Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Apolipoprotein C-II

Gene

APOC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL.1 Publication1 Publication

GO - Molecular functioni

  • lipase inhibitor activity Source: BHF-UCL
  • lipid binding Source: BHF-UCL
  • lipoprotein lipase activator activity Source: BHF-UCL
  • phospholipase activator activity Source: BHF-UCL
  • phospholipase binding Source: BHF-UCL
  • protein homodimerization activity Source: BHF-UCL

GO - Biological processi

  • cholesterol efflux Source: BHF-UCL
  • cholesterol homeostasis Source: BHF-UCL
  • chylomicron remnant clearance Source: BHF-UCL
  • chylomicron remodeling Source: BHF-UCL
  • high-density lipoprotein particle clearance Source: BHF-UCL
  • lipid catabolic process Source: UniProtKB-KW
  • lipoprotein metabolic process Source: Reactome
  • negative regulation of catalytic activity Source: GOC
  • negative regulation of cholesterol transport Source: BHF-UCL
  • negative regulation of lipid metabolic process Source: BHF-UCL
  • negative regulation of receptor-mediated endocytosis Source: BHF-UCL
  • negative regulation of very-low-density lipoprotein particle clearance Source: BHF-UCL
  • phospholipid efflux Source: BHF-UCL
  • phototransduction, visible light Source: Reactome
  • positive regulation of fatty acid biosynthetic process Source: BHF-UCL
  • positive regulation of lipoprotein lipase activity Source: BHF-UCL
  • positive regulation of phospholipase activity Source: BHF-UCL
  • positive regulation of phospholipid catabolic process Source: BHF-UCL
  • positive regulation of triglyceride catabolic process Source: BHF-UCL
  • positive regulation of very-low-density lipoprotein particle remodeling Source: BHF-UCL
  • retinoid metabolic process Source: Reactome
  • reverse cholesterol transport Source: BHF-UCL
  • small molecule metabolic process Source: Reactome
  • triglyceride homeostasis Source: BHF-UCL
  • triglyceride-rich lipoprotein particle remodeling Source: BHF-UCL
  • very-low-density lipoprotein particle remodeling Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Lipid degradation, Lipid metabolism, Lipid transport, Transport

Keywords - Ligandi

Sialic acid

Enzyme and pathway databases

ReactomeiREACT_13621. HDL-mediated lipid transport.
REACT_24968. Retinoid metabolism and transport.
REACT_6841. Chylomicron-mediated lipid transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein C-II
Short name:
Apo-CII
Short name:
ApoC-II
Alternative name(s):
Apolipoprotein C2
Cleaved into the following chain:
Proapolipoprotein C-II
Short name:
ProapoC-II
Gene namesi
Name:APOC2
Synonyms:APC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:609. APOC2.

Subcellular locationi

GO - Cellular componenti

  • chylomicron Source: BHF-UCL
  • early endosome Source: Reactome
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: UniProtKB
  • extracellular space Source: BHF-UCL
  • intermediate-density lipoprotein particle Source: BHF-UCL
  • low-density lipoprotein particle Source: BHF-UCL
  • spherical high-density lipoprotein particle Source: BHF-UCL
  • very-low-density lipoprotein particle Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Chylomicron, HDL, LDL, Secreted, VLDL

Pathology & Biotechi

Involvement in diseasei

Hyperlipoproteinemia 1B (HLPP1B)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAutosomal recessive trait characterized by hypertriglyceridemia, xanthomas, and increased risk of pancreatitis and early atherosclerosis.

See also OMIM:207750
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti48 – 481W → R in HLPP1B; variant Wakayama. 1 Publication
VAR_000640

Keywords - Diseasei

Disease mutation, Hyperlipidemia

Organism-specific databases

MIMi207750. phenotype.
Orphaneti309020. Familial apolipoprotein C-II deficiency.
PharmGKBiPA52.

Polymorphism and mutation databases

BioMutaiAPOC2.
DMDMi114022.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22222 PublicationsAdd
BLAST
Chaini23 – 10179Proapolipoprotein C-II2 PublicationsPRO_0000002024Add
BLAST
Chaini29 – 10173Apolipoprotein C-II1 PublicationPRO_0000430839Add
BLAST

Post-translational modificationi

Proapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing.1 Publication
Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma.1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP02655.
PaxDbiP02655.
PeptideAtlasiP02655.
PRIDEiP02655.

2D gel databases

DOSAC-COBS-2DPAGEP02655.
SWISS-2DPAGEP02655.

PTM databases

PhosphoSiteiP02655.

Miscellaneous databases

PMAP-CutDBP02655.

