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Protein

Acetylcholine receptor subunit alpha

Gene

CHRNA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

GO - Molecular functioni

  • acetylcholine-activated cation-selective channel activity Source: MGI
  • acetylcholine binding Source: Ensembl
  • acetylcholine receptor activity Source: ProtInc
  • ion channel activity Source: ProtInc
  • ligand-gated ion channel activity Source: Reactome

GO - Biological processi

  • muscle cell cellular homeostasis Source: BHF-UCL
  • musculoskeletal movement Source: BHF-UCL
  • neuromuscular junction development Source: MGI
  • neuromuscular process Source: BHF-UCL
  • neuromuscular synaptic transmission Source: MGI
  • neuronal action potential Source: BHF-UCL
  • neuron cellular homeostasis Source: BHF-UCL
  • regulation of membrane potential Source: BHF-UCL
  • response to nicotine Source: GO_Central
  • signal transduction Source: ProtInc
  • skeletal muscle contraction Source: BHF-UCL
  • skeletal muscle tissue growth Source: BHF-UCL
  • synaptic transmission, cholinergic Source: GO_Central
  • transport Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-629594. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
R-HSA-629597. Highly calcium permeable nicotinic acetylcholine receptors.
SIGNORiP02708.

Protein family/group databases

TCDBi1.A.9.1.1. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylcholine receptor subunit alpha
Gene namesi
Name:CHRNA1
Synonyms:ACHRA, CHNRA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:1955. CHRNA1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 255235ExtracellularAdd
BLAST
Transmembranei256 – 28025HelicalAdd
BLAST
Transmembranei288 – 30619HelicalAdd
BLAST
Transmembranei322 – 34120HelicalAdd
BLAST
Topological domaini342 – 453112CytoplasmicAdd
BLAST
Transmembranei454 – 47219HelicalAdd
BLAST

GO - Cellular componenti

  • acetylcholine-gated channel complex Source: BHF-UCL
  • cell junction Source: UniProtKB-KW
  • cell surface Source: BHF-UCL
  • neuromuscular junction Source: BHF-UCL
  • plasma membrane Source: BHF-UCL
  • postsynaptic membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Involvement in diseasei

Multiple pterygium syndrome, lethal type (LMPS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionMultiple pterygia are found infrequently in children with arthrogryposis and in fetuses with fetal akinesia syndrome. In lethal multiple pterygium syndrome there is intrauterine growth retardation, multiple pterygia, and flexion contractures causing severe arthrogryposis and fetal akinesia. Subcutaneous edema can be severe, causing fetal hydrops with cystic hygroma and lung hypoplasia. Oligohydramnios and facial anomalies are frequent.
See also OMIM:253290
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti254 – 2541R → L in LMPS. 1 Publication
Corresponds to variant rs137852809 [ dbSNP | Ensembl ].
VAR_043904

The alpha subunit is the main focus for antibody binding in myasthenia gravis. Myasthenia gravis is characterized by sporadic muscular fatigability and weakness, occurring chiefly in muscles innervated by cranial nerves, and characteristically improved by cholinesterase-inhibiting drugs.

