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P02655

- APOC2_HUMAN

UniProt

P02655 - APOC2_HUMAN

Protein

Apolipoprotein C-II

Gene

APOC2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly.

    GO - Molecular functioni

    1. lipase inhibitor activity Source: BHF-UCL
    2. lipid binding Source: BHF-UCL
    3. lipoprotein lipase activator activity Source: BHF-UCL
    4. phospholipase activator activity Source: BHF-UCL
    5. phospholipase binding Source: BHF-UCL
    6. protein homodimerization activity Source: BHF-UCL

    GO - Biological processi

    1. cholesterol efflux Source: BHF-UCL
    2. cholesterol homeostasis Source: BHF-UCL
    3. chylomicron remnant clearance Source: BHF-UCL
    4. chylomicron remodeling Source: BHF-UCL
    5. high-density lipoprotein particle clearance Source: BHF-UCL
    6. lipid catabolic process Source: UniProtKB-KW
    7. lipoprotein metabolic process Source: Reactome
    8. lipoprotein transport Source: Ensembl
    9. negative regulation of catalytic activity Source: GOC
    10. negative regulation of cholesterol transport Source: BHF-UCL
    11. negative regulation of lipid metabolic process Source: BHF-UCL
    12. negative regulation of receptor-mediated endocytosis Source: BHF-UCL
    13. negative regulation of very-low-density lipoprotein particle clearance Source: BHF-UCL
    14. phospholipid efflux Source: BHF-UCL
    15. phototransduction, visible light Source: Reactome
    16. positive regulation of fatty acid biosynthetic process Source: BHF-UCL
    17. positive regulation of lipoprotein lipase activity Source: BHF-UCL
    18. positive regulation of phospholipase activity Source: BHF-UCL
    19. positive regulation of phospholipid catabolic process Source: BHF-UCL
    20. positive regulation of triglyceride catabolic process Source: BHF-UCL
    21. positive regulation of very-low-density lipoprotein particle remodeling Source: BHF-UCL
    22. response to drug Source: Ensembl
    23. retinoid metabolic process Source: Reactome
    24. reverse cholesterol transport Source: BHF-UCL
    25. small molecule metabolic process Source: Reactome
    26. triglyceride homeostasis Source: BHF-UCL
    27. triglyceride-rich lipoprotein particle remodeling Source: BHF-UCL
    28. very-low-density lipoprotein particle remodeling Source: BHF-UCL

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism, Lipid transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_13621. HDL-mediated lipid transport.
    REACT_24968. Retinoid metabolism and transport.
    REACT_6841. Chylomicron-mediated lipid transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Apolipoprotein C-II
    Short name:
    Apo-CII
    Short name:
    ApoC-II
    Alternative name(s):
    Apolipoprotein C2
    Gene namesi
    Name:APOC2
    Synonyms:APC2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:609. APOC2.

    Subcellular locationi

    GO - Cellular componenti

    1. chylomicron Source: BHF-UCL
    2. early endosome Source: Reactome
    3. extracellular region Source: UniProtKB
    4. extracellular space Source: BHF-UCL
    5. extracellular vesicular exosome Source: UniProt
    6. intermediate-density lipoprotein particle Source: BHF-UCL
    7. low-density lipoprotein particle Source: BHF-UCL
    8. spherical high-density lipoprotein particle Source: BHF-UCL
    9. very-low-density lipoprotein particle Source: BHF-UCL

    Keywords - Cellular componenti

    Chylomicron, Secreted, VLDL

    Pathology & Biotechi

    Involvement in diseasei

    Hyperlipoproteinemia 1B (HLPP1B) [MIM:207750]: Autosomal recessive trait characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti48 – 481W → R in HLPP1B; variant Wakayama. 1 Publication
    VAR_000640

    Keywords - Diseasei

    Disease mutation, Hyperlipidemia

    Organism-specific databases

    MIMi207750. phenotype.
    Orphaneti309020. Familial apolipoprotein C-II deficiency.
    PharmGKBiPA52.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 22222 PublicationsAdd
    BLAST
    Chaini23 – 10179Apolipoprotein C-IIPRO_0000002024Add
    BLAST

    Proteomic databases

    MaxQBiP02655.
    PaxDbiP02655.
    PeptideAtlasiP02655.
    PRIDEiP02655.

    2D gel databases

    DOSAC-COBS-2DPAGEP02655.
    SWISS-2DPAGEP02655.

