SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P02662

- CASA1_BOVIN

UniProt

P02662 - CASA1_BOVIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Alpha-S1-casein
Gene
CSN1S1
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Important role in the capacity of milk to transport calcium phosphate.1 Publication
Antioxidant peptide has 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity.1 Publication

GO - Molecular functioni

  1. antioxidant activity Source: UniProtKB-KW
  2. transporter activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Antioxidant, Milk protein

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-S1-casein
Alternative name(s):
Allergen: Bos d 8
Cleaved into the following chain:
Gene namesi
Name:CSN1S1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 6

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Has six major and 3 minor IgE-binding regions and 5 major and 1 minor IgG-binding regions. Is a cause of cow's milk allergy (CMA).2 Publications

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei10197. Bos d 9.0101.
167. Bos d 8.
2734. Bos d 9.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 15152 Publications
Add
BLAST
Chaini16 – 214199Alpha-S1-casein
PRO_0000004446Add
BLAST
Peptidei95 – 10511Antioxidant peptide1 Publication
PRO_0000331578Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei56 – 561Phosphoserine2 Publications
Modified residuei61 – 611Phosphoserine1 Publication
Modified residuei63 – 631Phosphoserine1 Publication
Modified residuei79 – 791Phosphoserine1 Publication
Modified residuei81 – 811Phosphoserine1 Publication
Modified residuei82 – 821Phosphoserine1 Publication
Modified residuei83 – 831Phosphoserine1 Publication
Modified residuei90 – 901Phosphoserine1 Publication
Modified residuei130 – 1301Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP02662.
PRIDEiP02662.
ProMEXiP02662.

Miscellaneous databases

PMAP-CutDBP02662.

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Interactioni

Protein-protein interaction databases

BioGridi159482. 3 interactions.
DIPiDIP-29917N.
IntActiP02662. 2 interactions.
MINTiMINT-8184454.

Structurei

3D structure databases

DisProtiDP00330.
ProteinModelPortaliP02662.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati85 – 9915
Add
BLAST
Repeati125 – 14016
Add
BLAST

Sequence similaritiesi

Belongs to the alpha-casein family.

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG73245.
GeneTreeiENSGT00390000017378.
HOVERGENiHBG005242.
InParanoidiP02662.
KOiK17281.
OMAiENMESIT.
OrthoDBiEOG7W1561.
TreeFamiTF340763.

Family and domain databases

InterProiIPR026999. Alpha-s1_casein.
IPR001588. Casein.
[Graphical view]
PANTHERiPTHR10240. PTHR10240. 1 hit.
PfamiPF00363. Casein. 1 hit.
[Graphical view]
PROSITEiPS00306. CASEIN_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02662-1 [UniParc]FASTAAdd to Basket

