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Protein

Fibrinogen gamma chain

Gene

Fgg

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi344CalciumBy similarity1
Metal bindingi346CalciumBy similarity1
Metal bindingi350Calcium; via carbonyl oxygenBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processBlood coagulation, Hemostasis
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-114608 Platelet degranulation
R-RNO-140875 Common Pathway of Fibrin Clot Formation
R-RNO-216083 Integrin cell surface interactions
R-RNO-354192 Integrin alphaIIb beta3 signaling
R-RNO-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-RNO-372708 p130Cas linkage to MAPK signaling for integrins
R-RNO-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-RNO-5674135 MAP2K and MAPK activation
R-RNO-8957275 Post-translational protein phosphorylation

Names & Taxonomyi

Protein namesi
Recommended name:
Fibrinogen gamma chain
Gene namesi
Name:Fgg
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi2613 Fgg

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Add BLAST25
ChainiPRO_000000910126 – 445Fibrinogen gamma chainAdd BLAST420

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34Interchain (with gamma chain)PROSITE-ProRule annotation
Disulfide bondi35Interchain (with gamma chain)PROSITE-ProRule annotation
Disulfide bondi45Interchain (with beta chain)PROSITE-ProRule annotation
Disulfide bondi49Interchain (with alpha chain)PROSITE-ProRule annotation
Glycosylationi78N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi161Interchain (with beta chain)PROSITE-ProRule annotation
Disulfide bondi165Interchain (with gamma chain)PROSITE-ProRule annotation
Disulfide bondi179 ↔ 208PROSITE-ProRule annotation
Disulfide bondi352 ↔ 365PROSITE-ProRule annotation
Cross-linki424Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-432)By similarity
Modified residuei431PhosphoserineCombined sources1
Cross-linki432Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-424)By similarity

Post-translational modificationi

Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein

Proteomic databases

PaxDbiP02680
PRIDEiP02680

PTM databases

iPTMnetiP02680
PhosphoSitePlusiP02680

Expressioni

Gene expression databases

BgeeiENSRNOG00000025074
GenevisibleiP02680 RN

Interactioni

Subunit structurei

Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP02680, 1 interactor
STRINGi10116.ENSRNOP00000032735

Structurei

3D structure databases

ProteinModelPortaliP02680
SMRiP02680
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini170 – 416Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST247

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni400 – 422Gamma-chain polymerization, binding amino end of another fibrin alpha chainBy similarityAdd BLAST23

Domaini

A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha chains fold back, contributing a fourth strand to the coiled coil structure.By similarity

Keywords - Domaini

Coiled coil, Signal

Phylogenomic databases

eggNOGiKOG2579 Eukaryota
ENOG410ZYS4 LUCA
GeneTreeiENSGT00760000118809
HOGENOMiHOG000037127
HOVERGENiHBG099783
InParanoidiP02680
KOiK03905
OMAiRLTYAYF
OrthoDBiEOG091G03M1
PhylomeDBiP02680
TreeFamiTF336658

Family and domain databases

CDDicd00087 FReD, 1 hit
Gene3Di3.90.215.10, 1 hit
4.10.530.10, 1 hit
InterProiView protein in InterPro
IPR036056 Fibrinogen-like_C
IPR014716 Fibrinogen_a/b/g_C_1
IPR014715 Fibrinogen_a/b/g_C_2
IPR002181 Fibrinogen_a/b/g_C_dom
IPR012290 Fibrinogen_a/b/g_coil_dom
IPR020837 Fibrinogen_CS
IPR037581 Fibrinogen_gamma
PANTHERiPTHR19143:SF338 PTHR19143:SF338, 1 hit
PfamiView protein in Pfam
PF08702 Fib_alpha, 1 hit
PF00147 Fibrinogen_C, 1 hit
SMARTiView protein in SMART
SM00186 FBG, 1 hit
SM01212 Fib_alpha, 1 hit
SUPFAMiSSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00514 FIBRINOGEN_C_1, 1 hit
PS51406 FIBRINOGEN_C_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Gamma-B (identifier: P02680-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNWSLQLRSF ILCWALLLLS PTGLAQYTAT RDNCCILDER FGSYCPTTCG
60 70 80 90 100
ISDFLNSYQT DVDTDLQTLE NILQRAENRT TEAKELIKAI QVYYNPDQPP
110 120 130 140 150
KPGMIEGATQ KSKKMVEEIL KYEALLLTHE SSIRYLQDIY TSNKQKITNL
160 170 180 190 200
KQKVAQLEAQ CQEPCKDSVR IHDTTGKDCQ DIANKGAKES GLYFIRPLKA
210 220 230 240 250
TQQFLVYCEI DGSGNGWTVL QKRLDGSVDF KKNWIQYKEG FGHLSPTGTT
260 270 280 290 300
EFWLGNEKIH LISMQSTIPY ALRIQLKDWS GRTSTADYAM FRVGPESDKY
310 320 330 340 350
RLTYAYFIGG DAGDAFDGYD FGDDPSDKFF TSHNGMHFST WDNDNDKFEG
360 370 380 390 400
NCAEQDGSGW WMNKCHAGHL NGVYYQGGTY SKSSTPNGYD NGIIWATWKT
410 420 430 440
RWYSMKETTM KIIPFNRLSI GDGQQHHMGG SKQVSVEHEV DVEYP
Length:445
Mass (Da):50,633
Last modified:January 9, 2007 - v3
Checksum:iEB6F4FF7A7812054
GO
Isoform Gamma-A (identifier: P02680-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     435-437: SVE → GDM
     438-445: Missing.

