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P02647

- APOA1_HUMAN

UniProt

P02647 - APOA1_HUMAN

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Protein

Apolipoprotein A-I

Gene
APOA1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.1 Publication

GO - Molecular functioni

  1. apolipoprotein A-I receptor binding Source: BHF-UCL
  2. apolipoprotein receptor binding Source: BHF-UCL
  3. beta-amyloid binding Source: BHF-UCL
  4. cholesterol binding Source: BHF-UCL
  5. cholesterol transporter activity Source: BHF-UCL
  6. enzyme binding Source: BHF-UCL
  7. high-density lipoprotein particle binding Source: Ensembl
  8. high-density lipoprotein particle receptor binding Source: BHF-UCL
  9. identical protein binding Source: IntAct
  10. lipase inhibitor activity Source: Ensembl
  11. phosphatidylcholine-sterol O-acyltransferase activator activity Source: BHF-UCL
  12. phospholipid binding Source: BHF-UCL
  13. phospholipid transporter activity Source: Ensembl
  14. protein binding Source: UniProtKB

GO - Biological processi

  1. adrenal gland development Source: Ensembl
  2. blood coagulation Source: Reactome
  3. blood vessel endothelial cell migration Source: Ensembl
  4. cellular lipid metabolic process Source: Reactome
  5. cholesterol biosynthetic process Source: Ensembl
  6. cholesterol efflux Source: BHF-UCL
  7. cholesterol homeostasis Source: BHF-UCL
  8. cholesterol import Source: BHF-UCL
  9. cholesterol metabolic process Source: BHF-UCL
  10. cholesterol transport Source: MGI
  11. endothelial cell proliferation Source: Ensembl
  12. glucocorticoid metabolic process Source: Ensembl
  13. G-protein coupled receptor signaling pathway Source: BHF-UCL
  14. high-density lipoprotein particle assembly Source: BHF-UCL
  15. high-density lipoprotein particle clearance Source: BHF-UCL
  16. high-density lipoprotein particle remodeling Source: BHF-UCL
  17. lipid storage Source: Ensembl
  18. lipoprotein biosynthetic process Source: Ensembl
  19. lipoprotein metabolic process Source: Reactome
  20. negative regulation of cell adhesion molecule production Source: BHF-UCL
  21. negative regulation of cytokine secretion involved in immune response Source: BHF-UCL
  22. negative regulation of heterotypic cell-cell adhesion Source: BHF-UCL
  23. negative regulation of inflammatory response Source: BHF-UCL
  24. negative regulation of interleukin-1 beta secretion Source: BHF-UCL
  25. negative regulation of lipase activity Source: Ensembl
  26. negative regulation of response to cytokine stimulus Source: BHF-UCL
  27. negative regulation of tumor necrosis factor-mediated signaling pathway Source: BHF-UCL
  28. negative regulation of very-low-density lipoprotein particle remodeling Source: BHF-UCL
  29. organ regeneration Source: Ensembl
  30. peptidyl-methionine modification Source: UniProtKB
  31. peripheral nervous system axon regeneration Source: Ensembl
  32. phosphatidylcholine biosynthetic process Source: BHF-UCL
  33. phospholipid efflux Source: BHF-UCL
  34. phospholipid homeostasis Source: BHF-UCL
  35. phototransduction, visible light Source: Reactome
  36. platelet activation Source: Reactome
  37. platelet degranulation Source: Reactome
  38. positive regulation of cholesterol esterification Source: BHF-UCL
  39. positive regulation of hydrolase activity Source: BHF-UCL
  40. positive regulation of transferase activity Source: Ensembl
  41. protein oxidation Source: UniProtKB
  42. protein stabilization Source: BHF-UCL
  43. regulation of Cdc42 protein signal transduction Source: BHF-UCL
  44. regulation of intestinal cholesterol absorption Source: Ensembl
  45. regulation of protein phosphorylation Source: Ensembl
  46. response to drug Source: Ensembl
  47. response to estrogen Source: Ensembl
  48. response to nutrient Source: Ensembl
  49. retinoid metabolic process Source: Reactome
  50. reverse cholesterol transport Source: BHF-UCL
  51. small molecule metabolic process Source: Reactome
  52. transmembrane transport Source: Reactome
  53. triglyceride homeostasis Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Cholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Enzyme and pathway databases

ReactomeiREACT_111158. ABCA transporters in lipid homeostasis.
REACT_116145. PPARA activates gene expression.
REACT_13621. HDL-mediated lipid transport.
REACT_160163. Scavenging of heme from plasma.
REACT_163679. Scavenging by Class B Receptors.
REACT_163699. Scavenging by Class A Receptors.
REACT_24968. Retinoid metabolism and transport.
REACT_6841. Chylomicron-mediated lipid transport.
REACT_75925. Amyloids.

