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Protein

Myelin P2 protein

Gene

PMP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in lipid transport protein in Schwann cells. May bind cholesterol.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei107 – 1071Fatty acid

GO - Molecular functioni

  1. cholesterol binding Source: UniProtKB
  2. fatty acid binding Source: UniProtKB
  3. transporter activity Source: InterPro

GO - Biological processi

  1. membrane organization Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin P2 protein
Alternative name(s):
Peripheral myelin protein 2
Gene namesi
Name:PMP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 8

Organism-specific databases

HGNCiHGNC:9117. PMP2.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. extracellular vesicular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33443.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 132131Myelin P2 proteinPRO_0000067388Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Disulfide bondi118 ↔ 1251 Publication

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

PaxDbiP02689.
PRIDEiP02689.

PTM databases

PhosphoSiteiP02689.

Expressioni

Gene expression databases

BgeeiP02689.
CleanExiHS_PMP2.
ExpressionAtlasiP02689. baseline and differential.
GenevestigatoriP02689.

Interactioni

Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

BioGridi111388. 1 interaction.
MINTiMINT-5006340.
STRINGi9606.ENSP00000256103.

Structurei

Secondary structure

1
132
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 53Combined sources
Beta strandi7 – 1610Combined sources
Helixi17 – 237Combined sources
Helixi28 – 369Combined sources
Beta strandi40 – 467Combined sources
Beta strandi49 – 557Combined sources
Beta strandi61 – 655Combined sources
Beta strandi71 – 744Combined sources
Beta strandi80 – 889Combined sources
Beta strandi91 – 988Combined sources
Beta strandi101 – 11010Combined sources
Beta strandi113 – 1208Combined sources
Beta strandi123 – 1319Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WUTX-ray1.85A1-132[»]
3NR3X-ray1.95A3-132[»]
4A1HX-ray2.20A/B/C1-132[»]
4A1YX-ray1.20A/B/C/D1-132[»]
4A8ZX-ray1.80A1-132[»]
4BVMX-ray0.93A1-132[»]
ProteinModelPortaliP02689.
SMRiP02689. Positions 1-132.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02689.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni127 – 1293Fatty acid binding

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.1 Publication

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG322298.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiP02689.
OMAiMCNRFVG.
OrthoDBiEOG7NW6BZ.
PhylomeDBiP02689.
TreeFamiTF316894.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02689-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNKFLGTWK LVSSENFDDY MKALGVGLAT RKLGNLAKPT VIISKKGDII
60 70 80 90 100
TIRTESTFKN TEISFKLGQE FEETTADNRK TKSIVTLQRG SLNQVQRWDG
110 120 130
KETTIKRKLV NGKMVAECKM KGVVCTRIYE KV
Length:132
Mass (Da):14,909
Last modified:January 23, 2007 - v3
Checksum:i3D515D32695899D2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251G → GG AA sequence (PubMed:6183401).Curated
Sequence conflicti99 – 991D → N AA sequence (PubMed:6183401).Curated
Sequence conflicti111 – 1111N → D AA sequence (PubMed:6183401).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16181 Genomic DNA. Translation: BAA03726.1.
X62167 mRNA. Translation: CAA44096.1.
AK311758 mRNA. Translation: BAG34701.1.
CR541649 mRNA. Translation: CAG46450.1.
CR541738 mRNA. Translation: CAG46538.1.
AC018616 Genomic DNA. No translation available.
CH471068 Genomic DNA. Translation: EAW87090.1.
BC034997 mRNA. Translation: AAH34997.1.
AH004648 Genomic DNA. Translation: AAB32592.2.
CCDSiCCDS6229.1.
PIRiJT0977. MPHU2.
RefSeqiNP_002668.1. NM_002677.3.
UniGeneiHs.571512.

Genome annotation databases

EnsembliENST00000256103; ENSP00000256103; ENSG00000147588.
GeneIDi5375.
KEGGihsa:5375.
UCSCiuc003ycb.1. human.

