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P02651 (APOA4_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Apolipoprotein A-IV

Short name=Apo-AIV
Short name=ApoA-IV
Alternative name(s):
Apolipoprotein A4
Gene names
Name:Apoa4
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length391 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.

Subunit structure

Homodimer By similarity.

Subcellular location

Secreted.

Tissue specificity

Secreted in plasma.

Domain

Nine of the thirteen 22-amino acid tandem repeats (each 22-mer is actually a tandem array of two, A and B, related 11-mers) occurring in this sequence are predicted to be highly alpha-helical, and many of these helices are amphipathic. They may therefore serve as lipid-binding domains with lecithin:cholesterol acyltransferase (LCAT) activating abilities.

Sequence similarities

Belongs to the apolipoprotein A1/A4/E family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020
Chain21 – 391371Apolipoprotein A-IV
PRO_0000001980

Regions

Repeat33 – 54221
Repeat60 – 81222
Repeat82 – 103223
Repeat115 – 136224
Repeat137 – 158225
Repeat159 – 180226
Repeat181 – 202227
Repeat203 – 224228
Repeat225 – 246229
Repeat247 – 2682210
Repeat269 – 2861811
Repeat287 – 3082212
Repeat309 – 3302213
Region33 – 33029813 X 22 AA approximate tandem repeats
Compositional bias374 – 38512Gln/Glu-rich

Natural variations

Natural variant2531Q → H.

Sequences

Sequence LengthMass (Da)Tools
P02651 [UniParc].

Last modified July 1, 1989. Version 2.
Checksum: 24095004A809201D

FASTA39144,456
        10         20         30         40         50         60 
MFLKAVVLTV ALVAITGTQA EVTSDQVANV MWDYFTQLSN NAKEAVEQLQ KTDVTQQLNT 

        70         80         90        100        110        120 
LFQDKLGNIN TYADDLQNKL VPFAVQLSGH LTKETERVRE EIQKELEDLR ANMMPHANKV 

       130        140        150        160        170        180 
SQMFGDNVQK LQEHLRPYAT DLQAQINAQT QDMKRQLTPY IQRMQTTIQD NVENLQSSMV 

       190        200        210        220        230        240 
PFANELKEKF NQNMEGLKGQ LTPRANELKA TIDQNLEDLR SRLAPLAEGV QEKLNHQMEG 

       250        260        270        280        290        300 
LAFQMKKNAE ELQTKVSTNI DQLQKNLAPL VEDVQSKLKG NTEGLQKSLE DLNKQLDQQV 

       310        320        330        340        350        360 
EVFRRAVEPL GDKFNMALVQ QMEKFRQQLG SDSGDVESHL SFLEKNLREK VSSFMSTLQK 

       370        380        390 
KGSPDQPLAL PLPEQVQEQV QEQVQPKPLE S 

« Hide

References

« Hide 'large scale' references
[1]"Evolution of the apolipoproteins. Structure of the rat apo-A-IV gene and its relationship to the human genes for apo-A-I, C-III, and E."
Boguski M.S., Birkenmeier E.H., Elshourbagy N.A., Taylor J.M., Gordon J.I.
J. Biol. Chem. 261:6398-6407(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Rat apolipoprotein A-IV contains 13 tandem repetitions of a 22-amino acid segment with amphipathic helical potential."
Boguski M.S., Elshourbagy N.A., Taylor J.M., Gordon J.I.
Proc. Natl. Acad. Sci. U.S.A. 81:5021-5025(1984) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Linkage, evolution, and expression of the rat apolipoprotein A-I, C-III, and A-IV genes."
Haddad I.A., Ordovas J.M., Fitzpatrick T., Karathanasis S.K.
J. Biol. Chem. 261:13268-13277(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M00002 mRNA. Translation: AAA85909.1.
J02588 Genomic DNA. Translation: AAA40747.1.
M13508 Genomic DNA. Translation: AAA40748.1.
BC091159 mRNA. Translation: AAH91159.1.
PIRLPRTA4. A03095.
RefSeqNP_036869.1. NM_012737.1.
UniGeneRn.15739.

3D structure databases

ProteinModelPortalP02651.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000056172.

PTM databases

PhosphoSiteP02651.

Proteomic databases

PaxDbP02651.
PRIDEP02651.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID25080.
KEGGrno:25080.
UCSCRGD:2132. rat.

Organism-specific databases

CTD337.
RGD2132. Apoa4.

Phylogenomic databases

HOVERGENHBG105707.
KOK08760.
PhylomeDBP02651.

Gene expression databases

GenevestigatorP02651.

Family and domain databases

InterProIPR000074. ApoA1_A4_E.
[Graphical view]
PfamPF01442. Apolipoprotein. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio605330.
PROP02651.

Entry information

Entry nameAPOA4_RAT
AccessionPrimary (citable) accession number: P02651
Secondary accession number(s): Q5BK92
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 1989
Last modified: April 16, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families