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P02662

- CASA1_BOVIN

UniProt

P02662 - CASA1_BOVIN

Protein

Alpha-S1-casein

Gene

CSN1S1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 2 (01 Nov 1990)
      Previous versions | rss
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    Functioni

    Important role in the capacity of milk to transport calcium phosphate.1 Publication
    Antioxidant peptide has 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity.1 Publication

    GO - Molecular functioni

    1. antioxidant activity Source: UniProtKB-KW
    2. transporter activity Source: InterPro

    Keywords - Molecular functioni

    Antioxidant, Milk protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alpha-S1-casein
    Alternative name(s):
    Allergen: Bos d 8
    Cleaved into the following chain:
    Gene namesi
    Name:CSN1S1
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 6

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human. Has six major and 3 minor IgE-binding regions and 5 major and 1 minor IgG-binding regions. Is a cause of cow's milk allergy (CMA).2 Publications

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei10197. Bos d 9.0101.
    167. Bos d 8.
    2734. Bos d 9.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 15152 PublicationsAdd
    BLAST
    Chaini16 – 214199Alpha-S1-caseinPRO_0000004446Add
    BLAST
    Peptidei95 – 10511Antioxidant peptidePRO_0000331578Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei56 – 561Phosphoserine2 Publications
    Modified residuei61 – 611Phosphoserine1 Publication
    Modified residuei63 – 631Phosphoserine1 Publication
    Modified residuei79 – 791Phosphoserine1 Publication
    Modified residuei81 – 811Phosphoserine1 Publication
    Modified residuei82 – 821Phosphoserine1 Publication
    Modified residuei83 – 831Phosphoserine1 Publication
    Modified residuei90 – 901Phosphoserine1 Publication
    Modified residuei130 – 1301Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP02662.
    PRIDEiP02662.
    ProMEXiP02662.

    Miscellaneous databases

    PMAP-CutDBP02662.

    Expressioni

    Tissue specificityi

    Mammary gland specific. Secreted in milk.

    Interactioni

    Protein-protein interaction databases

    BioGridi159482. 3 interactions.
    DIPiDIP-29917N.
    IntActiP02662. 2 interactions.
    MINTiMINT-8184454.

    Structurei

    3D structure databases

    DisProtiDP00330.
    ProteinModelPortaliP02662.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati85 – 9915Add
    BLAST
    Repeati125 – 14016Add
    BLAST

    Sequence similaritiesi

    Belongs to the alpha-casein family.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG73245.
    GeneTreeiENSGT00390000017378.
    HOVERGENiHBG005242.
    InParanoidiP02662.
    KOiK17281.
    OMAiENMESIT.
    OrthoDBiEOG7W1561.
    TreeFamiTF340763.

