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P02654

- APOC1_HUMAN

UniProt

P02654 - APOC1_HUMAN

Protein

Apolipoprotein C-I

Gene

APOC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Appears to modulate the interaction of APOE with beta-migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein. Binds free fatty acids and reduces their intracellular esterification.1 Publication

    GO - Molecular functioni

    1. fatty acid binding Source: BHF-UCL
    2. lipase inhibitor activity Source: BHF-UCL
    3. phosphatidylcholine binding Source: BHF-UCL
    4. phosphatidylcholine-sterol O-acyltransferase activator activity Source: BHF-UCL
    5. phospholipase inhibitor activity Source: BHF-UCL

    GO - Biological processi

    1. cholesterol efflux Source: BHF-UCL
    2. cholesterol metabolic process Source: Ensembl
    3. chylomicron remnant clearance Source: BHF-UCL
    4. high-density lipoprotein particle remodeling Source: BHF-UCL
    5. lipid metabolic process Source: ProtInc
    6. lipoprotein metabolic process Source: InterPro
    7. negative regulation of cholesterol transport Source: BHF-UCL
    8. negative regulation of fatty acid biosynthetic process Source: BHF-UCL
    9. negative regulation of lipid catabolic process Source: BHF-UCL
    10. negative regulation of lipid metabolic process Source: BHF-UCL
    11. negative regulation of lipoprotein lipase activity Source: BHF-UCL
    12. negative regulation of phosphatidylcholine catabolic process Source: BHF-UCL
    13. negative regulation of receptor-mediated endocytosis Source: BHF-UCL
    14. negative regulation of very-low-density lipoprotein particle clearance Source: BHF-UCL
    15. phospholipid efflux Source: BHF-UCL
    16. plasma lipoprotein particle remodeling Source: BHF-UCL
    17. positive regulation of catalytic activity Source: GOC
    18. positive regulation of cholesterol esterification Source: BHF-UCL
    19. regulation of cholesterol transport Source: BHF-UCL
    20. triglyceride metabolic process Source: Ensembl
    21. very-low-density lipoprotein particle assembly Source: BHF-UCL
    22. very-low-density lipoprotein particle clearance Source: BHF-UCL

    Keywords - Biological processi

    Lipid transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Apolipoprotein C-I
    Alternative name(s):
    Apolipoprotein C1
    Cleaved into the following chain:
    Gene namesi
    Name:APOC1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:607. APOC1.

    Subcellular locationi

    GO - Cellular componenti

    1. chylomicron Source: BHF-UCL
    2. endoplasmic reticulum Source: LIFEdb
    3. extracellular vesicular exosome Source: UniProt
    4. high-density lipoprotein particle Source: BHF-UCL
    5. very-low-density lipoprotein particle Source: BHF-UCL

    Keywords - Cellular componenti

    Secreted, VLDL

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA51.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 26262 PublicationsAdd
    BLAST
    Chaini27 – 8357Apolipoprotein C-IPRO_0000002014Add
    BLAST
    Chaini29 – 8355Truncated apolipoprotein C-IBy similarityPRO_0000391843Add
    BLAST

    Proteomic databases

    MaxQBiP02654.
    PaxDbiP02654.
    PeptideAtlasiP02654.
    PRIDEiP02654.

    PTM databases

    PhosphoSiteiP02654.

    Expressioni

    Tissue specificityi

    Synthesized mainly in liver and to a minor degree in intestine. Secreted in plasma.

    Gene expression databases

    ArrayExpressiP02654.
    BgeeiP02654.
    CleanExiHS_APOC1.
    GenevestigatoriP02654.

    Organism-specific databases

    HPAiHPA051518.

    Interactioni

    Protein-protein interaction databases

    BioGridi106838. 4 interactions.
    IntActiP02654. 5 interactions.
    MINTiMINT-3004014.
    STRINGi9606.ENSP00000252491.

    Structurei

    Secondary structure

    1
    83
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi31 – 333
    Helixi35 – 4814
    Turni52 – 543
    Beta strandi56 – 627
    Helixi65 – 7814
    Beta strandi79 – 813

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1ALENMR-A33-50[»]
    1ALFNMR-A61-79[»]
    1IOJNMR-A27-83[»]
    1OPPNMR-A27-64[»]
    ProteinModelPortaliP02654.
    SMRiP02654. Positions 27-83.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP02654.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the apolipoprotein C1 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG47204.
    HOGENOMiHOG000034001.
    HOVERGENiHBG050547.
    InParanoidiP02654.
    OrthoDBiEOG7PK92M.
    PhylomeDBiP02654.

