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Protein

Apolipoprotein C-I

Gene

APOC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein.1 Publication1 Publication

GO - Molecular functioni

  • fatty acid binding Source: BHF-UCL
  • lipase inhibitor activity Source: BHF-UCL
  • phosphatidylcholine binding Source: BHF-UCL
  • phosphatidylcholine-sterol O-acyltransferase activator activity Source: BHF-UCL
  • phospholipase inhibitor activity Source: BHF-UCL

GO - Biological processi

  • cholesterol efflux Source: BHF-UCL
  • cholesterol metabolic process Source: Ensembl
  • chylomicron remnant clearance Source: BHF-UCL
  • high-density lipoprotein particle remodeling Source: BHF-UCL
  • lipid metabolic process Source: ProtInc
  • lipoprotein metabolic process Source: InterPro
  • negative regulation of cholesterol transport Source: BHF-UCL
  • negative regulation of fatty acid biosynthetic process Source: BHF-UCL
  • negative regulation of lipid catabolic process Source: BHF-UCL
  • negative regulation of lipid metabolic process Source: BHF-UCL
  • negative regulation of lipoprotein lipase activity Source: BHF-UCL
  • negative regulation of phosphatidylcholine catabolic process Source: BHF-UCL
  • negative regulation of receptor-mediated endocytosis Source: BHF-UCL
  • negative regulation of very-low-density lipoprotein particle clearance Source: BHF-UCL
  • phospholipid efflux Source: BHF-UCL
  • plasma lipoprotein particle remodeling Source: BHF-UCL
  • positive regulation of cholesterol esterification Source: BHF-UCL
  • regulation of cholesterol transport Source: BHF-UCL
  • triglyceride metabolic process Source: Ensembl
  • very-low-density lipoprotein particle assembly Source: BHF-UCL
  • very-low-density lipoprotein particle clearance Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-8855121. VLDL interactions.
R-HSA-8866423. VLDL biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein C-I
Short name:
Apo-CI
Short name:
ApoC-I
Alternative name(s):
Apolipoprotein C1
Cleaved into the following chain:
Gene namesi
Name:APOC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:607. APOC1.

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

  • chylomicron Source: BHF-UCL
  • endoplasmic reticulum Source: LIFEdb
  • extracellular exosome Source: UniProtKB
  • high-density lipoprotein particle Source: BHF-UCL
  • very-low-density lipoprotein particle Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted, VLDL

Pathology & Biotechi

Organism-specific databases

DisGeNETi341.
OpenTargetsiENSG00000130208.
PharmGKBiPA51.

Polymorphism and mutation databases

BioMutaiAPOC1.
DMDMi114016.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 262 PublicationsAdd BLAST26
ChainiPRO_000000201427 – 83Apolipoprotein C-IAdd BLAST57
ChainiPRO_000039184329 – 83Truncated apolipoprotein C-IBy similarityAdd BLAST55

Proteomic databases

EPDiP02654.
MaxQBiP02654.
PaxDbiP02654.
PeptideAtlasiP02654.
PRIDEiP02654.
TopDownProteomicsiP02654.

PTM databases

PhosphoSitePlusiP02654.

Expressioni

Tissue specificityi

Synthesized mainly in liver and to a minor degree in intestine. Also found in the lung and spleen.1 Publication

Gene expression databases

BgeeiENSG00000130208.
CleanExiHS_APOC1.
ExpressionAtlasiP02654. baseline and differential.
GenevisibleiP02654. HS.

Organism-specific databases

HPAiHPA051518.

Interactioni

Protein-protein interaction databases

BioGridi106838. 4 interactors.
IntActiP02654. 5 interactors.
MINTiMINT-3004014.
STRINGi9606.ENSP00000252491.

Structurei

Secondary structure

183
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi31 – 33Combined sources3
Helixi35 – 48Combined sources14
Turni52 – 54Combined sources3
Beta strandi56 – 62Combined sources7
Helixi65 – 78Combined sources14
Beta strandi79 – 81Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ALENMR-A33-50[»]
1ALFNMR-A61-79[»]
1IOJNMR-A27-83[»]
1OPPNMR-A27-64[»]
ProteinModelPortaliP02654.
SMRiP02654.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02654.

Family & Domainsi

Sequence similaritiesi

Belongs to the apolipoprotein C1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J7EM. Eukaryota.
ENOG410ZDUT. LUCA.
GeneTreeiENSGT00390000011584.
HOGENOMiHOG000034001.
HOVERGENiHBG050547.
InParanoidiP02654.
PhylomeDBiP02654.

