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Protein

Kappa-casein

Gene

CSN3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.
Casoxins A, B and C have opioid antagonist activity. Casoxin C causes biphasic ileal contractions through the binding to the complement C3a receptors.
Casoplatelin inhibits platelet aggregation.

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • zymogen binding Source: AgBase

GO - Biological processi

  • lactation Source: GO_Central
  • protein homooligomerization Source: AgBase
  • protein stabilization Source: GO_Central
  • response to 11-deoxycorticosterone Source: AgBase
  • response to dehydroepiandrosterone Source: AgBase
  • response to estradiol Source: AgBase
  • response to progesterone Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Milk protein

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-casein
Cleaved into the following 5 chains:
Gene namesi
Name:CSN3
Synonyms:CSN10, CSNK
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: AgBase
  • Golgi apparatus Source: AgBase
  • Golgi lumen Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei10200. Bos d 12.0101.
167. Bos d 8.
2737. Bos d 12.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21213 PublicationsAdd
BLAST
Chaini22 – 190169Kappa-caseinPRO_0000004483Add
BLAST
Peptidei46 – 5510Casoxin-CPRO_0000004484
Peptidei54 – 596Casoxin-6PRO_0000004485
Peptidei56 – 627Casoxin-APRO_0000004486
Peptidei79 – 824Casoxin-BPRO_0000004487
Peptidei127 – 13711CasoplatelinPRO_0000004488Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei22 – 221Pyrrolidone carboxylic acid
Disulfide bondi32 ↔ 109
Disulfide bondi32 – 32Interchain (with C-109); in linked form
Disulfide bondi109 – 109Interchain (with C-32); in linked form
Glycosylationi142 – 1421O-linked (GalNAc...)3 Publications
Modified residuei148 – 1481Phosphoserine1 Publication
Glycosylationi152 – 1521O-linked (GalNAc...)3 Publications
Glycosylationi153 – 1531O-linked (GalNAc...)1 Publication
Glycosylationi154 – 1541O-linked (GalNAc...)3 Publications
Glycosylationi157 – 1571O-linked (GalNAc...)3 Publications
Glycosylationi163 – 1631O-linked (GalNAc...)3 Publications
Modified residuei166 – 1661Phosphothreonine1 Publication
Modified residuei170 – 1701Phosphoserine; alternate2 Publications
Glycosylationi170 – 1701O-linked (GalNAc...); alternate1 Publication
Glycosylationi186 – 1861O-linked (GalNAc...); partial3 Publications
Modified residuei187 – 1871PhosphoserineBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei126 – 1272Cleavage; by chymosin/rennin

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP02668.
PeptideAtlasiP02668.
PRIDEiP02668.

PTM databases

iPTMnetiP02668.
UniCarbKBiP02668.

Miscellaneous databases

PMAP-CutDBP02668.

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Interactioni

Subunit structurei

Monomer or homomultimer; disulfide-linked.

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-7234047,EBI-7234047
clpBQ9RA633EBI-7234047,EBI-7698530From a different organism.

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • zymogen binding Source: AgBase

Protein-protein interaction databases

BioGridi159044. 2 interactions.
IntActiP02668. 1 interaction.
MINTiMINT-7258912.
STRINGi9913.ENSBTAP00000028685.

Structurei

3D structure databases

DisProtiDP00192.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the kappa-casein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JCVG. Eukaryota.
ENOG4111E7Q. LUCA.
HOVERGENiHBG005246.
InParanoidiP02668.
KOiK17282.
TreeFamiTF338369.

