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Protein

Alpha-S1-casein

Gene

Csn1s1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Important role in the capacity of milk to transport calcium phosphate.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Milk protein

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-S1-casein
Short name:
Alpha-casein
Gene namesi
Name:Csn1s1
Synonyms:Csna
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2430. Csn1s1.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei2151. Rat n 8.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515By similarityAdd
BLAST
Chaini16 – 284269Alpha-S1-caseinPRO_0000004458Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei79 – 791PhosphoserineBy similarity
Modified residuei94 – 941PhosphoserineBy similarity
Modified residuei95 – 951PhosphoserineBy similarity
Modified residuei96 – 961PhosphoserineBy similarity
Modified residuei97 – 971PhosphoserineBy similarity
Modified residuei98 – 981PhosphoserineBy similarity
Modified residuei99 – 991PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP02661.
PRIDEiP02661.

Expressioni

Tissue specificityi

Mammary gland specific. Secreted in milk.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000056956.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati138 – 14361
Repeati144 – 14962
Repeati150 – 15563
Repeati156 – 16164
Repeati162 – 16765
Repeati168 – 17366
Repeati174 – 17967
Repeati180 – 18568
Repeati186 – 19169
Repeati192 – 197610

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni138 – 1976010 X 6 AA tandem repeatsAdd
BLAST

Sequence similaritiesi

Belongs to the alpha-casein family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410J2MD. Eukaryota.
ENOG41114JX. LUCA.
HOGENOMiHOG000214193.
HOVERGENiHBG098347.
InParanoidiP02661.

Family and domain databases

InterProiIPR026999. Alpha-s1_casein.
IPR001588. Casein.
IPR031305. Casein_CS.
[Graphical view]
PANTHERiPTHR10240. PTHR10240. 1 hit.
PfamiPF00363. Casein. 1 hit.
[Graphical view]
PROSITEiPS00306. CASEIN_ALPHA_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02661-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLLILTCLV AAALALPRAH RRNAVSSQTQ QENSSSEEQE IVKQPKYLSL
60 70 80 90 100
NEEFVNNLNR QRELLTEQDN EIKITMDSSA EEQATASAQE DSSSSSSSSE
110 120 130 140 150
ESKDAIPSAT EQKNIANKEI LNRCTLEQLQ RQIKYSQLLQ QASLAQQASL
160 170 180 190 200
AQQASLAQQA LLAQQPSLAQ QAALAQQASL AQQASLAQQA SLAQKHHPRL
210 220 230 240 250
SQVYYPNMEQ PYRMNAYSQV QMRHPMSVVD QAQFSVQSFP QLSQYGAYPL
260 270 280
WLYFPQDMQY LTPEAVLNTF KPIAPKDAEN TNVW
Length:284
Mass (Da):31,802
Last modified:July 21, 1986 - v1
Checksum:iFB3D34DA46417CD5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00710 mRNA. No translation available.
X03585 Genomic DNA. Translation: CAA27261.1.
X03586 Genomic DNA. Translation: CAA27262.1.
X03587 Genomic DNA. Translation: CAA27263.1.
X03588 Genomic DNA. Translation: CAA27264.1.
PIRiA03105. KART.
RefSeqiNP_620229.2. NM_138874.2.
UniGeneiRn.10744.

Genome annotation databases

GeneIDi24284.
KEGGirno:24284.
UCSCiRGD:2430. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00710 mRNA. No translation available.
X03585 Genomic DNA. Translation: CAA27261.1.
X03586 Genomic DNA. Translation: CAA27262.1.
X03587 Genomic DNA. Translation: CAA27263.1.
X03588 Genomic DNA. Translation: CAA27264.1.
PIRiA03105. KART.
RefSeqiNP_620229.2. NM_138874.2.
UniGeneiRn.10744.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000056956.

Protein family/group databases

Allergomei2151. Rat n 8.

Proteomic databases

PaxDbiP02661.
PRIDEiP02661.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24284.
KEGGirno:24284.
UCSCiRGD:2430. rat.

Organism-specific databases

CTDi1446.
RGDi2430. Csn1s1.

Phylogenomic databases

eggNOGiENOG410J2MD. Eukaryota.
ENOG41114JX. LUCA.
HOGENOMiHOG000214193.
HOVERGENiHBG098347.
InParanoidiP02661.

Miscellaneous databases

NextBioi602874.
PROiP02661.

Family and domain databases

InterProiIPR026999. Alpha-s1_casein.
IPR001588. Casein.
IPR031305. Casein_CS.
[Graphical view]
PANTHERiPTHR10240. PTHR10240. 1 hit.
PfamiPF00363. Casein. 1 hit.
[Graphical view]
PROSITEiPS00306. CASEIN_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of rat alpha- and gamma-casein mRNAs: evolutionary comparison of the calcium-dependent rat casein multigene family."
    Hobbs A.A., Rosen J.M.
    Nucleic Acids Res. 10:8079-8098(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Evolution of the casein multigene family: conserved sequences in the 5' flanking and exon regions."
    Yu-Lee L.Y., Richter-Mann L., Couch C.H., Stewart A.F., Mackinlay A.G., Rosen J.M.
    Nucleic Acids Res. 14:1883-1902(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-52.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCASA1_RAT
AccessioniPrimary (citable) accession number: P02661
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 11, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.