Expressioni

Tissue specificityi

Liver and intestine.1 Publication

Gene expression databases

BgeeiP02655.
CleanExiHS_APC2.
HS_APOC2.
ExpressionAtlasiP02655. baseline.
GenevisibleiP02655. HS.

Organism-specific databases

HPAiHPA055877.

Interactioni

Protein-protein interaction databases

BioGridi106841. 3 interactions.
IntActiP02655. 4 interactions.
STRINGi9606.ENSP00000466775.

Structurei

Secondary structure

1
101
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi28 – 314Combined sources
Helixi37 – 5721Combined sources
Turni58 – 614Combined sources
Beta strandi62 – 643Combined sources
Turni68 – 703Combined sources
Beta strandi71 – 744Combined sources
Turni75 – 773Combined sources
Turni79 – 813Combined sources
Beta strandi86 – 883Combined sources
Helixi92 – 943Combined sources
Helixi97 – 993Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BY6NMR-A66-101[»]
1I5JNMR-A23-101[»]
1O8TNMR-A23-101[»]
1SOHNMR-A23-101[»]
ProteinModelPortaliP02655.
SMRiP02655. Positions 23-101.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02655.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni23 – 3816O-glycosylated at one siteAdd
BLAST
Regioni43 – 519Lipid binding
Regioni55 – 7824Lipoprotein lipase cofactorAdd
BLAST

Sequence similaritiesi

Belongs to the apolipoprotein C2 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG25045.
GeneTreeiENSGT00390000007913.
HOGENOMiHOG000034002.
HOVERGENiHBG050548.
InParanoidiP02655.
PhylomeDBiP02655.

Family and domain databases

Gene3Di1.10.1440.10. 1 hit.
InterProiIPR008019. Apo-CII.
IPR023121. ApoC-II_domain.
[Graphical view]
PANTHERiPTHR16566. PTHR16566. 1 hit.
PfamiPF05355. Apo-CII. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02655-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTRLLPALF LVLLVLGFEV QGTQQPQQDE MPSPTFLTQV KESLSSYWES
60 70 80 90 100
AKTAAQNLYE KTYLPAVDEK LRDLYSKSTA AMSTYTGIFT DQVLSVLKGE

E
Length:101
Mass (Da):11,284
Last modified:July 21, 1986 - v1
Checksum:i51CB86FEDB174D84
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti36 – 361F → L in AAP35354 (Ref. 7) Curated
Sequence conflicti36 – 361F → L in ACN81313 (Ref. 8) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti41 – 411K → T.2 Publications
VAR_000639
Natural varianti48 – 481W → R in HLPP1B; variant Wakayama. 1 Publication
VAR_000640
Natural varianti60 – 601E → K in San Francisco; found in hyperlipidemic patients. 1 Publication
Corresponds to variant rs5122 [ dbSNP | Ensembl ].
VAR_000641
Natural varianti77 – 771K → Q in Africa. 2 Publications
Corresponds to variant rs5126 [ dbSNP | Ensembl ].
VAR_000642

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05151 Genomic DNA. Translation: CAA28798.1.
X00568 mRNA. Translation: CAA25234.1.
J02698 Genomic DNA. Translation: AAA98743.1.
AY422955 Genomic DNA. Translation: AAQ91814.1.
BT006708 mRNA. Translation: AAP35354.1.
FJ525875 Genomic DNA. Translation: ACN81313.1.
CH471126 Genomic DNA. Translation: EAW57311.1.
BC005348 mRNA. Translation: AAH05348.3.
M29844 mRNA. Translation: AAA51743.1.
M10612 Genomic DNA. Translation: AAB59380.1.
AF113884 mRNA. Translation: AAD28193.1.
CCDSiCCDS12650.1.
PIRiA24238. LPHUC2.
RefSeqiNP_000474.2. NM_000483.4.
UniGeneiHs.75615.

Genome annotation databases

EnsembliENST00000590360; ENSP00000466775; ENSG00000234906.
GeneIDi344.
KEGGihsa:344.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05151 Genomic DNA. Translation: CAA28798.1.
X00568 mRNA. Translation: CAA25234.1.
J02698 Genomic DNA. Translation: AAA98743.1.
AY422955 Genomic DNA. Translation: AAQ91814.1.
BT006708 mRNA. Translation: AAP35354.1.
FJ525875 Genomic DNA. Translation: ACN81313.1.
CH471126 Genomic DNA. Translation: EAW57311.1.
BC005348 mRNA. Translation: AAH05348.3.
M29844 mRNA. Translation: AAA51743.1.
M10612 Genomic DNA. Translation: AAB59380.1.
AF113884 mRNA. Translation: AAD28193.1.
CCDSiCCDS12650.1.
PIRiA24238. LPHUC2.
RefSeqiNP_000474.2. NM_000483.4.
UniGeneiHs.75615.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BY6NMR-A66-101[»]
1I5JNMR-A23-101[»]
1O8TNMR-A23-101[»]
1SOHNMR-A23-101[»]
ProteinModelPortaliP02655.
SMRiP02655. Positions 23-101.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106841. 3 interactions.
IntActiP02655. 4 interactions.
STRINGi9606.ENSP00000466775.

