Reviewed,
UniProtKB/Swiss-Prot P02686 (MBP_HUMAN)
Last modified
July 7, 2009.
Version 119.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
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Names and origin
| Protein names | Recommended name: Myelin basic protein Short name=MBP Alternative name(s): Myelin A1 protein Myelin membrane encephalitogenic protein | ||
| Gene names |
| ||
| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 304 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. Ref.7 |
| Subunit structure | |
| Subcellular location | Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note: Cytoplasmic side of myelin. |
| Tissue specificity | MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system. Ref.6 |
| Developmental stage | Expression begins abruptly in 14-16 week old fetuses. Even smaller isoforms seem to be produced during embryogenesis; some of these persisting in the adult. Expression of isoform MBP2 is more evident at 16 weeks and its relative proportion declines thereafter. |
| Post-translational modification | Several charge isomers of MBP; C1 (the most cationic, least modified, and most abundant form), C2, C3, C4, C5, C6, C7, C8-A and C8-B (the least cationic form); are produced as a result of optional PTM, such as phosphorylation, deamidation of glutamine or asparagine, arginine citrullination and methylation. C8-A and C8-B contain each two mass isoforms termed C8-A(H), C8-A(L), C8-B(H) and C8-B(L), (H) standing for higher and (L) for lower molecular weight. C3, C4 and C5 are phosphorylated. The ratio of methylated arginine residues decreases during aging, making the protein more cationic. Ref.23 The N-terminal alanine is acetylated (isoform 3, isoform 4, isoform 5 and isoform 6). Arg-241 was found to be 6% monomethylated and 60% symmetrically dimethylated. Ref.22 |
| Involvement in disease | The reduction in the surface charge of citrullinated and/or methylated MBP could result in a weakened attachment to the myelin membrane. This mechanism could be operative in demyelinating diseases such as chronical multiple sclerosis (MS), and fulminating MS (Marburg disease). |
| Sequence similarities | Belongs to the myelin basic protein family. |
| Sequence caution | The sequence AAC41944.1 differs from that shown. Reason: Miscellaneous discrepancy. Contaminating sequence. The C-terminus contains a Histidine tag. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane |
| Coding sequence diversity | Alternative splicing |
| Disease | Autoimmune encephalomyelitis |
| PTM | Acetylation Citrullination Methylation Phosphoprotein |
| Technical term | 3D-structure Complete proteome Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | central nervous system development Traceable author statement. Source: ProtInc immune response Ref.6Traceable author statement. Source: ProtInc synaptic transmissionTraceable author statement. Source: ProtInc |
| Cellular component | myelin sheath Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | structural constituent of myelin sheath Inferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Alternative products
| This entry describes 7 isoforms produced by alternative splicing. [Align] [Select] Note: Additional isoforms seem to exist. | ||||||
| Isoform 1 (identifier: P02686-1) Also known as: Golli-MBP1; HOG7; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: P02686-2) Also known as: Golli-MBP2; HOG5; The sequence of this isoform differs from the canonical sequence as follows: 193-304: DSHHPARTAH...SRSGSPMARR → VSSEE | ||||||
| Isoform 3 (identifier: P02686-3) Also known as: MBP1; 21.5 kDa; The sequence of this isoform differs from the canonical sequence as follows: 1-133: Missing. 192-192: K → KVPWLKPGRSPLPSHARSQPGLCNMYK | ||||||
| Note: Met-1 is removed. Contains N-acetylalanine at position 2. Mutagenesis of Cys-81 to Ser prevents dimerization. | ||||||
| Isoform 4 (identifier: P02686-4) Also known as: MBP2; 20.2 kDa; The sequence of this isoform differs from the canonical sequence as follows: 1-133: Missing. 192-192: K → KVPWLKPGRSPLPSHARSQPGLCNMYK 240-250: Missing. | ||||||
