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Protein

Myelin P2 protein

Gene

PMP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in lipid transport protein in Schwann cells. May bind cholesterol.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei107Fatty acid1

GO - Molecular functioni

  • cholesterol binding Source: UniProtKB
  • fatty acid binding Source: UniProtKB
  • transporter activity Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000147588-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Myelin P2 protein
Alternative name(s):
Peripheral myelin protein 2
Gene namesi
Name:PMP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:9117. PMP2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • extracellular exosome Source: UniProtKB
  • myelin sheath Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi5375.
OpenTargetsiENSG00000147588.
PharmGKBiPA33443.

Chemistry databases

DrugBankiDB04224. Oleic Acid.

Polymorphism and mutation databases

BioMutaiPMP2.
DMDMi127725.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000673882 – 132Myelin P2 proteinAdd BLAST131

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Disulfide bondi118 ↔ 1251 Publication

Keywords - PTMi

Acetylation, Disulfide bond

Proteomic databases

MaxQBiP02689.
PaxDbiP02689.
PeptideAtlasiP02689.
PRIDEiP02689.

PTM databases

iPTMnetiP02689.
PhosphoSitePlusiP02689.
SwissPalmiP02689.

Expressioni

Gene expression databases

BgeeiENSG00000147588.
CleanExiHS_PMP2.
ExpressionAtlasiP02689. baseline and differential.
GenevisibleiP02689. HS.

Interactioni

Subunit structurei

Monomer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CCNDBP1O952733EBI-10193858,EBI-748961

Protein-protein interaction databases

BioGridi111388. 7 interactors.
IntActiP02689. 1 interactor.
MINTiMINT-5006340.
STRINGi9606.ENSP00000256103.

Structurei

Secondary structure

1132
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 5Combined sources3
Beta strandi7 – 16Combined sources10
Helixi17 – 23Combined sources7
Helixi28 – 36Combined sources9
Beta strandi40 – 46Combined sources7
Beta strandi49 – 55Combined sources7
Beta strandi61 – 65Combined sources5
Beta strandi71 – 74Combined sources4
Beta strandi80 – 88Combined sources9
Beta strandi91 – 98Combined sources8
Beta strandi101 – 110Combined sources10
Beta strandi113 – 120Combined sources8
Beta strandi123 – 131Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WUTX-ray1.85A1-132[»]
3NR3X-ray1.95A3-132[»]
4A1HX-ray2.20A/B/C1-132[»]
4A1YX-ray1.20A/B/C/D1-132[»]
4A8ZX-ray1.80A1-132[»]
4BVMX-ray0.93A1-132[»]
4D6AX-ray1.45A1-132[»]
4D6BX-ray2.12A1-132[»]
ProteinModelPortaliP02689.
SMRiP02689.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02689.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni127 – 129Fatty acid binding3

Domaini

Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.1 Publication

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiP02689.
OMAiHFDDYMK.
OrthoDBiEOG091G0QSV.
PhylomeDBiP02689.
TreeFamiTF316894.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR031256. Myelin_P2.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PTHR11955:SF64. PTHR11955:SF64. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02689-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNKFLGTWK LVSSENFDDY MKALGVGLAT RKLGNLAKPT VIISKKGDII
60 70 80 90 100
TIRTESTFKN TEISFKLGQE FEETTADNRK TKSIVTLQRG SLNQVQRWDG
110 120 130
KETTIKRKLV NGKMVAECKM KGVVCTRIYE KV
Length:132
Mass (Da):14,909
Last modified:January 23, 2007 - v3
Checksum:i3D515D32695899D2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25G → GG AA sequence (PubMed:6183401).Curated1
Sequence conflicti99D → N AA sequence (PubMed:6183401).Curated1
Sequence conflicti111N → D AA sequence (PubMed:6183401).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16181 Genomic DNA. Translation: BAA03726.1.
X62167 mRNA. Translation: CAA44096.1.
AK311758 mRNA. Translation: BAG34701.1.
CR541649 mRNA. Translation: CAG46450.1.
CR541738 mRNA. Translation: CAG46538.1.
AC018616 Genomic DNA. No translation available.
CH471068 Genomic DNA. Translation: EAW87090.1.
BC034997 mRNA. Translation: AAH34997.1.
AH004648 Genomic DNA. Translation: AAB32592.2.
CCDSiCCDS6229.1.
PIRiJT0977. MPHU2.
RefSeqiNP_002668.1. NM_002677.3.
UniGeneiHs.571512.

