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P02663

- CASA2_BOVIN

UniProt

P02663 - CASA2_BOVIN

Protein

Alpha-S2-casein

Gene

CSN1S2

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    Important role in the capacity of milk to transport calcium phosphate.
    Casocidin-I inhibits the growth of E.coli and S.carnosus.

    GO - Molecular functioni

    1. transporter activity Source: InterPro

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Milk protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-S2-casein
    Cleaved into the following chain:
    Alternative name(s):
    Casocidin-I
    Gene namesi
    Name:CSN1S2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 6

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Protein family/group databases

    Allergomei10198. Bos d 10.0101.
    167. Bos d 8.
    2735. Bos d 10.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 15151 PublicationAdd
    BLAST
    Chaini16 – 222207Alpha-S2-caseinPRO_0000004460Add
    BLAST
    Peptidei165 – 20339Casocidin-1PRO_0000004461Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei23 – 231Phosphoserine1 Publication
    Modified residuei24 – 241Phosphoserine1 Publication
    Modified residuei25 – 251Phosphoserine1 Publication
    Modified residuei28 – 281Phosphoserine1 Publication
    Modified residuei46 – 461Phosphoserine1 Publication
    Modified residuei71 – 711Phosphoserine1 Publication
    Modified residuei72 – 721Phosphoserine1 Publication
    Modified residuei73 – 731Phosphoserine1 Publication
    Modified residuei76 – 761Phosphoserine1 Publication
    Modified residuei144 – 1441Phosphoserine
    Modified residuei146 – 1461Phosphoserine
    Modified residuei158 – 1581Phosphoserine2 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP02663.
    PRIDEiP02663.

    Miscellaneous databases

    PMAP-CutDBP02663.

    Expressioni

    Tissue specificityi

    Mammary gland specific. Secreted in milk.

    Structurei

    3D structure databases

    ProteinModelPortaliP02663.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati76 – 14065Add
    BLAST
    Repeati158 – 22265Add
    BLAST

    Sequence similaritiesi

    Belongs to the alpha-casein family.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG128783.
    GeneTreeiENSGT00530000065240.
    HOGENOMiHOG000111307.
    HOVERGENiHBG005244.
    InParanoidiP02663.
    OMAiVMNPWDQ.
    OrthoDBiEOG7MWH0G.
    TreeFamiTF339561.

    Family and domain databases

    InterProiIPR011175. Alpha-s2_casein.
    IPR001588. Casein.
    [Graphical view]
    PfamiPF00363. Casein. 2 hits.
    [Graphical view]
    PIRSFiPIRSF002371. Alpha-s2-casein. 1 hit.
    PROSITEiPS00306. CASEIN_ALPHA_BETA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P02663-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFFIFTCLL AVALAKNTME HVSSSEESII SQETYKQEKN MAINPSKENL    50
    CSTFCKEVVR NANEEEYSIG SSSEESAEVA TEEVKITVDD KHYQKALNEI 100
    NQFYQKFPQY LQYLYQGPIV LNPWDQVKRN AVPITPTLNR EQLSTSEENS 150
    KKTVDMESTE VFTKKTKLTE EEKNRLNFLK KISQRYQKFA LPQYLKTVYQ 200
    HQKAMKPWIQ PKTKVIPYVR YL 222
    Length:222
    Mass (Da):26,019
    Last modified:July 1, 1989 - v2
    Checksum:i81E7408AF1C12F7C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti42 – 421A → D in AAI14774. 1 PublicationCurated
    Sequence conflicti102 – 1021Q → E AA sequence (PubMed:862906)Curated
    Sequence conflicti105 – 1051Q → R in AAI14774. 1 PublicationCurated

    Mass spectrometryi

    Molecular mass is 4870 Da from positions 165 - 203. Determined by ESI. 1 Publication

    Polymorphismi

    At least two alleles exist. The sequence of the A allele is shown here. The D allele sequence differs from that shown in having a deletion of nine residues, which may be 49-58, 50-59, or 51-60.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M16644 mRNA. Translation: AAA30479.1.
    BC114773 mRNA. Translation: AAI14774.1.
    PIRiJQ2008. KABOS2.
    RefSeqiNP_776953.1. NM_174528.2.
    UniGeneiBt.57616.

