Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Kappa-casein

Gene

CSN3

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.

GO - Biological processi

Keywordsi

Molecular functionMilk protein

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-casein
Gene namesi
Name:CSN3
Synonyms:CSN10, CSNK
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Chromosome 6

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei1241. Ovi a 8.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000000450722 – 192Kappa-caseinAdd BLAST171

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei148PhosphoserineBy similarity1
Glycosylationi152O-linked (GalNAc...) threonineBy similarity1
Glycosylationi155O-linked (GalNAc...) serineBy similarity1
Glycosylationi156O-linked (GalNAc...) threonineBy similarity1
Glycosylationi159O-linked (GalNAc...) threonineBy similarity1
Modified residuei172Phosphoserine; alternateBy similarity1
Glycosylationi172O-linked (GalNAc...) serine; alternateBy similarity1
Glycosylationi188O-linked (GalNAc...) threonineBy similarity1
Modified residuei189PhosphoserineBy similarity1

Post-translational modificationi

O-glycosylated on Thr at position 156, 158 or 159.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei126 – 127Cleavage; by chymosin/rennin2

Keywords - PTMi

Glycoprotein, Phosphoprotein

Miscellaneous databases

PMAP-CutDBiP02669.

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Gene expression databases

ExpressionAtlasiP02669. baseline.

Structurei

3D structure databases

SMRiP02669.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the kappa-casein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000009184.
HOVERGENiHBG005246.
KOiK17282.
OMAiIPPKKIQ.
OrthoDBiEOG091G105X.

Family and domain databases

InterProiView protein in InterPro
IPR000117. Casein_kappa.
PANTHERiPTHR11470. PTHR11470. 1 hit.
PfamiView protein in Pfam
PF00997. Casein_kappa. 1 hit.
PIRSFiPIRSF002374. Casein_kappa. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02669-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKSFFLVVT ILALTLPFLG AQEQNQEQRI CCEKDERFFD DKIAKYIPIQ
60 70 80 90 100
YVLSRYPSYG LNYYQQRPVA LINNQFLPYP YYAKPVAVRS PAQTLQWQVL
110 120 130 140 150
PNAVPAKSCQ DQPTAMARHP HPHLSFMAIP PKKDQDKTEI PAINTIASAE
160 170 180 190
PTVHSTPTTE AVVNAVDNPE ASSESIASAP ETNTAQVTST EV
Length:192
Mass (Da):21,438
Last modified:April 1, 1990 - v2
Checksum:i0FA87E633F939E58
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23E → Q AA sequence (PubMed:4605338).Curated1
Sequence conflicti28Q → E AA sequence (PubMed:4605338).Curated1

Polymorphismi

The frequency of variant Leu-125 is 0.015 in the Italian breed Sopravissana.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti125S → L1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51822 mRNA. Translation: CAA36122.1.
AY237637 Genomic DNA. Translation: AAP69943.1.
AY444505 Genomic DNA. Translation: AAS17943.1.
U84256 Genomic DNA. Translation: AAB47262.1.
PIRiS14711. KKSHA.
RefSeqiNP_001009378.1. NM_001009378.1.
UniGeneiOar.438.

Genome annotation databases

EnsembliENSOART00000012054; ENSOARP00000011880; ENSOARG00000011084.
GeneIDi443394.
KEGGioas:443394.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51822 mRNA. Translation: CAA36122.1.
AY237637 Genomic DNA. Translation: AAP69943.1.
AY444505 Genomic DNA. Translation: AAS17943.1.
U84256 Genomic DNA. Translation: AAB47262.1.
PIRiS14711. KKSHA.
RefSeqiNP_001009378.1. NM_001009378.1.
UniGeneiOar.438.

3D structure databases

SMRiP02669.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei1241. Ovi a 8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOART00000012054; ENSOARP00000011880; ENSOARG00000011084.
GeneIDi443394.
KEGGioas:443394.

Organism-specific databases

CTDi1448.

Phylogenomic databases

GeneTreeiENSGT00390000009184.
HOVERGENiHBG005246.
KOiK17282.
OMAiIPPKKIQ.
OrthoDBiEOG091G105X.

Miscellaneous databases

PMAP-CutDBiP02669.

Gene expression databases

ExpressionAtlasiP02669. baseline.

Family and domain databases

InterProiView protein in InterPro
IPR000117. Casein_kappa.
PANTHERiPTHR11470. PTHR11470. 1 hit.
PfamiView protein in Pfam
PF00997. Casein_kappa. 1 hit.
PIRSFiPIRSF002374. Casein_kappa. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCASK_SHEEP
AccessioniPrimary (citable) accession number: P02669
Secondary accession number(s): Q69B24, Q6JZK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 1, 1990
Last modified: May 10, 2017
This is version 104 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.