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Protein

ADP/ATP translocase 1

Gene

SLC25A4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei80Nucleotide1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-BTA-422356. Regulation of insulin secretion.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP/ATP translocase 1
Alternative name(s):
ADP,ATP carrier protein 1
ADP,ATP carrier protein, heart isoform T1
Adenine nucleotide translocator 1
Short name:
ANT 1
Solute carrier family 25 member 4
Gene namesi
Name:SLC25A4
Synonyms:ANT1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 27

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 37Helical; Name=1Add BLAST34
Transmembranei73 – 99Helical; Name=2Add BLAST27
Transmembranei108 – 142Helical; Name=3Add BLAST35
Transmembranei176 – 199Helical; Name=4Add BLAST24
Transmembranei209 – 238Helical; Name=5Add BLAST30
Transmembranei273 – 290Helical; Name=6Add BLAST18

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000905732 – 298ADP/ATP translocase 1Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei52N6-methyllysineSequence analysis1
Modified residuei147N6-succinyllysineBy similarity1
Modified residuei160S-nitrosocysteineBy similarity1
Modified residuei245N6-succinyllysineBy similarity1
Modified residuei272N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Methylation, S-nitrosylation

Proteomic databases

PaxDbiP02722.
PeptideAtlasiP02722.
PRIDEiP02722.

Expressioni

Gene expression databases

BgeeiENSBTAG00000013208.

Interactioni

Subunit structurei

Found in a complex with ARL2, ARL2BP and SLC25A4. Interacts with ARL2BP (By similarity). Homodimer.By similarity1 Publication

Protein-protein interaction databases

IntActiP02722. 1 interactor.
STRINGi9913.ENSBTAP00000017580.

Structurei

Secondary structure

1298
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 25Combined sources21
Helixi27 – 38Combined sources12
Helixi39 – 41Combined sources3
Helixi47 – 49Combined sources3
Helixi54 – 65Combined sources12
Helixi67 – 71Combined sources5
Turni72 – 74Combined sources3
Helixi75 – 100Combined sources26
Turni105 – 107Combined sources3
Helixi109 – 143Combined sources35
Turni149 – 151Combined sources3
Helixi157 – 168Combined sources12
Helixi170 – 173Combined sources4
Turni174 – 176Combined sources3
Helixi177 – 200Combined sources24
Helixi204 – 206Combined sources3
Helixi210 – 239Combined sources30
Turni240 – 243Combined sources4
Helixi246 – 248Combined sources3
Helixi254 – 265Combined sources12
Helixi267 – 271Combined sources5
Helixi274 – 292Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OKCX-ray2.20A2-298[»]
1YM6model-A1-298[»]
1YMJmodel-A1-298[»]
2C3EX-ray2.80A2-298[»]
ProteinModelPortaliP02722.
SMRiP02722.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02722.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 98Solcar 1Add BLAST93
Repeati111 – 201Solcar 2Add BLAST91
Repeati212 – 297Solcar 3Add BLAST86

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi235 – 240Substrate recognition6

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0749. Eukaryota.
ENOG410XNW0. LUCA.
GeneTreeiENSGT00390000011543.
HOGENOMiHOG000165727.
HOVERGENiHBG108348.
InParanoidiP02722.
KOiK05863.
OMAiGSSQREF.
OrthoDBiEOG091G0ULB.
TreeFamiTF300743.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02722-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDQALSFLK DFLAGGVAAA ISKTAVAPIE RVKLLLQVQH ASKQISAEKQ
60 70 80 90 100
YKGIIDCVVR IPKEQGFLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL
110 120 130 140 150
GGVDRHKQFW RYFAGNLASG GAAGATSLCF VYPLDFARTR LAADVGKGAA
160 170 180 190 200
QREFTGLGNC ITKIFKSDGL RGLYQGFNVS VQGIIIYRAA YFGVYDTAKG
210 220 230 240 250
MLPDPKNVHI IVSWMIAQTV TAVAGLVSYP FDTVRRRMMM QSGRKGADIM
260 270 280 290
YTGTVDCWRK IAKDEGPKAF FKGAWSNVLR GMGGAFVLVL YDEIKKFV
Length:298
Mass (Da):32,967
Last modified:January 23, 2007 - v3
Checksum:iAAE851F8406479C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13783 mRNA. Translation: AAA30363.1.
M24102 mRNA. Translation: AAA30768.1.
PIRiA43646. XWBO.
RefSeqiNP_777083.1. NM_174658.2.
UniGeneiBt.49723.

Genome annotation databases

EnsembliENSBTAT00000017580; ENSBTAP00000017580; ENSBTAG00000013208.
GeneIDi282478.
KEGGibta:282478.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13783 mRNA. Translation: AAA30363.1.
M24102 mRNA. Translation: AAA30768.1.
PIRiA43646. XWBO.
RefSeqiNP_777083.1. NM_174658.2.
UniGeneiBt.49723.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OKCX-ray2.20A2-298[»]
1YM6model-A1-298[»]
1YMJmodel-A1-298[»]
2C3EX-ray2.80A2-298[»]
ProteinModelPortaliP02722.
SMRiP02722.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP02722. 1 interactor.
STRINGi9913.ENSBTAP00000017580.

Proteomic databases

PaxDbiP02722.
PeptideAtlasiP02722.
PRIDEiP02722.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000017580; ENSBTAP00000017580; ENSBTAG00000013208.
GeneIDi282478.
KEGGibta:282478.

Organism-specific databases

CTDi291.

Phylogenomic databases

eggNOGiKOG0749. Eukaryota.
ENOG410XNW0. LUCA.
GeneTreeiENSGT00390000011543.
HOGENOMiHOG000165727.
HOVERGENiHBG108348.
InParanoidiP02722.
KOiK05863.
OMAiGSSQREF.
OrthoDBiEOG091G0ULB.
TreeFamiTF300743.

Enzyme and pathway databases

ReactomeiR-BTA-422356. Regulation of insulin secretion.

Miscellaneous databases

EvolutionaryTraceiP02722.

Gene expression databases

BgeeiENSBTAG00000013208.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADT1_BOVIN
AccessioniPrimary (citable) accession number: P02722
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 143 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.