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P02666

- CASB_BOVIN

UniProt

P02666 - CASB_BOVIN

Protein

Beta-casein

Gene

CSN2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 2 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Important role in determination of the surface properties of the casein micelles.
    Casoparan acts as a macrophage activator, increasing the phagocytic activity of macrophages and peroxide release from macrophages. It also acts as a bradykinin-potentiating peptide.
    Casohypotensin acts as a bradykinin-potentiating peptide. Induces hypotension in rats. Acts as a strong competitive inhibitor of endo-oligopeptidase A.
    Antioxidant peptide has antioxidant activity.

    GO - Molecular functioni

    1. antioxidant activity Source: UniProtKB-KW
    2. metalloendopeptidase inhibitor activity Source: UniProtKB-KW
    3. protein binding Source: IntAct
    4. transporter activity Source: InterPro

    GO - Biological processi

    1. regulation of blood pressure Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antioxidant, Hypotensive agent, Metalloenzyme inhibitor, Metalloprotease inhibitor, Milk protein, Protease inhibitor

    Enzyme and pathway databases

    ReactomeiREACT_220588. Nuclear signaling by ERBB4.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-casein
    Cleaved into the following 3 chains:
    Gene namesi
    Name:CSN2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 6

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Protein family/group databases

    Allergomei10199. Bos d 11.0101.
    167. Bos d 8.
    2736. Bos d 11.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 15153 PublicationsAdd
    BLAST
    Chaini16 – 224209Beta-caseinPRO_0000004470Add
    BLAST
    Peptidei41 – 455CasoparanPRO_0000292031
    Peptidei113 – 1208Antioxidant peptidePRO_0000320153
    Peptidei129 – 1368CasohypotensinPRO_0000308464

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei30 – 301Phosphoserine4 Publications
    Modified residuei32 – 321Phosphoserine4 Publications
    Modified residuei33 – 331Phosphoserine4 Publications
    Modified residuei34 – 341Phosphoserine4 Publications
    Modified residuei50 – 501Phosphoserine; in variant A1, variant A2, variant A3, variant B, variant E, variant F, variant G and variant H3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP02666.
    PRIDEiP02666.

    Miscellaneous databases

    PMAP-CutDBP02666.

    Expressioni

    Tissue specificityi

    Mammary gland specific. Secreted in milk.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    HTRA2O434645EBI-5260183,EBI-517086From a different organism.
    LONP1P367766EBI-5260183,EBI-357448From a different organism.

    Protein-protein interaction databases

    BioGridi158462. 1 interaction.
    DIPiDIP-46257N.
    IntActiP02666. 2 interactions.
    STRINGi9913.ENSBTAP00000003409.

    Structurei

    3D structure databases

    DisProtiDP00329.
    ProteinModelPortaliP02666.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-casein family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG45871.
    GeneTreeiENSGT00390000001890.
    HOVERGENiHBG004973.
    InParanoidiP02666.
    OMAiEIMEVPK.
    OrthoDBiEOG7WQ7VM.
    TreeFamiTF336929.

    Family and domain databases

    InterProiIPR001588. Casein.
    IPR016345. Casein_beta.
    [Graphical view]
    PANTHERiPTHR11500. PTHR11500. 1 hit.
    PfamiPF00363. Casein. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002372. Beta-casein. 1 hit.
    PROSITEiPS00306. CASEIN_ALPHA_BETA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P02666-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKVLILACLV ALALARELEE LNVPGEIVES LSSSEESITR INKKIEKFQS    50
    EEQQQTEDEL QDKIHPFAQT QSLVYPFPGP IPNSLPQNIP PLTQTPVVVP 100
    PFLQPEVMGV SKVKEAMAPK HKEMPFPKYP VEPFTESQSL TLTDVENLHL 150
    PLPLLQSWMH QPHQPLPPTV MFPPQSVLSL SQSKVLPVPQ KAVPYPQRDM 200
    PIQAFLLYQE PVLGPVRGPF PIIV 224
    Length:224
    Mass (Da):25,107
    Last modified:July 1, 1989 - v2
    Checksum:iF0BBDD8148A238AE
    GO

    Sequence cautioni

    The sequence ABL74247.1 differs from that shown. Reason: Frameshift at positions 65 and 71.
    The sequence AAW84270.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAW84271.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti50 – 501S → Z AA sequence (PubMed:1804413)Curated
    Sequence conflicti69 – 691Q → R in ABL74247. 1 PublicationCurated
    Sequence conflicti112 – 1121K → R in ABL74247. 1 PublicationCurated
    Sequence conflicti208 – 2081Y → V in CAC37028. 1 PublicationCurated
    Sequence conflicti209 – 2102QE → EQ AA sequence (PubMed:1804413)Curated
    Sequence conflicti210 – 2101E → Q in AAA30430. (PubMed:3814153)Curated
    Sequence conflicti210 – 2101E → Q no nucleotide entry (PubMed:4557764)Curated
    Sequence conflicti212 – 2121V → A in ABR10906. 1 PublicationCurated

