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P02722

- ADT1_BOVIN

UniProt

P02722 - ADT1_BOVIN

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Protein
ADP/ATP translocase 1
Gene
SLC25A4, ANT1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei80 – 801Nucleotide

GO - Molecular functioni

  1. transporter activity Source: InterPro

GO - Biological processi

  1. apoptotic mitochondrial changes Source: Ensembl
  2. negative regulation of necrotic cell death Source: Ensembl
  3. transmembrane transport Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiREACT_209110. Regulation of insulin secretion.
REACT_215731. Mitochondrial protein import.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP/ATP translocase 1
Alternative name(s):
ADP,ATP carrier protein 1
ADP,ATP carrier protein, heart isoform T1
Adenine nucleotide translocator 1
Short name:
ANT 1
Solute carrier family 25 member 4
Gene namesi
Name:SLC25A4
Synonyms:ANT1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 27

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 3734Helical; Name=1
Add
BLAST
Transmembranei73 – 9927Helical; Name=2
Add
BLAST
Transmembranei108 – 14235Helical; Name=3
Add
BLAST
Transmembranei176 – 19924Helical; Name=4
Add
BLAST
Transmembranei209 – 23830Helical; Name=5
Add
BLAST
Transmembranei273 – 29018Helical; Name=6
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 298297ADP/ATP translocase 1
PRO_0000090573Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Cross-linki10 – 10Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) By similarity
Modified residuei52 – 521N6-methyllysine Reviewed prediction
Modified residuei147 – 1471N6-succinyllysine By similarity
Modified residuei160 – 1601S-nitrosocysteine By similarity
Modified residuei245 – 2451N6-succinyllysine By similarity
Modified residuei272 – 2721N6-succinyllysine By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, S-nitrosylation, Ubl conjugation

Proteomic databases

PaxDbiP02722.
PRIDEiP02722.

Interactioni

Subunit structurei

Found in a complex with ARL2, ARL2BP and SLC25A4. Interacts with ARL2BP By similarity. Homodimer.

Protein-protein interaction databases

IntActiP02722. 1 interaction.
STRINGi9913.ENSBTAP00000017580.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 2521
Helixi27 – 3812
Helixi39 – 413
Helixi47 – 493
Helixi54 – 6512
Helixi67 – 715
Turni72 – 743
Helixi75 – 10026
Turni105 – 1073
Helixi109 – 14335
Turni149 – 1513
Helixi157 – 16812
Helixi170 – 1734
Turni174 – 1763
Helixi177 – 20024
Helixi204 – 2063
Helixi210 – 23930
Turni240 – 2434
Helixi246 – 2483
Helixi254 – 26512
Helixi267 – 2715
Helixi274 – 29219

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OKCX-ray2.20A2-298[»]
1YM6model-A1-298[»]
1YMJmodel-A1-298[»]
2C3EX-ray2.80A2-298[»]
ProteinModelPortaliP02722.
SMRiP02722. Positions 2-294.

Miscellaneous databases

EvolutionaryTraceiP02722.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati6 – 9893Solcar 1
Add
BLAST
Repeati111 – 20191Solcar 2
Add
BLAST
Repeati212 – 29786Solcar 3
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi235 – 2406Substrate recognition

Sequence similaritiesi

Contains 3 Solcar repeats.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG238123.
GeneTreeiENSGT00390000011543.
HOGENOMiHOG000165727.
HOVERGENiHBG108348.
InParanoidiP02722.
KOiK05863.
OMAiTAETQYK.
OrthoDBiEOG7T1RBR.
TreeFamiTF300743.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02722-1 [UniParc]FASTAAdd to Basket

« Hide

MSDQALSFLK DFLAGGVAAA ISKTAVAPIE RVKLLLQVQH ASKQISAEKQ    50
YKGIIDCVVR IPKEQGFLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL 100
GGVDRHKQFW RYFAGNLASG GAAGATSLCF VYPLDFARTR LAADVGKGAA 150
QREFTGLGNC ITKIFKSDGL RGLYQGFNVS VQGIIIYRAA YFGVYDTAKG 200
MLPDPKNVHI IVSWMIAQTV TAVAGLVSYP FDTVRRRMMM QSGRKGADIM 250
YTGTVDCWRK IAKDEGPKAF FKGAWSNVLR GMGGAFVLVL YDEIKKFV 298
Length:298
Mass (Da):32,967
Last modified:January 23, 2007 - v3
Checksum:iAAE851F8406479C2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M13783 mRNA. Translation: AAA30363.1.
M24102 mRNA. Translation: AAA30768.1.
PIRiA43646. XWBO.
RefSeqiNP_777083.1. NM_174658.2.
UniGeneiBt.49723.

Genome annotation databases

EnsembliENSBTAT00000017580; ENSBTAP00000017580; ENSBTAG00000013208.
GeneIDi282478.
KEGGibta:282478.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M13783 mRNA. Translation: AAA30363.1 .
M24102 mRNA. Translation: AAA30768.1 .
PIRi A43646. XWBO.
RefSeqi NP_777083.1. NM_174658.2.
UniGenei Bt.49723.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1OKC X-ray 2.20 A 2-298 [» ]
1YM6 model - A 1-298 [» ]
1YMJ model - A 1-298 [» ]
2C3E X-ray 2.80 A 2-298 [» ]
ProteinModelPortali P02722.
SMRi P02722. Positions 2-294.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P02722. 1 interaction.
STRINGi 9913.ENSBTAP00000017580.

Proteomic databases

PaxDbi P02722.
PRIDEi P02722.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000017580 ; ENSBTAP00000017580 ; ENSBTAG00000013208 .
GeneIDi 282478.
KEGGi bta:282478.

Organism-specific databases

CTDi 291.

Phylogenomic databases

eggNOGi NOG238123.
GeneTreei ENSGT00390000011543.
HOGENOMi HOG000165727.
HOVERGENi HBG108348.
InParanoidi P02722.
KOi K05863.
OMAi TAETQYK.
OrthoDBi EOG7T1RBR.
TreeFami TF300743.

Enzyme and pathway databases

Reactomei REACT_209110. Regulation of insulin secretion.
REACT_215731. Mitochondrial protein import.

Miscellaneous databases

EvolutionaryTracei P02722.
NextBioi 20806242.

Family and domain databases

Gene3Di 1.50.40.10. 1 hit.
InterProi IPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view ]
Pfami PF00153. Mito_carr. 3 hits.
[Graphical view ]
PRINTSi PR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMi SSF103506. SSF103506. 1 hit.
PROSITEi PS50920. SOLCAR. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Two bovine genes for mitochondrial ADP/ATP translocase expressed differences in various tissues."
    Powell S.J., Medd S.M., Runswick M.J., Walker J.E.
    Biochemistry 28:866-873(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete amino acid sequence of the ADP/ATP carrier from beef heart mitochondria."
    Aquila H., Misra D., Eulitz M., Klingenberg M.
    Hoppe-Seyler's Z. Physiol. Chem. 363:345-349(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-298, ACETYLATION AT SER-2.
  3. "Bovine cardiac mitochondrial ADP/ATP-carrier: two distinct mRNAs and an unusually short 3'-noncoding sequence."
    Rasmussen U.B., Wohlrab H.
    Biochem. Biophys. Res. Commun. 138:850-857(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 208-298.
  4. "Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside."
    Pebay-Peyroula E., Dahout-Gonzalez C., Kahn R., Trezeguet V., Lauquin G.J.-M., Brandolin G.
    Nature 426:39-44(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) IN COMPLEX WITH INHIBITOR.

Entry informationi

Entry nameiADT1_BOVIN
AccessioniPrimary (citable) accession number: P02722
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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