Family and domain databases

InterProiIPR000117. Casein_kappa.
[Graphical view]
PANTHERiPTHR11470. PTHR11470. 1 hit.
PfamiPF00997. Casein_kappa. 1 hit.
[Graphical view]
PIRSFiPIRSF002374. Casein_kappa. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02668-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKSFFLVVT ILALTLPFLG AQEQNQEQPI RCEKDERFFS DKIAKYIPIQ
60 70 80 90 100
YVLSRYPSYG LNYYQQKPVA LINNQFLPYP YYAKPAAVRS PAQILQWQVL
110 120 130 140 150
SNTVPAKSCQ AQPTTMARHP HPHLSFMAIP PKKNQDKTEI PTINTIASGE
160 170 180 190
PTSTPTTEAV ESTVATLEDS PEVIESPPEI NTVQVTSTAV
Length:190
Mass (Da):21,269
Last modified:April 1, 1988 - v1
Checksum:iF12D8310C3B93EDA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231E → Q AA sequence (Ref. 7) Curated
Sequence conflicti26 – 261Q → E AA sequence (Ref. 7) Curated
Sequence conflicti28 – 281Q → E AA sequence (Ref. 7) Curated
Sequence conflicti102 – 1021N → D AA sequence (PubMed:4577852).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti31 – 311R → H in variant F.
Natural varianti118 – 1181R → C in variant G.
Natural varianti156 – 1561T → I in variant G and variant H.
Natural varianti157 – 1571T → I in variant B and variant B2.
Natural varianti169 – 1691D → A in variant B and variant B2.
Natural varianti174 – 1741I → T in variant B2.
Natural varianti176 – 1761S → G in variant E.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00565 mRNA. Translation: CAA25231.1.
M36641 mRNA. Translation: AAA30433.1.
X14907, X14908 Genomic DNA. Translation: CAA33034.1.
AY380228 Genomic DNA. Translation: AAQ87922.1.
AY380229 Genomic DNA. Translation: AAQ87923.1.
BC102120 mRNA. Translation: AAI02121.1.
K01085 mRNA. Translation: AAA30482.1.
AF123250 Genomic DNA. Translation: AAD32139.1.
AF123251 Genomic DNA. Translation: AAD32140.1.
AF105260 Genomic DNA. Translation: AAF72097.1.
M38333 mRNA. Translation: AAA30432.1.
AF041482 Genomic DNA. Translation: AAB97519.1.
U84250 Genomic DNA. Translation: AAB47260.1.
U84251 Genomic DNA. Translation: AAB47261.1.
PIRiS02076. KKBOB.
RefSeqiNP_776719.1. NM_174294.2.
UniGeneiBt.49421.

Genome annotation databases

GeneIDi281728.
KEGGibta:281728.

Cross-referencesi

Web resourcesi

Protein Spotlight

Of buttons, digestion and glue - Issue 16 of November 2001

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00565 mRNA. Translation: CAA25231.1.
M36641 mRNA. Translation: AAA30433.1.
X14907, X14908 Genomic DNA. Translation: CAA33034.1.
AY380228 Genomic DNA. Translation: AAQ87922.1.
AY380229 Genomic DNA. Translation: AAQ87923.1.
BC102120 mRNA. Translation: AAI02121.1.
K01085 mRNA. Translation: AAA30482.1.
AF123250 Genomic DNA. Translation: AAD32139.1.
AF123251 Genomic DNA. Translation: AAD32140.1.
AF105260 Genomic DNA. Translation: AAF72097.1.
M38333 mRNA. Translation: AAA30432.1.
AF041482 Genomic DNA. Translation: AAB97519.1.
U84250 Genomic DNA. Translation: AAB47260.1.
U84251 Genomic DNA. Translation: AAB47261.1.
PIRiS02076. KKBOB.
RefSeqiNP_776719.1. NM_174294.2.
UniGeneiBt.49421.

3D structure databases

DisProtiDP00192.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi159044. 2 interactions.
IntActiP02668. 1 interaction.
MINTiMINT-7258912.
STRINGi9913.ENSBTAP00000028685.

Protein family/group databases

Allergomei10200. Bos d 12.0101.
167. Bos d 8.
2737. Bos d 12.

PTM databases

iPTMnetiP02668.
UniCarbKBiP02668.

Proteomic databases

PaxDbiP02668.
PeptideAtlasiP02668.
PRIDEiP02668.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281728.
KEGGibta:281728.

Organism-specific databases

CTDi1448.

Phylogenomic databases

eggNOGiENOG410JCVG. Eukaryota.
ENOG4111E7Q. LUCA.
HOVERGENiHBG005246.
InParanoidiP02668.
KOiK17282.
TreeFamiTF338369.

Miscellaneous databases

PMAP-CutDBP02668.

Family and domain databases

InterProiIPR000117. Casein_kappa.
[Graphical view]
PANTHERiPTHR11470. PTHR11470. 1 hit.
PfamiPF00997. Casein_kappa. 1 hit.
[Graphical view]
PIRSFiPIRSF002374. Casein_kappa. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCASK_BOVIN
AccessioniPrimary (citable) accession number: P02668
Secondary accession number(s): O46566
, Q597F3, Q6U205, Q9N271, Q9TRQ3, Q9TV96, Q9TV97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 1, 1988
Last modified: September 7, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The sequence shown is the A variant.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.