Myasthenic syndrome, congenital, 1A, slow-channel (CMS1A)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA common congenital myasthenic syndrome. Congenital myasthenic syndromes are characterized by muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. CMS1A is a slow-channel myasthenic syndrome. It is caused by kinetic abnormalities of the AChR, resulting in prolonged AChR channel opening episodes, prolonged endplate currents, and depolarization block. This is associated with calcium overload, which may contribute to subsequent degeneration of the endplate and postsynaptic membrane.
See also OMIM:601462
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti198 – 1981G → S in CMS1A. 2 Publications
Corresponds to variant rs137852801 [ dbSNP | Ensembl ].
VAR_000282
Natural varianti201 – 2011V → M in CMS1A. 1 Publication
Corresponds to variant rs137852799 [ dbSNP | Ensembl ].
VAR_000283
Natural varianti262 – 2621N → K in CMS1A. 1 Publication
Corresponds to variant rs137852798 [ dbSNP | Ensembl ].
VAR_000284
Natural varianti294 – 2941V → F in CMS1A; causes increased channel opening in absence of ACh; prolonged opening in presence of ACh; increased affinity for ACh and enhanced desensitization. 1 Publication
Corresponds to variant rs137852803 [ dbSNP | Ensembl ].
VAR_021207
Natural varianti299 – 2991T → I in CMS1A. 1 Publication
Corresponds to variant rs137852800 [ dbSNP | Ensembl ].
VAR_000285
Natural varianti314 – 3141S → I in CMS1A. 1 Publication
Corresponds to variant rs137852802 [ dbSNP | Ensembl ].
VAR_000286
Natural varianti463 – 4631C → W in CMS1A; increases the rate of channel opening and slows the rate of channel closing but has no effect on agonist binding. 1 Publication
Corresponds to variant rs137852808 [ dbSNP | Ensembl ].
VAR_038601
Myasthenic syndrome, congenital, 1B, fast-channel (CMS1B)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. CMS1B is a fast-channel myasthenic syndrome. It is caused by kinetic abnormalities of the AChR, resulting in brief opening and activity of the channel, with a rapid decay in endplate current, failure to achieve threshold depolarization of the endplate and consequent failure to fire an action potential.
See also OMIM:608930
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti177 – 1771V → L in CMS1B; mutant channel shows an approximately 30-fold decrease of ACh binding affinity for the second of 2 closed-state binding sites but only a 2-fold decrease in gating efficiency. 1 Publication
Corresponds to variant rs137852807 [ dbSNP | Ensembl ].
VAR_038599
Natural varianti278 – 2781F → V in CMS1B; markedly reduced protein expression. 1 Publication
Corresponds to variant rs137852805 [ dbSNP | Ensembl ].
VAR_021206
Natural varianti301 – 3011F → L in CMS1B; fewer and shorter ion channel activations with decreased channel opening rate and increased channel closing rate. 1 Publication
Corresponds to variant rs137852806 [ dbSNP | Ensembl ].
VAR_021208
Natural varianti330 – 3301V → I in CMS1B; abnormally slow channel opening and closing resulting in abnormally brief current. 1 Publication
Corresponds to variant rs137852804 [ dbSNP | Ensembl ].
VAR_021209

Keywords - Diseasei

Congenital myasthenic syndrome, Disease mutation

Organism-specific databases

MalaCardsiCHRNA1.
MIMi253290. phenotype.
254200. phenotype.
601462. phenotype.
608930. phenotype.
Orphaneti33108. Lethal multiple pterygium syndrome.
98913. Postsynaptic congenital myasthenic syndromes.
PharmGKBiPA26487.

Chemistry

ChEMBLiCHEMBL2362997.
DrugBankiDB00674. Galantamine.
GuidetoPHARMACOLOGYi462.

Polymorphism and mutation databases

BioMutaiCHRNA1.
DMDMi113071.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 20201 PublicationAdd
BLAST
Chaini21 – 482462Acetylcholine receptor subunit alphaPRO_0000000305Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi173 ↔ 187
Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence analysis
Disulfide bondi237 ↔ 238Associated with receptor activation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP02708.
PeptideAtlasiP02708.
PRIDEiP02708.

PTM databases

iPTMnetiP02708.
PhosphoSiteiP02708.

Expressioni

Tissue specificityi

Isoform 1 is only expressed in skeletal muscle. Isoform 2 is constitutively expressed in skeletal muscle, brain, heart, kidney, liver, lung and thymus.

Gene expression databases

BgeeiENSG00000138435.
CleanExiHS_CHRNA1.
ExpressionAtlasiP02708. baseline and differential.
GenevisibleiP02708. HS.

Organism-specific databases

HPAiCAB010902.
HPA071554.

Interactioni

Subunit structurei

Pentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains.

Protein-protein interaction databases

BioGridi107556. 4 interactions.
IntActiP02708. 3 interactions.
STRINGi9606.ENSP00000261007.

Chemistry

BindingDBiP02708.