    Family and domain databases

    InterProiIPR026999. Alpha-s1_casein.
    IPR001588. Casein.
    [Graphical view]
    PANTHERiPTHR10240. PTHR10240. 1 hit.
    PfamiPF00363. Casein. 1 hit.
    [Graphical view]
    PROSITEiPS00306. CASEIN_ALPHA_BETA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P02662-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLLILTCLV AVALARPKHP IKHQGLPQEV LNENLLRFFV APFPEVFGKE    50
    KVNELSKDIG SESTEDQAME DIKQMEAESI SSSEEIVPNS VEQKHIQKED 100
    VPSERYLGYL EQLLRLKKYK VPQLEIVPNS AEERLHSMKE GIHAQQKEPM 150
    IGVNQELAYF YPELFRQFYQ LDAYPSGAWY YVPLGTQYTD APSFSDIPNP 200
    IGSENSEKTT MPLW 214
    Length:214
    Mass (Da):24,529
    Last modified:November 1, 1990 - v2
    Checksum:iF066B5C8AE55828B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti11 – 122AV → SA in ABW98943. (PubMed:19454699)Curated
    Sequence conflicti42 – 421P → L in AAA30429. (PubMed:3022833)Curated
    Sequence conflicti44 – 441P → S in ABW98945. (PubMed:19454699)Curated
    Sequence conflicti95 – 951H → Q in AAA30478. (PubMed:6897774)Curated
    Sequence conflicti99 – 991E → D in ABQ88318. 1 PublicationCurated
    Sequence conflicti143 – 1431H → D in AAA30429. (PubMed:3022833)Curated
    Sequence conflicti171 – 1711L → P in ABW98953. (PubMed:19454699)Curated
    Sequence conflicti203 – 2031S → L in AAA62707. (PubMed:3838718)Curated
    Sequence conflicti211 – 2122MP → IS in AAA30429. (PubMed:3022833)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti29 – 4113Missing in variant A.
    Add
    BLAST
    Natural varianti68 – 681A → T in variant D.
    Natural varianti207 – 2071E → G in variant C.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X00564 mRNA. Translation: CAB57792.1.
    M33123 mRNA. Translation: AAA30428.1.
    M38641 mRNA. Translation: AAA30429.1.
    X59856 Genomic DNA. Translation: CAA42516.1.
    EU221551 Genomic DNA. Translation: ABW98936.1.
    EU221552 Genomic DNA. Translation: ABW98937.1.
    EU221553 Genomic DNA. Translation: ABW98938.1.
    EU221554 Genomic DNA. Translation: ABW98939.1.
    EU221555 Genomic DNA. Translation: ABW98940.1.
    EU221556 Genomic DNA. Translation: ABW98941.1.
    EU221557 Genomic DNA. Translation: ABW98942.1.
    EU221558 Genomic DNA. Translation: ABW98943.1.
    EU221559 Genomic DNA. Translation: ABW98944.1.
    EU221560 Genomic DNA. Translation: ABW98945.1.
    EU221561 Genomic DNA. Translation: ABW98946.1.
    EU221562 Genomic DNA. Translation: ABW98947.1.
    EU221563 Genomic DNA. Translation: ABW98948.1.
    EU221564 Genomic DNA. Translation: ABW98949.1.
    EU221565 Genomic DNA. Translation: ABW98950.1.
    EU221566 Genomic DNA. Translation: ABW98951.1.
    EU221567 Genomic DNA. Translation: ABW98952.1.
    EU221568 Genomic DNA. Translation: ABW98953.1.
    EU221569 Genomic DNA. Translation: ABW98954.1.
    EU221570 Genomic DNA. Translation: ABW98955.1.
    EU221571 Genomic DNA. Translation: ABW98956.1.
    EU221572 Genomic DNA. Translation: ABW98957.1.
    EU221573 Genomic DNA. Translation: ABW98958.1.
    EU221574 Genomic DNA. Translation: ABW98959.1.
    EU221575 Genomic DNA. Translation: ABW98960.1.
    EU221576 Genomic DNA. Translation: ABW98961.1.