Show »
Length:437
Mass (Da):49,652
Checksum:iDB58661DF73A0C06
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti160Q → L in J00734 (PubMed:6897622).Curated1
Sequence conflicti160Q → L in CAA29289 (PubMed:3562236).Curated1
Sequence conflicti162Q → K in J00734 (PubMed:6897622).Curated1
Sequence conflicti172 – 174HDT → YDI in J00734 (PubMed:6897622).Curated3
Sequence conflicti172 – 174HDT → YDI in CAA29289 (PubMed:3562236).Curated3
Sequence conflicti182I → T in J00734 (PubMed:6897622).Curated1
Sequence conflicti182I → T in CAA29289 (PubMed:3562236).Curated1
Sequence conflicti194F → S in J00734 (PubMed:6897622).Curated1
Sequence conflicti194F → S in CAA29289 (PubMed:3562236).Curated1
Sequence conflicti202Q → E in J00734 (PubMed:6897622).Curated1
Sequence conflicti202Q → E in CAA29289 (PubMed:3562236).Curated1
Sequence conflicti204F → S in J00734 (PubMed:6897622).Curated1
Sequence conflicti210I → T in J00734 (PubMed:6897622).Curated1
Sequence conflicti210I → T in CAA29289 (PubMed:3562236).Curated1
Sequence conflicti213S → P in J00734 (PubMed:6897622).Curated1
Sequence conflicti213S → P in CAA29289 (PubMed:3562236).Curated1
Sequence conflicti219 – 221VLQ → EFK in J00734 (PubMed:6897622).Curated3
Sequence conflicti219 – 221VLQ → EFK in CAA29289 (PubMed:3562236).Curated3
Sequence conflicti231K → L in J00734 (PubMed:6897622).Curated1
Sequence conflicti231K → L in CAA29289 (PubMed:3562236).Curated1
Sequence conflicti259I → N in J00734 (PubMed:6897622).Curated1
Sequence conflicti259I → N in CAA29289 (PubMed:3562236).Curated1
Sequence conflicti296E → G in J00734 (PubMed:6897622).Curated1
Sequence conflicti373V → G in J00735 (PubMed:6897622).Curated1
Sequence conflicti401R → S in J00735 (PubMed:6897622).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001538435 – 437SVE → GDM in isoform Gamma-A. 2 Publications3
Alternative sequenceiVSP_001539438 – 445Missing in isoform Gamma-A. 2 Publications8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00733 Genomic DNA No translation available.
J00734 mRNA No translation available.
J00735 mRNA No translation available.
X05860, X05861 Genomic DNA Translation: CAA29289.1
BC078893 mRNA Translation: AAH78893.1
K01337 Genomic DNA Translation: AAA98626.1
PIRiA03128 FGRTGB
A90828 FGRTGA
RefSeqiNP_036691.2, NM_012559.2 [P02680-2]
XP_006232587.1, XM_006232525.1 [P02680-1]
UniGeneiRn.1702

Genome annotation databases

EnsembliENSRNOT00000034521; ENSRNOP00000032735; ENSRNOG00000025074 [P02680-2]
GeneIDi24367
KEGGirno:24367
UCSCiRGD:2613 rat [P02680-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFIBG_RAT
AccessioniPrimary (citable) accession number: P02680
Secondary accession number(s): Q68FY3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 9, 2007
Last modified: May 23, 2018
This is version 143 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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