    Genome annotation databases

    EnsembliENSBTAT00000006590; ENSBTAP00000006590; ENSBTAG00000005005.
    GeneIDi282209.
    KEGGibta:282209.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    Of buttons, digestion and glue - Issue 16 of November 2001

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M16644 mRNA. Translation: AAA30479.1 .
    BC114773 mRNA. Translation: AAI14774.1 .
    PIRi JQ2008. KABOS2.
    RefSeqi NP_776953.1. NM_174528.2.
    UniGenei Bt.57616.

    3D structure databases

    ProteinModelPortali P02663.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 10198. Bos d 10.0101.
    167. Bos d 8.
    2735. Bos d 10.

    Proteomic databases

    PaxDbi P02663.
    PRIDEi P02663.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000006590 ; ENSBTAP00000006590 ; ENSBTAG00000005005 .
    GeneIDi 282209.
    KEGGi bta:282209.

    Organism-specific databases

    CTDi 100327035.

    Phylogenomic databases

    eggNOGi NOG128783.
    GeneTreei ENSGT00530000065240.
    HOGENOMi HOG000111307.
    HOVERGENi HBG005244.
    InParanoidi P02663.
    OMAi VMNPWDQ.
    OrthoDBi EOG7MWH0G.
    TreeFami TF339561.

    Miscellaneous databases

    NextBioi 20806034.
    PMAP-CutDB P02663.

    Family and domain databases

    InterProi IPR011175. Alpha-s2_casein.
    IPR001588. Casein.
    [Graphical view ]
    Pfami PF00363. Casein. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF002371. Alpha-s2-casein. 1 hit.
    PROSITEi PS00306. CASEIN_ALPHA_BETA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete nucleotide sequences of bovine alpha S2- and beta-casein cDNAs: comparisons with related sequences in other species."
      Stewart A.F., Bonsing J., Beattie C.W., Shah F., Willis I.M., Mackinlay A.G.
      Mol. Biol. Evol. 4:231-241(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. NIH - Mammalian Gene Collection (MGC) project
      Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Liver.
    3. Cited for: PROTEIN SEQUENCE OF 16-222 (A ALLELE).
      Tissue: Milk.
    4. "A genetic and biochemical analysis of a polymorphism of bovine alpha S2-casein."
      Grosclaude F., Joudrier P., Mahe M.-F.
      J. Dairy Res. 46:211-213(1979) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE (D ALLELE).
      Tissue: Milk.
    5. "Casocidin-I: a casein-alpha s2 derived peptide exhibits antibacterial activity."
      Zucht H.-D., Raida M., Adermann K., Meagert H.-J., Forssmann W.-G.
      FEBS Lett. 372:185-188(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 165-203, CHARACTERIZATION OF CASOCIDIN, MASS SPECTROMETRY.
      Tissue: Milk.
    6. Bai F., Liu S., Witzmann F.A.
      Submitted (SEP-2005) to UniProtKB
      Cited for: PHOSPHORYLATION AT SER-46 AND SER-158.
    7. "Reference-facilitated phosphoproteomics: fast and reliable phosphopeptide validation by micro LC-ESI-Q-TOF MS/MS."
      Imanishi S.Y., Kochin V., Ferraris S.E., de Thonel A., Pallari H.M., Corthals G.L., Eriksson J.E.
      Mol. Cell. Proteomics 6:1380-1391(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-23; SER-24; SER-25; SER-28; SER-71; SER-72; SER-73; SER-76 AND SER-158, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiCASA2_BOVIN
    AccessioniPrimary (citable) accession number: P02663
    Secondary accession number(s): Q1RMQ6, Q9TR51
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3