    Mass spectrometryi

    Molecular mass is 872.51 Da from positions 113 - 120. Determined by ESI. 1 Publication

    Polymorphismi

    Leu-152 is present in the variants F and G; Gln-190 and Glu-210 are present in the variant H. The sequence shown is the A2 variant.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti33 – 331S → K in variant D. 1 Publication
    Natural varianti40 – 401R → C in variant H.
    Natural varianti51 – 511E → K in variant E. 1 Publication
    Natural varianti52 – 521E → K in variant C.
    Natural varianti82 – 821P → H in variants A1, B, C, F and G. 3 Publications
    Natural varianti103 – 1031L → I in variant H.
    Natural varianti108 – 1081M → L.4 Publications
    Natural varianti121 – 1211H → Q in variant A3. 2 Publications
    Natural varianti132 – 1321E → Q in variants A1 and G. 2 Publications
    Natural varianti137 – 1371S → R in variant B. 1 Publication
    Natural varianti152 – 1521L → P in variants A1 and H. 1 Publication
    Natural varianti153 – 1531P → L in variants A1, G and H. 1 Publication
    Natural varianti167 – 1671P → L in variant F.
    Natural varianti190 – 1901Q → E in variants A1 and G.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M15132 mRNA. Translation: AAA30430.1.
    X06359 mRNA. Translation: CAA29658.1.
    M16645 mRNA. Translation: AAA30480.1.
    M55158 Genomic DNA. Translation: AAA30431.1.
    S67277 mRNA. Translation: AAB29137.1.
    BC111172 mRNA. Translation: AAI11173.1.
    AY899917 mRNA. Translation: AAW84270.1. Different initiation.
    AY899918 mRNA. Translation: AAW84271.1. Different initiation.
    AH007287 Genomic DNA. Translation: AAD09813.1.
    EF123100 Genomic DNA. Translation: ABL74247.1. Frameshift.
    EF628290 Genomic DNA. Translation: ABR10906.1.
    AJ296330 Genomic DNA. Translation: CAC37028.1.
    M64756 mRNA. Translation: AAB59254.1.
    AY366419 Genomic DNA. Translation: AAR14677.1.
    K01087 mRNA. Translation: AAA30481.1.
    PIRiA59068.
    I45873. KBBOA2.
    UniGeneiBt.53272.

    Genome annotation databases

    EnsembliENSBTAT00000003409; ENSBTAP00000003409; ENSBTAG00000002632.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Of buttons, digestion and glue - Issue 16 of November 2001

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M15132 mRNA. Translation: AAA30430.1 .
    X06359 mRNA. Translation: CAA29658.1 .
    M16645 mRNA. Translation: AAA30480.1 .
    M55158 Genomic DNA. Translation: AAA30431.1 .
    S67277 mRNA. Translation: AAB29137.1 .
    BC111172 mRNA. Translation: AAI11173.1 .
    AY899917 mRNA. Translation: AAW84270.1 . Different initiation.
    AY899918 mRNA. Translation: AAW84271.1 . Different initiation.
    AH007287 Genomic DNA. Translation: AAD09813.1 .
    EF123100 Genomic DNA. Translation: ABL74247.1 . Frameshift.
    EF628290 Genomic DNA. Translation: ABR10906.1 .
    AJ296330 Genomic DNA. Translation: CAC37028.1 .
    M64756 mRNA. Translation: AAB59254.1 .
    AY366419 Genomic DNA. Translation: AAR14677.1 .
    K01087 mRNA. Translation: AAA30481.1 .
    PIRi A59068.
    I45873. KBBOA2.
    UniGenei Bt.53272.

    3D structure databases

    DisProti DP00329.
    ProteinModelPortali P02666.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 158462. 1 interaction.
    DIPi DIP-46257N.
    IntActi P02666. 2 interactions.
    STRINGi 9913.ENSBTAP00000003409.

    Protein family/group databases

    Allergomei 10199. Bos d 11.0101.
    167. Bos d 8.
    2736. Bos d 11.

    Proteomic databases

    PaxDbi P02666.
    PRIDEi P02666.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000003409 ; ENSBTAP00000003409 ; ENSBTAG00000002632 .

    Phylogenomic databases

    eggNOGi NOG45871.
    GeneTreei ENSGT00390000001890.
    HOVERGENi HBG004973.
    InParanoidi P02666.
    OMAi EIMEVPK.
    OrthoDBi EOG7WQ7VM.
    TreeFami TF336929.