PTM databases

PhosphoSiteiP02655.

Polymorphism and mutation databases

BioMutaiAPOC2.
DMDMi114022.

2D gel databases

DOSAC-COBS-2DPAGEP02655.
SWISS-2DPAGEP02655.

Proteomic databases

MaxQBiP02655.
PaxDbiP02655.
PeptideAtlasiP02655.
PRIDEiP02655.

Protocols and materials databases

DNASUi344.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000590360; ENSP00000466775; ENSG00000234906.
GeneIDi344.
KEGGihsa:344.

Organism-specific databases

CTDi344.
GeneCardsiGC19P045449.
HGNCiHGNC:609. APOC2.
HPAiHPA055877.
MIMi207750. phenotype.
608083. gene.
neXtProtiNX_P02655.
Orphaneti309020. Familial apolipoprotein C-II deficiency.
PharmGKBiPA52.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG25045.
GeneTreeiENSGT00390000007913.
HOGENOMiHOG000034002.
HOVERGENiHBG050548.
InParanoidiP02655.
PhylomeDBiP02655.

Enzyme and pathway databases

ReactomeiREACT_13621. HDL-mediated lipid transport.
REACT_24968. Retinoid metabolism and transport.
REACT_6841. Chylomicron-mediated lipid transport.

Miscellaneous databases

EvolutionaryTraceiP02655.
GeneWikiiApolipoprotein_C2.
GenomeRNAii344.
NextBioi1419.
PMAP-CutDBP02655.
PROiP02655.
SOURCEiSearch...

Gene expression databases

BgeeiP02655.
CleanExiHS_APC2.
HS_APOC2.
ExpressionAtlasiP02655. baseline.
GenevisibleiP02655. HS.