    PTM databases

    PhosphoSiteiP02655.

    Miscellaneous databases

    PMAP-CutDBP02655.

    Expressioni

    Tissue specificityi

    Secreted in plasma.

    Gene expression databases

    BgeeiP02655.
    CleanExiHS_APC2.
    HS_APOC2.
    GenevestigatoriP02655.

    Organism-specific databases

    HPAiHPA055877.

    Interactioni

    Protein-protein interaction databases

    BioGridi106841. 2 interactions.
    IntActiP02655. 4 interactions.
    STRINGi9606.ENSP00000252490.

    Structurei

    Secondary structure

    1
    101
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi28 – 314
    Helixi37 – 5721
    Turni58 – 614
    Beta strandi62 – 643
    Turni68 – 703
    Beta strandi71 – 744
    Turni75 – 773
    Turni79 – 813
    Beta strandi86 – 883
    Helixi92 – 943
    Helixi97 – 993

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1BY6NMR-A66-101[»]
    1I5JNMR-A23-101[»]
    1O8TNMR-A23-101[»]
    1SOHNMR-A23-101[»]
    ProteinModelPortaliP02655.
    SMRiP02655. Positions 23-101.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP02655.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni23 – 3816O-glycosylated at one siteAdd
    BLAST
    Regioni43 – 519Lipid binding
    Regioni55 – 7824Lipoprotein lipase cofactorAdd
    BLAST

    Sequence similaritiesi

    Belongs to the apolipoprotein C2 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG25045.
    HOGENOMiHOG000034002.
    HOVERGENiHBG050548.
    InParanoidiP02655.
    PhylomeDBiP02655.

    Family and domain databases

    Gene3Di1.10.1440.10. 1 hit.
    InterProiIPR008019. Apo-CII.
    IPR023121. ApoC-II_domain.
    [Graphical view]
    PANTHERiPTHR16566. PTHR16566. 1 hit.
    PfamiPF05355. Apo-CII. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P02655-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGTRLLPALF LVLLVLGFEV QGTQQPQQDE MPSPTFLTQV KESLSSYWES    50
    AKTAAQNLYE KTYLPAVDEK LRDLYSKSTA AMSTYTGIFT DQVLSVLKGE 100
    E 101
    Length:101
    Mass (Da):11,284
    Last modified:July 21, 1986 - v1
    Checksum:i51CB86FEDB174D84
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti36 – 361F → L1 PublicationCurated
    Sequence conflicti36 – 361F → L1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti41 – 411K → T.2 Publications
    VAR_000639
    Natural varianti48 – 481W → R in HLPP1B; variant Wakayama. 1 Publication
    VAR_000640
    Natural varianti60 – 601E → K in San Francisco; found in hyperlipidemic patients. 1 Publication
    Corresponds to variant rs5122 [ dbSNP | Ensembl ].
    VAR_000641
    Natural varianti77 – 771K → Q in Africa. 2 Publications
    Corresponds to variant rs5126 [ dbSNP | Ensembl ].
    VAR_000642

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X05151 Genomic DNA. Translation: CAA28798.1.
    X00568 mRNA. Translation: CAA25234.1.
    J02698 Genomic DNA. Translation: AAA98743.1.
    AY422955 Genomic DNA. Translation: AAQ91814.1.
    BT006708 mRNA. Translation: AAP35354.1.
    FJ525875 Genomic DNA. Translation: ACN81313.1.
    CH471126 Genomic DNA. Translation: EAW57311.1.
    BC005348 mRNA. Translation: AAH05348.3.
    M29844 mRNA. Translation: AAA51743.1.
    M10612 Genomic DNA. Translation: AAB59380.1.
    AF113884 mRNA. Translation: AAD28193.1.
    CCDSiCCDS12650.1.
    PIRiA24238. LPHUC2.
    RefSeqiNP_000474.2. NM_000483.4.
    UniGeneiHs.75615.

    Genome annotation databases

    EnsembliENST00000590360; ENSP00000466775; ENSG00000234906.
    GeneIDi344.
    KEGGihsa:344.

