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Protein

Acetylcholine receptor subunit alpha

Gene

CHRNA1

Organism
Tetronarce californica (Pacific electric ray) (Torpedo californica)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylcholine receptor subunit alpha
Gene namesi
Name:CHRNA1
OrganismiTetronarce californica (Pacific electric ray) (Torpedo californica)
Taxonomic identifieri7787 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataChondrichthyesElasmobranchiiBatoideaTorpediniformesTorpedinidaeTetronarce

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 234210ExtracellularAdd
BLAST
Transmembranei235 – 25925HelicalAdd
BLAST
Transmembranei267 – 28519HelicalAdd
BLAST
Transmembranei301 – 32020HelicalAdd
BLAST
Topological domaini321 – 432112CytoplasmicAdd
BLAST
Transmembranei433 – 45119HelicalAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL2096975.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24241 PublicationAdd
BLAST
Chaini25 – 461437Acetylcholine receptor subunit alphaPRO_0000000310Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi152 ↔ 166
Glycosylationi165 – 1651N-linked (GlcNAc...)2 Publications
Disulfide bondi216 ↔ 217Associated with receptor activation

Keywords - PTMi

Disulfide bond, Glycoprotein

PTM databases

SwissPalmiP02710.
UniCarbKBiP02710.

Interactioni

Subunit structurei

Pentamer of two alpha chains, and one each of the beta, delta, and gamma chains.

Protein-protein interaction databases

IntActiP02710. 3 interactions.

Chemistry

BindingDBiP02710.

Structurei

Secondary structure

1
461
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni93 – 997Combined sources
Beta strandi214 – 2185Combined sources
Beta strandi262 – 2643Combined sources
Helixi265 – 28723Combined sources
Turni288 – 2903Combined sources
Helixi304 – 3063Combined sources
Helixi307 – 32317Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ABTNMR-B209-220[»]
1DXZNMR-A260-291[»]
1IDGNMR-B205-222[»]
1IDHNMR-B205-222[»]
1LK1model-A/E26-235[»]
1LXGNMR-B205-222[»]
1LXHNMR-B205-222[»]
1OLKmodel-A/C27-235[»]
1TORNMR-A91-100[»]
1TOSNMR-A91-99[»]
3MRANMR-A301-325[»]
ProteinModelPortaliP02710.
SMRiP02710. Positions 25-339, 427-461.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02710.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG003756.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 2 hits.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02710-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILCSYWHVG LVLLLFSCCG LVLGSEHETR LVANLLENYN KVIRPVEHHT
60 70 80 90 100
HFVDITVGLQ LIQLISVDEV NQIVETNVRL RQQWIDVRLR WNPADYGGIK
110 120 130 140 150
KIRLPSDDVW LPDLVLYNNA DGDFAIVHMT KLLLDYTGKI MWTPPAIFKS
160 170 180 190 200
YCEIIVTHFP FDQQNCTMKL GIWTYDGTKV SISPESDRPD LSTFMESGEW
210 220 230 240 250
VMKDYRGWKH WVYYTCCPDT PYLDITYHFI MQRIPLYFVV NVIIPCLLFS
260 270 280 290 300
FLTGLVFYLP TDSGEKMTLS ISVLLSLTVF LLVIVELIPS TSSAVPLIGK
310 320 330 340 350
YMLFTMIFVI SSIIITVVVI NTHHRSPSTH TMPQWVRKIF IDTIPNVMFF
360 370 380 390 400
STMKRASKEK QENKIFADDI DISDISGKQV TGEVIFQTPL IKNPDVKSAI
410 420 430 440 450
EGVKYIAEHM KSDEESSNAA EEWKYVAMVI DHILLCVFML ICIIGTVSVF
460
AGRLIELSQE G
Length:461
Mass (Da):52,741
Last modified:July 21, 1986 - v1
Checksum:i398C86C9309AF0D8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00963 mRNA. Translation: AAA96705.1.
PIRiA03170. ACRYA1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00963 mRNA. Translation: AAA96705.1.
PIRiA03170. ACRYA1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ABTNMR-B209-220[»]
1DXZNMR-A260-291[»]
1IDGNMR-B205-222[»]
1IDHNMR-B205-222[»]
1LK1model-A/E26-235[»]
1LXGNMR-B205-222[»]
1LXHNMR-B205-222[»]
1OLKmodel-A/C27-235[»]
1TORNMR-A91-100[»]
1TOSNMR-A91-99[»]
3MRANMR-A301-325[»]
ProteinModelPortaliP02710.
SMRiP02710. Positions 25-339, 427-461.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP02710. 3 interactions.

Chemistry

BindingDBiP02710.
ChEMBLiCHEMBL2096975.

PTM databases

SwissPalmiP02710.
UniCarbKBiP02710.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG003756.

Miscellaneous databases

EvolutionaryTraceiP02710.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 1 hit.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 2 hits.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACHA_TETCF
AccessioniPrimary (citable) accession number: P02710
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 11, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.