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Protein

Kappa-casein

Gene

CSN3

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Milk protein

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-casein
Gene namesi
Name:CSN3
Synonyms:CSN10, CSNK
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Chromosome 6

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei1241. Ovi a 8.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 192171Kappa-caseinPRO_0000004507Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei148 – 1481PhosphoserineBy similarity
Glycosylationi152 – 1521O-linked (GalNAc...)By similarity
Glycosylationi155 – 1551O-linked (GalNAc...)By similarity
Glycosylationi156 – 1561O-linked (GalNAc...)By similarity
Glycosylationi159 – 1591O-linked (GalNAc...)By similarity
Modified residuei172 – 1721Phosphoserine; alternateBy similarity
Glycosylationi172 – 1721O-linked (GalNAc...); alternateBy similarity
Glycosylationi188 – 1881O-linked (GalNAc...)By similarity
Modified residuei189 – 1891PhosphoserineBy similarity

Post-translational modificationi

O-glycosylated on Thr at position 156, 158 or 159.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei126 – 1272Cleavage; by chymosin/rennin

Keywords - PTMi

Glycoprotein, Phosphoprotein

Miscellaneous databases

PMAP-CutDBP02669.

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Gene expression databases

ExpressionAtlasiP02669. baseline.

Family & Domainsi

Sequence similaritiesi

Belongs to the kappa-casein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000009184.
HOVERGENiHBG005246.
KOiK17282.
OMAiIPPKKIQ.
OrthoDBiEOG091G105X.

Family and domain databases

InterProiIPR000117. Casein_kappa.
[Graphical view]
PANTHERiPTHR11470. PTHR11470. 1 hit.
PfamiPF00997. Casein_kappa. 1 hit.
[Graphical view]
PIRSFiPIRSF002374. Casein_kappa. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02669-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKSFFLVVT ILALTLPFLG AQEQNQEQRI CCEKDERFFD DKIAKYIPIQ
60 70 80 90 100
YVLSRYPSYG LNYYQQRPVA LINNQFLPYP YYAKPVAVRS PAQTLQWQVL
110 120 130 140 150
PNAVPAKSCQ DQPTAMARHP HPHLSFMAIP PKKDQDKTEI PAINTIASAE
160 170 180 190
PTVHSTPTTE AVVNAVDNPE ASSESIASAP ETNTAQVTST EV
Length:192
Mass (Da):21,438
Last modified:April 1, 1990 - v2
Checksum:i0FA87E633F939E58
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231E → Q AA sequence (PubMed:4605338).Curated
Sequence conflicti28 – 281Q → E AA sequence (PubMed:4605338).Curated

Polymorphismi

The frequency of variant Leu-125 is 0.015 in the Italian breed Sopravissana.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti125 – 1251S → L.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51822 mRNA. Translation: CAA36122.1.
AY237637 Genomic DNA. Translation: AAP69943.1.
AY444505 Genomic DNA. Translation: AAS17943.1.
U84256 Genomic DNA. Translation: AAB47262.1.
PIRiS14711. KKSHA.
RefSeqiNP_001009378.1. NM_001009378.1.
UniGeneiOar.438.

Genome annotation databases

EnsembliENSOART00000012054; ENSOARP00000011880; ENSOARG00000011084.
GeneIDi443394.
KEGGioas:443394.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51822 mRNA. Translation: CAA36122.1.
AY237637 Genomic DNA. Translation: AAP69943.1.
AY444505 Genomic DNA. Translation: AAS17943.1.
U84256 Genomic DNA. Translation: AAB47262.1.
PIRiS14711. KKSHA.
RefSeqiNP_001009378.1. NM_001009378.1.
UniGeneiOar.438.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei1241. Ovi a 8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOART00000012054; ENSOARP00000011880; ENSOARG00000011084.
GeneIDi443394.
KEGGioas:443394.

Organism-specific databases

CTDi1448.

Phylogenomic databases

GeneTreeiENSGT00390000009184.
HOVERGENiHBG005246.
KOiK17282.
OMAiIPPKKIQ.
OrthoDBiEOG091G105X.

Miscellaneous databases

PMAP-CutDBP02669.

Gene expression databases

ExpressionAtlasiP02669. baseline.

Family and domain databases

InterProiIPR000117. Casein_kappa.
[Graphical view]
PANTHERiPTHR11470. PTHR11470. 1 hit.
PfamiPF00997. Casein_kappa. 1 hit.
[Graphical view]
PIRSFiPIRSF002374. Casein_kappa. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCASK_SHEEP
AccessioniPrimary (citable) accession number: P02669
Secondary accession number(s): Q69B24, Q6JZK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 1, 1990
Last modified: September 7, 2016
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.