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Protein

Kappa-casein

Gene

CSN3

Organism
Capra hircus (Goat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.

Keywords - Molecular functioni

Milk protein

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-casein
Short name:
Kappa-CN
Gene namesi
Name:CSN3
Synonyms:CSN10, CSNK
OrganismiCapra hircus (Goat)
Taxonomic identifieri9925 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeCapra

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei1242. Cap h 8.
2969. Cap h 12.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 192171Kappa-caseinPRO_0000004492Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei22 – 221Pyrrolidone carboxylic acid1 Publication
Modified residuei148 – 1481PhosphoserineBy similarity
Glycosylationi152 – 1521O-linked (GalNAc...)By similarity
Glycosylationi155 – 1551O-linked (GalNAc...)By similarity
Glycosylationi156 – 1561O-linked (GalNAc...)By similarity
Glycosylationi159 – 1591O-linked (GalNAc...)By similarity
Glycosylationi165 – 1651O-linked (GalNAc...)By similarity
Modified residuei172 – 1721Phosphoserine; alternate1 Publication
Glycosylationi172 – 1721O-linked (GalNAc...); alternateBy similarity
Glycosylationi188 – 1881O-linked (GalNAc...)By similarity
Modified residuei189 – 1891Phosphoserine1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei126 – 1272Cleavage; by chymosin/rennin

Keywords - PTMi

Glycoprotein, Phosphoprotein, Pyrrolidone carboxylic acid

PTM databases

iPTMnetiP02670.

Miscellaneous databases

PMAP-CutDBP02670.

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Structurei

3D structure databases

ProteinModelPortaliP02670.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the kappa-casein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG005246.
KOiK17282.

Family and domain databases

InterProiIPR000117. Casein_kappa.
[Graphical view]
PANTHERiPTHR11470. PTHR11470. 1 hit.
PfamiPF00997. Casein_kappa. 1 hit.
[Graphical view]
PIRSFiPIRSF002374. Casein_kappa. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02670-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKSFFLVVT ILALTLPFLG AQEQNQEQPI CCEKDERFFD DKIAKYIPIQ
60 70 80 90 100
YVLSRYPSYG LNYYQQRPVA LINNQFLPYP YYAKPVAVRS PAQTLQWQVL
110 120 130 140 150
PNTVPAKSCQ DQPTTLARHP HPHLSFMAIP PKKDQDKTEV PAINTIASAE
160 170 180 190
PTVHSTPTTE AIVNTVDNPE ASSESIASAS ETNTAQVTST EV
Length:192
Mass (Da):21,441
Last modified:August 1, 1992 - v2
Checksum:i009F5858F4BFB178
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti134 – 1341D → N AA sequence (PubMed:16386026).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti65 – 651Q → R in allele CSN3-B. 2 Publications
Natural varianti86 – 861V → I in allele CSN3-B, allele C and allele G. 3 Publications
Natural varianti111 – 1111D → G in allele E. 1 Publication
Natural varianti140 – 1401V → I in allele CSN3-B, allele B, allele C, allele E, allele F and allele G. 5 Publications
Natural varianti177 – 1771A → V in allele C. 1 Publication
Natural varianti180 – 1801S → P in allele CSN3-B, allele C, allele F and allele G. 3 Publications

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14373 Genomic DNA. Translation: BAA03286.1.
X60763 mRNA. Translation: CAA43174.1.
AY027868 Genomic DNA. Translation: AAK17010.1.
AF485339 Genomic DNA. Translation: AAL90871.1.
AF485340 Genomic DNA. Translation: AAL90872.1.
AF485341 Genomic DNA. Translation: AAL90873.1.
AF486523 Genomic DNA. Translation: AAL93193.1.
AY090465 Genomic DNA. Translation: AAM12025.1.
AY090466 Genomic DNA. Translation: AAM12026.1.
AY090467 Genomic DNA. Translation: AAM12027.1.
AF434988 Genomic DNA. Translation: AAL31535.1.
PIRiA94479. KKGT.
S15513.
RefSeqiNP_001272516.1. NM_001285587.1.
UniGeneiChi.520.