    Polymorphism databases

    DMDMi114022.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X05151 Genomic DNA. Translation: CAA28798.1 .
    X00568 mRNA. Translation: CAA25234.1 .
    J02698 Genomic DNA. Translation: AAA98743.1 .
    AY422955 Genomic DNA. Translation: AAQ91814.1 .
    BT006708 mRNA. Translation: AAP35354.1 .
    FJ525875 Genomic DNA. Translation: ACN81313.1 .
    CH471126 Genomic DNA. Translation: EAW57311.1 .
    BC005348 mRNA. Translation: AAH05348.3 .
    M29844 mRNA. Translation: AAA51743.1 .
    M10612 Genomic DNA. Translation: AAB59380.1 .
    AF113884 mRNA. Translation: AAD28193.1 .
    CCDSi CCDS12650.1.
    PIRi A24238. LPHUC2.
    RefSeqi NP_000474.2. NM_000483.4.
    UniGenei Hs.75615.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1BY6 NMR - A 66-101 [» ]
    1I5J NMR - A 23-101 [» ]
    1O8T NMR - A 23-101 [» ]
    1SOH NMR - A 23-101 [» ]
    ProteinModelPortali P02655.
    SMRi P02655. Positions 23-101.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106841. 2 interactions.
    IntActi P02655. 4 interactions.
    STRINGi 9606.ENSP00000252490.

    PTM databases

    PhosphoSitei P02655.

    Polymorphism databases

    DMDMi 114022.

    2D gel databases

    DOSAC-COBS-2DPAGE P02655.
    SWISS-2DPAGE P02655.

    Proteomic databases

    MaxQBi P02655.
    PaxDbi P02655.
    PeptideAtlasi P02655.
    PRIDEi P02655.

    Protocols and materials databases

    DNASUi 344.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000590360 ; ENSP00000466775 ; ENSG00000234906 .
    GeneIDi 344.
    KEGGi hsa:344.

    Organism-specific databases

    CTDi 344.
    GeneCardsi GC19P045449.
    HGNCi HGNC:609. APOC2.
    HPAi HPA055877.
    MIMi 207750. phenotype.
    608083. gene.
    neXtProti NX_P02655.
    Orphaneti 309020. Familial apolipoprotein C-II deficiency.
    PharmGKBi PA52.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG25045.
    HOGENOMi HOG000034002.
    HOVERGENi HBG050548.
    InParanoidi P02655.
    PhylomeDBi P02655.

    Enzyme and pathway databases

    Reactomei REACT_13621. HDL-mediated lipid transport.
    REACT_24968. Retinoid metabolism and transport.
    REACT_6841. Chylomicron-mediated lipid transport.

    Miscellaneous databases

    EvolutionaryTracei P02655.
    GeneWikii Apolipoprotein_C2.
    GenomeRNAii 344.
    NextBioi 1419.
    PMAP-CutDB P02655.
    PROi P02655.
    SOURCEi Search...

    Gene expression databases

    Bgeei P02655.
    CleanExi HS_APC2.
    HS_APOC2.
    Genevestigatori P02655.