Family and domain databases

Gene3Di1.10.1440.10. 1 hit.
InterProiIPR008019. Apo-CII.
IPR023121. ApoC-II_domain.
[Graphical view]
PANTHERiPTHR16566. PTHR16566. 1 hit.
PfamiPF05355. Apo-CII. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The human preproapolipoprotein C-II gene. Complete nucleic acid sequence and genomic organization."
    Fojo S.S., Law S.W., Brewer H.B. Jr.
    FEBS Lett. 213:221-226(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Human apolipoprotein C-II: complete nucleic acid sequence of preapolipoprotein C-II."
    Fojo S.S., Law S.W., Brewer H.B. Jr.
    Proc. Natl. Acad. Sci. U.S.A. 81:6354-6357(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  3. "Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance."
    Sharpe C.R., Sidoli A., Shelley C.S., Lucero M.A., Shoulders C.C., Baralle F.E.
    Nucleic Acids Res. 12:3917-3932(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The human apolipoprotein C-II gene sequence contains a novel chromosome 19-specific minisatellite in its third intron."
    Das H.K., Jackson C.L., Miller D.A., Leff T., Breslow J.L.
    J. Biol. Chem. 262:4787-4793(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "The structure of the human apolipoprotein C-II gene. Electron microscopic analysis of RNA:DNA hybrids, complete nucleotide sequence, and identification of 5' homologous sequences among apolipoprotein genes."
    Wei C.F., Tsao Y.K., Robberson D.L., Gotto A.M. Jr., Brown K., Chan L.
    J. Biol. Chem. 260:15211-15221(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
  6. Nickerson D.A., Smith J.D., Fullerton S.M., Clark A.G., Stengard J.H., Salomaa V., Boerwinkle E., Sing C.F., Weiss K.M.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  7. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. NHLBI resequencing and genotyping service (RS&G)
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skeletal muscle.
  11. "The isolation and characterization of cDNA clones for human apolipoprotein CII."
    Myklebost O., Williamson B., Markham A.F., Myklebost S.R., Rogers J., Woods D.E., Humphries S.E.
    J. Biol. Chem. 259:4401-4404(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-101, TISSUE SPECIFICITY.
  12. "Isolation of cDNA and genomic clones for apolipoprotein C-II."
    Jackson C.L., Bruns G.A.P., Breslow J.L.
    Methods Enzymol. 128:788-800(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 11-101.
  13. "Amino acid sequence of human plasma apolipoprotein C-II from normal and hyperlipoproteinemic subjects."
    Hospattankar A.V., Fairwell T., Ronan R., Brewer H.B. Jr.
    J. Biol. Chem. 259:318-322(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 23-101.
  14. "Primary structure of very low density apolipoprotein C-II of human plasma."
    Jackson R.L., Baker H.N., Gilliam E.B., Gotto A.M. Jr.
    Proc. Natl. Acad. Sci. U.S.A. 74:1942-1945(1977) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 23-101.
  15. "Human preproapolipoprotein C-II. Analysis of major plasma isoforms."
    Fojo S.S., Taam L., Fairwell T., Ronan R., Bishop C., Meng M.S., Hoeg J.M., Sprecher D.L., Brewer H.B. Jr.
    J. Biol. Chem. 261:9591-9594(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 29-35, PROTEOLYTIC PROCESSING, GLYCOSYLATION, SUBCELLULAR LOCATION.
  16. "Expression of the apolipoprotein C-II gene during myelomonocytic differentiation of human leukemic cells."
    Chun E.M., Park Y.J., Kang H.S., Cho H.M., Jun D.Y., Kim Y.H.
    J. Leukoc. Biol. 69:645-650(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 77-101.
  17. "Primary structure of the bovine analogues to human apolipoproteins CII and CIII. Studies on isoforms and evidence for proteolytic processing."
    Bengtsson-Olivecrona G., Sletten K.
    Eur. J. Biochem. 192:515-521(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  18. "A review of the role of apolipoprotein C-II in lipoprotein metabolism and cardiovascular disease."
    Kei A.A., Filippatos T.D., Tsimihodimos V., Elisaf M.S.
    Metabolism 61:906-921(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  19. "LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."
    Halim A., Ruetschi U., Larson G., Nilsson J.
    J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION, IDENTIFICATION BY MASS SPECTROMETRY.
  20. "Sequence specific 1H-NMR assignments and secondary structure of a carboxy-terminal functional fragment of apolipoprotein CII."
    Lycksell P.-O., Oehman A., Bengtsson-Olivecrona G., Johansson L.B.-A., Wijmenga S.S., Wernic D., Graeslund A.
    Eur. J. Biochem. 205:223-231(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 72-101.
  21. "A refined three-dimensional solution structure of a carboxy terminal fragment of apolipoprotein CII."
    Oehman A., Lycksell P.-O., Graeslund A.
    Eur. Biophys. J. 22:351-357(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 72-101.
  22. "A variant primary structure of apolipoprotein C-II in individuals of African descent."
    Menzel H.-J., Kane J.P., Malloy M.J., Havel R.J.
    J. Clin. Invest. 77:595-601(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT AFRICA GLN-77.
  23. "Molecular cloning and characteristics of a new apolipoprotein C-II mutant identified in three unrelated individuals with hypercholesterolemia and hypertriglyceridemia."
    Pullinger C.R., Zysow B.R., Hennessy L.K., Frost P.H., Malloy M.J., Kanr J.P.
    Hum. Mol. Genet. 2:69-74(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT SAN FRANCISCO LYS-60.
  24. "An apolipoprotein CII mutation, CII Lys-19-->Thr identified in patients with hyperlipidemia."
    Hegele R.A., Connelly P.W., Maguire G.F., Huff M.W., Leiter L., Wolfe B.M., Evans A.J., Little J.A.
    Dis. Markers 9:73-80(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT THR-41.
  25. "The apolipoprotein C-II variant apoC-II Lys-19-->Thr is not associated with dyslipidemia in an affected kindred."
    Zysow B.R., Pullinger C.R., Hennessy L.K., Farese R.V. Jr., Ghassemzadeh M., Kane J.P.
    Clin. Genet. 45:292-297(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT THR-41.
  26. "A missense mutation (Trp 26-->Arg) in exon 3 of the apolipoprotein CII gene in a patient with apolipoprotein CII deficiency (apo CII-Wakayama)."
    Inadera H., Hibino A., Kobayashi J., Kanzaki T., Shirai K., Yukawa S., Saito Y., Yoshida S.
    Biochem. Biophys. Res. Commun. 193:1174-1183(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT HLPP1B WAKAYAMA ARG-48.
  27. "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."
    Halushka M.K., Fan J.-B., Bentley K., Hsie L., Shen N., Weder A., Cooper R., Lipshutz R., Chakravarti A.
    Nat. Genet. 22:239-247(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GLN-77.

Entry informationi

Entry nameiAPOC2_HUMAN
AccessioniPrimary (citable) accession number: P02655
Secondary accession number(s): C0JYY4
, Q9BS39, Q9UDE3, Q9UNK3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: June 24, 2015
This is version 179 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.