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Protein

Folate receptor alpha

Gene

FOLR1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei102FolateBy similarity1
Binding sitei106FolateBy similarity1
Binding sitei195FolateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMilk protein, Receptor
Biological processTransport
LigandFolate-binding

Enzyme and pathway databases

ReactomeiR-BTA-204005 COPII-mediated vesicle transport
R-BTA-5694530 Cargo concentration in the ER
R-BTA-6807878 COPI-mediated anterograde transport

Names & Taxonomyi

Protein namesi
Recommended name:
Folate receptor alpha
Short name:
FR-alpha
Alternative name(s):
Folate receptor 1
Folate-binding protein 1
Short name:
FBP
Milk folate-binding protein
Gene namesi
Name:FOLR1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endosome, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 192 PublicationsAdd BLAST19
ChainiPRO_000014739420 – 234Folate receptor alphaAdd BLAST215
PropeptideiPRO_0000424694235 – 241Removed in mature form7

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi36 ↔ 64By similarity
Disulfide bondi56 ↔ 104By similarity
Disulfide bondi65 ↔ 108By similarity
Glycosylationi68N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi88 ↔ 174By similarity
Disulfide bondi95 ↔ 145By similarity
Disulfide bondi134 ↔ 208By similarity
Disulfide bondi138 ↔ 188By similarity
Disulfide bondi151 ↔ 168By similarity
Glycosylationi160N-linked (GlcNAc...) asparagine1 Publication1
Lipidationi234GPI-anchor amidated serineBy similarity1

Post-translational modificationi

The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP02702
PeptideAtlasiP02702
PRIDEiP02702

Expressioni

Tissue specificityi

Detected in milk (at protein level).1 Publication

Gene expression databases

BgeeiENSBTAG00000038532

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000027602

Structurei

3D structure databases

SMRiP02702
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni123 – 127Folate bindingBy similarity5
Regioni156 – 161Folate bindingBy similarity6

Sequence similaritiesi

Belongs to the folate receptor family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFFP Eukaryota
ENOG4111IU4 LUCA
GeneTreeiENSGT00390000010470
HOGENOMiHOG000006539
HOVERGENiHBG039612
InParanoidiP02702
KOiK13649
OMAiWNWTSGF
OrthoDBiEOG091G0GIA

Family and domain databases

InterProiView protein in InterPro
IPR004269 Folate_rcpt
IPR018143 Folate_rcpt-like
IPR032935 FOLR1
PANTHERiPTHR10517 PTHR10517, 1 hit
PTHR10517:SF15 PTHR10517:SF15, 1 hit
PfamiView protein in Pfam
PF03024 Folate_rec, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02702-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWQMTQLLL LALVAAAWGA QAPRTPRART DLLNVCMDAK HHKAEPGPED
60 70 80 90 100
SLHEQCSPWR KNACCSVNTS IEAHKDISYL YRFNWDHCGK MEPACKRHFI
110 120 130 140 150
QDTCLYECSP NLGPWIREVN QRWRKERVLG VPLCKEDCQS WWEDCRTSYT
160 170 180 190 200
CKSNWHKGWN WTSGYNQCPV KAACHRFDFY FPTPAALCNE IWSHSYKVSN
210 220 230 240
YSRGSGRCIQ MWFDPFQGNP NEEVARFYAE NPTSGSTPQG I
Length:241
Mass (Da):27,922
Last modified:December 11, 2013 - v3
Checksum:iAC6EDC070594C2B2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti174 – 175CH → HC AA sequence (Ref. 2) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DN512948 mRNA No translation available.
PIRiA03161 BFBO
RefSeqiNP_001193456.1, NM_001206527.1
NP_001193459.1, NM_001206530.1
NP_001265501.1, NM_001278572.1
NP_001265502.1, NM_001278573.1
UniGeneiBt.62067

Genome annotation databases

EnsembliENSBTAT00000027602; ENSBTAP00000027602; ENSBTAG00000038532
GeneIDi516067
KEGGibta:516067

Similar proteinsi

Entry informationi

Entry nameiFOLR1_BOVIN
AccessioniPrimary (citable) accession number: P02702
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: December 11, 2013
Last modified: May 23, 2018
This is version 97 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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