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P02651

- APOA4_RAT

UniProt

P02651 - APOA4_RAT

Protein

Apolipoprotein A-IV

Gene

Apoa4

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (01 Jul 1989)
      Previous versions | rss
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    Functioni

    May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.

    GO - Molecular functioni

    1. lipid binding Source: InterPro

    GO - Biological processi

    1. lipid transport Source: RGD
    2. lipoprotein metabolic process Source: InterPro
    3. peripheral nervous system axon regeneration Source: RGD
    4. response to food Source: RGD
    5. response to triglyceride Source: RGD

    Keywords - Biological processi

    Lipid transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Apolipoprotein A-IV
    Short name:
    Apo-AIV
    Short name:
    ApoA-IV
    Alternative name(s):
    Apolipoprotein A4
    Gene namesi
    Name:Apoa4
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2132. Apoa4.

    Subcellular locationi

    GO - Cellular componenti

    1. chylomicron Source: RGD
    2. high-density lipoprotein particle Source: UniProtKB-KW

    Keywords - Cellular componenti

    Chylomicron, HDL, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Add
    BLAST
    Chaini21 – 391371Apolipoprotein A-IVPRO_0000001980Add
    BLAST

    Proteomic databases

    PaxDbiP02651.
    PRIDEiP02651.

    PTM databases

    PhosphoSiteiP02651.

    Expressioni

    Tissue specificityi

    Secreted in plasma.

    Gene expression databases

    GenevestigatoriP02651.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000056172.

    Structurei

    3D structure databases

    ProteinModelPortaliP02651.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati33 – 54221Add
    BLAST
    Repeati60 – 81222Add
    BLAST
    Repeati82 – 103223Add
    BLAST
    Repeati115 – 136224Add
    BLAST
    Repeati137 – 158225Add
    BLAST
    Repeati159 – 180226Add
    BLAST
    Repeati181 – 202227Add
    BLAST
    Repeati203 – 224228Add
    BLAST
    Repeati225 – 246229Add
    BLAST
    Repeati247 – 2682210Add
    BLAST
    Repeati269 – 2861811Add
    BLAST
    Repeati287 – 3082212Add
    BLAST
    Repeati309 – 3302213Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni33 – 33029813 X 22 AA approximate tandem repeatsAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi374 – 38512Gln/Glu-richAdd
    BLAST

    Domaini

    Nine of the thirteen 22-amino acid tandem repeats (each 22-mer is actually a tandem array of two, A and B, related 11-mers) occurring in this sequence are predicted to be highly alpha-helical, and many of these helices are amphipathic. They may therefore serve as lipid-binding domains with lecithin:cholesterol acyltransferase (LCAT) activating abilities.

    Sequence similaritiesi

    Belongs to the apolipoprotein A1/A4/E family.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    HOVERGENiHBG105707.
    KOiK08760.
    PhylomeDBiP02651.

    Family and domain databases

    InterProiIPR000074. ApoA1_A4_E.
    [Graphical view]
    PfamiPF01442. Apolipoprotein. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P02651-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFLKAVVLTV ALVAITGTQA EVTSDQVANV MWDYFTQLSN NAKEAVEQLQ    50
    KTDVTQQLNT LFQDKLGNIN TYADDLQNKL VPFAVQLSGH LTKETERVRE 100
    EIQKELEDLR ANMMPHANKV SQMFGDNVQK LQEHLRPYAT DLQAQINAQT 150
    QDMKRQLTPY IQRMQTTIQD NVENLQSSMV PFANELKEKF NQNMEGLKGQ 200
    LTPRANELKA TIDQNLEDLR SRLAPLAEGV QEKLNHQMEG LAFQMKKNAE 250
    ELQTKVSTNI DQLQKNLAPL VEDVQSKLKG NTEGLQKSLE DLNKQLDQQV 300
    EVFRRAVEPL GDKFNMALVQ QMEKFRQQLG SDSGDVESHL SFLEKNLREK 350
    VSSFMSTLQK KGSPDQPLAL PLPEQVQEQV QEQVQPKPLE S 391
    Length:391
    Mass (Da):44,456
    Last modified:July 1, 1989 - v2
    Checksum:i24095004A809201D
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti253 – 2531Q → H.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M00002 mRNA. Translation: AAA85909.1.
    J02588 Genomic DNA. Translation: AAA40747.1.
    M13508 Genomic DNA. Translation: AAA40748.1.
    BC091159 mRNA. Translation: AAH91159.1.
    PIRiA03095. LPRTA4.
    RefSeqiNP_036869.1. NM_012737.1.
    UniGeneiRn.15739.

    Genome annotation databases

    GeneIDi25080.
    KEGGirno:25080.
    UCSCiRGD:2132. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M00002 mRNA. Translation: AAA85909.1 .
    J02588 Genomic DNA. Translation: AAA40747.1 .
    M13508 Genomic DNA. Translation: AAA40748.1 .
    BC091159 mRNA. Translation: AAH91159.1 .
    PIRi A03095. LPRTA4.
    RefSeqi NP_036869.1. NM_012737.1.
    UniGenei Rn.15739.

    3D structure databases

    ProteinModelPortali P02651.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000056172.

    PTM databases

    PhosphoSitei P02651.

    Proteomic databases

    PaxDbi P02651.
    PRIDEi P02651.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 25080.
    KEGGi rno:25080.
    UCSCi RGD:2132. rat.

    Organism-specific databases

    CTDi 337.
    RGDi 2132. Apoa4.

    Phylogenomic databases

    HOVERGENi HBG105707.
    KOi K08760.
    PhylomeDBi P02651.

    Miscellaneous databases

    NextBioi 605330.
    PROi P02651.

    Gene expression databases

    Genevestigatori P02651.

    Family and domain databases

    InterProi IPR000074. ApoA1_A4_E.
    [Graphical view ]
    Pfami PF01442. Apolipoprotein. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolution of the apolipoproteins. Structure of the rat apo-A-IV gene and its relationship to the human genes for apo-A-I, C-III, and E."
      Boguski M.S., Birkenmeier E.H., Elshourbagy N.A., Taylor J.M., Gordon J.I.
      J. Biol. Chem. 261:6398-6407(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Rat apolipoprotein A-IV contains 13 tandem repetitions of a 22-amino acid segment with amphipathic helical potential."
      Boguski M.S., Elshourbagy N.A., Taylor J.M., Gordon J.I.
      Proc. Natl. Acad. Sci. U.S.A. 81:5021-5025(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Linkage, evolution, and expression of the rat apolipoprotein A-I, C-III, and A-IV genes."
      Haddad I.A., Ordovas J.M., Fitzpatrick T., Karathanasis S.K.
      J. Biol. Chem. 261:13268-13277(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiAPOA4_RAT
    AccessioniPrimary (citable) accession number: P02651
    Secondary accession number(s): Q5BK92
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 1, 1989
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3