Genome annotation databases

EnsembliENST00000256103; ENSP00000256103; ENSG00000147588.
GeneIDi5375.
KEGGihsa:5375.
UCSCiuc003ycb.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D16181 Genomic DNA. Translation: BAA03726.1.
X62167 mRNA. Translation: CAA44096.1.
AK311758 mRNA. Translation: BAG34701.1.
CR541649 mRNA. Translation: CAG46450.1.
CR541738 mRNA. Translation: CAG46538.1.
AC018616 Genomic DNA. No translation available.
CH471068 Genomic DNA. Translation: EAW87090.1.
BC034997 mRNA. Translation: AAH34997.1.
AH004648 Genomic DNA. Translation: AAB32592.2.
CCDSiCCDS6229.1.
PIRiJT0977. MPHU2.
RefSeqiNP_002668.1. NM_002677.3.
UniGeneiHs.571512.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WUTX-ray1.85A1-132[»]
3NR3X-ray1.95A3-132[»]
4A1HX-ray2.20A/B/C1-132[»]
4A1YX-ray1.20A/B/C/D1-132[»]
4A8ZX-ray1.80A1-132[»]
4BVMX-ray0.93A1-132[»]
4D6AX-ray1.45A1-132[»]
4D6BX-ray2.12A1-132[»]
ProteinModelPortaliP02689.
SMRiP02689.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111388. 7 interactors.
IntActiP02689. 1 interactor.
MINTiMINT-5006340.
STRINGi9606.ENSP00000256103.

Chemistry databases

DrugBankiDB04224. Oleic Acid.

PTM databases

iPTMnetiP02689.
PhosphoSitePlusiP02689.
SwissPalmiP02689.

Polymorphism and mutation databases

BioMutaiPMP2.
DMDMi127725.

Proteomic databases

MaxQBiP02689.
PaxDbiP02689.
PeptideAtlasiP02689.
PRIDEiP02689.

Protocols and materials databases

DNASUi5375.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256103; ENSP00000256103; ENSG00000147588.
GeneIDi5375.
KEGGihsa:5375.
UCSCiuc003ycb.3. human.

Organism-specific databases

CTDi5375.
DisGeNETi5375.
GeneCardsiPMP2.
HGNCiHGNC:9117. PMP2.
MIMi170715. gene.
neXtProtiNX_P02689.
OpenTargetsiENSG00000147588.
PharmGKBiPA33443.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4015. Eukaryota.
ENOG4111US8. LUCA.
GeneTreeiENSGT00760000118898.
HOGENOMiHOG000004829.
HOVERGENiHBG005633.
InParanoidiP02689.
OMAiHFDDYMK.
OrthoDBiEOG091G0QSV.
PhylomeDBiP02689.
TreeFamiTF316894.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000147588-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP02689.
GeneWikiiPMP2.
GenomeRNAii5375.
PROiP02689.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147588.
CleanExiHS_PMP2.
ExpressionAtlasiP02689. baseline and differential.
GenevisibleiP02689. HS.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR012674. Calycin.
IPR011038. Calycin-like.
IPR000463. Fatty_acid-bd.
IPR031259. iLBP.
IPR000566. Lipocln_cytosolic_FA-bd_dom.
IPR031256. Myelin_P2.
[Graphical view]
PANTHERiPTHR11955. PTHR11955. 1 hit.
PTHR11955:SF64. PTHR11955:SF64. 1 hit.
PfamiPF00061. Lipocalin. 1 hit.
[Graphical view]
PRINTSiPR00178. FATTYACIDBP.
SUPFAMiSSF50814. SSF50814. 1 hit.
PROSITEiPS00214. FABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYP2_HUMAN
AccessioniPrimary (citable) accession number: P02689
Secondary accession number(s): Q6FHL4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 147 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

P2 protein and myelin basic protein together constitute a major fraction of peripheral nervous system myelin protein.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.