« Hide

MKLLILTCLV AVALARPKHP IKHQGLPQEV LNENLLRFFV APFPEVFGKE    50
KVNELSKDIG SESTEDQAME DIKQMEAESI SSSEEIVPNS VEQKHIQKED 100
VPSERYLGYL EQLLRLKKYK VPQLEIVPNS AEERLHSMKE GIHAQQKEPM 150
IGVNQELAYF YPELFRQFYQ LDAYPSGAWY YVPLGTQYTD APSFSDIPNP 200
IGSENSEKTT MPLW 214
Length:214
Mass (Da):24,529
Last modified:November 1, 1990 - v2
Checksum:iF066B5C8AE55828B
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti29 – 4113Missing in variant A.
Add
BLAST
Natural varianti68 – 681A → T in variant D.
Natural varianti207 – 2071E → G in variant C.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti11 – 122AV → SA in ABW98943. 1 Publication
Sequence conflicti42 – 421P → L in AAA30429. 1 Publication
Sequence conflicti44 – 441P → S in ABW98945. 1 Publication
Sequence conflicti95 – 951H → Q in AAA30478. 1 Publication
Sequence conflicti99 – 991E → D in ABQ88318. 1 Publication
Sequence conflicti143 – 1431H → D in AAA30429. 1 Publication
Sequence conflicti171 – 1711L → P in ABW98953. 1 Publication
Sequence conflicti203 – 2031S → L in AAA62707. 1 Publication
Sequence conflicti211 – 2122MP → IS in AAA30429. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X00564 mRNA. Translation: CAB57792.1.
M33123 mRNA. Translation: AAA30428.1.
M38641 mRNA. Translation: AAA30429.1.
X59856 Genomic DNA. Translation: CAA42516.1.
EU221551 Genomic DNA. Translation: ABW98936.1.
EU221552 Genomic DNA. Translation: ABW98937.1.
EU221553 Genomic DNA. Translation: ABW98938.1.
EU221554 Genomic DNA. Translation: ABW98939.1.
EU221555 Genomic DNA. Translation: ABW98940.1.
EU221556 Genomic DNA. Translation: ABW98941.1.
EU221557 Genomic DNA. Translation: ABW98942.1.
EU221558 Genomic DNA. Translation: ABW98943.1.
EU221559 Genomic DNA. Translation: ABW98944.1.
EU221560 Genomic DNA. Translation: ABW98945.1.
EU221561 Genomic DNA. Translation: ABW98946.1.
EU221562 Genomic DNA. Translation: ABW98947.1.
EU221563 Genomic DNA. Translation: ABW98948.1.
EU221564 Genomic DNA. Translation: ABW98949.1.
EU221565 Genomic DNA. Translation: ABW98950.1.
EU221566 Genomic DNA. Translation: ABW98951.1.
EU221567 Genomic DNA. Translation: ABW98952.1.
EU221568 Genomic DNA. Translation: ABW98953.1.
EU221569 Genomic DNA. Translation: ABW98954.1.
EU221570 Genomic DNA. Translation: ABW98955.1.
EU221571 Genomic DNA. Translation: ABW98956.1.
EU221572 Genomic DNA. Translation: ABW98957.1.
EU221573 Genomic DNA. Translation: ABW98958.1.
EU221574 Genomic DNA. Translation: ABW98959.1.
EU221575 Genomic DNA. Translation: ABW98960.1.
EU221576 Genomic DNA. Translation: ABW98961.1.
EU221577 Genomic DNA. Translation: ABW98962.1.
EU221578 Genomic DNA. Translation: ABW98963.1.
EU221579 Genomic DNA. Translation: ABW98964.1.
EU221580 Genomic DNA. Translation: ABW98965.1.
EU221581 Genomic DNA. Translation: ABW98966.1.
BC109618 mRNA. Translation: AAI09619.1.
K01084 mRNA. Translation: AAA30478.1.
EF538766 Genomic DNA. Translation: ABQ88318.1.
M38658 mRNA. Translation: AAA62707.1.
AH007360 Genomic DNA. Translation: AAD14099.1.
D00412 mRNA. Translation: BAA00313.1.
PIRiS22575. KABOSB.
S72220.
RefSeqiNP_851372.1. NM_181029.2.
UniGeneiBt.59369.

Genome annotation databases

EnsembliENSBTAT00000010119; ENSBTAP00000010119; ENSBTAG00000007695.
GeneIDi282208.
KEGGibta:282208.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Worthington enzyme manual
Protein Spotlight

Of buttons, digestion and glue - Issue 16 of November 2001

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X00564 mRNA. Translation: CAB57792.1 .
M33123 mRNA. Translation: AAA30428.1 .
M38641 mRNA. Translation: AAA30429.1 .
X59856 Genomic DNA. Translation: CAA42516.1 .
EU221551 Genomic DNA. Translation: ABW98936.1 .
EU221552 Genomic DNA. Translation: ABW98937.1 .
EU221553 Genomic DNA. Translation: ABW98938.1 .
EU221554 Genomic DNA. Translation: ABW98939.1 .
EU221555 Genomic DNA. Translation: ABW98940.1 .
EU221556 Genomic DNA. Translation: ABW98941.1 .
EU221557 Genomic DNA. Translation: ABW98942.1 .
EU221558 Genomic DNA. Translation: ABW98943.1 .
EU221559 Genomic DNA. Translation: ABW98944.1 .
EU221560 Genomic DNA. Translation: ABW98945.1 .
EU221561 Genomic DNA. Translation: ABW98946.1 .
EU221562 Genomic DNA. Translation: ABW98947.1 .
EU221563 Genomic DNA. Translation: ABW98948.1 .
EU221564 Genomic DNA. Translation: ABW98949.1 .
EU221565 Genomic DNA. Translation: ABW98950.1 .
EU221566 Genomic DNA. Translation: ABW98951.1 .
EU221567 Genomic DNA. Translation: ABW98952.1 .
EU221568 Genomic DNA. Translation: ABW98953.1 .
EU221569 Genomic DNA. Translation: ABW98954.1 .
EU221570 Genomic DNA. Translation: ABW98955.1 .
EU221571 Genomic DNA. Translation: ABW98956.1 .
EU221572 Genomic DNA. Translation: ABW98957.1 .
EU221573 Genomic DNA. Translation: ABW98958.1 .
EU221574 Genomic DNA. Translation: ABW98959.1 .
EU221575 Genomic DNA. Translation: ABW98960.1 .
EU221576 Genomic DNA. Translation: ABW98961.1 .
EU221577 Genomic DNA. Translation: ABW98962.1 .
EU221578 Genomic DNA. Translation: ABW98963.1 .
EU221579 Genomic DNA. Translation: ABW98964.1 .
EU221580 Genomic DNA. Translation: ABW98965.1 .
EU221581 Genomic DNA. Translation: ABW98966.1 .
BC109618 mRNA. Translation: AAI09619.1 .
K01084 mRNA. Translation: AAA30478.1 .
EF538766 Genomic DNA. Translation: ABQ88318.1 .
M38658 mRNA. Translation: AAA62707.1 .
AH007360 Genomic DNA. Translation: AAD14099.1 .
D00412 mRNA. Translation: BAA00313.1 .
PIRi S22575. KABOSB.
S72220.
RefSeqi NP_851372.1. NM_181029.2.
UniGenei Bt.59369.