Family and domain databases

InterProiIPR006781. ApoC-I.
[Graphical view]
PANTHERiPTHR16565. PTHR16565. 1 hit.
PfamiPF04691. ApoC-I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02654-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLFLSLPVL VVVLSIVLEG PAPAQGTPDV SSALDKLKEF GNTLEDKARE
60 70 80
LISRIKQSEL SAKMREWFSE TFQKVKEKLK IDS
Length:83
Mass (Da):9,332
Last modified:October 23, 1986 - v1
Checksum:i4A3614626624AE6A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01418316I → M.1 PublicationCorresponds to variant rs5112dbSNPEnsembl.1
Natural variantiVAR_02901171T → S Polymorphism found only in persons of American Indian or Mexican ancestry; more susceptible to N-terminal truncation and shows greater distribution to the VLDL than the protein with T-71. 1 PublicationCorresponds to variant rs142372275dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00570 mRNA. Translation: CAA25235.1.
M20843 Genomic DNA. Translation: AAA51763.1.
AF050154 Genomic DNA. Translation: AAD02506.1.
AY422954 Genomic DNA. Translation: AAQ91813.1.
BT007142 mRNA. Translation: AAP35806.1.
AK312036 mRNA. Translation: BAG34973.1.
CR456907 mRNA. Translation: CAG33188.1.
AM392727 mRNA. Translation: CAL37605.1.
FJ525874 Genomic DNA. Translation: ACN81312.1.
CH471126 Genomic DNA. Translation: EAW57307.1.
BC009698 mRNA. Translation: AAH09698.1.
BC055093 mRNA. Translation: AAH55093.1.
M20902 Genomic DNA. Translation: AAA88018.1.
M27359 mRNA. Translation: AAA51762.1.
CCDSiCCDS12648.1.
PIRiA28057. LPHUC1.
RefSeqiNP_001307994.1. NM_001321065.1.
NP_001307995.1. NM_001321066.1.
NP_001636.1. NM_001645.4.
UniGeneiHs.110675.
Hs.737668.

Genome annotation databases

EnsembliENST00000588750; ENSP00000465356; ENSG00000130208.
ENST00000588802; ENSP00000468029; ENSG00000130208.
GeneIDi341.
KEGGihsa:341.
UCSCiuc002pac.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Apolipoprotein C1 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00570 mRNA. Translation: CAA25235.1.
M20843 Genomic DNA. Translation: AAA51763.1.
AF050154 Genomic DNA. Translation: AAD02506.1.
AY422954 Genomic DNA. Translation: AAQ91813.1.
BT007142 mRNA. Translation: AAP35806.1.
AK312036 mRNA. Translation: BAG34973.1.
CR456907 mRNA. Translation: CAG33188.1.
AM392727 mRNA. Translation: CAL37605.1.
FJ525874 Genomic DNA. Translation: ACN81312.1.
CH471126 Genomic DNA. Translation: EAW57307.1.
BC009698 mRNA. Translation: AAH09698.1.
BC055093 mRNA. Translation: AAH55093.1.
M20902 Genomic DNA. Translation: AAA88018.1.
M27359 mRNA. Translation: AAA51762.1.
CCDSiCCDS12648.1.
PIRiA28057. LPHUC1.
RefSeqiNP_001307994.1. NM_001321065.1.
NP_001307995.1. NM_001321066.1.
NP_001636.1. NM_001645.4.
UniGeneiHs.110675.
Hs.737668.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ALENMR-A33-50[»]
1ALFNMR-A61-79[»]
1IOJNMR-A27-83[»]
1OPPNMR-A27-64[»]
ProteinModelPortaliP02654.
SMRiP02654.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106838. 4 interactors.
IntActiP02654. 5 interactors.
MINTiMINT-3004014.
STRINGi9606.ENSP00000252491.

PTM databases

PhosphoSitePlusiP02654.

Polymorphism and mutation databases

BioMutaiAPOC1.
DMDMi114016.

Proteomic databases

EPDiP02654.
MaxQBiP02654.
PaxDbiP02654.
PeptideAtlasiP02654.
PRIDEiP02654.
TopDownProteomicsiP02654.

Protocols and materials databases

DNASUi341.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000588750; ENSP00000465356; ENSG00000130208.
ENST00000588802; ENSP00000468029; ENSG00000130208.
GeneIDi341.
KEGGihsa:341.
UCSCiuc002pac.2. human.

Organism-specific databases

CTDi341.
DisGeNETi341.
GeneCardsiAPOC1.
HGNCiHGNC:607. APOC1.
HPAiHPA051518.
MIMi107710. gene.
neXtProtiNX_P02654.
OpenTargetsiENSG00000130208.
PharmGKBiPA51.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J7EM. Eukaryota.
ENOG410ZDUT. LUCA.
GeneTreeiENSGT00390000011584.
HOGENOMiHOG000034001.
HOVERGENiHBG050547.
InParanoidiP02654.
PhylomeDBiP02654.

Enzyme and pathway databases

ReactomeiR-HSA-8855121. VLDL interactions.
R-HSA-8866423. VLDL biosynthesis.

Miscellaneous databases

ChiTaRSiAPOC1. human.
EvolutionaryTraceiP02654.
GeneWikiiApolipoprotein_C1.
GenomeRNAii341.
PROiP02654.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130208.
CleanExiHS_APOC1.
ExpressionAtlasiP02654. baseline and differential.
GenevisibleiP02654. HS.

Family and domain databases

InterProiIPR006781. ApoC-I.
[Graphical view]
PANTHERiPTHR16565. PTHR16565. 1 hit.
PfamiPF04691. ApoC-I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAPOC1_HUMAN
AccessioniPrimary (citable) accession number: P02654
Secondary accession number(s): B2R526, Q6IB97
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 23, 1986
Last modified: November 2, 2016
This is version 168 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Apolipoprotein C-I is present in acidic (APOC1A) and basic (APOC1B) forms in P.paniscus, P.abelii and P.troglodytes and perhaps also in baboons and macaques. The two genes for ApoC-I arose through a duplication process that occurred after the divergence of New World monkeys from the human lineage. In human, the acidic form has become a pseudogene sometime between the divergence of bonobos and chimpanzees from the human lineage and the appearance of the Denisovans. Pseudogenization resulted when the codon for the penultimate amino acid in the signal sequence was changed to a stop codon.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.