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Protein

Kappa-casein

Gene

CSN3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.
Casoxins A, B and C have opioid antagonist activity. Casoxin C causes biphasic ileal contractions through the binding to the complement C3a receptors.
Casoplatelin inhibits platelet aggregation.

Miscellaneous

The sequence shown is the A variant.

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • zymogen binding Source: AgBase

GO - Biological processi

  • lactation Source: GO_Central
  • protein homooligomerization Source: AgBase
  • protein stabilization Source: GO_Central
  • response to 11-deoxycorticosterone Source: AgBase
  • response to dehydroepiandrosterone Source: AgBase
  • response to estradiol Source: AgBase
  • response to progesterone Source: AgBase

Keywordsi

Molecular functionMilk protein

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-casein
Cleaved into the following 5 chains:
Gene namesi
Name:CSN3
Synonyms:CSN10, CSNK
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei10200. Bos d 12.0101.
167. Bos d 8.
2737. Bos d 12.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 213 PublicationsAdd BLAST21
ChainiPRO_000000448322 – 190Kappa-caseinAdd BLAST169
PeptideiPRO_000000448446 – 55Casoxin-C10
PeptideiPRO_000000448554 – 59Casoxin-66
PeptideiPRO_000000448656 – 62Casoxin-A7
PeptideiPRO_000000448779 – 82Casoxin-B4
PeptideiPRO_0000004488127 – 137CasoplatelinAdd BLAST11

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22Pyrrolidone carboxylic acid1 Publication1
Disulfide bondi32 ↔ 109
Disulfide bondi32Interchain (with C-109); in linked form
Disulfide bondi109Interchain (with C-32); in linked form
Glycosylationi142O-linked (GalNAc...) threonine3 Publications1
Modified residuei148Phosphoserine1 Publication1
Glycosylationi152O-linked (GalNAc...) threonine3 Publications1
Glycosylationi153O-linked (GalNAc...) serine1 Publication1
Glycosylationi154O-linked (GalNAc...) threonine3 Publications1
Glycosylationi157O-linked (GalNAc...) threonine3 Publications1
Glycosylationi163O-linked (GalNAc...) threonine3 Publications1
Modified residuei166Phosphothreonine1 Publication1
Modified residuei170Phosphoserine; alternate2 Publications1
Glycosylationi170O-linked (GalNAc...) serine; alternate1 Publication1
Glycosylationi186O-linked (GalNAc...) threonine; partial3 Publications1
Modified residuei187PhosphoserineBy similarity1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei126 – 127Cleavage; by chymosin/rennin2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP02668.
PeptideAtlasiP02668.
PRIDEiP02668.

PTM databases

iPTMnetiP02668.
UniCarbKBiP02668.

Miscellaneous databases

PMAP-CutDBiP02668.

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Interactioni

Subunit structurei

Monomer or homomultimer; disulfide-linked.

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • zymogen binding Source: AgBase

Protein-protein interaction databases

BioGridi159044. 2 interactors.
IntActiP02668. 1 interactor.
MINTiMINT-7258912.
STRINGi9913.ENSBTAP00000028685.

Structurei

3D structure databases

DisProtiDP00192.
ProteinModelPortaliP02668.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the kappa-casein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JCVG. Eukaryota.
ENOG4111E7Q. LUCA.
HOVERGENiHBG005246.
InParanoidiP02668.
KOiK17282.
TreeFamiTF338369.

Family and domain databases

InterProiView protein in InterPro
IPR000117. Casein_kappa.
PANTHERiPTHR11470. PTHR11470. 1 hit.
PfamiView protein in Pfam
PF00997. Casein_kappa. 1 hit.
PIRSFiPIRSF002374. Casein_kappa. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02668-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMKSFFLVVT ILALTLPFLG AQEQNQEQPI RCEKDERFFS DKIAKYIPIQ
60 70 80 90 100
YVLSRYPSYG LNYYQQKPVA LINNQFLPYP YYAKPAAVRS PAQILQWQVL
110 120 130 140 150
SNTVPAKSCQ AQPTTMARHP HPHLSFMAIP PKKNQDKTEI PTINTIASGE
160 170 180 190
PTSTPTTEAV ESTVATLEDS PEVIESPPEI NTVQVTSTAV
Length:190
Mass (Da):21,269
Last modified:April 1, 1988 - v1
Checksum:iF12D8310C3B93EDA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23E → Q AA sequence (Ref. 7) Curated1
Sequence conflicti26Q → E AA sequence (Ref. 7) Curated1
Sequence conflicti28Q → E AA sequence (Ref. 7) Curated1
Sequence conflicti102N → D AA sequence (PubMed:4577852).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti31R → H in variant F. 1
Natural varianti118R → C in variant G. 1
Natural varianti156T → I in variant G and variant H. 1
Natural varianti157T → I in variant B and variant B2. 1
Natural varianti169D → A in variant B and variant B2. 1
Natural varianti174I → T in variant B2. 1
Natural varianti176S → G in variant E. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00565 mRNA. Translation: CAA25231.1.
M36641 mRNA. Translation: AAA30433.1.
X14907, X14908 Genomic DNA. Translation: CAA33034.1.
AY380228 Genomic DNA. Translation: AAQ87922.1.
AY380229 Genomic DNA. Translation: AAQ87923.1.
BC102120 mRNA. Translation: AAI02121.1.
K01085 mRNA. Translation: AAA30482.1.
AF123250 Genomic DNA. Translation: AAD32139.1.
AF123251 Genomic DNA. Translation: AAD32140.1.
AF105260 Genomic DNA. Translation: AAF72097.1.
M38333 mRNA. Translation: AAA30432.1.
AF041482 Genomic DNA. Translation: AAB97519.1.
U84250 Genomic DNA. Translation: AAB47260.1.
U84251 Genomic DNA. Translation: AAB47261.1.
PIRiS02076. KKBOB.
RefSeqiNP_776719.1. NM_174294.2.
UniGeneiBt.49421.

Genome annotation databases

GeneIDi281728.
KEGGibta:281728.

Similar proteinsi

Entry informationi

Entry nameiCASK_BOVIN
AccessioniPrimary (citable) accession number: P02668
Secondary accession number(s): O46566
, Q597F3, Q6U205, Q9N271, Q9TRQ3, Q9TV96, Q9TV97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: April 1, 1988
Last modified: November 22, 2017
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families