    EU221577 Genomic DNA. Translation: ABW98962.1.
    EU221578 Genomic DNA. Translation: ABW98963.1.
    EU221579 Genomic DNA. Translation: ABW98964.1.
    EU221580 Genomic DNA. Translation: ABW98965.1.
    EU221581 Genomic DNA. Translation: ABW98966.1.
    BC109618 mRNA. Translation: AAI09619.1.
    K01084 mRNA. Translation: AAA30478.1.
    EF538766 Genomic DNA. Translation: ABQ88318.1.
    M38658 mRNA. Translation: AAA62707.1.
    AH007360 Genomic DNA. Translation: AAD14099.1.
    D00412 mRNA. Translation: BAA00313.1.
    PIRiS22575. KABOSB.
    S72220.
    RefSeqiNP_851372.1. NM_181029.2.
    UniGeneiBt.59369.

    Genome annotation databases

    EnsembliENSBTAT00000010119; ENSBTAP00000010119; ENSBTAG00000007695.
    GeneIDi282208.
    KEGGibta:282208.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Worthington enzyme manual
    Protein Spotlight

    Of buttons, digestion and glue - Issue 16 of November 2001

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X00564 mRNA. Translation: CAB57792.1 .
    M33123 mRNA. Translation: AAA30428.1 .
    M38641 mRNA. Translation: AAA30429.1 .
    X59856 Genomic DNA. Translation: CAA42516.1 .
    EU221551 Genomic DNA. Translation: ABW98936.1 .
    EU221552 Genomic DNA. Translation: ABW98937.1 .
    EU221553 Genomic DNA. Translation: ABW98938.1 .
    EU221554 Genomic DNA. Translation: ABW98939.1 .
    EU221555 Genomic DNA. Translation: ABW98940.1 .
    EU221556 Genomic DNA. Translation: ABW98941.1 .
    EU221557 Genomic DNA. Translation: ABW98942.1 .
    EU221558 Genomic DNA. Translation: ABW98943.1 .
    EU221559 Genomic DNA. Translation: ABW98944.1 .
    EU221560 Genomic DNA. Translation: ABW98945.1 .
    EU221561 Genomic DNA. Translation: ABW98946.1 .
    EU221562 Genomic DNA. Translation: ABW98947.1 .
    EU221563 Genomic DNA. Translation: ABW98948.1 .
    EU221564 Genomic DNA. Translation: ABW98949.1 .
    EU221565 Genomic DNA. Translation: ABW98950.1 .
    EU221566 Genomic DNA. Translation: ABW98951.1 .
    EU221567 Genomic DNA. Translation: ABW98952.1 .
    EU221568 Genomic DNA. Translation: ABW98953.1 .
    EU221569 Genomic DNA. Translation: ABW98954.1 .
    EU221570 Genomic DNA. Translation: ABW98955.1 .
    EU221571 Genomic DNA. Translation: ABW98956.1 .
    EU221572 Genomic DNA. Translation: ABW98957.1 .
    EU221573 Genomic DNA. Translation: ABW98958.1 .
    EU221574 Genomic DNA. Translation: ABW98959.1 .
    EU221575 Genomic DNA. Translation: ABW98960.1 .
    EU221576 Genomic DNA. Translation: ABW98961.1 .
    EU221577 Genomic DNA. Translation: ABW98962.1 .
    EU221578 Genomic DNA. Translation: ABW98963.1 .
    EU221579 Genomic DNA. Translation: ABW98964.1 .
    EU221580 Genomic DNA. Translation: ABW98965.1 .
    EU221581 Genomic DNA. Translation: ABW98966.1 .
    BC109618 mRNA. Translation: AAI09619.1 .
    K01084 mRNA. Translation: AAA30478.1 .
    EF538766 Genomic DNA. Translation: ABQ88318.1 .
    M38658 mRNA. Translation: AAA62707.1 .
    AH007360 Genomic DNA. Translation: AAD14099.1 .
    D00412 mRNA. Translation: BAA00313.1 .
    PIRi S22575. KABOSB.
    S72220.
    RefSeqi NP_851372.1. NM_181029.2.
    UniGenei Bt.59369.

