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Protein

Colipase A

Gene

CLPS1

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
Enterostatin has a biological activity as a satiety signal.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei63Bile salt micelles1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDigestion, Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Colipase A
Gene namesi
Name:CLPS1
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei‹1 – 113 PublicationsAdd BLAST›11
PropeptideiPRO_000000569212 – 16Enterostatin, activation peptide5
ChainiPRO_000000569317 – 106Colipase AAdd BLAST90

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 39PROSITE-ProRule annotation
Disulfide bondi34 ↔ 50PROSITE-ProRule annotation
Disulfide bondi38 ↔ 72PROSITE-ProRule annotation
Disulfide bondi60 ↔ 80PROSITE-ProRule annotation
Disulfide bondi74 ↔ 98PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the pancreas.

Interactioni

Subunit structurei

Forms a 1:1 stoichiometric complex with pancreatic lipase.

Structurei

3D structure databases

ProteinModelPortaliP02704.
SMRiP02704.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the colipase family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYZJ. Eukaryota.
ENOG410YQC6. LUCA.
HOVERGENiHBG005373.
InParanoidiP02704.

Family and domain databases

CDDicd00039. COLIPASE. 1 hit.
InterProiView protein in InterPro
IPR001981. Colipase.
IPR017914. Colipase_C.
IPR017915. Colipase_CS.
IPR017913. Colipase_N.
PANTHERiPTHR10041. PTHR10041. 1 hit.
PfamiView protein in Pfam
PF01114. Colipase. 1 hit.
PF02740. Colipase_C. 1 hit.
PRINTSiPR00128. COLIPASE.
SMARTiView protein in SMART
SM00023. COLIPASE. 1 hit.
PROSITEiView protein in PROSITE
PS00121. COLIPASE_1. 1 hit.
PS51342. COLIPASE_2. 1 hit.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02704-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
LLLVALAVAY AVPDPRGVII NLEAGEICLN SAQCKSECCH QESSLSLARC
60 70 80 90 100
AAKASENSEC SAWTLYGVYY KCPCERGLTC QVDKTLVGSI MNTNFGICFD

AARSEE
Length:106
Mass (Da):11,388
Last modified:November 1, 1995 - v2
Checksum:iC0DC26747D94810C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Sequence conflicti33Q → E AA sequence (PubMed:6691986).Curated1
Sequence conflicti33Q → E AA sequence (PubMed:7075593).Curated1
Sequence conflicti43S → E AA sequence (PubMed:6691986).Curated1
Sequence conflicti43S → E AA sequence (PubMed:7075593).Curated1
Sequence conflicti43S → E AA sequence (PubMed:7417313).Curated1
Sequence conflicti100D → N AA sequence (PubMed:7075593).Curated1
Sequence conflicti103R → K AA sequence (PubMed:7075593).Curated1
Sequence conflicti106E → ER AA sequence (PubMed:7075593).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74503 mRNA. Translation: CAA52611.1.
PIRiA03164. XLHOA.
UniGeneiEca.12632.

Similar proteinsi

Entry informationi

Entry nameiCOLA_HORSE
AccessioniPrimary (citable) accession number: P02704
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1995
Last modified: January 31, 2018
This is version 91 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families