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P02689

- MYP2_HUMAN

UniProt

P02689 - MYP2_HUMAN

Protein

Myelin P2 protein

Gene

PMP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May play a role in lipid transport protein in Schwann cells. May bind cholesterol.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei107 – 1071Fatty acid

    GO - Molecular functioni

    1. cholesterol binding Source: UniProtKB
    2. fatty acid binding Source: UniProtKB
    3. transporter activity Source: InterPro

    GO - Biological processi

    1. membrane organization Source: Ensembl

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myelin P2 protein
    Alternative name(s):
    Peripheral myelin protein 2
    Gene namesi
    Name:PMP2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:9117. PMP2.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33443.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 132131Myelin P2 proteinPRO_0000067388Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication
    Disulfide bondi118 ↔ 1251 Publication

    Keywords - PTMi

    Acetylation, Disulfide bond

    Proteomic databases

    PaxDbiP02689.
    PRIDEiP02689.

    PTM databases

    PhosphoSiteiP02689.

    Expressioni

    Gene expression databases

    ArrayExpressiP02689.
    BgeeiP02689.
    CleanExiHS_PMP2.
    GenevestigatoriP02689.

    Interactioni

    Subunit structurei

    Monomer.1 Publication

    Protein-protein interaction databases

    MINTiMINT-5006340.
    STRINGi9606.ENSP00000256103.

    Structurei

    Secondary structure

    1
    132
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi3 – 53
    Beta strandi7 – 1610
    Helixi17 – 237
    Helixi28 – 369
    Beta strandi40 – 467
    Beta strandi49 – 557
    Beta strandi61 – 655
    Beta strandi71 – 744
    Beta strandi80 – 889
    Beta strandi91 – 988
    Beta strandi101 – 11010
    Beta strandi113 – 1208
    Beta strandi123 – 1319

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2WUTX-ray1.85A1-132[»]
    3NR3X-ray1.95A3-132[»]
    4A1HX-ray2.20A/B/C1-132[»]
    4A1YX-ray1.20A/B/C/D1-132[»]
    4A8ZX-ray1.80A1-132[»]
    4BVMX-ray0.93A1-132[»]
    ProteinModelPortaliP02689.
    SMRiP02689. Positions 1-132.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP02689.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni127 – 1293Fatty acid binding

    Domaini

    Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.1 Publication

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG322298.
    HOGENOMiHOG000004829.
    HOVERGENiHBG005633.
    InParanoidiP02689.
    OMAiRTESAFK.
    OrthoDBiEOG7NW6BZ.
    PhylomeDBiP02689.
    TreeFamiTF316894.

    Family and domain databases

    Gene3Di2.40.128.20. 1 hit.
    InterProiIPR012674. Calycin.
    IPR011038. Calycin-like.
    IPR000463. Fatty_acid-bd.
    IPR000566. Lipocln_cytosolic_FA-bd_dom.
    [Graphical view]
    PfamiPF00061. Lipocalin. 1 hit.
    [Graphical view]
    PRINTSiPR00178. FATTYACIDBP.
    SUPFAMiSSF50814. SSF50814. 1 hit.
    PROSITEiPS00214. FABP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P02689-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNKFLGTWK LVSSENFDDY MKALGVGLAT RKLGNLAKPT VIISKKGDII    50
    TIRTESTFKN TEISFKLGQE FEETTADNRK TKSIVTLQRG SLNQVQRWDG 100
    KETTIKRKLV NGKMVAECKM KGVVCTRIYE KV 132
    Length:132
    Mass (Da):14,909
    Last modified:January 23, 2007 - v3
    Checksum:i3D515D32695899D2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti25 – 251G → GG AA sequence (PubMed:6183401)Curated
    Sequence conflicti99 – 991D → N AA sequence (PubMed:6183401)Curated
    Sequence conflicti111 – 1111N → D AA sequence (PubMed:6183401)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16181 Genomic DNA. Translation: BAA03726.1.
    X62167 mRNA. Translation: CAA44096.1.
    AK311758 mRNA. Translation: BAG34701.1.
    CR541649 mRNA. Translation: CAG46450.1.
    CR541738 mRNA. Translation: CAG46538.1.
    AC018616 Genomic DNA. No translation available.
    CH471068 Genomic DNA. Translation: EAW87090.1.
    BC034997 mRNA. Translation: AAH34997.1.
    AH004648 Genomic DNA. Translation: AAB32592.2.
    CCDSiCCDS6229.1.
    PIRiJT0977. MPHU2.
    RefSeqiNP_002668.1. NM_002677.3.
    UniGeneiHs.571512.

    Genome annotation databases

    EnsembliENST00000256103; ENSP00000256103; ENSG00000147588.
    GeneIDi5375.
    KEGGihsa:5375.
    UCSCiuc003ycb.1. human.