    Family and domain databases

    Gene3Di 1.10.1440.10. 1 hit.
    InterProi IPR008019. Apo-CII.
    IPR023121. ApoC-II_domain.
    [Graphical view ]
    PANTHERi PTHR16566. PTHR16566. 1 hit.
    Pfami PF05355. Apo-CII. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human preproapolipoprotein C-II gene. Complete nucleic acid sequence and genomic organization."
      Fojo S.S., Law S.W., Brewer H.B. Jr.
      FEBS Lett. 213:221-226(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Human apolipoprotein C-II: complete nucleic acid sequence of preapolipoprotein C-II."
      Fojo S.S., Law S.W., Brewer H.B. Jr.
      Proc. Natl. Acad. Sci. U.S.A. 81:6354-6357(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    3. "Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance."
      Sharpe C.R., Sidoli A., Shelley C.S., Lucero M.A., Shoulders C.C., Baralle F.E.
      Nucleic Acids Res. 12:3917-3932(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The human apolipoprotein C-II gene sequence contains a novel chromosome 19-specific minisatellite in its third intron."
      Das H.K., Jackson C.L., Miller D.A., Leff T., Breslow J.L.
      J. Biol. Chem. 262:4787-4793(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "The structure of the human apolipoprotein C-II gene. Electron microscopic analysis of RNA:DNA hybrids, complete nucleotide sequence, and identification of 5' homologous sequences among apolipoprotein genes."
      Wei C.F., Tsao Y.K., Robberson D.L., Gotto A.M. Jr., Brown K., Chan L.
      J. Biol. Chem. 260:15211-15221(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    6. Nickerson D.A., Smith J.D., Fullerton S.M., Clark A.G., Stengard J.H., Salomaa V., Boerwinkle E., Sing C.F., Weiss K.M.
      Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    7. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    8. NHLBI resequencing and genotyping service (RS&G)
      Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skeletal muscle.
    11. "The isolation and characterization of cDNA clones for human apolipoprotein CII."
      Myklebost O., Williamson B., Markham A.F., Myklebost S.R., Rogers J., Woods D.E., Humphries S.E.
      J. Biol. Chem. 259:4401-4404(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-101.
    12. "Isolation of cDNA and genomic clones for apolipoprotein C-II."
      Jackson C.L., Bruns G.A.P., Breslow J.L.
      Methods Enzymol. 128:788-800(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 11-101.
    13. "Amino acid sequence of human plasma apolipoprotein C-II from normal and hyperlipoproteinemic subjects."
      Hospattankar A.V., Fairwell T., Ronan R., Brewer H.B. Jr.
      J. Biol. Chem. 259:318-322(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 23-101.
    14. "Primary structure of very low density apolipoprotein C-II of human plasma."
      Jackson R.L., Baker H.N., Gilliam E.B., Gotto A.M. Jr.
      Proc. Natl. Acad. Sci. U.S.A. 74:1942-1945(1977) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 23-101.
    15. "Expression of the apolipoprotein C-II gene during myelomonocytic differentiation of human leukemic cells."
      Chun E.M., Park Y.J., Kang H.S., Cho H.M., Jun D.Y., Kim Y.H.
      J. Leukoc. Biol. 69:645-650(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 77-101.
    16. "LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."
      Halim A., Ruetschi U., Larson G., Nilsson J.
      J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION, IDENTIFICATION BY MASS SPECTROMETRY.
    17. "Sequence specific 1H-NMR assignments and secondary structure of a carboxy-terminal functional fragment of apolipoprotein CII."
      Lycksell P.-O., Oehman A., Bengtsson-Olivecrona G., Johansson L.B.-A., Wijmenga S.S., Wernic D., Graeslund A.
      Eur. J. Biochem. 205:223-231(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 72-101.
    18. "A refined three-dimensional solution structure of a carboxy terminal fragment of apolipoprotein CII."
      Oehman A., Lycksell P.-O., Graeslund A.
      Eur. Biophys. J. 22:351-357(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 72-101.
    19. "A variant primary structure of apolipoprotein C-II in individuals of African descent."
      Menzel H.-J., Kane J.P., Malloy M.J., Havel R.J.
      J. Clin. Invest. 77:595-601(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT AFRICA GLN-77.
    20. "Molecular cloning and characteristics of a new apolipoprotein C-II mutant identified in three unrelated individuals with hypercholesterolemia and hypertriglyceridemia."
      Pullinger C.R., Zysow B.R., Hennessy L.K., Frost P.H., Malloy M.J., Kanr J.P.
      Hum. Mol. Genet. 2:69-74(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT SAN FRANCISCO LYS-60.
    21. "An apolipoprotein CII mutation, CII Lys-19-->Thr identified in patients with hyperlipidemia."
      Hegele R.A., Connelly P.W., Maguire G.F., Huff M.W., Leiter L., Wolfe B.M., Evans A.J., Little J.A.
      Dis. Markers 9:73-80(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT THR-41.
    22. "The apolipoprotein C-II variant apoC-II Lys-19-->Thr is not associated with dyslipidemia in an affected kindred."
      Zysow B.R., Pullinger C.R., Hennessy L.K., Farese R.V. Jr., Ghassemzadeh M., Kane J.P.
      Clin. Genet. 45:292-297(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT THR-41.
    23. "A missense mutation (Trp 26-->Arg) in exon 3 of the apolipoprotein CII gene in a patient with apolipoprotein CII deficiency (apo CII-Wakayama)."
      Inadera H., Hibino A., Kobayashi J., Kanzaki T., Shirai K., Yukawa S., Saito Y., Yoshida S.
      Biochem. Biophys. Res. Commun. 193:1174-1183(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT HLPP1B WAKAYAMA ARG-48.
    24. "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."
      Halushka M.K., Fan J.-B., Bentley K., Hsie L., Shen N., Weder A., Cooper R., Lipshutz R., Chakravarti A.
      Nat. Genet. 22:239-247(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT GLN-77.

    Entry informationi

    Entry nameiAPOC2_HUMAN
    AccessioniPrimary (citable) accession number: P02655
    Secondary accession number(s): C0JYY4
    , Q9BS39, Q9UDE3, Q9UNK3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 173 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3