Polymorphism databases

DMDMi127725.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16181 Genomic DNA. Translation: BAA03726.1.
X62167 mRNA. Translation: CAA44096.1.
AK311758 mRNA. Translation: BAG34701.1.
CR541649 mRNA. Translation: CAG46450.1.
CR541738 mRNA. Translation: CAG46538.1.
AC018616 Genomic DNA. No translation available.
CH471068 Genomic DNA. Translation: EAW87090.1.
BC034997 mRNA. Translation: AAH34997.1.
AH004648 Genomic DNA. Translation: AAB32592.2.
CCDSiCCDS6229.1.
PIRiJT0977. MPHU2.
RefSeqiNP_002668.1. NM_002677.3.
UniGeneiHs.571512.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2WUTX-ray1.85A1-132[»]
3NR3X-ray1.95A3-132[»]
4A1HX-ray2.20A/B/C1-132[»]
4A1YX-ray1.20A/B/C/D1-132[»]
4A8ZX-ray1.80A1-132[»]
4BVMX-ray0.93A1-132[»]
ProteinModelPortaliP02689.
SMRiP02689. Positions 1-132.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111388. 1 interaction.
MINTiMINT-5006340.
STRINGi9606.ENSP00000256103.

PTM databases

PhosphoSiteiP02689.

Polymorphism databases

DMDMi127725.

Proteomic databases

PaxDbiP02689.
PRIDEiP02689.

Protocols and materials databases

DNASUi5375.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256103; ENSP00000256103; ENSG00000147588.
GeneIDi5375.
KEGGihsa:5375.
UCSCiuc003ycb.1. human.

Organism-specific databases

CTDi5375.
GeneCardsiGC08M082352.
HGNCiHGNC:9117. PMP2.
MIMi170715. gene.
neXtProtiNX_P02689.
PharmGKBiPA33443.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG322298.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiP02689.
OMAiMCNRFVG.
OrthoDBiEOG7NW6BZ.
PhylomeDBiP02689.
TreeFamiTF316894.

Miscellaneous databases

EvolutionaryTraceiP02689.
GeneWikiiPMP2.
GenomeRNAii5375.
NextBioi20852.
PROiP02689.
SOURCEiSearch...

Gene expression databases

BgeeiP02689.
CleanExiHS_PMP2.
ExpressionAtlasiP02689. baseline and differential.
GenevestigatoriP02689.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
[Graphical view]
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and sequence determination of cDNA encoding P2 protein of human peripheral myelin."
    Hayasaka K., Nanao K., Tahara M., Sato W., Takada G., Miura M., Uyemura K.
    Biochem. Biophys. Res. Commun. 181:204-207(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  7. "Partial structure and mapping of the human myelin P2 protein gene."
    Narayanan V., Ripepi B., Jabs E.W., Hawkins A., Griffin C., Tennekoon G.
    J. Neurochem. 63:2010-2013(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-116.
  8. "The complete amino acid sequence of human P2 protein."
    Suzuki M., Kitamura K., Sakamoto Y., Uyemura K.
    J. Neurochem. 39:1759-1762(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-132, ACETYLATION AT SER-2.
  9. "Structural and functional characterization of human peripheral nervous system myelin protein P2."
    Majava V., Polverini E., Mazzini A., Nanekar R., Knoll W., Peters J., Natali F., Baumgartel P., Kursula I., Kursula P.
    PLoS ONE 5:E10300-E10300(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) IN COMPLEX WITH PALMITATE, FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY, SUBUNIT, CIRCULAR DICHROISM, DOMAIN.
  10. "Crystal structure of human peripheral myelin protein 2."
    Structural genomics consortium (SGC)
    Submitted (AUG-2010) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 3-132.

Entry informationi

Entry nameiMYP2_HUMAN
AccessioniPrimary (citable) accession number: P02689
Secondary accession number(s): Q6FHL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: February 4, 2015
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

P2 protein and myelin basic protein together constitute a major fraction of peripheral nervous system myelin protein.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.