| Note: Met-1 is removed. Contains N-acetylalanine at position 2. | ||||||
| Isoform 5 (identifier: P02686-5) Also known as: MBP3; 18.5 kDa; The sequence of this isoform differs from the canonical sequence as follows: 1-133: Missing. | ||||||
| Note: Met-1 is removed. Contains N-acetylalanine at position 2. | ||||||
| Isoform 6 (identifier: P02686-6) Also known as: MBP4; 17.2 kDa; The sequence of this isoform differs from the canonical sequence as follows: 1-133: Missing. 240-250: Missing. | ||||||
| Note: Met-1 is removed. Contains N-acetylalanine at position 2. | ||||||
| Isoform 7 (identifier: P02686-7) The sequence of this isoform differs from the canonical sequence as follows: 1-133: Missing. 161-203: Missing. 251-304: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||
Molecule processing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 304 | 304 | Myelin basic protein | PRO_0000158990 | |||||||||||||||
Regions | |||||||||||||||||||
| Region | 179 – 222 | 44 | Induces experimental autoimmune encephalomyelitis (EAE) 1 | ||||||||||||||||
| Region | 246 – 256 | 11 | Induces experimental autoimmune encephalomyelitis (EAE) 2 | ||||||||||||||||
Amino acid modifications | |||||||||||||||||||
| Modified residue | 96 | 1 | Phosphoserine Ref.23 | ||||||||||||||||
| Modified residue | 141 | 1 | Phosphoserine By similarity | ||||||||||||||||
| Modified residue | 146 | 1 | Phosphoserine By similarity | ||||||||||||||||
| Modified residue | 159 | 1 | Citrulline; in form C8 | ||||||||||||||||
| Modified residue | 165 | 1 | Citrulline; in form C8 | ||||||||||||||||
| Modified residue | 169 | 1 | Phosphothreonine By similarity | ||||||||||||||||
| Modified residue | 174 | 1 | Phosphoserine By similarity | ||||||||||||||||
| Modified residue | 203 | 1 | Phosphotyrosine By similarity | ||||||||||||||||
| Modified residue | 205 | 1 | Phosphoserine By similarity | ||||||||||||||||
| Modified residue | 229 | 1 | Phosphothreonine By similarity | ||||||||||||||||
| Modified residue | 232 | 1 | Phosphothreonine By similarity | ||||||||||||||||
| Modified residue | 237 | 1 | Deamidated glutamine By similarity | ||||||||||||||||
| Modified residue | 241 | 1 | Omega-N-methylarginine; alternate Ref.22 | ||||||||||||||||
| Modified residue | 241 | 1 | Symmetric dimethylarginine; alternate Ref.22 | ||||||||||||||||
| Modified residue | 249 | 1 | Phosphoserine By similarity | ||||||||||||||||
| Modified residue | 256 | 1 | Citrulline; in form C8 | ||||||||||||||||
| Modified residue | 264 | 1 | Citrulline; in form C8 | ||||||||||||||||
| Modified residue | 281 | 1 | Deamidated glutamine By similarity | ||||||||||||||||
| Modified residue | 293 | 1 | Citrulline; in form C8 | ||||||||||||||||
| Modified residue | 295 | 1 | Phosphoserine By similarity | ||||||||||||||||
| Modified residue | 299 | 1 | Phosphoserine By similarity | ||||||||||||||||
| Modified residue | 304 | 1 | Citrulline; in form C8 | ||||||||||||||||
Natural variations | |||||||||||||||||||
| Alternative sequence | 1 – 133 | 133 | Missing in isoform 3, isoform 4, isoform 5, isoform 6 and isoform 7. | VSP_003308 | |||||||||||||||
| Alternative sequence | 161 – 203 | 43 | Missing in isoform 7. | VSP_019259 | |||||||||||||||
| Alternative sequence | 192 | 1 | K → KVPWLKPGRSPLPSHARSQP GLCNMYK in isoform 3 and isoform 4. | VSP_003309 | |||||||||||||||
| Alternative sequence | 193 – 304 | 112 | DSHHP…PMARR → VSSEE in isoform 2. | VSP_003311 | |||||||||||||||
| Alternative sequence | 240 – 250 | 11 | Missing in isoform 4 and isoform 6. | VSP_003310 | |||||||||||||||
| Alternative sequence | 251 – 304 | 54 | Missing in isoform 7. | VSP_019260 | |||||||||||||||
Experimental info | |||||||||||||||||||
| Sequence conflict | 300 | 1 | P → T in CAG38771. Ref.8 | ||||||||||||||||
Secondary structure | |||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||
| Beta strand | 146 – 154 | 9 | |||||||||||||||||
| Beta strand | 160 – 162 | 3 | |||||||||||||||||
| Beta strand | 173 – 179 | 7 | |||||||||||||||||
