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P02722

- ADT1_BOVIN

UniProt

P02722 - ADT1_BOVIN

Protein

ADP/ATP translocase 1

Gene

SLC25A4

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei80 – 801Nucleotide

    GO - Molecular functioni

    1. transporter activity Source: InterPro

    GO - Biological processi

    1. apoptotic mitochondrial changes Source: Ensembl
    2. negative regulation of necrotic cell death Source: Ensembl
    3. transmembrane transport Source: InterPro

    Keywords - Biological processi

    Transport

    Enzyme and pathway databases

    ReactomeiREACT_209110. Regulation of insulin secretion.
    REACT_215731. Mitochondrial protein import.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ADP/ATP translocase 1
    Alternative name(s):
    ADP,ATP carrier protein 1
    ADP,ATP carrier protein, heart isoform T1
    Adenine nucleotide translocator 1
    Short name:
    ANT 1
    Solute carrier family 25 member 4
    Gene namesi
    Name:SLC25A4
    Synonyms:ANT1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 27

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 298297ADP/ATP translocase 1PRO_0000090573Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication
    Cross-linki10 – 10Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
    Modified residuei52 – 521N6-methyllysineSequence Analysis
    Modified residuei147 – 1471N6-succinyllysineBy similarity
    Modified residuei160 – 1601S-nitrosocysteineBy similarity
    Modified residuei245 – 2451N6-succinyllysineBy similarity
    Modified residuei272 – 2721N6-succinyllysineBy similarity

    Keywords - PTMi

    Acetylation, Isopeptide bond, Methylation, S-nitrosylation, Ubl conjugation

    Proteomic databases

    PaxDbiP02722.
    PRIDEiP02722.

    Interactioni

    Subunit structurei

    Found in a complex with ARL2, ARL2BP and SLC25A4. Interacts with ARL2BP By similarity. Homodimer.By similarity1 Publication

    Protein-protein interaction databases

    IntActiP02722. 1 interaction.
    STRINGi9913.ENSBTAP00000017580.

    Structurei

    Secondary structure

    1
    298
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi5 – 2521
    Helixi27 – 3812
    Helixi39 – 413
    Helixi47 – 493
    Helixi54 – 6512
    Helixi67 – 715
    Turni72 – 743
    Helixi75 – 10026
    Turni105 – 1073
    Helixi109 – 14335
    Turni149 – 1513
    Helixi157 – 16812
    Helixi170 – 1734
    Turni174 – 1763
    Helixi177 – 20024
    Helixi204 – 2063
    Helixi210 – 23930
    Turni240 – 2434
    Helixi246 – 2483
    Helixi254 – 26512
    Helixi267 – 2715
    Helixi274 – 29219

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1OKCX-ray2.20A2-298[»]
    1YM6model-A1-298[»]
    1YMJmodel-A1-298[»]
    2C3EX-ray2.80A2-298[»]
    ProteinModelPortaliP02722.
    SMRiP02722. Positions 2-294.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP02722.

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei4 – 3734Helical; Name=1Add
    BLAST
    Transmembranei73 – 9927Helical; Name=2Add
    BLAST
    Transmembranei108 – 14235Helical; Name=3Add
    BLAST
    Transmembranei176 – 19924Helical; Name=4Add
    BLAST
    Transmembranei209 – 23830Helical; Name=5Add
    BLAST
    Transmembranei273 – 29018Helical; Name=6Add
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati6 – 9893Solcar 1Add
    BLAST
    Repeati111 – 20191Solcar 2Add
    BLAST
    Repeati212 – 29786Solcar 3Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi235 – 2406Substrate recognition

    Sequence similaritiesi

    Contains 3 Solcar repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG238123.
    GeneTreeiENSGT00390000011543.
    HOGENOMiHOG000165727.
    HOVERGENiHBG108348.
    InParanoidiP02722.
    KOiK05863.
    OMAiTAETQYK.
    OrthoDBiEOG7T1RBR.
    TreeFamiTF300743.