    Polymorphism databases

    DMDMi127725.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D16181 Genomic DNA. Translation: BAA03726.1 .
    X62167 mRNA. Translation: CAA44096.1 .
    AK311758 mRNA. Translation: BAG34701.1 .
    CR541649 mRNA. Translation: CAG46450.1 .
    CR541738 mRNA. Translation: CAG46538.1 .
    AC018616 Genomic DNA. No translation available.
    CH471068 Genomic DNA. Translation: EAW87090.1 .
    BC034997 mRNA. Translation: AAH34997.1 .
    AH004648 Genomic DNA. Translation: AAB32592.2 .
    CCDSi CCDS6229.1.
    PIRi JT0977. MPHU2.
    RefSeqi NP_002668.1. NM_002677.3.
    UniGenei Hs.571512.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2WUT X-ray 1.85 A 1-132 [» ]
    3NR3 X-ray 1.95 A 3-132 [» ]
    4A1H X-ray 2.20 A/B/C 1-132 [» ]
    4A1Y X-ray 1.20 A/B/C/D 1-132 [» ]
    4A8Z X-ray 1.80 A 1-132 [» ]
    4BVM X-ray 0.93 A 1-132 [» ]
    ProteinModelPortali P02689.
    SMRi P02689. Positions 1-132.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-5006340.
    STRINGi 9606.ENSP00000256103.

    PTM databases

    PhosphoSitei P02689.

    Polymorphism databases

    DMDMi 127725.

    Proteomic databases

    PaxDbi P02689.
    PRIDEi P02689.

    Protocols and materials databases

    DNASUi 5375.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000256103 ; ENSP00000256103 ; ENSG00000147588 .
    GeneIDi 5375.
    KEGGi hsa:5375.
    UCSCi uc003ycb.1. human.

    Organism-specific databases

    CTDi 5375.
    GeneCardsi GC08M082352.
    HGNCi HGNC:9117. PMP2.
    MIMi 170715. gene.
    neXtProti NX_P02689.
    PharmGKBi PA33443.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG322298.
    HOGENOMi HOG000004829.
    HOVERGENi HBG005633.
    InParanoidi P02689.
    OMAi RTESAFK.
    OrthoDBi EOG7NW6BZ.
    PhylomeDBi P02689.
    TreeFami TF316894.

    Miscellaneous databases

    EvolutionaryTracei P02689.
    GeneWikii PMP2.
    GenomeRNAii 5375.
    NextBioi 20852.
    PROi P02689.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P02689.
    Bgeei P02689.
    CleanExi HS_PMP2.
    Genevestigatori P02689.

    Family and domain databases

    Gene3Di 2.40.128.20. 1 hit.
    InterProi IPR012674. Calycin.
    IPR011038. Calycin-like.
    IPR000463. Fatty_acid-bd.
    IPR000566. Lipocln_cytosolic_FA-bd_dom.
    [Graphical view ]
    Pfami PF00061. Lipocalin. 1 hit.
    [Graphical view ]
    PRINTSi PR00178. FATTYACIDBP.
    SUPFAMi SSF50814. SSF50814. 1 hit.
    PROSITEi PS00214. FABP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and sequence determination of cDNA encoding P2 protein of human peripheral myelin."
      Hayasaka K., Nanao K., Tahara M., Sato W., Takada G., Miura M., Uyemura K.
      Biochem. Biophys. Res. Commun. 181:204-207(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    7. "Partial structure and mapping of the human myelin P2 protein gene."
      Narayanan V., Ripepi B., Jabs E.W., Hawkins A., Griffin C., Tennekoon G.
      J. Neurochem. 63:2010-2013(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-116.
    8. "The complete amino acid sequence of human P2 protein."
      Suzuki M., Kitamura K., Sakamoto Y., Uyemura K.
      J. Neurochem. 39:1759-1762(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-132, ACETYLATION AT SER-2.
    9. "Structural and functional characterization of human peripheral nervous system myelin protein P2."
      Majava V., Polverini E., Mazzini A., Nanekar R., Knoll W., Peters J., Natali F., Baumgartel P., Kursula I., Kursula P.
      PLoS ONE 5:E10300-E10300(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) IN COMPLEX WITH PALMITATE, FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, SUBUNIT, CIRCULAR DICHROISM, DOMAIN.
    10. "Crystal structure of human peripheral myelin protein 2."
      Structural genomics consortium (SGC)
      Submitted (AUG-2010) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 3-132.

    Entry informationi

    Entry nameiMYP2_HUMAN
    AccessioniPrimary (citable) accession number: P02689
    Secondary accession number(s): Q6FHL4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 127 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    P2 protein and myelin basic protein together constitute a major fraction of peripheral nervous system myelin protein.

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3