3D structure databases

DisProti DP00330.
ProteinModelPortali P02662.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 159482. 3 interactions.
DIPi DIP-29917N.
IntActi P02662. 2 interactions.
MINTi MINT-8184454.

Protein family/group databases

Allergomei 10197. Bos d 9.0101.
167. Bos d 8.
2734. Bos d 9.

Proteomic databases

PaxDbi P02662.
PRIDEi P02662.
ProMEXi P02662.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000010119 ; ENSBTAP00000010119 ; ENSBTAG00000007695 .
GeneIDi 282208.
KEGGi bta:282208.

Organism-specific databases

CTDi 1446.

Phylogenomic databases

eggNOGi NOG73245.
GeneTreei ENSGT00390000017378.
HOVERGENi HBG005242.
InParanoidi P02662.
KOi K17281.
OMAi ENMESIT.
OrthoDBi EOG7W1561.
TreeFami TF340763.

Miscellaneous databases

NextBioi 20806033.
PMAP-CutDB P02662.

Family and domain databases

InterProi IPR026999. Alpha-s1_casein.
IPR001588. Casein.
[Graphical view ]
PANTHERi PTHR10240. PTHR10240. 1 hit.
Pfami PF00363. Casein. 1 hit.
[Graphical view ]
PROSITEi PS00306. CASEIN_ALPHA_BETA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequences of bovine alpha S1- and kappa-casein cDNAs."
    Stewart A.F., Willis I.M., Mackinlay A.G.
    Nucleic Acids Res. 12:3895-3907(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Isolation and sequence analysis of bovine alpha-S1-casein cDNA clone."
    Nagao M., Maki M., Sasaki R., Chiba R.
    Agric. Biol. Chem. 48:1663-1667(1984)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "cDNA of cattle alpha S1-casein: cloning and nucleotide sequence."
    Gorodetskii S.I., Zakhar'ev V.M., Kyarshulite D.R., Kapelinskaya T.V., Skryabin K.G.
    Biokhimiia 51:1641-1648(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Mammary gland.
  4. "Genomic organization of the bovine alpha-S1 casein gene."
    Koczan D., Hobom G., Seyfert H.-M.
    Nucleic Acids Res. 19:5591-5596(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALLERGEN.
  6. NIH - Mammalian Gene Collection (MGC) project
    Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.
  7. "Primary structure of bovine alpha-s1 casein. Complete sequence."
    Mercier J.-C., Grosclaude F., Ribadeau-Dumas B.
    Eur. J. Biochem. 23:41-51(1971) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 16-214 (VARIANT B).
  8. "Primary structure of alpha casein and of bovine beta casein. Correction."
    Mercier J.-C., Grosclaude F., Ribadeau-Dumas B.
    Eur. J. Biochem. 40:323-323(1973) [PubMed] [Europe PMC] [Abstract]
    Cited for: SEQUENCE REVISION TO 74 AND 92-93 (VARIANTS A; B; C AND D).
  9. "Characterization of genetic variants of alpha-S1 and beta bovine caseins."
    Grosclaude F., Mahe M.-F., Mercier J.-C., Ribadeau-Dumas B.
    Eur. J. Biochem. 26:328-337(1972) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 16-214 (VARIANT D).
  10. "Localization in the N-terminal part of bovine casein alpha-s1 of a 13 amino-acid deletion that differentiates variant A from variants B and C."
    Grosclaude F., Mahe M.-F., Mercier J.-C., Ribadeau-Dumas B.
    FEBS Lett. 11:109-112(1970) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 23-49 (VARIANT A).
  11. "Isolation of a new ligand-carrying casein fragment from bovine mammary gland microsomes."
    Neuteboom B., Giuffrida M.G., Conti A.
    FEBS Lett. 305:189-191(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 39-55.
    Tissue: Mammary gland.
  12. "Action on bovine alpha s1-casein of cardosins A and B, aspartic proteinases from the flowers of the cardoon Cynara cardunculus L."
