SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P02654

- APOC1_HUMAN

UniProt

P02654 - APOC1_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Apolipoprotein C-I

Gene
APOC1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Appears to modulate the interaction of APOE with beta-migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein. Binds free fatty acids and reduces their intracellular esterification.1 Publication

GO - Molecular functioni

  1. fatty acid binding Source: BHF-UCL
  2. lipase inhibitor activity Source: BHF-UCL
  3. phosphatidylcholine binding Source: BHF-UCL
  4. phosphatidylcholine-sterol O-acyltransferase activator activity Source: BHF-UCL
  5. phospholipase inhibitor activity Source: BHF-UCL

GO - Biological processi

  1. cholesterol efflux Source: BHF-UCL
  2. cholesterol metabolic process Source: Ensembl
  3. chylomicron remnant clearance Source: BHF-UCL
  4. high-density lipoprotein particle remodeling Source: BHF-UCL
  5. lipid metabolic process Source: ProtInc
  6. lipoprotein metabolic process Source: InterPro
  7. negative regulation of cholesterol transport Source: BHF-UCL
  8. negative regulation of fatty acid biosynthetic process Source: BHF-UCL
  9. negative regulation of lipid catabolic process Source: BHF-UCL
  10. negative regulation of lipid metabolic process Source: BHF-UCL
  11. negative regulation of lipoprotein lipase activity Source: BHF-UCL
  12. negative regulation of phosphatidylcholine catabolic process Source: BHF-UCL
  13. negative regulation of receptor-mediated endocytosis Source: BHF-UCL
  14. negative regulation of very-low-density lipoprotein particle clearance Source: BHF-UCL
  15. phospholipid efflux Source: BHF-UCL
  16. plasma lipoprotein particle remodeling Source: BHF-UCL
  17. positive regulation of catalytic activity Source: GOC
  18. positive regulation of cholesterol esterification Source: BHF-UCL
  19. regulation of cholesterol transport Source: BHF-UCL
  20. triglyceride metabolic process Source: Ensembl
  21. very-low-density lipoprotein particle assembly Source: BHF-UCL
  22. very-low-density lipoprotein particle clearance Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein C-I
Alternative name(s):
Apolipoprotein C1
Cleaved into the following chain:
Gene namesi
Name:APOC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:607. APOC1.

Subcellular locationi

GO - Cellular componenti

  1. chylomicron Source: BHF-UCL
  2. endoplasmic reticulum Source: LIFEdb
  3. extracellular vesicular exosome Source: UniProt
  4. high-density lipoprotein particle Source: BHF-UCL
  5. very-low-density lipoprotein particle Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted, VLDL

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA51.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 26262 PublicationsAdd
BLAST
Chaini27 – 8357Apolipoprotein C-IPRO_0000002014Add
BLAST
Chaini29 – 8355Truncated apolipoprotein C-I By similarityPRO_0000391843Add
BLAST

Proteomic databases

MaxQBiP02654.
PaxDbiP02654.
PeptideAtlasiP02654.
PRIDEiP02654.

PTM databases

PhosphoSiteiP02654.

Expressioni

Tissue specificityi

Synthesized mainly in liver and to a minor degree in intestine. Secreted in plasma.

Gene expression databases

ArrayExpressiP02654.
BgeeiP02654.
CleanExiHS_APOC1.
GenevestigatoriP02654.

Organism-specific databases

HPAiHPA051518.

Interactioni

Protein-protein interaction databases

BioGridi106838. 4 interactions.
IntActiP02654. 5 interactions.
MINTiMINT-3004014.
STRINGi9606.ENSP00000252491.

Structurei

Secondary structure

1
83
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi31 – 333
Helixi35 – 4814
Turni52 – 543
Beta strandi56 – 627
Helixi65 – 7814
Beta strandi79 – 813

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ALENMR-A33-50[»]
1ALFNMR-A61-79[»]
1IOJNMR-A27-83[»]
1OPPNMR-A27-64[»]
ProteinModelPortaliP02654.
SMRiP02654. Positions 27-83.

Miscellaneous databases

EvolutionaryTraceiP02654.

Family & Domainsi

Sequence similaritiesi

Belongs to the apolipoprotein C1 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG47204.
HOGENOMiHOG000034001.
HOVERGENiHBG050547.
InParanoidiP02654.
OrthoDBiEOG7PK92M.
PhylomeDBiP02654.

