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Protein

Alpha-S1-casein

Gene

CSN1S1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Important role in the capacity of milk to transport calcium phosphate.1 Publication
Antioxidant peptide has 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity.1 Publication

Miscellaneous

The B variant sequence is shown.

GO - Molecular functioni

  • amyloid-beta binding Source: CAFA
  • antioxidant activity Source: UniProtKB-KW
  • transporter activity Source: InterPro

GO - Biological processi

  • negative regulation of apoptotic process Source: AgBase
  • negative regulation of gene expression Source: AgBase
  • negative regulation of supramolecular fiber organization Source: CAFA
  • positive regulation of androst-4-ene-3,17-dione biosynthetic process Source: AgBase
  • positive regulation of androstenedione secretion Source: AgBase
  • positive regulation of progesterone biosynthetic process Source: AgBase
  • positive regulation of progesterone secretion Source: AgBase
  • protein stabilization Source: CAFA
  • response to 11-deoxycorticosterone Source: AgBase
  • response to dehydroepiandrosterone Source: AgBase
  • response to estradiol Source: AgBase
  • response to growth hormone Source: AgBase
  • response to progesterone Source: AgBase

Keywordsi

Molecular functionAntioxidant, Milk protein

Enzyme and pathway databases

ReactomeiR-BTA-5223345. Miscellaneous transport and binding events.

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-S1-casein
Alternative name(s):
Allergen: Bos d 8
Cleaved into the following chain:
Gene namesi
Name:CSN1S1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Has six major and 3 minor IgE-binding regions and 5 major and 1 minor IgG-binding regions. Is a cause of cow's milk allergy (CMA).2 Publications

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei10197. Bos d 9.0101.
167. Bos d 8.
2734. Bos d 9.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 152 PublicationsAdd BLAST15
ChainiPRO_000000444616 – 214Alpha-S1-caseinAdd BLAST199
PeptideiPRO_000033157895 – 105Antioxidant peptideAdd BLAST11

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei56Phosphoserine2 Publications1
Modified residuei61Phosphoserine1 Publication1
Modified residuei63Phosphoserine1 Publication1
Modified residuei79Phosphoserine1 Publication1
Modified residuei81Phosphoserine1 Publication1
Modified residuei82Phosphoserine1 Publication1
Modified residuei83Phosphoserine1 Publication1
Modified residuei90Phosphoserine1 Publication1
Modified residuei130Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP02662.
PeptideAtlasiP02662.
PRIDEiP02662.

PTM databases

iPTMnetiP02662.

Miscellaneous databases

PMAP-CutDBiP02662.

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Gene expression databases

BgeeiENSBTAG00000007695.

Interactioni

Protein-protein interaction databases

BioGridi159482. 3 interactors.
DIPiDIP-29917N.
IntActiP02662. 3 interactors.
MINTiMINT-8184454.
STRINGi9913.ENSBTAP00000010119.

Structurei

3D structure databases

ProteinModelPortaliP02662.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati85 – 99Add BLAST15
Repeati125 – 140Add BLAST16

Sequence similaritiesi

Belongs to the alpha-casein family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410J2MD. Eukaryota.
ENOG41114JX. LUCA.
GeneTreeiENSGT00390000017378.
HOVERGENiHBG005242.
InParanoidiP02662.
KOiK17281.
OMAiSKCAEQF.
OrthoDBiEOG091G0XI1.
TreeFamiTF340763.