    Enzyme and pathway databases

    Reactomei REACT_220588. Nuclear signaling by ERBB4.

    Miscellaneous databases

    NextBioi 20805172.
    PMAP-CutDB P02666.

    Family and domain databases

    InterProi IPR001588. Casein.
    IPR016345. Casein_beta.
    [Graphical view ]
    PANTHERi PTHR11500. PTHR11500. 1 hit.
    Pfami PF00363. Casein. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002372. Beta-casein. 1 hit.
    PROSITEi PS00306. CASEIN_ALPHA_BETA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS LEU-108; PRO-152 AND LEU-153.
    2. "Primary structure of bovine beta-casein cDNA."
      Baev A.A., Smirnov I.K., Gorodetsky S.I.
      Mol. Biol. (Mosk.) 21:214-222(1987)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT HIS-82.
    3. "Complete nucleotide sequences of bovine alpha S2- and beta-casein cDNAs: comparisons with related sequences in other species."
      Stewart A.F., Bonsing J., Beattie C.W., Shah F., Willis I.M., Mackinlay A.G.
      Mol. Biol. Evol. 4:231-241(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "Complete nucleotide sequence of the bovine beta-casein gene."
      Bonsing J., Ring J.M., Stewart A.F., Mackinlay A.G.
      Aust. J. Biol. Sci. 41:527-537(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT HIS-82.
    5. "Overproduction of bovine beta-casein in Escherichia coli and engineering of its main chymosin cleavage site."
      Simons G., van den Heuvel W., Reynen T., Frijters A., Rutten G., Slangen C.J., Groenen M., de Vos W.M., Siezen R.J.
      Protein Eng. 6:763-770(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT A3 GLN-121.
      Tissue: Mammary gland.
    6. NIH - Mammalian Gene Collection (MGC) project
      Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS HIS-82 AND ARG-137.
      Strain: Crossbred X Angus.
      Tissue: Liver.
    7. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-101.
      Tissue: Mammary epithelium.
    8. "Primary structure of bovine beta casein. Complete sequence."
      Ribadeau-Dumas B., Brignon G., Grosclaude F., Mercier J.-C.
      Eur. J. Biochem. 25:505-514(1972) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 16-224 (VARIANT A2), VARIANT LEU-108.
    9. "A new strategy for primary structure determination of proteins: application to bovine beta-casein."
      Carles C., Huet J.-C., Ribadeau-Dumas B.
      FEBS Lett. 229:265-272(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 16-224 (VARIANT A2).
    10. "Biochemical, molecular and physiological characterization of a new beta-casein variant detected in Korean cattle."
      Han S.K., Shin Y.C., Byun H.D.
      Anim. Genet. 31:49-51(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 18-57, PROTEIN SEQUENCE OF 16-224 (VARIANT H), VARIANT D LYS-33.
      Strain: Korean.
      Tissue: Milk.
    11. "Analysis of bovine beta-casein tryptic digest by continuous-flow fast-atom bombardment mass spectrometry."
      Jones D.S., Heerma W., van Wassenaar P.D., Haverkamp J.
      Rapid Commun. Mass Spectrom. 5:192-195(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 41-71; 113-157 AND 180-224, VARIANT GLN-132.
    12. "Effects of 'casoparan', a peptide isolated from casein hydrolysates with mastoparan-like properties."
      Lebrun I., Cavallaro V., Juliano L., Juliano M.A., de Sousa e Silva M.C.C.
      Mediators Inflamm. 13:263-268(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 41-45, FUNCTION.
    13. "The beta E variant and the phosphorylation code of bovine caseins."
      Grosclaude F., Mahe M.-F., Voglino G.-F.
      FEBS Lett. 45:3-5(1974) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 48-63, VARIANT E LYS-51.
    14. "Polymorphisms in beta and kappa casein genes in bubaline and bovine."
      Otaviano A.R., Lima A.L.F., Laureano M.M.M., Albuquerque L.G., Tonhati H., Sena J.A.D.
      Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 58-223.
    15. "Polymorphism in the cattle beta casein gene."
      Shahla M.N., Cheema F.R., Naeem M.K., Riazuddin S.
      Submitted (MAY-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 58-223.
    16. "Characterization of milk proteins."
      Klotz A., Buchberger J., Krause I., Einspanier R.
      Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 63-208.
      Tissue: Mammary gland.
    17. "Identification of bacterial clones encoding bovine caseins by direct immunological screening of the cDNA library."
      Ivanov V.N., Kershulite D.R., Bayev A.A., Akhundova A.A., Sulimova G.E., Judinkova E.S., Gorodetsky S.I.
      Gene 32:381-388(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 68-105.
    18. "Identification of bacterial clones that encode cow's caseins by direct immunological screening of the cDNA library."
      Ivanov V.N., Kershulite D.R., Bayev A.A., Akhundova A.A., Silimova G.E.
      Mol. Biol. (Mosk.) 19:955-963(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 68-95.
    19. "Peptic digestion of beta-casein: Time course and fate of possible bioactive peptides."
      Schmelzer C.E.H., Schoeps R., Reynell L., Ulbrich-Hofmann R., Neubert R.H.H., Raith K.
      J. Chromatogr. A 1166:108-115(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 74-108, VARIANT LEU-108, PHOSPHORYLATION, IDENTIFICATION BY MASS SPECTROMETRY.
    20. "A new variant in exon VII of bovine beta-casein gene (CSN2) and its contribution among European cattle breeds."
      Jann O., Ceriotti G., Caroli A., Erhardt G.
      J. Anim. Breed. Genet. 119:65-68(2002)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 80-143, VARIANT LEU-108.
    21. "Studies on antioxidative peptides generated in cheddar cheese."
      Gupta A., Mann B., Kumar Bajaj R., Sangwan R.B.
      Submitted (JAN-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 113-120, FUNCTION, MASS SPECTROMETRY.
    22. "Localization in the peptide chain of bovine beta casein of the His-Gln substitution differentiating the A2 and A3 genetic variants."
      Ribadeau-Dumas B., Grosclaude F., Mercier J.-C.
      C. R. Hebd. Seances Acad. Sci., D, Sci. Nat. 270:2369-2372(1970) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 118-124, VARIANT A3 GLN-121.
    23. "Characterization of a non-electrophoretic genetic variant of beta-casein by peptide mapping and mass spectrometric analysis."
      Dong C., Ng-Kwai-Hang K.F.
      Int. Dairy J. 8:967-972(1998)
      [AGRICOLA] [Europe PMC]
      Cited for: PROTEIN SEQUENCE OF 125-195 (VARIANTS A1 AND G).
    24. "Isolation and characterization of a new bradykinin potentiating octapeptide from gamma-casein."
      Lebrun I., Lebrun F.L.A.S., Henriques O.B., Carmona A.K., Juliano L., Camargo A.C.M.
      Can. J. Physiol. Pharmacol. 73:85-91(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 129-136, FUNCTION, VARIANT GLN-132.
    25. "Biochemical and pharmacological aspects of two bradykinin-potentiating peptides obtained from tryptic hydrolysis of casein."
      Perpetuo E.A., Juliano L., Lebrun I.
      J. Protein Chem. 22:601-606(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 129-136, FUNCTION.
    26. "Identification of a new genetic variant of bovine beta-casein using reversed-phase high-performance liquid chromatography and mass spectrometric analysis."
      Visser S., Slangen C.J., Lagerwerf F.M., Van Dongen W.D., Haverkamp J.
      J. Chromatogr. A 711:141-150(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 160-171 (VARIANT F).
    27. "Construction and identification by partial nucleotide sequence analysis of bovine casein and beta-lactoglobulin cDNA clones."
      Willis I.M., Stewart A.F., Caputo A., Thompson A.R., McKinlay A.G.
      DNA 1:375-386(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 170-184.
    28. "Extended Range Proteomic Analysis (ERPA): a new and sensitive LC-MS platform for high sequence coverage of complex proteins with extensive post-translational modifications-comprehensive analysis of beta-casein and epidermal growth factor receptor (EGFR)."
      Wu S.L., Kim J., Hancock W.S., Karger B.
      J. Proteome Res. 4:1155-1170(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-30; SER-32; SER-33; SER-34 AND SER-50, IDENTIFICATION BY MASS SPECTROMETRY.
    29. "Reference-facilitated phosphoproteomics: fast and reliable phosphopeptide validation by micro LC-ESI-Q-TOF MS/MS."
      Imanishi S.Y., Kochin V., Ferraris S.E., de Thonel A., Pallari H.M., Corthals G.L., Eriksson J.E.
      Mol. Cell. Proteomics 6:1380-1391(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-30; SER-32; SER-33; SER-34 AND SER-50, IDENTIFICATION BY MASS SPECTROMETRY.
    30. "Characterization of genetic variants of alpha-S1 and beta bovine caseins."
      Grosclaude F., Mahe M.-F., Mercier J.-C., Ribadeau-Dumas B.
      Eur. J. Biochem. 26:328-337(1972) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS A1; B AND C.

    Entry informationi

    Entry nameiCASB_BOVIN
    AccessioniPrimary (citable) accession number: P02666
    Secondary accession number(s): A1YQZ8
    , A6N8V0, Q2TA13, Q5EEQ6, Q5EEQ7, Q6UN63, Q9BDG5, Q9TSD5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 131 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3