Family and domain databases

Gene3Di4.10.260.30. 1 hit.
InterProiIPR006781. ApoC-I.
[Graphical view]
PANTHERiPTHR16565. PTHR16565. 1 hit.
PfamiPF04691. ApoC-I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02654-1 [UniParc]FASTAAdd to Basket

« Hide

MRLFLSLPVL VVVLSIVLEG PAPAQGTPDV SSALDKLKEF GNTLEDKARE   50
LISRIKQSEL SAKMREWFSE TFQKVKEKLK IDS 83
Length:83
Mass (Da):9,332
Last modified:October 23, 1986 - v1
Checksum:i4A3614626624AE6A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161I → M.1 Publication
Corresponds to variant rs5112 [ dbSNP | Ensembl ].
VAR_014183
Natural varianti71 – 711T → S Polymorphism found only in persons of American Indian or Mexican ancestry; more susceptible to N-terminal truncation and shows greater distribution to the VLDL than the protein with T-71. 1 Publication
Corresponds to variant rs142372275 [ dbSNP | Ensembl ].
VAR_029011

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X00570 mRNA. Translation: CAA25235.1.
M20843 Genomic DNA. Translation: AAA51763.1.
AF050154 Genomic DNA. Translation: AAD02506.1.
AY422954 Genomic DNA. Translation: AAQ91813.1.
BT007142 mRNA. Translation: AAP35806.1.
AK312036 mRNA. Translation: BAG34973.1.
CR456907 mRNA. Translation: CAG33188.1.
AM392727 mRNA. Translation: CAL37605.1.
FJ525874 Genomic DNA. Translation: ACN81312.1.
CH471126 Genomic DNA. Translation: EAW57307.1.
BC009698 mRNA. Translation: AAH09698.1.
BC055093 mRNA. Translation: AAH55093.1.
M20902 Genomic DNA. Translation: AAA88018.1.
M27359 mRNA. Translation: AAA51762.1.
CCDSiCCDS12648.1.
PIRiA28057. LPHUC1.
RefSeqiNP_001636.1. NM_001645.3.
XP_005258912.1. XM_005258855.1.
UniGeneiHs.110675.
Hs.737668.

Genome annotation databases

EnsembliENST00000252491; ENSP00000252491; ENSG00000130208.
ENST00000588750; ENSP00000465356; ENSG00000130208.
ENST00000588802; ENSP00000468029; ENSG00000130208.
GeneIDi341.
KEGGihsa:341.
UCSCiuc002pac.1. human.

Polymorphism databases

DMDMi114016.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Apolipoprotein C1 entry

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X00570 mRNA. Translation: CAA25235.1 .
M20843 Genomic DNA. Translation: AAA51763.1 .
AF050154 Genomic DNA. Translation: AAD02506.1 .
AY422954 Genomic DNA. Translation: AAQ91813.1 .
BT007142 mRNA. Translation: AAP35806.1 .
AK312036 mRNA. Translation: BAG34973.1 .
CR456907 mRNA. Translation: CAG33188.1 .
AM392727 mRNA. Translation: CAL37605.1 .
FJ525874 Genomic DNA. Translation: ACN81312.1 .
CH471126 Genomic DNA. Translation: EAW57307.1 .
BC009698 mRNA. Translation: AAH09698.1 .
BC055093 mRNA. Translation: AAH55093.1 .
M20902 Genomic DNA. Translation: AAA88018.1 .
M27359 mRNA. Translation: AAA51762.1 .
CCDSi CCDS12648.1.
PIRi A28057. LPHUC1.
RefSeqi NP_001636.1. NM_001645.3.
XP_005258912.1. XM_005258855.1.
UniGenei Hs.110675.
Hs.737668.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1ALE NMR - A 33-50 [» ]
1ALF NMR - A 61-79 [» ]
1IOJ NMR - A 27-83 [» ]
1OPP NMR - A 27-64 [» ]
ProteinModelPortali P02654.
SMRi P02654. Positions 27-83.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106838. 4 interactions.
IntActi P02654. 5 interactions.
MINTi MINT-3004014.
STRINGi 9606.ENSP00000252491.

PTM databases

PhosphoSitei P02654.

Polymorphism databases

DMDMi 114016.

Proteomic databases

MaxQBi P02654.
PaxDbi P02654.
PeptideAtlasi P02654.
PRIDEi P02654.

Protocols and materials databases

DNASUi 341.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000252491 ; ENSP00000252491 ; ENSG00000130208 .
ENST00000588750 ; ENSP00000465356 ; ENSG00000130208 .
ENST00000588802 ; ENSP00000468029 ; ENSG00000130208 .
GeneIDi 341.
KEGGi hsa:341.
UCSCi uc002pac.1. human.

Organism-specific databases

CTDi 341.
GeneCardsi GC19P045417.
HGNCi HGNC:607. APOC1.
HPAi HPA051518.
MIMi 107710. gene.
neXtProti NX_P02654.
PharmGKBi PA51.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG47204.
HOGENOMi HOG000034001.
HOVERGENi HBG050547.
InParanoidi P02654.
OrthoDBi EOG7PK92M.
PhylomeDBi P02654.

Miscellaneous databases

ChiTaRSi APOC1. human.
EvolutionaryTracei P02654.
GeneWikii Apolipoprotein_C1.
GenomeRNAii 341.
NextBioi 1409.
PROi P02654.
SOURCEi Search...

Gene expression databases

ArrayExpressi P02654.
Bgeei P02654.
CleanExi HS_APOC1.
Genevestigatori P02654.