Genome annotation databases

GeneIDi100861231.
KEGGichx:100861231.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14373 Genomic DNA. Translation: BAA03286.1.
X60763 mRNA. Translation: CAA43174.1.
AY027868 Genomic DNA. Translation: AAK17010.1.
AF485339 Genomic DNA. Translation: AAL90871.1.
AF485340 Genomic DNA. Translation: AAL90872.1.
AF485341 Genomic DNA. Translation: AAL90873.1.
AF486523 Genomic DNA. Translation: AAL93193.1.
AY090465 Genomic DNA. Translation: AAM12025.1.
AY090466 Genomic DNA. Translation: AAM12026.1.
AY090467 Genomic DNA. Translation: AAM12027.1.
AF434988 Genomic DNA. Translation: AAL31535.1.
PIRiA94479. KKGT.
S15513.
RefSeqiNP_001272516.1. NM_001285587.1.
UniGeneiChi.520.

3D structure databases

ProteinModelPortaliP02670.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei1242. Cap h 8.
2969. Cap h 12.

PTM databases

iPTMnetiP02670.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100861231.
KEGGichx:100861231.

Organism-specific databases

CTDi1448.

Phylogenomic databases

HOVERGENiHBG005246.
KOiK17282.

Miscellaneous databases

PMAP-CutDBP02670.

Family and domain databases

InterProiIPR000117. Casein_kappa.
[Graphical view]
PANTHERiPTHR11470. PTHR11470. 1 hit.
PfamiPF00997. Casein_kappa. 1 hit.
[Graphical view]
PIRSFiPIRSF002374. Casein_kappa. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of the goat kappa-casein cDNA."
    Coll A., Folch J.M., Sanchez A.
    J. Anim. Sci. 71:2833-2833(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Ssp. aegagrus.
    Tissue: Mammary gland.
  2. "Molecular phylogeny based on the kappa-casein and cytochrome b sequences in the mammalian suborder ruminantia."
    Chikuni K., Mori Y., Tabata T., Saito M., Monma M., Kosugiyama M.
    J. Mol. Evol. 41:859-866(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Comparative study of the amino acid sequences of the caseinomacropeptides from seven species."
    Mercier J.-C., Chobert J.-M., Addeo F.
    FEBS Lett. 72:208-214(1976) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 22-192, PYROGLUTAMATE FORMATION AT Q-22.
  4. "Genetic polymorphism of goat kappa-casein (CSN3) in different breeds and characterization at DNA level."
    Caroli A., Jann O., Budelli E., Bolla P., Jaeger S., Erhardt G.
    Anim. Genet. 32:226-230(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 31-192, VARIANTS ARG-65; ILE-86; ILE-140 AND PRO-180.
  5. "Genetic polymorphism of the caprine kappa casein gene."
    Yahyaoui M.H., Coll A., Sanchez A., Folch J.M.
    J. Dairy Res. 68:209-216(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 31-192, VARIANTS ILE-86; ILE-140; VAL-177 AND PRO-180.
  6. "Characterization of a new genetic variant in the caprine k-casein gene."
    Angiolillo A., Yahyaoui M.H., Sanchez A., Pilla F., Folch J.M.
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 31-192, VARIANTS GLY-111 AND ILE-140.
  7. "Characterization of new genetic variants and genotyping of the caprine kappa casein gene."
    Yahyaoui M.H., Sanchez A., Folch J.M.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 31-192, VARIANTS ARG-65; ILE-86; ILE-140 AND PRO-180.
  8. "Polymorphism of kappa-casein in Italian goat breeds: a new ACRS-PCR designed DNA test for discrimination of A and B alleles."
    Feligini M., Cubric-Curik V., Parma P., Curik I., Greppi G., Enne G.
    Food Technol. Biotechnol. 40:293-298(2002)
    Cited for: NUCLEOTIDE SEQUENCE OF 31-189, VARIANT ILE-140.
  9. "Primary structure of the casein macropeptide of caprine kappa casein."
    Mercier J.-C., Addeo F., Pelissier J.-P.
    Biochimie 58:1303-1310(1976) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 127-192, PHOSPHORYLATION AT SER-172 AND SER-189.

Entry informationi

Entry nameiCASK_CAPHI
AccessioniPrimary (citable) accession number: P02670
Secondary accession number(s): Q8SPM9
, Q8SPN0, Q8SPV1, Q8SPW6, Q8SPW7, Q8SPW8, Q8WMV5, Q8WN74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: August 1, 1992
Last modified: January 20, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.