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P02722 (ADT1_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
ADP/ATP translocase 1
Alternative name(s):
ADP,ATP carrier protein 1
ADP,ATP carrier protein, heart isoform T1
Adenine nucleotide translocator 1
Short name=ANT 1
Solute carrier family 25 member 4
Gene names
Name:SLC25A4
Synonyms:ANT1
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length298 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane.

Subunit structure

Found in a complex with ARL2, ARL2BP and SLC25A4. Interacts with ARL2BP By similarity. Homodimer.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Miscellaneous

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.

Sequence similarities

Belongs to the mitochondrial carrier (TC 2.A.29) family. [View classification]

Contains 3 Solcar repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2
Chain2 – 298297ADP/ATP translocase 1
PRO_0000090573

Regions

Transmembrane5 – 3935Helical; Name=1
Transmembrane75 – 10026Helical; Name=2
Transmembrane109 – 14335Helical; Name=3
Transmembrane176 – 20227Helical; Name=4
Transmembrane207 – 24135Helical; Name=5
Transmembrane273 – 29826Helical; Name=6
Repeat6 – 9893Solcar 1
Repeat111 – 20191Solcar 2
Repeat212 – 29786Solcar 3
Motif235 – 2406Substrate recognition

Sites

Binding site801Nucleotide

Amino acid modifications

Modified residue21N-acetylserine Ref.2
Modified residue521N6-methyllysine Potential
Modified residue961N6-acetyllysine By similarity
Modified residue1261Phosphothreonine By similarity
Modified residue1271Phosphoserine By similarity
Modified residue1911Phosphotyrosine By similarity
Modified residue1951Phosphotyrosine By similarity
Cross-link10Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity

Secondary structure

1 ....................................... 298
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P02722 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: AAE851F8406479C2

FASTA29832,967
        10         20         30         40         50         60 
MSDQALSFLK DFLAGGVAAA ISKTAVAPIE RVKLLLQVQH ASKQISAEKQ YKGIIDCVVR 

        70         80         90        100        110        120 
IPKEQGFLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL GGVDRHKQFW RYFAGNLASG 

       130        140        150        160        170        180 
GAAGATSLCF VYPLDFARTR LAADVGKGAA QREFTGLGNC ITKIFKSDGL RGLYQGFNVS 

       190        200        210        220        230        240 
VQGIIIYRAA YFGVYDTAKG MLPDPKNVHI IVSWMIAQTV TAVAGLVSYP FDTVRRRMMM 

       250        260        270        280        290 
QSGRKGADIM YTGTVDCWRK IAKDEGPKAF FKGAWSNVLR GMGGAFVLVL YDEIKKFV

« Hide

References

[1]"Two bovine genes for mitochondrial ADP/ATP translocase expressed differences in various tissues."
Powell S.J., Medd S.M., Runswick M.J., Walker J.E.
Biochemistry 28:866-873(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Complete amino acid sequence of the ADP/ATP carrier from beef heart mitochondria."
Aquila H., Misra D., Eulitz M., Klingenberg M.
Hoppe-Seyler's Z. Physiol. Chem. 363:345-349(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-298, ACETYLATION AT SER-2.
[3]"Bovine cardiac mitochondrial ADP/ATP-carrier: two distinct mRNAs and an unusually short 3'-noncoding sequence."
Rasmussen U.B., Wohlrab H.
Biochem. Biophys. Res. Commun. 138:850-857(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 208-298.
[4]"Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside."
Pebay-Peyroula E., Dahout-Gonzalez C., Kahn R., Trezeguet V., Lauquin G.J.-M., Brandolin G.
Nature 426:39-44(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) IN COMPLEX WITH INHIBITOR.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M13783 mRNA. Translation: AAA30363.1.
M24102 mRNA. Translation: AAA30768.1.
IPIIPI00706314.
PIRXWBO. A43646.
RefSeqNP_777083.1. NM_174658.2.
UniGeneBt.49723.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1OKCX-ray2.20A2-298[»]
1YM6model-A1-298[»]
1YMJmodel-A1-298[»]
2C3EX-ray2.80A2-298[»]
ProteinModelPortalP02722.
SMRP02722. Positions 2-294.
ModBaseSearch...

Protein-protein interaction databases

IntActP02722. 1 interaction.
STRING9913.ENSBTAP00000017580.

Proteomic databases

PaxDbP02722.
PRIDEP02722.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSBTAT00000017580; ENSBTAP00000017580; ENSBTAG00000013208.
GeneID282478.
KEGGbta:282478.

Organism-specific databases

CTD291.

Phylogenomic databases

eggNOGNOG238123.
GeneTreeENSGT00390000011543.
HOGENOMHOG000165727.
HOVERGENHBG108348.
InParanoidP02722.
KOK05863.
OMAAKDEGSK.
OrthoDBEOG49CQ86.

Enzyme and pathway databases

BioCycCATTLE:282478-MONOMER.

Family and domain databases

Gene3D1.50.40.10. 1 hit.
InterProIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMSSF103506. Mitoch_carrier. 1 hit.
PROSITEPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP02722.
NextBio20806242.

Entry information

Entry nameADT1_BOVIN
AccessionPrimary (citable) accession number: P02722
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: May 29, 2013
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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