| Beta strand | 241 – 248 | 8 | |||||||||||||||||
| Beta strand | 284 – 289 | 6 | |||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Amino acid sequence of the encephalitogenic basic protein from human myelin." Carnegie P.R. Biochem. J. 123:57-67(1971) [PubMed: 4108501] [Abstract] Cited for: PROTEIN SEQUENCE (ISOFORM 5). |
| [2] | "Isolation and characterization of a cDNA coding for a novel human 17.3K myelin basic protein (MBP) variant." Roth H.J., Kronquist K.E., Pretorius P.J., Crandall B.F., Campagnoni A.T. J. Neurosci. Res. 16:227-238(1986) [PubMed: 2427738] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6). Tissue: Embryonic spinal cord. |
| [3] | "Identification of three forms of human myelin basic protein by cDNA cloning." Kamholz J., de Ferra F., Puckett C., Lazzarini R.A. Proc. Natl. Acad. Sci. U.S.A. 83:4962-4966(1986) [PubMed: 2425357] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 5). |
| [4] | "Evidence for the expression of four myelin basic protein variants in the developing human spinal cord through cDNA cloning." Roth H.J., Kronquist K.E., de Rosbo N., Crandall B.F., Campagnoni A.T. J. Neurosci. Res. 17:321-328(1987) [PubMed: 2442403] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3; 4; 5 AND 6). Tissue: Embryonic spinal cord. |
| [5] | "The organization of the human myelin basic protein gene. Comparison with the mouse gene." Streicher R., Stoffel W. Biol. Chem. Hoppe-Seyler 370:503-510(1989) [PubMed: 2472816] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 3; 4; 5 AND 6). |
| [6] | "The human myelin basic protein gene is included within a 179-kilobase transcription unit: expression in the immune and central nervous systems." Pribyl T.M., Campagnoni C.W., Kampf K., Kashima T., Handley V.W., McMahon J., Campagnoni A.T. Proc. Natl. Acad. Sci. U.S.A. 90:10695-10699(1993) [PubMed: 7504278] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY. Tissue: Brain. |
| [7] | "Purification of immunologically active recombinant 21.5 kDa isoform of human myelin basic protein." Nye S.H., Pelfrey C.M., Burkwit J.J., Voskuhl R.R., Lenardo M.J., Mueller J.P. Mol. Immunol. 32:1131-1141(1995) [PubMed: 8544862] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 3), FUNCTION, DIMERIZATION, MUTAGENESIS. |
| [8] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6). |
| [9] | The German cDNA consortium Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7). Tissue: Amygdala. |
| [10] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Hippocampus and Subthalamic nucleus. |
| [11] | Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S., Ohara O., Nagase T., Kikuno R.F. Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Brain. |
| [12] | "DNA sequence and analysis of human chromosome 18." Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. Lander E.S.Nature 437:551-555(2005) [PubMed: 16177791] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [13] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5). Tissue: Brain, Lung and Skin. |
| [14] | "Repetitive DNA (TGGA)n 5' to the human myelin basic protein gene: a new form of oligonucleotide repetitive sequence showing length polymorphism." Boylan K.B., Ayres T.M., Popko B., Takahashi N., Hood L.E., Prusiner S.B. Genomics 6:16-22(1990) [PubMed: 1689270] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 135-192. |
| [15] | "Analysis of the primary sequence of human myelin basic protein peptides 1-44 and 90-170 by fast atom bombardment mass spectrometry." Scoble H.A., Whitaker J.N., Biemann K. J. Neurochem. 47:614-616(1986) [PubMed: 2426402] [Abstract] Cited for: PROTEIN SEQUENCE OF 135-178 AND 224-304 (ISOFORM 3), MASS SPECTROMETRY. |
| [16] | "The isolation, characterization, and lipid-aggregating properties of a citrulline containing myelin basic protein." Wood D.D., Moscarello M.A. J. Biol. Chem. 264:5121-5127(1989) [PubMed: 2466844] [Abstract] Cited for: PROTEIN SEQUENCE OF 148-304 (ISOFORM 5), CITRULLINATION OF C8. Tissue: Brain. |