    Family and domain databases

    Gene3Di1.50.40.10. 1 hit.
    InterProiIPR002113. Aden_trnslctor.
    IPR002067. Mit_carrier.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view]
    PfamiPF00153. Mito_carr. 3 hits.
    [Graphical view]
    PRINTSiPR00927. ADPTRNSLCASE.
    PR00926. MITOCARRIER.
    SUPFAMiSSF103506. SSF103506. 1 hit.
    PROSITEiPS50920. SOLCAR. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P02722-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDQALSFLK DFLAGGVAAA ISKTAVAPIE RVKLLLQVQH ASKQISAEKQ    50
    YKGIIDCVVR IPKEQGFLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL 100
    GGVDRHKQFW RYFAGNLASG GAAGATSLCF VYPLDFARTR LAADVGKGAA 150
    QREFTGLGNC ITKIFKSDGL RGLYQGFNVS VQGIIIYRAA YFGVYDTAKG 200
    MLPDPKNVHI IVSWMIAQTV TAVAGLVSYP FDTVRRRMMM QSGRKGADIM 250
    YTGTVDCWRK IAKDEGPKAF FKGAWSNVLR GMGGAFVLVL YDEIKKFV 298
    Length:298
    Mass (Da):32,967
    Last modified:January 23, 2007 - v3
    Checksum:iAAE851F8406479C2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M13783 mRNA. Translation: AAA30363.1.
    M24102 mRNA. Translation: AAA30768.1.
    PIRiA43646. XWBO.
    RefSeqiNP_777083.1. NM_174658.2.
    UniGeneiBt.49723.

    Genome annotation databases

    EnsembliENSBTAT00000017580; ENSBTAP00000017580; ENSBTAG00000013208.
    GeneIDi282478.
    KEGGibta:282478.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M13783 mRNA. Translation: AAA30363.1 .
    M24102 mRNA. Translation: AAA30768.1 .
    PIRi A43646. XWBO.
    RefSeqi NP_777083.1. NM_174658.2.
    UniGenei Bt.49723.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1OKC X-ray 2.20 A 2-298 [» ]
    1YM6 model - A 1-298 [» ]
    1YMJ model - A 1-298 [» ]
    2C3E X-ray 2.80 A 2-298 [» ]
    ProteinModelPortali P02722.
    SMRi P02722. Positions 2-294.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P02722. 1 interaction.
    STRINGi 9913.ENSBTAP00000017580.

    Proteomic databases

    PaxDbi P02722.
    PRIDEi P02722.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000017580 ; ENSBTAP00000017580 ; ENSBTAG00000013208 .
    GeneIDi 282478.
    KEGGi bta:282478.

    Organism-specific databases

    CTDi 291.

    Phylogenomic databases

    eggNOGi NOG238123.
    GeneTreei ENSGT00390000011543.
    HOGENOMi HOG000165727.
    HOVERGENi HBG108348.
    InParanoidi P02722.
    KOi K05863.
    OMAi TAETQYK.
    OrthoDBi EOG7T1RBR.
    TreeFami TF300743.

    Enzyme and pathway databases

    Reactomei REACT_209110. Regulation of insulin secretion.
    REACT_215731. Mitochondrial protein import.

    Miscellaneous databases

    EvolutionaryTracei P02722.
    NextBioi 20806242.

    Family and domain databases

    Gene3Di 1.50.40.10. 1 hit.
    InterProi IPR002113. Aden_trnslctor.
    IPR002067. Mit_carrier.
    IPR018108. Mitochondrial_sb/sol_carrier.
    IPR023395. Mt_carrier_dom.
    [Graphical view ]
    Pfami PF00153. Mito_carr. 3 hits.
    [Graphical view ]
    PRINTSi PR00927. ADPTRNSLCASE.
    PR00926. MITOCARRIER.
    SUPFAMi SSF103506. SSF103506. 1 hit.
    PROSITEi PS50920. SOLCAR. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Two bovine genes for mitochondrial ADP/ATP translocase expressed differences in various tissues."
      Powell S.J., Medd S.M., Runswick M.J., Walker J.E.
      Biochemistry 28:866-873(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete amino acid sequence of the ADP/ATP carrier from beef heart mitochondria."
      Aquila H., Misra D., Eulitz M., Klingenberg M.
      Hoppe-Seyler's Z. Physiol. Chem. 363:345-349(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-298, ACETYLATION AT SER-2.
    3. "Bovine cardiac mitochondrial ADP/ATP-carrier: two distinct mRNAs and an unusually short 3'-noncoding sequence."
      Rasmussen U.B., Wohlrab H.
      Biochem. Biophys. Res. Commun. 138:850-857(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 208-298.
    4. "Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside."
      Pebay-Peyroula E., Dahout-Gonzalez C., Kahn R., Trezeguet V., Lauquin G.J.-M., Brandolin G.
      Nature 426:39-44(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) IN COMPLEX WITH INHIBITOR.

    Entry informationi

    Entry nameiADT1_BOVIN
    AccessioniPrimary (citable) accession number: P02722
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 125 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3