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Protein

Alpha-S2-casein

Gene

CSN1S2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Important role in the capacity of milk to transport calcium phosphate.
Casocidin-I inhibits the growth of E.coli and S.carnosus.

GO - Molecular functioni

  • protein homodimerization activity Source: AgBase
  • transporter activity Source: InterPro
  • zymogen binding Source: AgBase

GO - Biological processi

  • defense response to bacterium Source: UniProtKB-KW
  • response to 11-deoxycorticosterone Source: AgBase
  • response to dehydroepiandrosterone Source: AgBase
  • response to estradiol Source: AgBase
  • response to growth hormone Source: AgBase
  • response to progesterone Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Milk protein

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-S2-casein
Cleaved into the following chain:
Alternative name(s):
Casocidin-I
Gene namesi
Name:CSN1S2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 6

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: AgBase
  • Golgi apparatus Source: AgBase
  • Golgi lumen Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei10198. Bos d 10.0101.
167. Bos d 8.
2735. Bos d 10.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 151 PublicationAdd BLAST15
ChainiPRO_000000446016 – 222Alpha-S2-caseinAdd BLAST207
PeptideiPRO_0000004461165 – 203Casocidin-1Add BLAST39

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23Phosphoserine1 Publication1
Modified residuei24Phosphoserine1 Publication1
Modified residuei25Phosphoserine1 Publication1
Modified residuei28Phosphoserine1 Publication1
Modified residuei46Phosphoserine1 Publication1
Modified residuei71Phosphoserine1 Publication1
Modified residuei72Phosphoserine1 Publication1
Modified residuei73Phosphoserine1 Publication1
Modified residuei76Phosphoserine1 Publication1
Modified residuei158Phosphoserine2 Publications1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP02663.
PeptideAtlasiP02663.
PRIDEiP02663.

PTM databases

iPTMnetiP02663.

Miscellaneous databases

PMAP-CutDBP02663.

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Interactioni

GO - Molecular functioni

  • protein homodimerization activity Source: AgBase
  • zymogen binding Source: AgBase

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006590.

Structurei

3D structure databases

ProteinModelPortaliP02663.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati76 – 140Add BLAST65
Repeati158 – 222Add BLAST65

Sequence similaritiesi

Belongs to the alpha-casein family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410JE87. Eukaryota.
ENOG4111369. LUCA.
GeneTreeiENSGT00530000065240.
HOGENOMiHOG000111307.
HOVERGENiHBG005244.
InParanoidiP02663.
OMAiVMNPWDQ.
OrthoDBiEOG091G0QMQ.
TreeFamiTF339561.

Family and domain databases

InterProiIPR011175. Alpha-s2_casein.
IPR001588. Casein.
IPR031305. Casein_CS.
[Graphical view]
PfamiPF00363. Casein. 2 hits.
[Graphical view]
PIRSFiPIRSF002371. Alpha-s2-casein. 1 hit.
PROSITEiPS00306. CASEIN_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02663-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFFIFTCLL AVALAKNTME HVSSSEESII SQETYKQEKN MAINPSKENL
60 70 80 90 100
CSTFCKEVVR NANEEEYSIG SSSEESAEVA TEEVKITVDD KHYQKALNEI
110 120 130 140 150
NQFYQKFPQY LQYLYQGPIV LNPWDQVKRN AVPITPTLNR EQLSTSEENS
160 170 180 190 200
KKTVDMESTE VFTKKTKLTE EEKNRLNFLK KISQRYQKFA LPQYLKTVYQ
210 220
HQKAMKPWIQ PKTKVIPYVR YL
Length:222
Mass (Da):26,019
Last modified:July 1, 1989 - v2
Checksum:i81E7408AF1C12F7C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42A → D in AAI14774 (Ref. 2) Curated1
Sequence conflicti102Q → E AA sequence (PubMed:862906).Curated1
Sequence conflicti105Q → R in AAI14774 (Ref. 2) Curated1

Mass spectrometryi

Molecular mass is 4870 Da from positions 165 - 203. Determined by ESI. 1 Publication

Polymorphismi

At least two alleles exist. The sequence of the A allele is shown here. The D allele sequence differs from that shown in having a deletion of nine residues, which may be 49-58, 50-59, or 51-60.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16644 mRNA. Translation: AAA30479.1.
BC114773 mRNA. Translation: AAI14774.1.
PIRiJQ2008. KABOS2.
RefSeqiNP_776953.1. NM_174528.2.
UniGeneiBt.57616.

Genome annotation databases

EnsembliENSBTAT00000006590; ENSBTAP00000006590; ENSBTAG00000005005.
GeneIDi282209.
KEGGibta:282209.

Cross-referencesi

Web resourcesi

Protein Spotlight

Of buttons, digestion and glue - Issue 16 of November 2001

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M16644 mRNA. Translation: AAA30479.1.
BC114773 mRNA. Translation: AAI14774.1.
PIRiJQ2008. KABOS2.
RefSeqiNP_776953.1. NM_174528.2.
UniGeneiBt.57616.

3D structure databases

ProteinModelPortaliP02663.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000006590.

Protein family/group databases

Allergomei10198. Bos d 10.0101.
167. Bos d 8.
2735. Bos d 10.

PTM databases

iPTMnetiP02663.

Proteomic databases

PaxDbiP02663.
PeptideAtlasiP02663.
PRIDEiP02663.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000006590; ENSBTAP00000006590; ENSBTAG00000005005.
GeneIDi282209.
KEGGibta:282209.

Organism-specific databases

CTDi100327035.

Phylogenomic databases

eggNOGiENOG410JE87. Eukaryota.
ENOG4111369. LUCA.
GeneTreeiENSGT00530000065240.
HOGENOMiHOG000111307.
HOVERGENiHBG005244.
InParanoidiP02663.
OMAiVMNPWDQ.
OrthoDBiEOG091G0QMQ.
TreeFamiTF339561.

Miscellaneous databases

PMAP-CutDBP02663.
PROiP02663.

Family and domain databases

InterProiIPR011175. Alpha-s2_casein.
IPR001588. Casein.
IPR031305. Casein_CS.
[Graphical view]
PfamiPF00363. Casein. 2 hits.
[Graphical view]
PIRSFiPIRSF002371. Alpha-s2-casein. 1 hit.
PROSITEiPS00306. CASEIN_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCASA2_BOVIN
AccessioniPrimary (citable) accession number: P02663
Secondary accession number(s): Q1RMQ6, Q9TR51
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 1989
Last modified: September 7, 2016
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.