| [17] | "The isolation and characterization of four myelin basic proteins from the unbound fraction during CM52 chromatography." Boulias C., Pang H., Mastronardi F., Moscarello M.A. Arch. Biochem. Biophys. 322:174-182(1995) [PubMed: 7574672] [Abstract] Cited for: PROTEIN SEQUENCE OF 156-172 AND 302-304, CHARACTERIZATION OF C8. Tissue: Brain. |
| [18] | "Amino acid sequence of human myelin basic protein peptide 45-89 as determined by mass spectrometry." Gibson B.W., Gilliom R.D., Whitaker J.N., Biemann K. J. Biol. Chem. 259:5028-5031(1984) [PubMed: 6201481] [Abstract] Cited for: PROTEIN SEQUENCE OF 179-223 (ISOFORM 5), MASS SPECTROMETRY. |
| [19] | "Encephalitogenic fragment of myelin basic protein. Amino acid sequence of bovine, rabbit, guinea pig, monkey, and human fragments." Shapira R., McKneally S.S., Chou F., Kibler R.F. J. Biol. Chem. 246:4630-4640(1971) Cited for: PROTEIN SEQUENCE OF 179-222 (ISOFORM 5), SEQUENCE REVISION. |
| [20] | "Immunologic properties of the main encephalitogenic peptide from the basic protein of human myelin." Lennon V.A., Wilks A.V., Carnegie P.R. J. Immunol. 105:1223-1230(1970) [PubMed: 4099924] [Abstract] Cited for: PROTEIN SEQUENCE OF 246-269 (ISOFORM 3), ENCEPHALITOGENIC PEPTIDE. |
| [21] | "Leukocyte gelatinase B cleavage releases encephalitogens from human myelin basic protein." Proost P., Van Damme J., Opdenakker G. Biochem. Biophys. Res. Commun. 192:1175-1181(1993) [PubMed: 7685161] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE. Tissue: Brain. |
| [22] | "Isolation and partial characterization of methylated arginines from the encephalitogenic basic protein of myelin." Baldwin G.S., Carnegie P.R. Biochem. J. 123:69-74(1971) [PubMed: 5128665] [Abstract] Cited for: METHYLATION AT ARG-241. |
| [23] | "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed: 17081983] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-96, MASS SPECTROMETRY. Tissue: Epithelium. |
| [24] | "Conformation of a tetradecapeptide epitope of myelin basic protein." Mendz G.L., Barden J.A., Martenson R.E. Eur. J. Biochem. 231:659-666(1995) [PubMed: 7544282] [Abstract] Cited for: STRUCTURE BY NMR OF 135-148, ACETYLATION. |
| [25] | "Three-dimensional structure of myelin basic protein. II. Molecular modeling and considerations of predicted structures in multiple sclerosis." Ridsdale R.A., Beniac D.R., Tompkins T.A., Moscarello M.A., Harauz G. J. Biol. Chem. 272:4269-4275(1997) [PubMed: 9020143] [Abstract] Cited for: 3D-STRUCTURE MODELING OF 135-279 (ISOFORM 5). |
| [26] | "Structural basis for the binding of an immunodominant peptide from myelin basic protein in different registers by two HLA-DR2 proteins." Li Y., Li H., Martin R., Mariuzza R.A. J. Mol. Biol. 304:177-188(2000) [PubMed: 11080454] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 218-237 IN COMPLEX WITH HLA-DRA; HLA-DRB1 AND TCRB. |
| [27] | "Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule." Li Y., Huang Y., Lue J., Quandt J.A., Martin R., Mariuzza R.A. EMBO J. 24:2968-2979(2005) [PubMed: 16079912] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 45-57 IN COMPLEX WITH HLA-DRA AND HLA-DRB1. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| M30047 mRNA. Translation: AAA59559.1. M20009 mRNA. Translation: AAA59561.1. M13577 mRNA. Translation: AAA59562.1. M30516 mRNA. Translation: AAA59563.1. M30515 mRNA. Translation: AAA59564.1. X17286 X17289 Genomic DNA. Translation: CAA35179.1. L18862 Genomic DNA. Translation: AAA72008.1. L18864 Genomic DNA. Translation: AAA72009.1. L18865 Genomic DNA. Translation: AAA72010.1. L18866 Genomic DNA. Translation: AAA72011.1. L41657 Genomic DNA. Translation: AAC41944.1. Sequence problems. CR536534 mRNA. Translation: CAG38771.1. CR541919 mRNA. Translation: CAG46717.1. CR627018 mRNA. Translation: CAH10359.1. AK128770 mRNA. Translation: BAG54728.1. AK128788 mRNA. Translation: BAG54734.1. AB208986 mRNA. Translation: BAD92223.1. Different initiation. AC093330 Genomic DNA. No translation available. BC008749 mRNA. Translation: AAH08749.3. BC065248 mRNA. Translation: AAH65248.1. BC080654 mRNA. Translation: AAH80654.1. BC101771 mRNA. Translation: AAI01772.1. BC101773 mRNA. Translation: AAI01774.1. M63599 Genomic DNA. Translation: AAA59560.1. | |||||||||||||||||||||||||||||||||||||||||||