    Family and domain databases

    Gene3Di4.10.260.30. 1 hit.
    InterProiIPR006781. ApoC-I.
    [Graphical view]
    PANTHERiPTHR16565. PTHR16565. 1 hit.
    PfamiPF04691. ApoC-I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P02654-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRLFLSLPVL VVVLSIVLEG PAPAQGTPDV SSALDKLKEF GNTLEDKARE   50
    LISRIKQSEL SAKMREWFSE TFQKVKEKLK IDS 83
    Length:83
    Mass (Da):9,332
    Last modified:October 23, 1986 - v1
    Checksum:i4A3614626624AE6A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti16 – 161I → M.1 Publication
    Corresponds to variant rs5112 [ dbSNP | Ensembl ].
    VAR_014183
    Natural varianti71 – 711T → S Polymorphism found only in persons of American Indian or Mexican ancestry; more susceptible to N-terminal truncation and shows greater distribution to the VLDL than the protein with T-71. 1 Publication
    Corresponds to variant rs142372275 [ dbSNP | Ensembl ].
    VAR_029011

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X00570 mRNA. Translation: CAA25235.1.
    M20843 Genomic DNA. Translation: AAA51763.1.
    AF050154 Genomic DNA. Translation: AAD02506.1.
    AY422954 Genomic DNA. Translation: AAQ91813.1.
    BT007142 mRNA. Translation: AAP35806.1.
    AK312036 mRNA. Translation: BAG34973.1.
    CR456907 mRNA. Translation: CAG33188.1.
    AM392727 mRNA. Translation: CAL37605.1.
    FJ525874 Genomic DNA. Translation: ACN81312.1.
    CH471126 Genomic DNA. Translation: EAW57307.1.
    BC009698 mRNA. Translation: AAH09698.1.
    BC055093 mRNA. Translation: AAH55093.1.
    M20902 Genomic DNA. Translation: AAA88018.1.
    M27359 mRNA. Translation: AAA51762.1.
    CCDSiCCDS12648.1.
    PIRiA28057. LPHUC1.
    RefSeqiNP_001636.1. NM_001645.3.
    XP_005258912.1. XM_005258855.1.
    UniGeneiHs.110675.
    Hs.737668.

    Genome annotation databases

    EnsembliENST00000588750; ENSP00000465356; ENSG00000130208.
    ENST00000588802; ENSP00000468029; ENSG00000130208.
    GeneIDi341.
    KEGGihsa:341.
    UCSCiuc002pac.1. human.

    Polymorphism databases

    DMDMi114016.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Apolipoprotein C1 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X00570 mRNA. Translation: CAA25235.1 .
    M20843 Genomic DNA. Translation: AAA51763.1 .
    AF050154 Genomic DNA. Translation: AAD02506.1 .
    AY422954 Genomic DNA. Translation: AAQ91813.1 .
    BT007142 mRNA. Translation: AAP35806.1 .
    AK312036 mRNA. Translation: BAG34973.1 .
    CR456907 mRNA. Translation: CAG33188.1 .
    AM392727 mRNA. Translation: CAL37605.1 .
    FJ525874 Genomic DNA. Translation: ACN81312.1 .
    CH471126 Genomic DNA. Translation: EAW57307.1 .
    BC009698 mRNA. Translation: AAH09698.1 .
    BC055093 mRNA. Translation: AAH55093.1 .
    M20902 Genomic DNA. Translation: AAA88018.1 .
    M27359 mRNA. Translation: AAA51762.1 .
    CCDSi CCDS12648.1.
    PIRi A28057. LPHUC1.
    RefSeqi NP_001636.1. NM_001645.3.
    XP_005258912.1. XM_005258855.1.
    UniGenei Hs.110675.
    Hs.737668.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1ALE NMR - A 33-50 [» ]
    1ALF NMR - A 61-79 [» ]
    1IOJ NMR - A 27-83 [» ]
    1OPP NMR - A 27-64 [» ]
    ProteinModelPortali P02654.
    SMRi P02654. Positions 27-83.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106838. 4 interactions.
    IntActi P02654. 5 interactions.
    MINTi MINT-3004014.
    STRINGi 9606.ENSP00000252491.

    PTM databases

    PhosphoSitei P02654.

    Polymorphism databases

    DMDMi 114016.

    Proteomic databases

    MaxQBi P02654.
    PaxDbi P02654.
    PeptideAtlasi P02654.
    PRIDEi P02654.

    Protocols and materials databases

    DNASUi 341.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000588750 ; ENSP00000465356 ; ENSG00000130208 .
    ENST00000588802 ; ENSP00000468029 ; ENSG00000130208 .
    GeneIDi 341.
    KEGGi hsa:341.
    UCSCi uc002pac.1. human.

    Organism-specific databases

    CTDi 341.
    GeneCardsi GC19P045417.
    HGNCi HGNC:607. APOC1.
    HPAi HPA051518.
    MIMi 107710. gene.
    neXtProti NX_P02654.
    PharmGKBi PA51.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47204.
    HOGENOMi HOG000034001.
    HOVERGENi HBG050547.
    InParanoidi P02654.
    OrthoDBi EOG7PK92M.
    PhylomeDBi P02654.

    Miscellaneous databases

    ChiTaRSi APOC1. human.
    EvolutionaryTracei P02654.
    GeneWikii Apolipoprotein_C1.
    GenomeRNAii 341.
    NextBioi 1409.
    PROi P02654.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P02654.
    Bgeei P02654.
    CleanExi HS_APOC1.
    Genevestigatori P02654.