    3D structure databases

    DisProti DP00330.
    ProteinModelPortali P02662.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 159482. 3 interactions.
    DIPi DIP-29917N.
    IntActi P02662. 2 interactions.
    MINTi MINT-8184454.

    Protein family/group databases

    Allergomei 10197. Bos d 9.0101.
    167. Bos d 8.
    2734. Bos d 9.

    Proteomic databases

    PaxDbi P02662.
    PRIDEi P02662.
    ProMEXi P02662.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000010119 ; ENSBTAP00000010119 ; ENSBTAG00000007695 .
    GeneIDi 282208.
    KEGGi bta:282208.

    Organism-specific databases

    CTDi 1446.

    Phylogenomic databases

    eggNOGi NOG73245.
    GeneTreei ENSGT00390000017378.
    HOVERGENi HBG005242.
    InParanoidi P02662.
    KOi K17281.
    OMAi ENMESIT.
    OrthoDBi EOG7W1561.
    TreeFami TF340763.

    Miscellaneous databases

    NextBioi 20806033.
    PMAP-CutDB P02662.

    Family and domain databases

    InterProi IPR026999. Alpha-s1_casein.
    IPR001588. Casein.
    [Graphical view ]
    PANTHERi PTHR10240. PTHR10240. 1 hit.
    Pfami PF00363. Casein. 1 hit.
    [Graphical view ]
    PROSITEi PS00306. CASEIN_ALPHA_BETA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequences of bovine alpha S1- and kappa-casein cDNAs."
      Stewart A.F., Willis I.M., Mackinlay A.G.
      Nucleic Acids Res. 12:3895-3907(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Isolation and sequence analysis of bovine alpha-S1-casein cDNA clone."
      Nagao M., Maki M., Sasaki R., Chiba R.
      Agric. Biol. Chem. 48:1663-1667(1984)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "cDNA of cattle alpha S1-casein: cloning and nucleotide sequence."
      Gorodetskii S.I., Zakhar'ev V.M., Kyarshulite D.R., Kapelinskaya T.V., Skryabin K.G.
      Biokhimiia 51:1641-1648(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Mammary gland.
    4. "Genomic organization of the bovine alpha-S1 casein gene."
      Koczan D., Hobom G., Seyfert H.-M.
      Nucleic Acids Res. 19:5591-5596(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALLERGEN.
    6. NIH - Mammalian Gene Collection (MGC) project
      Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Crossbred X Angus.
      Tissue: Liver.
    7. "Primary structure of bovine alpha-s1 casein. Complete sequence."
      Mercier J.-C., Grosclaude F., Ribadeau-Dumas B.
      Eur. J. Biochem. 23:41-51(1971) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 16-214 (VARIANT B).
    8. "Primary structure of alpha casein and of bovine beta casein. Correction."
      Mercier J.-C., Grosclaude F., Ribadeau-Dumas B.
      Eur. J. Biochem. 40:323-323(1973) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION TO 74 AND 92-93 (VARIANTS A; B; C AND D).
    9. "Characterization of genetic variants of alpha-S1 and beta bovine caseins."
      Grosclaude F., Mahe M.-F., Mercier J.-C., Ribadeau-Dumas B.
      Eur. J. Biochem. 26:328-337(1972) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 16-214 (VARIANT D).
    10. "Localization in the N-terminal part of bovine casein alpha-s1 of a 13 amino-acid deletion that differentiates variant A from variants B and C."
      Grosclaude F., Mahe M.-F., Mercier J.-C., Ribadeau-Dumas B.
      FEBS Lett. 11:109-112(1970) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 23-49 (VARIANT A).
    11. "Isolation of a new ligand-carrying casein fragment from bovine mammary gland microsomes."
      Neuteboom B., Giuffrida M.G., Conti A.
      FEBS Lett. 305:189-191(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 39-55.
      Tissue: Mammary gland.
    12. "Action on bovine alpha s1-casein of cardosins A and B, aspartic proteinases from the flowers of the cardoon Cynara cardunculus L."
      Ramalho-Santos M., Verissimo P., Faro C., Pires E.
      Biochim. Biophys. Acta 1297:83-89(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 39-47 AND 166-188.
    13. "Construction and identification by partial nucleotide sequence analysis of bovine casein and beta-lactoglobulin cDNA clones."
      Willis I.M., Stewart A.F., Caputo A., Thompson A.R., McKinlay A.G.
      DNA 1:375-386(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 55-130.
    14. Shahla M.N., Farooq M.S., Naeem M.K., Riazuddin S.
      Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 85-110.
    15. "Antioxidant peptides isolated from cheddar cheese made with adjunct culture L.casei ssp. casei 300."
      Gupta A., Mann B., Kumar R., Sangwan R.B.
      Submitted (MAR-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 95-105, FUNCTION.
    16. "Nucleotide sequence of the 3'-nontranslated region of the mRNA of alpha S1-casein in cows."
      Kiarshulite D.R., Zakhar'ev V.M., Gorodetskii S.I.
      Dokl. Akad. Nauk SSSR 280:1433-1437(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 122-214.
    17. "Cloning, mapping, and sequencing of 3' and its flanking region of bovine alpha-s1 casein gene."
      Chen R., Wang B., Zhang Y., Liu W., Zhang J., Lao W.
      Chin. J. Biotechnol. 8:235-245(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 164-214.
    18. "Cloning of cDNA sequence coding for bovine alpha-s1-casein."
      Maki M., Nagao M., Hirose M., Chiba H.
      Agric. Biol. Chem. 47:441-444(1983)
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 185-202.
      Tissue: Mammary gland.
    19. "On the localization in the C-terminal sequence of bovine casein alpha-s1 of a Glu/Gly substitution that differentiates the genetic variants B and C."
      Grosclaude F., Mercier J.-C., Ribadeau-Dumas B.
      C. R. Hebd. Seances Acad. Sci., D, Sci. Nat. 268:3133-3136(1970)
      Cited for: PROTEIN SEQUENCE OF 205-214 (VARIANT C).
    20. Erratum
      Grosclaude F., Mercier J.-C., Ribadeau-Dumas B.
      C. R. Hebd. Seances Acad. Sci., D, Sci. Nat. 271:563-563(1970)
      Cited for: SEQUENCE REVISION.
    21. "Identification of IgE- and IgG-binding epitopes on alpha(s1)-casein: differences in patients with persistent and transient cow's milk allergy."
      Chatchatee P., Jaervinen K.M., Bardina L., Beyer K., Sampson H.A.
      J. Allergy Clin. Immunol. 107:379-383(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALLERGEN.
    22. "Highly selective enrichment of phosphorylated peptides from peptide mixtures using titanium dioxide microcolumns."
      Larsen M.R., Thingholm T.E., Jensen O.N., Roepstorff P., Jorgensen T.J.
      Mol. Cell. Proteomics 4:873-886(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-56; SER-61; SER-63; SER-79; SER-81; SER-82; SER-83; SER-90 AND SER-130, IDENTIFICATION BY MASS SPECTROMETRY.
    23. Bai F., Liu S., Witzmann F.A.
      Submitted (SEP-2005) to UniProtKB
      Cited for: PHOSPHORYLATION AT SER-56.

    Entry informationi

    Entry nameiCASA1_BOVIN
    AccessioniPrimary (citable) accession number: P02662
    Secondary accession number(s): A5YK80
    , A8WCP1, A8WCP2, A8WCP3, A8WCP4, A8WCP5, A8WCP6, A8WCP7, A8WCP8, A8WCP9, A8WCQ0, A8WCQ1, A8WCQ2, A8WCQ3, A8WCQ4, A8WCQ5, A8WCQ6, A8WCQ7, A8WCQ8, A8WCQ9, A8WCR0, A8WCR1, A8WCR2, A8WCR3, A8WCR4, A8WCR5, A8WCR6, A8WCR7, A8WCR8, A8WCR9, A8WCS0, A8WCS1, Q28048, Q28069, Q32LE8, Q7M2U6, Q9TRH5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: November 1, 1990
    Last modified: October 1, 2014
    This is version 119 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The B variant sequence is shown.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3