| IPI | IPI00021907. IPI00216474. IPI00216475. IPI00216477. IPI00216478. IPI00607642. IPI00718832. | ||||||||||||||||||||||||||||||||||||||||||
| PIR | A49635. MBHUB. S10482. | ||||||||||||||||||||||||||||||||||||||||||
| RefSeq | NP_001020252.1. NP_001020261.1. NP_001020263.1. NP_001020271.1. NP_001020272.1. NP_002376.1. | ||||||||||||||||||||||||||||||||||||||||||
| UniGene | Hs.551713 | ||||||||||||||||||||||||||||||||||||||||||
3D structure databases | |||||||||||||||||||||||||||||||||||||||||||
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| DisProt | DP00236. | ||||||||||||||||||||||||||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||||||||||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||||||||||||||||||||||||||
| IntAct | P02686. 4 interactions. | ||||||||||||||||||||||||||||||||||||||||||
PTM databases | |||||||||||||||||||||||||||||||||||||||||||
| PhosphoSite | P02686. | ||||||||||||||||||||||||||||||||||||||||||
Proteomic databases | |||||||||||||||||||||||||||||||||||||||||||
| PRIDE | P02686. | ||||||||||||||||||||||||||||||||||||||||||
Genome annotation databases | |||||||||||||||||||||||||||||||||||||||||||
| Ensembl | ENSG00000197971. Homo sapiens. [Contig view] | ||||||||||||||||||||||||||||||||||||||||||
| GeneID | 4155. | ||||||||||||||||||||||||||||||||||||||||||
| KEGG | hsa:4155. | ||||||||||||||||||||||||||||||||||||||||||
| UCSC | uc002lml.1. human. uc002lmn.1. human. uc002lmp.1. human. uc002lmq.1. human. uc002lmr.1. human. | ||||||||||||||||||||||||||||||||||||||||||
Organism-specific databases | |||||||||||||||||||||||||||||||||||||||||||
| GeneCards | GC18M072819. | ||||||||||||||||||||||||||||||||||||||||||
| H-InvDB | HIX0014534. | ||||||||||||||||||||||||||||||||||||||||||
| HGNC | HGNC:6925. MBP. | ||||||||||||||||||||||||||||||||||||||||||
| HPA | CAB002300. | ||||||||||||||||||||||||||||||||||||||||||
| MIM | 159430. gene. | ||||||||||||||||||||||||||||||||||||||||||
| PharmGKB | PA24759. | ||||||||||||||||||||||||||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||||||||||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||||||||||||||||||||||||||
| HOVERGEN | P02686. | ||||||||||||||||||||||||||||||||||||||||||
| OMA | P02686. KMASAST. | ||||||||||||||||||||||||||||||||||||||||||
Gene expression databases | |||||||||||||||||||||||||||||||||||||||||||
| ArrayExpress | P02686. | ||||||||||||||||||||||||||||||||||||||||||
| Bgee | P02686. | ||||||||||||||||||||||||||||||||||||||||||
| CleanEx | HS_MBP. | ||||||||||||||||||||||||||||||||||||||||||
| GermOnline | ENSG00000197971. Homo sapiens. | ||||||||||||||||||||||||||||||||||||||||||
Family and domain databases | |||||||||||||||||||||||||||||||||||||||||||
| InterPro | IPR000548. Myelin_BP. [Graphical view] | ||||||||||||||||||||||||||||||||||||||||||
| PANTHER | PTHR11429. Myelin_BP. 1 hit. | ||||||||||||||||||||||||||||||||||||||||||
| Pfam | PF01669. Myelin_MBP. 1 hit. [Graphical view] | ||||||||||||||||||||||||||||||||||||||||||
| PRINTS | PR00212. MYELINMBP. | ||||||||||||||||||||||||||||||||||||||||||
| ProDom | PD004542. Myelin_BP. 1 hit. [Graphical view] [Entries sharing at least one domain] | ||||||||||||||||||||||||||||||||||||||||||
| PROSITE | PS00569. MYELIN_MBP. 1 hit. [Graphical view] | ||||||||||||||||||||||||||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||||||||||||||||||||||||||
Other Resources | |||||||||||||||||||||||||||||||||||||||||||
| NextBio | 16362. | ||||||||||||||||||||||||||||||||||||||||||
| PMAP-CutDB | P02686. | ||||||||||||||||||||||||||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||||||||||||||||||||||||||
Entry information
| Entry name | MBP_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P02686 Secondary accession number(s): A4FU54 Q6PK23 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 18 Human chromosome 18: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


