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Protein

Colipase

Gene

CLPS

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
Enterostatin has a biological activity as a satiety signal.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Digestion, Lipid degradation, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-SSC-192456. Digestion of dietary lipid.
R-SSC-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Colipase
Alternative name(s):
Procolipase II
Gene namesi
Name:CLPS
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 7

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 171 PublicationAdd BLAST17
PropeptideiPRO_000000570218 – 22Enterostatin, activation peptide1 Publication5
ChainiPRO_000000570323 – 112ColipaseAdd BLAST90

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 45
Disulfide bondi40 ↔ 56
Disulfide bondi44 ↔ 78
Disulfide bondi66 ↔ 86
Disulfide bondi80 ↔ 104

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP02703.

Expressioni

Tissue specificityi

Expressed by the pancreas.

Gene expression databases

GenevisibleiP02703. SS.

Interactioni

Subunit structurei

Forms a 1:1 stoichiometric complex with pancreatic lipase.PROSITE-ProRule annotation4 Publications

Protein-protein interaction databases

MINTiMINT-1179431.
STRINGi9823.ENSSSCP00000001686.

Structurei

Secondary structure

1112
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi25 – 28Combined sources4
Beta strandi30 – 33Combined sources4
Helixi37 – 39Combined sources3
Beta strandi40 – 43Combined sources4
Beta strandi48 – 52Combined sources5
Beta strandi64 – 67Combined sources4
Beta strandi71 – 77Combined sources7
Beta strandi84 – 88Combined sources5
Helixi92 – 97Combined sources6
Beta strandi101 – 106Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ETHX-ray2.80B/D18-110[»]
1LPAX-ray3.04A18-110[»]
1LPBX-ray2.46A18-110[»]
1N8SX-ray3.04C18-110[»]
1PCNNMR-A18-110[»]
1PCONMR-A18-110[»]
ProteinModelPortaliP02703.
SMRiP02703.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02703.

Family & Domainsi

Sequence similaritiesi

Belongs to the colipase family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IYZJ. Eukaryota.
ENOG410YQC6. LUCA.
GeneTreeiENSGT00390000012644.
HOGENOMiHOG000059253.
HOVERGENiHBG005373.
InParanoidiP02703.
KOiK14460.
OMAiCSAKTLY.
OrthoDBiEOG091G0Z2E.
TreeFamiTF336178.

Family and domain databases

CDDicd00039. COLIPASE. 1 hit.
InterProiIPR001981. Colipase.
IPR017914. Colipase_C.
IPR017915. Colipase_CS.
IPR017913. Colipase_N.
[Graphical view]
PANTHERiPTHR10041. PTHR10041. 1 hit.
PfamiPF01114. Colipase. 1 hit.
PF02740. Colipase_C. 1 hit.
[Graphical view]
PRINTSiPR00128. COLIPASE.
SMARTiSM00023. COLIPASE. 1 hit.
[Graphical view]
PROSITEiPS00121. COLIPASE_1. 1 hit.
PS51342. COLIPASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02703-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKVLALLLV TLTVAYAVPD PRGIIINLDE GELCLNSAQC KSNCCQHDTI
60 70 80 90 100
LSLSRCALKA RENSECSAFT LYGVYYKCPC ERGLTCEGDK SLVGSITNTN
110
FGICHDVGRS SD
Length:112
Mass (Da):12,140
Last modified:October 25, 2002 - v3
Checksum:iAE0AE89956E5A846
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54Missing AA sequence (PubMed:4858821).Curated1
Sequence conflicti67Missing AA sequence (PubMed:4858821).Curated1
Sequence conflicti106D → N AA sequence (PubMed:6691986).Curated1
Sequence conflicti106D → N AA sequence (PubMed:4858821).Curated1
Sequence conflicti111 – 112SD → DS AA sequence (PubMed:6691986).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148567 mRNA. Translation: AAF67823.1.
DQ073448 Genomic DNA. Translation: AAZ22441.1.
PIRiA03162. XLPG2.
RefSeqiNP_999368.1. NM_214203.1.
XP_013833274.1. XM_013977820.1.
XP_013833275.1. XM_013977821.1.
XP_013833276.1. XM_013977822.1.
UniGeneiSsc.514.

Genome annotation databases

EnsembliENSSSCT00000001730; ENSSSCP00000001686; ENSSSCG00000001552.
GeneIDi397407.
KEGGissc:397407.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF148567 mRNA. Translation: AAF67823.1.
DQ073448 Genomic DNA. Translation: AAZ22441.1.
PIRiA03162. XLPG2.
RefSeqiNP_999368.1. NM_214203.1.
XP_013833274.1. XM_013977820.1.
XP_013833275.1. XM_013977821.1.
XP_013833276.1. XM_013977822.1.
UniGeneiSsc.514.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ETHX-ray2.80B/D18-110[»]
1LPAX-ray3.04A18-110[»]
1LPBX-ray2.46A18-110[»]
1N8SX-ray3.04C18-110[»]
1PCNNMR-A18-110[»]
1PCONMR-A18-110[»]
ProteinModelPortaliP02703.
SMRiP02703.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1179431.
STRINGi9823.ENSSSCP00000001686.

Proteomic databases

PaxDbiP02703.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000001730; ENSSSCP00000001686; ENSSSCG00000001552.
GeneIDi397407.
KEGGissc:397407.

Organism-specific databases

CTDi1208.

Phylogenomic databases

eggNOGiENOG410IYZJ. Eukaryota.
ENOG410YQC6. LUCA.
GeneTreeiENSGT00390000012644.
HOGENOMiHOG000059253.
HOVERGENiHBG005373.
InParanoidiP02703.
KOiK14460.
OMAiCSAKTLY.
OrthoDBiEOG091G0Z2E.
TreeFamiTF336178.

Enzyme and pathway databases

ReactomeiR-SSC-192456. Digestion of dietary lipid.
R-SSC-975634. Retinoid metabolism and transport.

Miscellaneous databases

EvolutionaryTraceiP02703.

Gene expression databases

GenevisibleiP02703. SS.

Family and domain databases

CDDicd00039. COLIPASE. 1 hit.
InterProiIPR001981. Colipase.
IPR017914. Colipase_C.
IPR017915. Colipase_CS.
IPR017913. Colipase_N.
[Graphical view]
PANTHERiPTHR10041. PTHR10041. 1 hit.
PfamiPF01114. Colipase. 1 hit.
PF02740. Colipase_C. 1 hit.
[Graphical view]
PRINTSiPR00128. COLIPASE.
SMARTiSM00023. COLIPASE. 1 hit.
[Graphical view]
PROSITEiPS00121. COLIPASE_1. 1 hit.
PS51342. COLIPASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOL_PIG
AccessioniPrimary (citable) accession number: P02703
Secondary accession number(s): Q3I5G6, Q9N1T6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 25, 2002
Last modified: November 30, 2016
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.