    Family and domain databases

    Gene3Di 4.10.260.30. 1 hit.
    InterProi IPR006781. ApoC-I.
    [Graphical view ]
    PANTHERi PTHR16565. PTHR16565. 1 hit.
    Pfami PF04691. ApoC-I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterisation of mRNAs encoding the precursor for human apolipoprotein CI."
      Knott T.J., Robertson M.E., Priestley L.M., Urdea M., Wallis S.C., Scott J.
      Nucleic Acids Res. 12:3909-3915(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Two copies of the human apolipoprotein C-I gene are linked closely to the apolipoprotein E gene."
      Lauer S.J., Walker D., Elshourbagy N.A., Reardon C.A., Levy-Wilson B., Taylor J.M.
      J. Biol. Chem. 263:7277-7286(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Sequencing of 42kb of the APO E-C2 gene cluster reveals a new gene: PEREC1."
      Freitas E.M., Zhang W.J., Lalonde J.P., Tay G.K., Gaudieri S., Ashworth L.K., Van Bockxmeer F.M., Dawkins R.L.
      DNA Seq. 9:89-100(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. Nickerson D.A., Smith J.D., Fullerton S.M., Clark A.G., Stengard J.H., Salomaa V., Boerwinkle E., Sing C.F., Weiss K.M.
      Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.
    7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    8. Bechtel S., Schupp I., Duda A., Wellenreuther R., Mehrle A., Ruschke V., Poustka A., Wiemann S.
      Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    9. NHLBI resequencing and genotyping service (RS&G)
      Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    12. "Isolation and characterisation of a cDNA clone for human apolipoprotein CI and assignment of the gene to chromosome 19."
      Tata F., Henry I., Markham A.F., Wallis S.C., Weil D., Grzeschik K.H., Junien C., Williamson R., Humphries S.E.
      Hum. Genet. 69:345-349(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 15-83.
    13. "The complete amino acid sequence of C-I (apoLp-Ser), an apolipoprotein from human very low density lipoproteins."
      Shulman R.S., Herbert P.N., Wehrly K., Fredrickson D.S.
      J. Biol. Chem. 250:182-190(1975) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 27-83.
    14. "The primary structure of apolipoprotein-serine."
      Jackson R.L., Sparrow J.T., Baker H.N., Morrisett J.D., Taunton O.D., Gotto A.M. Jr.
      J. Biol. Chem. 249:5308-5313(1974) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 27-83.
    15. "Exact localization of the familial dysbetalipoproteinemia associated HpaI restriction site in the promoter region of the APOC1 gene."
      Smit M.V.D., Kooij-Meijs E., Woudt L.P., Havekes L.M., Frants R.R.
      Biochem. Biophys. Res. Commun. 152:1282-1288(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-19.
    16. "Apolipoprotein C-I binds free fatty acids and reduces their intracellular esterification."
      Westerterp M., Berbee J.F., Delsing D.J., Jong M.C., Gijbels M.J., Dahlmans V.E., Offerman E.H., Romijn J.A., Havekes L.M., Rensen P.C.
      J. Lipid Res. 48:1353-1361(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    17. "Conformation of two peptides corresponding to human apolipoprotein C-I residues 7-24 and 35-53 in the presence of sodium dodecyl sulfate by CD and NMR spectroscopy."
      Rozek A., Buchko G.W., Cushley R.J.
      Biochemistry 34:7401-7408(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 33-50 AND 61-79.
    18. "Conformational studies of the N-terminal lipid-associating domain of human apolipoprotein C-I by CD and 1H NMR spectroscopy."
      Rozek A., Buchko G.W., Kanda P., Cushley R.J.
      Protein Sci. 6:1858-1868(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 27-64.
    19. "Conformation of human apolipoprotein C-I in a lipid-mimetic environment determined by CD and NMR spectroscopy."
      Rozek A., Sparrow J.T., Weisgraber K.H., Cushley R.J.
      Biochemistry 38:14475-14484(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 27-83.
    20. "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."
      Halushka M.K., Fan J.-B., Bentley K., Hsie L., Shen N., Weder A., Cooper R., Lipshutz R., Chakravarti A.
      Nat. Genet. 22:239-247(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT MET-16.
    21. Cited for: VARIANT SER-71, CHARACTERIZATION OF VARIANT SER-71.

    Entry informationi

    Entry nameiAPOC1_HUMAN
    AccessioniPrimary (citable) accession number: P02654
    Secondary accession number(s): B2R526, Q6IB97
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: October 23, 1986
    Last modified: October 1, 2014
    This is version 150 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Apolipoprotein C-I is present in acidic (APOC1A) and basic (APOC1B) forms in P.paniscus, P.abelii and P.troglodytes and perhaps also in baboons and macaques. In human, the acidic form has become a pseudogene. Apo-CI makes up about 10% of the protein of the VLDL (very low density lipoprotein) and 2% of that of HDL (high density lipoprotein).

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3