Structurei

Secondary structure

1
482
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi23 – 319Combined sources
Beta strandi106 – 1116Combined sources
Helixi114 – 1174Combined sources
Beta strandi122 – 1265Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Y5Pmodel-B230-235[»]
1Y5Tmodel-B230-235[»]
1Y6Cmodel-B230-235[»]
4ZJSX-ray2.23A/B/C/D/E21-50[»]
A/B/C/D/E106-126[»]
ProteinModelPortaliP02708.
SMRiP02708. Positions 21-351, 448-482.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00760000118930.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
InParanoidiP02708.
KOiK04803.
OMAiAMVMDHL.
OrthoDBiEOG091G0R20.
PhylomeDBiP02708.
TreeFamiTF315605.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 2 hits.
PF02932. Neur_chan_memb. 2 hits.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 2 hits.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: P02708-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPWPLLLLF SLCSAGLVLG SEHETRLVAK LFKDYSSVVR PVEDHRQVVE
60 70 80 90 100
VTVGLQLIQL INVDEVNQIV TTNVRLKQGD MVDLPRPSCV TLGVPLFSHL
110 120 130 140 150
QNEQWVDYNL KWNPDDYGGV KKIHIPSEKI WRPDLVLYNN ADGDFAIVKF
160 170 180 190 200
TKVLLQYTGH ITWTPPAIFK SYCEIIVTHF PFDEQNCSMK LGTWTYDGSV
210 220 230 240 250
VAINPESDQP DLSNFMESGE WVIKESRGWK HSVTYSCCPD TPYLDITYHF
260 270 280 290 300
VMQRLPLYFI VNVIIPCLLF SFLTGLVFYL PTDSGEKMTL SISVLLSLTV
310 320 330 340 350
FLLVIVELIP STSSAVPLIG KYMLFTMVFV IASIIITVIV INTHHRSPST
360 370 380 390 400
HVMPNWVRKV FIDTIPNIMF FSTMKRPSRE KQDKKIFTED IDISDISGKP
410 420 430 440 450
GPPPMGFHSP LIKHPEVKSA IEGIKYIAET MKSDQESNNA AAEWKYVAMV
460 470 480
MDHILLGVFM LVCIIGTLAV FAGRLIELNQ QG
Length:482
Mass (Da):54,546
Last modified:August 1, 1990 - v2
Checksum:i8B307AD69B91A28B
GO
Isoform 1 (identifier: P02708-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-103: Missing.

Show »
Length:457
Mass (Da):51,839
Checksum:i89480567D85C15B8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti415 – 4151P → F in AAD14247 (PubMed:7725386).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti177 – 1771V → L in CMS1B; mutant channel shows an approximately 30-fold decrease of ACh binding affinity for the second of 2 closed-state binding sites but only a 2-fold decrease in gating efficiency. 1 Publication
Corresponds to variant rs137852807 [ dbSNP | Ensembl ].
VAR_038599
Natural varianti198 – 1981G → S in CMS1A. 2 Publications
Corresponds to variant rs137852801 [ dbSNP | Ensembl ].
VAR_000282
Natural varianti201 – 2011V → M in CMS1A. 1 Publication
Corresponds to variant rs137852799 [ dbSNP | Ensembl ].
VAR_000283
Natural varianti254 – 2541R → L in LMPS. 1 Publication
Corresponds to variant rs137852809 [ dbSNP | Ensembl ].
VAR_043904
Natural varianti262 – 2621N → K in CMS1A. 1 Publication
Corresponds to variant rs137852798 [ dbSNP | Ensembl ].
VAR_000284
Natural varianti278 – 2781F → V in CMS1B; markedly reduced protein expression. 1 Publication
Corresponds to variant rs137852805 [ dbSNP | Ensembl ].
VAR_021206
Natural varianti294 – 2941V → F in CMS1A; causes increased channel opening in absence of ACh; prolonged opening in presence of ACh; increased affinity for ACh and enhanced desensitization. 1 Publication
Corresponds to variant rs137852803 [ dbSNP | Ensembl ].
VAR_021207
Natural varianti299 – 2991T → I in CMS1A. 1 Publication
Corresponds to variant rs137852800 [ dbSNP | Ensembl ].
VAR_000285
Natural varianti301 – 3011F → L in CMS1B; fewer and shorter ion channel activations with decreased channel opening rate and increased channel closing rate. 1 Publication
Corresponds to variant rs137852806 [ dbSNP | Ensembl ].
VAR_021208
Natural varianti314 – 3141S → I in CMS1A. 1 Publication
Corresponds to variant rs137852802 [ dbSNP | Ensembl ].
VAR_000286
Natural varianti330 – 3301V → I in CMS1B; abnormally slow channel opening and closing resulting in abnormally brief current. 1 Publication
Corresponds to variant rs137852804 [ dbSNP | Ensembl ].
VAR_021209
Natural varianti383 – 3831D → V.
Corresponds to variant rs6739001 [ dbSNP | Ensembl ].
VAR_038600
Natural varianti463 – 4631C → W in CMS1A; increases the rate of channel opening and slows the rate of channel closing but has no effect on agonist binding. 1 Publication
Corresponds to variant rs137852808 [ dbSNP | Ensembl ].
VAR_038601

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei79 – 10325Missing in isoform 1. 2 PublicationsVSP_000071Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02502
, X02503, X02504, X02505, X02506, X02507, X02508 Genomic DNA. Translation: CAA26344.1.
Y00762 mRNA. Translation: CAA68731.1.
X17104 Genomic DNA. Translation: CAA34960.1.
AK299445 mRNA. Translation: BAG61418.1.
CH471058 Genomic DNA. Translation: EAX11125.1.
CH471058 Genomic DNA. Translation: EAX11127.1.
S77094 mRNA. Translation: AAD14247.1.
X70108 Genomic DNA. Translation: CAA49705.1. Sequence problems.
CCDSiCCDS2261.1. [P02708-2]
CCDS33331.1. [P02708-1]
PIRiA03168. ACHUA1.
S10148.
RefSeqiNP_000070.1. NM_000079.3. [P02708-2]
NP_001034612.1. NM_001039523.2. [P02708-1]
UniGeneiHs.434479.

Genome annotation databases

EnsembliENST00000261007; ENSP00000261007; ENSG00000138435. [P02708-1]
ENST00000348749; ENSP00000261008; ENSG00000138435. [P02708-2]
GeneIDi1134.
KEGGihsa:1134.
UCSCiuc002ujd.3. human. [P02708-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02502
, X02503, X02504, X02505, X02506, X02507, X02508 Genomic DNA. Translation: CAA26344.1.
Y00762 mRNA. Translation: CAA68731.1.
X17104 Genomic DNA. Translation: CAA34960.1.
AK299445 mRNA. Translation: BAG61418.1.
CH471058 Genomic DNA. Translation: EAX11125.1.
CH471058 Genomic DNA. Translation: EAX11127.1.
S77094 mRNA. Translation: AAD14247.1.
X70108 Genomic DNA. Translation: CAA49705.1. Sequence problems.
CCDSiCCDS2261.1. [P02708-2]
CCDS33331.1. [P02708-1]
PIRiA03168. ACHUA1.
S10148.
RefSeqiNP_000070.1. NM_000079.3. [P02708-2]
NP_001034612.1. NM_001039523.2. [P02708-1]
UniGeneiHs.434479.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Y5Pmodel-B230-235[»]
1Y5Tmodel-B230-235[»]
1Y6Cmodel-B230-235[»]
4ZJSX-ray2.23A/B/C/D/E21-50[»]
A/B/C/D/E106-126[»]
ProteinModelPortaliP02708.
SMRiP02708. Positions 21-351, 448-482.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107556. 4 interactions.
IntActiP02708. 3 interactions.
STRINGi9606.ENSP00000261007.

Chemistry

BindingDBiP02708.
ChEMBLiCHEMBL2362997.
DrugBankiDB00674. Galantamine.
GuidetoPHARMACOLOGYi462.

Protein family/group databases

TCDBi1.A.9.1.1. the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family.

PTM databases

iPTMnetiP02708.
PhosphoSiteiP02708.

Polymorphism and mutation databases

BioMutaiCHRNA1.
DMDMi113071.

Proteomic databases

PaxDbiP02708.
PeptideAtlasiP02708.
PRIDEiP02708.

Protocols and materials databases

DNASUi1134.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261007; ENSP00000261007; ENSG00000138435. [P02708-1]
ENST00000348749; ENSP00000261008; ENSG00000138435. [P02708-2]
GeneIDi1134.
KEGGihsa:1134.
UCSCiuc002ujd.3. human. [P02708-1]

Organism-specific databases

CTDi1134.
GeneCardsiCHRNA1.
GeneReviewsiCHRNA1.
HGNCiHGNC:1955. CHRNA1.
HPAiCAB010902.
HPA071554.
MalaCardsiCHRNA1.
MIMi100690. gene.
253290. phenotype.
254200. phenotype.
601462. phenotype.
608930. phenotype.
neXtProtiNX_P02708.
Orphaneti33108. Lethal multiple pterygium syndrome.
98913. Postsynaptic congenital myasthenic syndromes.
PharmGKBiPA26487.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3645. Eukaryota.
ENOG410XQGR. LUCA.
GeneTreeiENSGT00760000118930.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
InParanoidiP02708.
KOiK04803.
OMAiAMVMDHL.
OrthoDBiEOG091G0R20.
PhylomeDBiP02708.
TreeFamiTF315605.

Enzyme and pathway databases

ReactomeiR-HSA-629594. Highly calcium permeable postsynaptic nicotinic acetylcholine receptors.
R-HSA-629597. Highly calcium permeable nicotinic acetylcholine receptors.
SIGNORiP02708.

Miscellaneous databases

GeneWikiiCholinergic_receptor,_nicotinic,_alpha_1.
GenomeRNAii1134.
PROiP02708.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138435.
CleanExiHS_CHRNA1.
ExpressionAtlasiP02708. baseline and differential.
GenevisibleiP02708. HS.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 2 hits.
PF02932. Neur_chan_memb. 2 hits.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 2 hits.
SSF90112. SSF90112. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACHA_HUMAN
AccessioniPrimary (citable) accession number: P02708
Secondary accession number(s): B4DRV6, D3DPE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1990
Last modified: September 7, 2016
This is version 188 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.