    Ramalho-Santos M., Verissimo P., Faro C., Pires E.
    Biochim. Biophys. Acta 1297:83-89(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 39-47 AND 166-188.
  13. "Construction and identification by partial nucleotide sequence analysis of bovine casein and beta-lactoglobulin cDNA clones."
    Willis I.M., Stewart A.F., Caputo A., Thompson A.R., McKinlay A.G.
    DNA 1:375-386(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 55-130.
  14. Shahla M.N., Farooq M.S., Naeem M.K., Riazuddin S.
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 85-110.
  15. "Antioxidant peptides isolated from cheddar cheese made with adjunct culture L.casei ssp. casei 300."
    Gupta A., Mann B., Kumar R., Sangwan R.B.
    Submitted (MAR-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 95-105, FUNCTION.
  16. "Nucleotide sequence of the 3'-nontranslated region of the mRNA of alpha S1-casein in cows."
    Kiarshulite D.R., Zakhar'ev V.M., Gorodetskii S.I.
    Dokl. Akad. Nauk SSSR 280:1433-1437(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 122-214.
  17. "Cloning, mapping, and sequencing of 3' and its flanking region of bovine alpha-s1 casein gene."
    Chen R., Wang B., Zhang Y., Liu W., Zhang J., Lao W.
    Chin. J. Biotechnol. 8:235-245(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 164-214.
  18. "Cloning of cDNA sequence coding for bovine alpha-s1-casein."
    Maki M., Nagao M., Hirose M., Chiba H.
    Agric. Biol. Chem. 47:441-444(1983)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 185-202.
    Tissue: Mammary gland.
  19. "On the localization in the C-terminal sequence of bovine casein alpha-s1 of a Glu/Gly substitution that differentiates the genetic variants B and C."
    Grosclaude F., Mercier J.-C., Ribadeau-Dumas B.
    C. R. Hebd. Seances Acad. Sci., D, Sci. Nat. 268:3133-3136(1970)
    Cited for: PROTEIN SEQUENCE OF 205-214 (VARIANT C).
  20. Erratum
    Grosclaude F., Mercier J.-C., Ribadeau-Dumas B.
    C. R. Hebd. Seances Acad. Sci., D, Sci. Nat. 271:563-563(1970)
    Cited for: SEQUENCE REVISION.
  21. "Identification of IgE- and IgG-binding epitopes on alpha(s1)-casein: differences in patients with persistent and transient cow's milk allergy."
    Chatchatee P., Jaervinen K.M., Bardina L., Beyer K., Sampson H.A.
    J. Allergy Clin. Immunol. 107:379-383(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALLERGEN.
  22. "Highly selective enrichment of phosphorylated peptides from peptide mixtures using titanium dioxide microcolumns."
    Larsen M.R., Thingholm T.E., Jensen O.N., Roepstorff P., Jorgensen T.J.
    Mol. Cell. Proteomics 4:873-886(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-56; SER-61; SER-63; SER-79; SER-81; SER-82; SER-83; SER-90 AND SER-130, IDENTIFICATION BY MASS SPECTROMETRY.
  23. Bai F., Liu S., Witzmann F.A.
    Submitted (SEP-2005) to UniProtKB
    Cited for: PHOSPHORYLATION AT SER-56.

Entry informationi

Entry nameiCASA1_BOVIN
AccessioniPrimary (citable) accession number: P02662
Secondary accession number(s): A5YK80
, A8WCP1, A8WCP2, A8WCP3, A8WCP4, A8WCP5, A8WCP6, A8WCP7, A8WCP8, A8WCP9, A8WCQ0, A8WCQ1, A8WCQ2, A8WCQ3, A8WCQ4, A8WCQ5, A8WCQ6, A8WCQ7, A8WCQ8, A8WCQ9, A8WCR0, A8WCR1, A8WCR2, A8WCR3, A8WCR4, A8WCR5, A8WCR6, A8WCR7, A8WCR8, A8WCR9, A8WCS0, A8WCS1, Q28048, Q28069, Q32LE8, Q7M2U6, Q9TRH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1990
Last modified: June 11, 2014
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The B variant sequence is shown.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi