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Protein

Asialoglycoprotein receptor 1

Gene

Asgr1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface.

Miscellaneous

Calcium is required for ligand binding.
Two types of rat hepatic lectin have been identified, RHL-1 and RHL-2/3, having a relative abundance of 4:1.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi190Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi196Calcium 1By similarity1
Metal bindingi215Calcium 2By similarity1
Metal bindingi239Calcium 3By similarity1
Binding sitei239CarbohydrateBy similarity1
Metal bindingi241Calcium 3By similarity1
Metal bindingi242Calcium 2By similarity1
Binding sitei243CarbohydrateBy similarity1
Metal bindingi252Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi252Calcium 3By similarity1
Binding sitei252CarbohydrateBy similarity1
Metal bindingi253Calcium 2By similarity1
Metal bindingi264Calcium 3By similarity1
Metal bindingi265Calcium 3By similarity1
Metal bindingi277Calcium 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processEndocytosis
LigandCalcium, Lectin, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-446203. Asparagine N-linked glycosylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Asialoglycoprotein receptor 1
Short name:
ASGP-R 1
Short name:
ASGPR 1
Alternative name(s):
Hepatic lectin 1
Short name:
HL-1
Short name:
rHL-1
Gene namesi
Name:Asgr1
Synonyms:Asgr-1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi2160. Asgr1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39CytoplasmicSequence analysisAdd BLAST39
Transmembranei40 – 60Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini61 – 284ExtracellularSequence analysisAdd BLAST224

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000466531 – 284Asialoglycoprotein receptor 1Add BLAST284

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi35S-palmitoyl cysteine1 Publication1
Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi78N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi146N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi153 ↔ 164PROSITE-ProRule annotation
Disulfide bondi181 ↔ 276PROSITE-ProRule annotation
Disulfide bondi254 ↔ 268PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated on a cytoplasmic Ser residue.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP02706.
PRIDEiP02706.

PTM databases

iPTMnetiP02706.
PhosphoSitePlusiP02706.
SwissPalmiP02706.

Expressioni

Tissue specificityi

Expressed exclusively in hepatic parenchymal cells.

Gene expression databases

BgeeiENSRNOG00000018693.
GenevisibleiP02706. RN.

Interactioni

Subunit structurei

Interacts with LASS2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

MINTiMINT-4585792.
STRINGi10116.ENSRNOP00000025254.

Structurei

3D structure databases

ProteinModelPortaliP02706.
SMRiP02706.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini160 – 277C-type lectinPROSITE-ProRule annotationAdd BLAST118

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili58 – 122Sequence analysisAdd BLAST65

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi5 – 8Endocytosis signalSequence analysis4

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00760000118924.
HOGENOMiHOG000034093.
HOVERGENiHBG000270.
InParanoidiP02706.
KOiK10063.
OMAiQHHMGPV.
OrthoDBiEOG091G062T.
PhylomeDBiP02706.
TreeFamiTF352155.

Family and domain databases

CDDicd03590. CLECT_DC-SIGN_like. 1 hit.
Gene3Di3.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR033989. CD209-like_CTLD.
IPR016187. CTDL_fold.
IPR005640. Lectin_N.
PfamiView protein in Pfam
PF00059. Lectin_C. 1 hit.
PF03954. Lectin_N. 1 hit.
SMARTiView protein in SMART
SM00034. CLECT. 1 hit.
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiView protein in PROSITE
PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P02706-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKDYQDFQH LDNENDHHQL QRGPPPAPRL LQRLCSGFRL FLLSLGLSIL
60 70 80 90 100
LLVVVCVITS QNSQLREDLR VLRQNFSNFT VSTEDQVKAL TTQGERVGRK
110 120 130 140 150
MKLVESQLEK HQEDLREDHS RLLLHVKQLV SDVRSLSCQM AALRGNGSER
160 170 180 190 200
ICCPINWVEY EGSCYWFSSS VKPWTEADKY CQLENAHLVV VTSWEEQRFV
210 220 230 240 250
QQHMGPLNTW IGLTDQNGPW KWVDGTDYET GFKNWRPGQP DDWYGHGLGG
260 270 280
GEDCAHFTTD GHWNDDVCRR PYRWVCETEL GKAN
Length:284
Mass (Da):32,849
Last modified:January 23, 2007 - v2
Checksum:i5D973A09458900BA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti61Q → R (PubMed:6095287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02817 Genomic DNA. Translation: AAA42037.1.
BC088154 mRNA. Translation: AAH88154.1.
M21770 mRNA. Translation: AAA40764.1.
PIRiA92497. LNRTL.
RefSeqiNP_036635.1. NM_012503.2.
XP_006246641.1. XM_006246579.1.
UniGeneiRn.44300.

Genome annotation databases

EnsembliENSRNOT00000025254; ENSRNOP00000025254; ENSRNOG00000018693.
ENSRNOT00000086919; ENSRNOP00000070316; ENSRNOG00000018693.
GeneIDi24210.
KEGGirno:24210.
UCSCiRGD:2160. rat.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Hepatic asialoglycoprotein receptor subunit 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
K02817 Genomic DNA. Translation: AAA42037.1.
BC088154 mRNA. Translation: AAH88154.1.
M21770 mRNA. Translation: AAA40764.1.
PIRiA92497. LNRTL.
RefSeqiNP_036635.1. NM_012503.2.
XP_006246641.1. XM_006246579.1.
UniGeneiRn.44300.

3D structure databases

ProteinModelPortaliP02706.
SMRiP02706.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4585792.
STRINGi10116.ENSRNOP00000025254.

PTM databases

iPTMnetiP02706.
PhosphoSitePlusiP02706.
SwissPalmiP02706.

Proteomic databases

PaxDbiP02706.
PRIDEiP02706.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025254; ENSRNOP00000025254; ENSRNOG00000018693.
ENSRNOT00000086919; ENSRNOP00000070316; ENSRNOG00000018693.
GeneIDi24210.
KEGGirno:24210.
UCSCiRGD:2160. rat.

Organism-specific databases

CTDi432.
RGDi2160. Asgr1.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00760000118924.
HOGENOMiHOG000034093.
HOVERGENiHBG000270.
InParanoidiP02706.
KOiK10063.
OMAiQHHMGPV.
OrthoDBiEOG091G062T.
PhylomeDBiP02706.
TreeFamiTF352155.

Enzyme and pathway databases

ReactomeiR-RNO-446203. Asparagine N-linked glycosylation.

Miscellaneous databases

PROiPR:P02706.

Gene expression databases

BgeeiENSRNOG00000018693.
GenevisibleiP02706. RN.

Family and domain databases

CDDicd03590. CLECT_DC-SIGN_like. 1 hit.
Gene3Di3.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR033989. CD209-like_CTLD.
IPR016187. CTDL_fold.
IPR005640. Lectin_N.
PfamiView protein in Pfam
PF00059. Lectin_C. 1 hit.
PF03954. Lectin_N. 1 hit.
SMARTiView protein in SMART
SM00034. CLECT. 1 hit.
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiView protein in PROSITE
PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiASGR1_RAT
AccessioniPrimary (citable) accession number: P02706
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: May 10, 2017
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.