Family and domain databases

InterProiView protein in InterPro
IPR026999. Alpha-s1_casein.
IPR001588. Casein.
IPR031305. Casein_CS.
PANTHERiPTHR10240. PTHR10240. 1 hit.
PfamiView protein in Pfam
PF00363. Casein. 1 hit.
PROSITEiView protein in PROSITE
PS00306. CASEIN_ALPHA_BETA. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02662-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLILTCLV AVALARPKHP IKHQGLPQEV LNENLLRFFV APFPEVFGKE
60 70 80 90 100
KVNELSKDIG SESTEDQAME DIKQMEAESI SSSEEIVPNS VEQKHIQKED
110 120 130 140 150
VPSERYLGYL EQLLRLKKYK VPQLEIVPNS AEERLHSMKE GIHAQQKEPM
160 170 180 190 200
IGVNQELAYF YPELFRQFYQ LDAYPSGAWY YVPLGTQYTD APSFSDIPNP
210
IGSENSEKTT MPLW
Length:214
Mass (Da):24,529
Last modified:November 1, 1990 - v2
Checksum:iF066B5C8AE55828B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11 – 12AV → SA in ABW98943 (PubMed:19454699).Curated2
Sequence conflicti42P → L in AAA30429 (PubMed:3022833).Curated1
Sequence conflicti44P → S in ABW98945 (PubMed:19454699).Curated1
Sequence conflicti95H → Q in AAA30478 (PubMed:6897774).Curated1
Sequence conflicti99E → D in ABQ88318 (Ref. 14) Curated1
Sequence conflicti143H → D in AAA30429 (PubMed:3022833).Curated1
Sequence conflicti171L → P in ABW98953 (PubMed:19454699).Curated1
Sequence conflicti203S → L in AAA62707 (PubMed:3838718).Curated1
Sequence conflicti211 – 212MP → IS in AAA30429 (PubMed:3022833).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti29 – 41Missing in variant A. Add BLAST13
Natural varianti68A → T in variant D. 1
Natural varianti207E → G in variant C. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00564 mRNA. Translation: CAB57792.1.
M33123 mRNA. Translation: AAA30428.1.
M38641 mRNA. Translation: AAA30429.1.
X59856 Genomic DNA. Translation: CAA42516.1.
EU221551 Genomic DNA. Translation: ABW98936.1.
EU221552 Genomic DNA. Translation: ABW98937.1.
EU221553 Genomic DNA. Translation: ABW98938.1.
EU221554 Genomic DNA. Translation: ABW98939.1.
EU221555 Genomic DNA. Translation: ABW98940.1.
EU221556 Genomic DNA. Translation: ABW98941.1.
EU221557 Genomic DNA. Translation: ABW98942.1.
EU221558 Genomic DNA. Translation: ABW98943.1.
EU221559 Genomic DNA. Translation: ABW98944.1.
EU221560 Genomic DNA. Translation: ABW98945.1.
EU221561 Genomic DNA. Translation: ABW98946.1.
EU221562 Genomic DNA. Translation: ABW98947.1.
EU221563 Genomic DNA. Translation: ABW98948.1.
EU221564 Genomic DNA. Translation: ABW98949.1.
EU221565 Genomic DNA. Translation: ABW98950.1.
EU221566 Genomic DNA. Translation: ABW98951.1.
EU221567 Genomic DNA. Translation: ABW98952.1.
EU221568 Genomic DNA. Translation: ABW98953.1.
EU221569 Genomic DNA. Translation: ABW98954.1.
EU221570 Genomic DNA. Translation: ABW98955.1.
EU221571 Genomic DNA. Translation: ABW98956.1.
EU221572 Genomic DNA. Translation: ABW98957.1.
EU221573 Genomic DNA. Translation: ABW98958.1.
EU221574 Genomic DNA. Translation: ABW98959.1.
EU221575 Genomic DNA. Translation: ABW98960.1.
EU221576 Genomic DNA. Translation: ABW98961.1.
EU221577 Genomic DNA. Translation: ABW98962.1.
EU221578 Genomic DNA. Translation: ABW98963.1.
EU221579 Genomic DNA. Translation: ABW98964.1.
EU221580 Genomic DNA. Translation: ABW98965.1.
EU221581 Genomic DNA. Translation: ABW98966.1.
BC109618 mRNA. Translation: AAI09619.1.
K01084 mRNA. Translation: AAA30478.1.
EF538766 Genomic DNA. Translation: ABQ88318.1.
M38658 mRNA. Translation: AAA62707.1.
AH007360 Genomic DNA. Translation: AAD14099.1.
D00412 mRNA. Translation: BAA00313.1.
PIRiS22575. KABOSB.
S72220.
RefSeqiNP_851372.1. NM_181029.2.
UniGeneiBt.59369.

Genome annotation databases

EnsembliENSBTAT00000010119; ENSBTAP00000010119; ENSBTAG00000007695.
GeneIDi282208.
KEGGibta:282208.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCASA1_BOVIN
AccessioniPrimary (citable) accession number: P02662
Secondary accession number(s): A5YK80
, A8WCP1, A8WCP2, A8WCP3, A8WCP4, A8WCP5, A8WCP6, A8WCP7, A8WCP8, A8WCP9, A8WCQ0, A8WCQ1, A8WCQ2, A8WCQ3, A8WCQ4, A8WCQ5, A8WCQ6, A8WCQ7, A8WCQ8, A8WCQ9, A8WCR0, A8WCR1, A8WCR2, A8WCR3, A8WCR4, A8WCR5, A8WCR6, A8WCR7, A8WCR8, A8WCR9, A8WCS0, A8WCS1, Q28048, Q28069, Q32LE8, Q7M2U6, Q9TRH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1990
Last modified: November 22, 2017
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families