SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P02663

- CASA2_BOVIN

UniProt

P02663 - CASA2_BOVIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Alpha-S2-casein

Gene
CSN1S2
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Important role in the capacity of milk to transport calcium phosphate.
Casocidin-I inhibits the growth of E.coli and S.carnosus.

GO - Molecular functioni

  1. transporter activity Source: InterPro

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Milk protein

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-S2-casein
Cleaved into the following chain:
Alternative name(s):
Casocidin-I
Gene namesi
Name:CSN1S2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 6

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei10198. Bos d 10.0101.
167. Bos d 8.
2735. Bos d 10.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 15151 PublicationAdd
BLAST
Chaini16 – 222207Alpha-S2-caseinPRO_0000004460Add
BLAST
Peptidei165 – 20339Casocidin-11 PublicationPRO_0000004461Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231Phosphoserine1 Publication
Modified residuei24 – 241Phosphoserine1 Publication
Modified residuei25 – 251Phosphoserine1 Publication
Modified residuei28 – 281Phosphoserine1 Publication
Modified residuei46 – 461Phosphoserine1 Publication
Modified residuei71 – 711Phosphoserine1 Publication
Modified residuei72 – 721Phosphoserine1 Publication
Modified residuei73 – 731Phosphoserine1 Publication
Modified residuei76 – 761Phosphoserine1 Publication
Modified residuei144 – 1441Phosphoserine
Modified residuei146 – 1461Phosphoserine
Modified residuei158 – 1581Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP02663.
PRIDEiP02663.

Miscellaneous databases

PMAP-CutDBP02663.

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Structurei

3D structure databases

ProteinModelPortaliP02663.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati76 – 14065Add
BLAST
Repeati158 – 22265Add
BLAST

Sequence similaritiesi

Belongs to the alpha-casein family.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG128783.
GeneTreeiENSGT00530000065240.
HOGENOMiHOG000111307.
HOVERGENiHBG005244.
InParanoidiP02663.
OMAiVMNPWDQ.
OrthoDBiEOG7MWH0G.
TreeFamiTF339561.

Family and domain databases

InterProiIPR011175. Alpha-s2_casein.
IPR001588. Casein.
[Graphical view]
PfamiPF00363. Casein. 2 hits.
[Graphical view]
PIRSFiPIRSF002371. Alpha-s2-casein. 1 hit.
PROSITEiPS00306. CASEIN_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02663-1 [UniParc]FASTAAdd to Basket

« Hide

MKFFIFTCLL AVALAKNTME HVSSSEESII SQETYKQEKN MAINPSKENL    50
CSTFCKEVVR NANEEEYSIG SSSEESAEVA TEEVKITVDD KHYQKALNEI 100
NQFYQKFPQY LQYLYQGPIV LNPWDQVKRN AVPITPTLNR EQLSTSEENS 150
KKTVDMESTE VFTKKTKLTE EEKNRLNFLK KISQRYQKFA LPQYLKTVYQ 200
HQKAMKPWIQ PKTKVIPYVR YL 222
Length:222
Mass (Da):26,019
Last modified:July 1, 1989 - v2
Checksum:i81E7408AF1C12F7C
GO

Mass spectrometryi

Molecular mass is 4870 Da from positions 165 - 203. Determined by ESI. 1 Publication

Polymorphismi

At least two alleles exist. The sequence of the A allele is shown here. The D allele sequence differs from that shown in having a deletion of nine residues, which may be 49-58, 50-59, or 51-60.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 421A → D in AAI14774. 1 Publication
Sequence conflicti102 – 1021Q → E AA sequence 1 Publication
Sequence conflicti105 – 1051Q → R in AAI14774. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M16644 mRNA. Translation: AAA30479.1.
BC114773 mRNA. Translation: AAI14774.1.
PIRiJQ2008. KABOS2.
RefSeqiNP_776953.1. NM_174528.2.
UniGeneiBt.57616.

Genome annotation databases

EnsembliENSBTAT00000006590; ENSBTAP00000006590; ENSBTAG00000005005.
GeneIDi282209.
KEGGibta:282209.

Cross-referencesi

Web resourcesi

Protein Spotlight

Of buttons, digestion and glue - Issue 16 of November 2001

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M16644 mRNA. Translation: AAA30479.1 .
BC114773 mRNA. Translation: AAI14774.1 .
PIRi JQ2008. KABOS2.
RefSeqi NP_776953.1. NM_174528.2.
UniGenei Bt.57616.

3D structure databases

ProteinModelPortali P02663.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 10198. Bos d 10.0101.
167. Bos d 8.
2735. Bos d 10.

Proteomic databases

PaxDbi P02663.
PRIDEi P02663.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000006590 ; ENSBTAP00000006590 ; ENSBTAG00000005005 .
GeneIDi 282209.
KEGGi bta:282209.

Organism-specific databases

CTDi 100327035.

Phylogenomic databases

eggNOGi NOG128783.
GeneTreei ENSGT00530000065240.
HOGENOMi HOG000111307.
HOVERGENi HBG005244.
InParanoidi P02663.
OMAi VMNPWDQ.
OrthoDBi EOG7MWH0G.
TreeFami TF339561.

Miscellaneous databases

NextBioi 20806034.
PMAP-CutDB P02663.

Family and domain databases

InterProi IPR011175. Alpha-s2_casein.
IPR001588. Casein.
[Graphical view ]
Pfami PF00363. Casein. 2 hits.
[Graphical view ]
PIRSFi PIRSF002371. Alpha-s2-casein. 1 hit.
PROSITEi PS00306. CASEIN_ALPHA_BETA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete nucleotide sequences of bovine alpha S2- and beta-casein cDNAs: comparisons with related sequences in other species."
    Stewart A.F., Bonsing J., Beattie C.W., Shah F., Willis I.M., Mackinlay A.G.
    Mol. Biol. Evol. 4:231-241(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.
  3. Cited for: PROTEIN SEQUENCE OF 16-222 (A ALLELE).
    Tissue: Milk.
  4. "A genetic and biochemical analysis of a polymorphism of bovine alpha S2-casein."
    Grosclaude F., Joudrier P., Mahe M.-F.
    J. Dairy Res. 46:211-213(1979) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE (D ALLELE).
    Tissue: Milk.
  5. "Casocidin-I: a casein-alpha s2 derived peptide exhibits antibacterial activity."
    Zucht H.-D., Raida M., Adermann K., Meagert H.-J., Forssmann W.-G.
    FEBS Lett. 372:185-188(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 165-203, CHARACTERIZATION OF CASOCIDIN, MASS SPECTROMETRY.
    Tissue: Milk.
  6. Bai F., Liu S., Witzmann F.A.
    Submitted (SEP-2005) to UniProtKB
    Cited for: PHOSPHORYLATION AT SER-46 AND SER-158.
  7. "Reference-facilitated phosphoproteomics: fast and reliable phosphopeptide validation by micro LC-ESI-Q-TOF MS/MS."
    Imanishi S.Y., Kochin V., Ferraris S.E., de Thonel A., Pallari H.M., Corthals G.L., Eriksson J.E.
    Mol. Cell. Proteomics 6:1380-1391(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-23; SER-24; SER-25; SER-28; SER-71; SER-72; SER-73; SER-76 AND SER-158, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiCASA2_BOVIN
AccessioniPrimary (citable) accession number: P02663
Secondary accession number(s): Q1RMQ6, Q9TR51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 1989
Last modified: June 11, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi