Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P02652

- APOA2_HUMAN

UniProt

P02652 - APOA2_HUMAN

Protein

Apolipoprotein A-II

Gene

APOA2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.

    GO - Molecular functioni

    1. apolipoprotein receptor binding Source: BHF-UCL
    2. cholesterol binding Source: BHF-UCL
    3. cholesterol transporter activity Source: Ensembl
    4. high-density lipoprotein particle binding Source: Ensembl
    5. high-density lipoprotein particle receptor binding Source: BHF-UCL
    6. lipase inhibitor activity Source: BHF-UCL
    7. lipid binding Source: BHF-UCL
    8. lipid transporter activity Source: BHF-UCL
    9. phosphatidylcholine binding Source: BHF-UCL
    10. phosphatidylcholine-sterol O-acyltransferase activator activity Source: BHF-UCL
    11. phospholipid binding Source: BHF-UCL
    12. protein binding Source: UniProtKB
    13. protein heterodimerization activity Source: UniProtKB
    14. protein homodimerization activity Source: BHF-UCL

    GO - Biological processi

    1. acute inflammatory response Source: Ensembl
    2. cellular lipid metabolic process Source: Reactome
    3. cholesterol efflux Source: BHF-UCL
    4. cholesterol homeostasis Source: BHF-UCL
    5. cholesterol metabolic process Source: Ensembl
    6. diacylglycerol catabolic process Source: BHF-UCL
    7. high-density lipoprotein particle assembly Source: BHF-UCL
    8. high-density lipoprotein particle clearance Source: BHF-UCL
    9. high-density lipoprotein particle remodeling Source: BHF-UCL
    10. lipoprotein metabolic process Source: Reactome
    11. low-density lipoprotein particle remodeling Source: BHF-UCL
    12. negative regulation of cholesterol import Source: BHF-UCL
    13. negative regulation of cholesterol transport Source: BHF-UCL
    14. negative regulation of cholesterol transporter activity Source: BHF-UCL
    15. negative regulation of cytokine secretion involved in immune response Source: BHF-UCL
    16. negative regulation of lipase activity Source: BHF-UCL
    17. negative regulation of lipid catabolic process Source: BHF-UCL
    18. negative regulation of very-low-density lipoprotein particle remodeling Source: BHF-UCL
    19. organ regeneration Source: Ensembl
    20. peptidyl-methionine modification Source: UniProtKB
    21. phosphatidylcholine biosynthetic process Source: BHF-UCL
    22. phospholipid catabolic process Source: BHF-UCL
    23. phospholipid efflux Source: BHF-UCL
    24. phototransduction, visible light Source: Reactome
    25. positive regulation of catalytic activity Source: GOC
    26. positive regulation of cholesterol esterification Source: BHF-UCL
    27. positive regulation of interleukin-8 biosynthetic process Source: UniProtKB
    28. positive regulation of lipid catabolic process Source: BHF-UCL
    29. protein folding Source: BHF-UCL
    30. protein oxidation Source: UniProtKB
    31. regulation of intestinal cholesterol absorption Source: Ensembl
    32. regulation of protein stability Source: BHF-UCL
    33. response to drug Source: Ensembl
    34. response to estrogen Source: Ensembl
    35. response to glucocorticoid Source: Ensembl
    36. response to glucose Source: BHF-UCL
    37. retinoid metabolic process Source: Reactome
    38. reverse cholesterol transport Source: BHF-UCL
    39. small molecule metabolic process Source: Reactome
    40. triglyceride metabolic process Source: BHF-UCL
    41. triglyceride-rich lipoprotein particle remodeling Source: BHF-UCL
    42. viral process Source: UniProtKB-KW

    Keywords - Biological processi

    Host-virus interaction, Lipid transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_116145. PPARA activates gene expression.
    REACT_24968. Retinoid metabolism and transport.
    REACT_6841. Chylomicron-mediated lipid transport.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Apolipoprotein A-II
    Short name:
    Apo-AII
    Short name:
    ApoA-II
    Alternative name(s):
    Apolipoprotein A2
    Cleaved into the following 2 chains:
    Proapolipoprotein A-II
    Short name:
    ProapoA-II
    Alternative name(s):
    Apolipoprotein A-II(1-76)
    Gene namesi
    Name:APOA2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:601. APOA2.

    Subcellular locationi

    GO - Cellular componenti

    1. blood microparticle Source: UniProt
    2. chylomicron Source: BHF-UCL
    3. cytosol Source: Reactome
    4. early endosome Source: Reactome
    5. endoplasmic reticulum lumen Source: Reactome
    6. extracellular region Source: UniProtKB
    7. extracellular vesicular exosome Source: UniProt
    8. high-density lipoprotein particle Source: BHF-UCL
    9. spherical high-density lipoprotein particle Source: BHF-UCL
    10. very-low-density lipoprotein particle Source: BHF-UCL

    Keywords - Cellular componenti

    HDL, Secreted

    Pathology & Biotechi

    Organism-specific databases

    MIMi107670. gene+phenotype.
    Orphaneti238269. Familial renal amyloidosis due to Apolipoprotein AII variant.
    PharmGKBiPA24886.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 18181 PublicationAdd
    BLAST
    Chaini19 – 10082Proapolipoprotein A-IIPRO_0000425351Add
    BLAST
    Chaini24 – 10077Apolipoprotein A-IIPRO_0000002003Add
    BLAST
    Chaini24 – 9976Truncated apolipoprotein A-IIPRO_0000002004Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei24 – 241Pyrrolidone carboxylic acid1 Publication
    Disulfide bondi29 – 29Interchain (with C-136 in APOD); in heterodimeric form1 Publication
    Modified residuei49 – 491Methionine sulfoxide1 Publication
    Modified residuei68 – 681Phosphoserine1 Publication

    Post-translational modificationi

    Phosphorylation sites are present in the extracellular medium.1 Publication
    Apolipoprotein A-II is O-glycosylated.1 Publication

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Oxidation, Phosphoprotein, Pyrrolidone carboxylic acid

    Proteomic databases

    MaxQBiP02652.
    PaxDbiP02652.
    PeptideAtlasiP02652.
    PRIDEiP02652.

    2D gel databases

    SWISS-2DPAGEP02652.

    PTM databases

    PhosphoSiteiP02652.

    Miscellaneous databases

    PMAP-CutDBP02652.

    Expressioni

    Tissue specificityi

    Plasma; synthesized in the liver and intestine.

    Gene expression databases

    BgeeiP02652.
    CleanExiHS_APOA2.
    GenevestigatoriP02652.

    Organism-specific databases

    HPAiCAB025885.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked. Also forms a disulfide-linked heterodimer with APOD. Interacts with HCV core protein. Interacts with APOA1BP and NDRG1.3 Publications

    Protein-protein interaction databases

    BioGridi106833. 10 interactions.
    IntActiP02652. 7 interactions.
    MINTiMINT-106326.
    STRINGi9606.ENSP00000356969.

    Structurei

    Secondary structure

    1
    100
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi31 – 5626
    Beta strandi58 – 603
    Helixi63 – 697
    Turni70 – 723
    Helixi74 – 774
    Helixi79 – 824
    Helixi88 – 958
    Turni96 – 983

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1L6LX-ray2.301/2/3/4/5/6/7/8/A/B/C/D/E/F/G/H/I/J/K/L/M/N/P/Q/S/T/U/V/W/X/Y/Z24-100[»]
    2OU1X-ray2.00A/B/C/D/E/F/G/H/I/J/K/L24-100[»]
    ProteinModelPortaliP02652.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP02652.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni32 – 4312O-glycosylated at one siteAdd
    BLAST

    Sequence similaritiesi

    Belongs to the apolipoprotein A2 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40617.
    HOGENOMiHOG000033999.
    HOVERGENiHBG050544.
    InParanoidiP02652.
    KOiK08758.
    OMAiAYFEKTQ.
    OrthoDBiEOG7G4QHG.
    PhylomeDBiP02652.
    TreeFamiTF338165.

    Family and domain databases

    InterProiIPR006801. ApoA-II.
    [Graphical view]
    PANTHERiPTHR11027. PTHR11027. 1 hit.
    PfamiPF04711. ApoA-II. 1 hit.
    [Graphical view]
    ProDomiPD010397. ApoA-II. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P02652-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLLAATVLL LTICSLEGAL VRRQAKEPCV ESLVSQYFQT VTDYGKDLME    50
    KVKSPELQAE AKSYFEKSKE QLTPLIKKAG TELVNFLSYF VELGTQPATQ 100
    Length:100
    Mass (Da):11,175
    Last modified:August 13, 1987 - v1
    Checksum:i1247868A25EC3AF2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti96 – 961Q → H in CAA28583. (PubMed:6428397)Curated

    Mass spectrometryi

    Molecular mass is 17252 Da from positions 24 - 100. Determined by ESI. Homodimer, without methionine sulfoxide.1 Publication
    Molecular mass is 17269 Da from positions 24 - 100. Determined by ESI. Homodimer, with 1 methionine sulfoxide, oxidation at Met-49.1 Publication
    Molecular mass is 8701.2 Da from positions 24 - 100. Determined by MALDI. 1 Publication
    Molecular mass is 8823.4 Da from positions 24 - 100. Determined by MALDI. Cysteinylated ApoA-II.1 Publication
    Molecular mass is 17421.3 Da from positions 24 - 100. Determined by MALDI. Homodimer.1 Publication
    Molecular mass is 17293.4 Da from positions 24 - 100. Determined by MALDI. Heterodimer with truncated apolipoprotein A-II.1 Publication
    Molecular mass is 8578.3 Da from positions 24 - 99. Determined by MALDI. 1 Publication
    Molecular mass is 17166.2 Da from positions 24 - 99. Determined by MALDI. Homodimer.1 Publication

    Polymorphismi

    A homozygous transition at position 1 of intron 3 of APOA2 results in deficiency of apolipoprotein A-II, without significant influence either on lipid and lipoprotein profiles or on the occurrence of coronary artery disease [MIMi:107670].

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X04898 Genomic DNA. Translation: CAA28583.1.
    X00955 mRNA. Translation: CAA25467.1.
    X02905 Genomic DNA. Translation: CAA26665.1.
    X02619 Genomic DNA. Translation: CAA26474.1.
    M29882 mRNA. Translation: AAA51701.1.
    AY100524 Genomic DNA. Translation: AAM49807.1.
    AK312034 mRNA. Translation: BAG34971.1.
    BT006786 mRNA. Translation: AAP35432.1.
    AL590714 Genomic DNA. Translation: CAH72151.1.
    BC005282 mRNA. Translation: AAH05282.1.
    CCDSiCCDS1226.1.
    PIRiA93586. LPHUA2.
    RefSeqiNP_001634.1. NM_001643.1.
    UniGeneiHs.237658.

    Genome annotation databases

    EnsembliENST00000367990; ENSP00000356969; ENSG00000158874.
    GeneIDi336.
    KEGGihsa:336.
    UCSCiuc001fzc.1. human.

    Polymorphism databases

    DMDMi114000.

    Cross-referencesi

    Web resourcesi

    SHMPD

    The Singapore human mutation and polymorphism database

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X04898 Genomic DNA. Translation: CAA28583.1 .
    X00955 mRNA. Translation: CAA25467.1 .
    X02905 Genomic DNA. Translation: CAA26665.1 .
    X02619 Genomic DNA. Translation: CAA26474.1 .
    M29882 mRNA. Translation: AAA51701.1 .
    AY100524 Genomic DNA. Translation: AAM49807.1 .
    AK312034 mRNA. Translation: BAG34971.1 .
    BT006786 mRNA. Translation: AAP35432.1 .
    AL590714 Genomic DNA. Translation: CAH72151.1 .
    BC005282 mRNA. Translation: AAH05282.1 .
    CCDSi CCDS1226.1.
    PIRi A93586. LPHUA2.
    RefSeqi NP_001634.1. NM_001643.1.
    UniGenei Hs.237658.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1L6L X-ray 2.30 1/2/3/4/5/6/7/8/A/B/C/D/E/F/G/H/I/J/K/L/M/N/P/Q/S/T/U/V/W/X/Y/Z 24-100 [» ]
    2OU1 X-ray 2.00 A/B/C/D/E/F/G/H/I/J/K/L 24-100 [» ]
    ProteinModelPortali P02652.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106833. 10 interactions.
    IntActi P02652. 7 interactions.
    MINTi MINT-106326.
    STRINGi 9606.ENSP00000356969.

    PTM databases

    PhosphoSitei P02652.

    Polymorphism databases

    DMDMi 114000.

    2D gel databases

    SWISS-2DPAGE P02652.

    Proteomic databases

    MaxQBi P02652.
    PaxDbi P02652.
    PeptideAtlasi P02652.
    PRIDEi P02652.

    Protocols and materials databases

    DNASUi 336.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367990 ; ENSP00000356969 ; ENSG00000158874 .
    GeneIDi 336.
    KEGGi hsa:336.
    UCSCi uc001fzc.1. human.

    Organism-specific databases

    CTDi 336.
    GeneCardsi GC01M161192.
    HGNCi HGNC:601. APOA2.
    HPAi CAB025885.
    MIMi 107670. gene+phenotype.
    neXtProti NX_P02652.
    Orphaneti 238269. Familial renal amyloidosis due to Apolipoprotein AII variant.
    PharmGKBi PA24886.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40617.
    HOGENOMi HOG000033999.
    HOVERGENi HBG050544.
    InParanoidi P02652.
    KOi K08758.
    OMAi AYFEKTQ.
    OrthoDBi EOG7G4QHG.
    PhylomeDBi P02652.
    TreeFami TF338165.

    Enzyme and pathway databases

    Reactomei REACT_116145. PPARA activates gene expression.
    REACT_24968. Retinoid metabolism and transport.
    REACT_6841. Chylomicron-mediated lipid transport.

    Miscellaneous databases

    ChiTaRSi APOA2. human.
    EvolutionaryTracei P02652.
    GeneWikii APOA2.
    GenomeRNAii 336.
    NextBioi 1391.
    PMAP-CutDB P02652.
    PROi P02652.
    SOURCEi Search...

    Gene expression databases

    Bgeei P02652.
    CleanExi HS_APOA2.
    Genevestigatori P02652.

    Family and domain databases

    InterProi IPR006801. ApoA-II.
    [Graphical view ]
    PANTHERi PTHR11027. PTHR11027. 1 hit.
    Pfami PF04711. ApoA-II. 1 hit.
    [Graphical view ]
    ProDomi PD010397. ApoA-II. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterisation of a cDNA encoding the precursor for human apolipoprotein AII."
      Knott T.J., Priestley L.M., Urdea M., Scott J.
      Biochem. Biophys. Res. Commun. 120:734-740(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Human apolipoprotein A-II: nucleotide sequence of a cloned cDNA, and localization of its structural gene on human chromosome 1."
      Moore M.N., Kao F.-T., Tsao Y.-K., Chan L.
      Biochem. Biophys. Res. Commun. 123:1-7(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance."
      Sharpe C.R., Sidoli A., Shelley C.S., Lucero M.A., Shoulders C.C., Baralle F.E.
      Nucleic Acids Res. 12:3917-3932(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    4. "The human apolipoprotein A-II gene: complete nucleic acid sequence and genomic organization."
      Lackner K.J., Law S.W., Brewer H.B. Jr.
      Nucleic Acids Res. 13:4597-4608(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "The human apolipoprotein AII gene: structural organization and sites of expression."
      Knott T.J., Wallis S.C., Robertson M.E., Priestley L.M., Urdea M., Rall L.B., Scott J.
      Nucleic Acids Res. 13:6387-6398(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "Molecular cloning and sequence analysis of human apolipoprotein A-II cDNA."
      Chan L., Moore M.N., Tsao Y.-K.
      Methods Enzymol. 128:745-752(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    7. "Sequence polymorphism at the human apolipoprotein AII gene (APOA2): unexpected deficit of variation in an African-American sample."
      Fullerton S.M., Clark A.G., Weiss K.M., Taylor S.L., Stengard J.H., Salomaa V., Boerwinkle E., Nickerson D.A.
      Hum. Genet. 111:75-87(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.
    9. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    10. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    11. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skeletal muscle.
    12. "Isolation and characterization of the tryptic and cyanogen bromide peptides of apoLp-Gln-II (apoA-II), plasma high density apolipoprotein."
      Lux S.E., John K.M., Ronan R., Brewer H.B. Jr.
      J. Biol. Chem. 247:7519-7527(1972) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 24-100, PYROGLUTAMATE FORMATION AT GLN-24.
    13. "Cell-free translation of human liver apolipoprotein AI and AII mRNA. Processing of primary translation products."
      Stoffel W., Krueger E., Deutzmann R.
      Hoppe-Seyler's Z. Physiol. Chem. 364:227-237(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE OF 1-29.
    14. "A splice-junction mutation responsible for familial apolipoprotein A-II deficiency."
      Deeb S.S., Takata K., Peng R.L., Kajiyama G., Albers J.J.
      Am. J. Hum. Genet. 46:822-827(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: POLYMORPHISM.
    15. "Structure of human apolipoprotein D: locations of the intermolecular and intramolecular disulfide links."
      Yang C.-Y., Gu Z.-W., Blanco-Vaca F., Gaskell S.J., Yang M., Massey J.B., Gotto A.M. Jr., Pownall H.J.
      Biochemistry 33:12451-12455(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERCHAIN DISULFIDE BOND WITH APOD.
      Tissue: Plasma.
    16. "Cloning and characterization of a novel apolipoprotein A-I-binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I."
      Ritter M., Buechler C., Boettcher A., Barlage S., Schmitz-Madry A., Orso E., Bared S.M., Schmiedeknecht G., Baehr C.H., Fricker G., Schmitz G.
      Genomics 79:693-702(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH APOA1BP.
    17. "Characterization of specifically oxidized apolipoproteins in mildly oxidized high density lipoprotein."
      Pankhurst G., Wang X.L., Wilcken D.E., Baernthaler G., Panzenboeck U., Raftery M., Stocker R.
      J. Lipid Res. 44:349-355(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: MASS SPECTROMETRY, OXIDATION AT MET-49.
    18. "Novel mass spectrometric immunoassays for the rapid structural characterization of plasma apolipoproteins."
      Niederkofler E.E., Tubbs K.A., Kiernan U.A., Nedelkov D., Nelson R.W.
      J. Lipid Res. 44:630-639(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: MASS SPECTROMETRY.
    19. "NDRG1 interacts with APO A-I and A-II and is a functional candidate for the HDL-C QTL on 8q24."
      Hunter M., Angelicheva D., Tournev I., Ingley E., Chan D.C., Watts G.F., Kremensky I., Kalaydjieva L.
      Biochem. Biophys. Res. Commun. 332:982-992(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NDRG1.
    20. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-68, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Serum.
    21. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    22. "LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."
      Halim A., Ruetschi U., Larson G., Nilsson J.
      J. Proteome Res. 12:573-584(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION, IDENTIFICATION BY MASS SPECTROMETRY.
    23. "Structures of apolipoprotein A-II and a lipid-surrogate complex provide insights into apolipoprotein-lipid interactions."
      Kumar M.S., Carson M., Hussain M.M., Murthy H.M.
      Biochemistry 41:11681-11691(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 24-100, SUBUNIT, DISULFIDE BOND.

    Entry informationi

    Entry nameiAPOA2_HUMAN
    AccessioniPrimary (citable) accession number: P02652
    Secondary accession number(s): B2R524
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: August 13, 1987
    Last modified: October 1, 2014
    This is version 177 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3