030476. Pentaxin_CS.
IPR001759. Pentraxin-related.
PfamiView protein in Pfam
PF00354. Pentaxin. 1 hit.
PRINTSiPR00895. PENTAXIN.
SMARTiView protein in SMART
SM00159. PTX. 1 hit.
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiView protein in PROSITE
PS00289. PTX_1. 1 hit.
PS51828. PTX_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P02741-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEKLLCFLVL TSLSHAFGQT DMSRKAFVFP KESDTSYVSL KAPLTKPLKA
60 70 80 90 100
FTVCLHFYTE LSSTRGYSIF SYATKRQDNE ILIFWSKDIG YSFTVGGSEI
110 120 130 140 150
LFEVPEVTVA PVHICTSWES ASGIVEFWVD GKPRVRKSLK KGYTVGAEAS
160 170 180 190 200
IILGQEQDSF GGNFEGSQSL VGDIGNVNMW DFVLSPDEIN TIYLGGPFSP
210 220
NVLNWRALKY EVQGEVFTKP QLWP
Length:224
Mass (Da):25,039
Last modified:January 1, 1988 - v1
Checksum:i669228636A8544F6
GO
Isoform 2 (identifier: P02741-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     67-199: Missing.

Note: No experimental confirmation available.
Show »
Length:91
Mass (Da):10,415
Checksum:iA5E24599540DAA05
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49K → G AA sequence (PubMed:403526).Curated1
Sequence conflicti52T → G AA sequence (PubMed:403526).Curated1
Sequence conflicti67 – 82YSIFS…DNEIL → TVFSRMPPRDKTMRFF in CAA39671 (Ref. 4) CuratedAdd BLAST16
Sequence conflicti80 – 98Missing AA sequence (PubMed:762075).CuratedAdd BLAST19
Sequence conflicti170L → V in AAA52074 (PubMed:6857266).Curated1

Mass spectrometryi

Molecular mass is 23028 Da from positions 19 - 224. Determined by MALDI. 1 Publication
Molecular mass is 22930 Da from positions 19 - 223. Determined by MALDI. 1 Publication

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00465667 – 199Missing in isoform 2. 1 PublicationAdd BLAST133

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11880 Genomic DNA. Translation: AAB59526.1.
M11725 Genomic DNA. Translation: AAA52075.1.
X56692 mRNA. Translation: CAA40020.1.
X56214 mRNA. Translation: CAA39671.1.
AF442818 Genomic DNA. Translation: AAL48218.2.
AK289443 mRNA. Translation: BAF82132.1.
AF449713 Genomic DNA. Translation: AAL40835.1.
AL445528 Genomic DNA. Translation: CAH73654.1.
AL445528 Genomic DNA. Translation: CAH73656.1.
CH471121 Genomic DNA. Translation: EAW52778.1.
CH471121 Genomic DNA. Translation: EAW52779.1.
CH471121 Genomic DNA. Translation: EAW52780.1.
BC020766 mRNA. Translation: AAH20766.1.
BC125135 mRNA. Translation: AAI25136.1.
M35163 mRNA. Translation: AAA52076.1.
K00518 mRNA. Translation: AAA52074.1.
CCDSiCCDS30911.1. [P02741-1]
PIRiA24515. CJHU.
RefSeqiNP_000558.2. NM_000567.2. [P02741-1]
NP_001315986.1. NM_001329057.1. [P02741-1]
NP_001315987.1. NM_001329058.1. [P02741-2]
UniGeneiHs.709456.
Hs.76452.

Genome annotation databases

EnsembliENST00000255030; ENSP00000255030; ENSG00000132693. [P02741-1]
ENST00000368112; ENSP00000357093; ENSG00000132693. [P02741-2]
GeneIDi1401.
KEGGihsa:1401.
UCSCiuc001ftw.3. human. [P02741-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCRP_HUMAN
AccessioniPrimary (citable) accession number: P02741
Secondary accession number(s): A8K078
, D3DVD9, D3DVE0, Q08AK3, Q8WW75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 1, 1988
Last modified: August 30, 2017
This is version 206 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  5. SIMILARITY comments
    Index of protein domains and families