Family and domain databases

Gene3Di 4.10.260.30. 1 hit.
InterProi IPR006781. ApoC-I.
[Graphical view ]
PANTHERi PTHR16565. PTHR16565. 1 hit.
Pfami PF04691. ApoC-I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterisation of mRNAs encoding the precursor for human apolipoprotein CI."
    Knott T.J., Robertson M.E., Priestley L.M., Urdea M., Wallis S.C., Scott J.
    Nucleic Acids Res. 12:3909-3915(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Two copies of the human apolipoprotein C-I gene are linked closely to the apolipoprotein E gene."
    Lauer S.J., Walker D., Elshourbagy N.A., Reardon C.A., Levy-Wilson B., Taylor J.M.
    J. Biol. Chem. 263:7277-7286(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Sequencing of 42kb of the APO E-C2 gene cluster reveals a new gene: PEREC1."
    Freitas E.M., Zhang W.J., Lalonde J.P., Tay G.K., Gaudieri S., Ashworth L.K., Van Bockxmeer F.M., Dawkins R.L.
    DNA Seq. 9:89-100(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. Nickerson D.A., Smith J.D., Fullerton S.M., Clark A.G., Stengard J.H., Salomaa V., Boerwinkle E., Sing C.F., Weiss K.M.
    Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  7. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  8. Bechtel S., Schupp I., Duda A., Wellenreuther R., Mehrle A., Ruschke V., Poustka A., Wiemann S.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  9. NHLBI resequencing and genotyping service (RS&G)
    Submitted (DEC-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  10. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  12. "Isolation and characterisation of a cDNA clone for human apolipoprotein CI and assignment of the gene to chromosome 19."
    Tata F., Henry I., Markham A.F., Wallis S.C., Weil D., Grzeschik K.H., Junien C., Williamson R., Humphries S.E.
    Hum. Genet. 69:345-349(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 15-83.
  13. "The complete amino acid sequence of C-I (apoLp-Ser), an apolipoprotein from human very low density lipoproteins."
    Shulman R.S., Herbert P.N., Wehrly K., Fredrickson D.S.
    J. Biol. Chem. 250:182-190(1975) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 27-83.
  14. "The primary structure of apolipoprotein-serine."
    Jackson R.L., Sparrow J.T., Baker H.N., Morrisett J.D., Taunton O.D., Gotto A.M. Jr.
    J. Biol. Chem. 249:5308-5313(1974) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 27-83.
  15. "Exact localization of the familial dysbetalipoproteinemia associated HpaI restriction site in the promoter region of the APOC1 gene."
    Smit M.V.D., Kooij-Meijs E., Woudt L.P., Havekes L.M., Frants R.R.
    Biochem. Biophys. Res. Commun. 152:1282-1288(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-19.
  16. "Apolipoprotein C-I binds free fatty acids and reduces their intracellular esterification."
    Westerterp M., Berbee J.F., Delsing D.J., Jong M.C., Gijbels M.J., Dahlmans V.E., Offerman E.H., Romijn J.A., Havekes L.M., Rensen P.C.
    J. Lipid Res. 48:1353-1361(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  17. "Conformation of two peptides corresponding to human apolipoprotein C-I residues 7-24 and 35-53 in the presence of sodium dodecyl sulfate by CD and NMR spectroscopy."
    Rozek A., Buchko G.W., Cushley R.J.
    Biochemistry 34:7401-7408(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 33-50 AND 61-79.
  18. "Conformational studies of the N-terminal lipid-associating domain of human apolipoprotein C-I by CD and 1H NMR spectroscopy."
    Rozek A., Buchko G.W., Kanda P., Cushley R.J.
    Protein Sci. 6:1858-1868(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 27-64.
  19. "Conformation of human apolipoprotein C-I in a lipid-mimetic environment determined by CD and NMR spectroscopy."
    Rozek A., Sparrow J.T., Weisgraber K.H., Cushley R.J.
    Biochemistry 38:14475-14484(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 27-83.
  20. "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."
    Halushka M.K., Fan J.-B., Bentley K., Hsie L., Shen N., Weder A., Cooper R., Lipshutz R., Chakravarti A.
    Nat. Genet. 22:239-247(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT MET-16.
  21. Cited for: VARIANT SER-71, CHARACTERIZATION OF VARIANT SER-71.

Entry informationi

Entry nameiAPOC1_HUMAN
AccessioniPrimary (citable) accession number: P02654
Secondary accession number(s): B2R526, Q6IB97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 23, 1986
Last modified: September 3, 2014
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Apolipoprotein C-I is present in acidic (APOC1A) and basic (APOC1B) forms in P.paniscus, P.abelii and P.troglodytes and perhaps also in baboons and macaques. In human, the acidic form has become a pseudogene. Apo-CI makes up about 10% of the protein of the VLDL (very low density lipoprotein) and 2% of that of HDL (high density lipoprotein).

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi