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Protein

Phosphatidylcholine transfer protein

Gene

PCTP

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of phosphatidylcholine between membranes. Binds phosphatidylcholine in a tight 1:1 stoichiometric complex.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei72 – 721PhosphatidylcholineBy similarity
Binding sitei78 – 781PhosphatidylcholineBy similarity
Binding sitei157 – 1571PhosphatidylcholineBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylcholine transfer protein
Short name:
PC-TP
Alternative name(s):
START domain-containing protein 2
Short name:
StARD2
StAR-related lipid transfer protein 2
Gene namesi
Name:PCTP
Synonyms:STARD2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi55 – 551K → I: Loss of activity. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213Phosphatidylcholine transfer proteinPRO_0000220657Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP02720.
PRIDEiP02720.

Interactioni

Subunit structurei

Interacts with ACOT13/THEM2.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024898.

Structurei

3D structure databases

ProteinModelPortaliP02720.
SMRiP02720. Positions 8-210.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 212212STARTPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni171 – 1766Part of the binding site for phosphatidylcholine

Sequence similaritiesi

Contains 1 START domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IPC9. Eukaryota.
ENOG4111CP6. LUCA.
GeneTreeiENSGT00530000063520.
HOGENOMiHOG000261644.
HOVERGENiHBG008237.
InParanoidiP02720.
OMAiCADVYMD.
OrthoDBiEOG70KGQK.
TreeFamiTF320705.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PfamiPF01852. START. 1 hit.
[Graphical view]
SMARTiSM00234. START. 1 hit.
[Graphical view]
PROSITEiPS50848. START. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P02720-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPGAGAFSE EQFREACAEL QRPALSGAAW ELLVETQGIS VYRLLDQQTG
60 70 80 90 100
LYAYKVFGVL EDCLPDLLAD VYMDLAYRKQ WDQYVKELYE KECSGETVVY
110 120 130 140 150
WQVKYPFPMS NRDYVYVRQR QELDFEGQKV HVILAQSTSE PQFPEKSGVI
160 170 180 190 200
RVKHYKQRLA IQSDGKRGSK VFMYYFDNPG GQIPSWVINW AAKNGVPNFL
210
KDMVKACQNY KKT
Length:213
Mass (Da):24,643
Last modified:July 21, 1986 - v1
Checksum:i3BDEE6E54567EF10
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti167 – 1671R → K in CAA90330 (PubMed:8645232).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21660 mRNA. Translation: AAA87003.1.
Z50026 mRNA. Translation: CAA90330.1.
BC116120 mRNA. Translation: AAI16121.1.
PIRiA91092. EPBO.
RefSeqiNP_777260.1. NM_174835.2.
UniGeneiBt.4718.

Genome annotation databases

EnsembliENSBTAT00000024898; ENSBTAP00000024898; ENSBTAG00000018706.
GeneIDi317656.
KEGGibta:317656.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U21660 mRNA. Translation: AAA87003.1.
Z50026 mRNA. Translation: CAA90330.1.
BC116120 mRNA. Translation: AAI16121.1.
PIRiA91092. EPBO.
RefSeqiNP_777260.1. NM_174835.2.
UniGeneiBt.4718.

3D structure databases

ProteinModelPortaliP02720.
SMRiP02720. Positions 8-210.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000024898.

Proteomic databases

PaxDbiP02720.
PRIDEiP02720.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000024898; ENSBTAP00000024898; ENSBTAG00000018706.
GeneIDi317656.
KEGGibta:317656.

Organism-specific databases

CTDi58488.

Phylogenomic databases

eggNOGiENOG410IPC9. Eukaryota.
ENOG4111CP6. LUCA.
GeneTreeiENSGT00530000063520.
HOGENOMiHOG000261644.
HOVERGENiHBG008237.
InParanoidiP02720.
OMAiCADVYMD.
OrthoDBiEOG70KGQK.
TreeFamiTF320705.

Miscellaneous databases

NextBioi20807132.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PfamiPF01852. START. 1 hit.
[Graphical view]
SMARTiSM00234. START. 1 hit.
[Graphical view]
PROSITEiPS50848. START. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a cDNA encoding the specific phosphatidylcholine transfer protein from bovine liver."
    Cohen D.E., Green R.M.
    Gene 163:327-328(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  2. "cDNA cloning and tissue-specific expression of the phosphatidylcholine transfer protein gene."
    Geijtenbeek T.B.H., Smith A.J., Borst P., Wirtz K.W.A.
    Biochem. J. 316:49-55(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Ascending colon.
  4. "The primary structure of the phosphatidylcholine-exchange protein from bovine liver. Isolation and characterization of the staphylococcal protease peptides and the amino-acid sequence of the N-terminal half (residues 1-122)."
    Moonen P., Akeroyd R., Westerman J., Puyk W.C., Smits P., Wirtz K.W.A.
    Eur. J. Biochem. 106:279-290(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-122.
  5. "The complete primary structure of the phosphatidylcholine-transfer protein from bovine liver. Isolation and characterization of the cyanogen bromide peptides."
    Akeroyd R., Moonen P., Westerman J., Puyk W.C., Wirtz K.W.A.
    Eur. J. Biochem. 114:385-391(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 110-213.
  6. "Determination of the hydrophobic binding site of phosphatidylcholine exchange protein with photosensitive phosphatidylcholine."
    Moonen P., Haagsman H.P., van Deenen L.L.M., Wirtz K.W.A.
    Eur. J. Biochem. 99:439-445(1979) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 146-183.
  7. "The binding of phosphatidylcholine to the phosphatidylcholine transfer protein: affinity and role in folding."
    de Brouwer A.P., Bouma B., van Tiel C.M., Heerma W., Brouwers J.F., Bevers L.E., Westerman J., Roelofsen B., Wirtz K.W.
    Chem. Phys. Lipids 112:109-119(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: MUTAGENESIS OF LYS-55.

Entry informationi

Entry nameiPPCT_BOVIN
AccessioniPrimary (citable) accession number: P02720
Secondary accession number(s): Q1LZA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 11, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.