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein A-I
Short name:
Apo-AI
Short name:
ApoA-I
Alternative name(s):
Apolipoprotein A1
Cleaved into the following 2 chains:
Proapolipoprotein A-I
Short name:
ProapoA-I
Alternative name(s):
Apolipoprotein A-I(1-242)
Gene namesi
Name:APOA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:600. APOA1.

Subcellular locationi

GO - Cellular componenti

  1. blood microparticle Source: UniProt
  2. cytoplasmic vesicle Source: BHF-UCL
  3. cytosol Source: Reactome
  4. early endosome Source: Reactome
  5. endocytic vesicle Source: BHF-UCL
  6. endocytic vesicle lumen Source: Reactome
  7. endoplasmic reticulum lumen Source: Reactome
  8. extracellular region Source: Reactome
  9. extracellular space Source: BHF-UCL
  10. extracellular vesicular exosome Source: UniProt
  11. high-density lipoprotein particle Source: BHF-UCL
  12. nucleus Source: Ensembl
  13. plasma membrane Source: Reactome
  14. secretory granule lumen Source: Reactome
  15. spherical high-density lipoprotein particle Source: BHF-UCL
  16. very-low-density lipoprotein particle Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Amyloid, HDL, Secreted

Pathology & Biotechi

Involvement in diseasei

High density lipoprotein deficiency 2 (HDLD2) [MIM:604091]: Inherited as autosomal dominant trait. It is characterized by moderately low HDL cholesterol, predilection toward premature coronary artery disease (CAD) and a reduction in cellular cholesterol efflux.
Note: The disease is caused by mutations affecting the gene represented in this entry.2 Publications
High density lipoprotein deficiency 1 (HDLD1) [MIM:205400]: Recessive disorder characterized by absence of high density lipoprotein (HDL) cholesterol from plasma, accumulation of cholesteryl esters, premature coronary artery disease (CAD), hepatosplenomegaly, recurrent peripheral neuropathy and progressive muscle wasting and weakness.
Note: The disease is caused by mutations affecting the gene represented in this entry.2 Publications
APOA1 mutations may be involved in the pathogenesis of amyloid polyneuropathy-nephropathy Iowa type, also known as amyloidosis van Allen type or familial amyloid polyneuropathy type III (1 Publication and 1 Publication). The clinical picture is dominated by neuropathy in the early stages of the disease and nephropathy late in the course. Death is due in most cases to renal amyloidosis.2 Publications
Amyloidosis 8 (AMYL8) [MIM:105200]: A hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash.
Note: The disease is caused by mutations affecting the gene represented in this entry.6 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti50 – 501G → R in AMYL8; also found in a family with amyloid polyneuropathy-nephropathy Iowa. 3 Publications
Corresponds to variant rs28931574 [ dbSNP | Ensembl ].
VAR_000609
Natural varianti84 – 841L → R in AMYL8. 1 Publication
VAR_000610

Keywords - Diseasei

Amyloidosis, Atherosclerosis, Disease mutation, Neuropathy

Organism-specific databases

MIMi105200. phenotype.
107680. gene+phenotype.
205400. phenotype.
604091. phenotype.
Orphaneti425. Apolipoprotein A-I deficiency.
93560. Familial renal amyloidosis due to Apolipoprotein AI variant.
314701. Primary systemic amyloidosis.
PharmGKBiPA49.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 18182 PublicationsAdd
BLAST
Chaini19 – 267249Proapolipoprotein A-IPRO_0000425323Add
BLAST
Chaini25 – 267243Apolipoprotein A-IPRO_0000001939Add
BLAST
Chaini25 – 266242Truncated apolipoprotein A-IPRO_0000001940Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei110 – 1101Methionine sulfoxide
Modified residuei136 – 1361Methionine sulfoxide
Glycosylationi263 – 2631N-linked (Glc) (glycation)1 Publication

Post-translational modificationi

Glycosylated By similarity.
Palmitoylated.1 Publication
Phosphorylation sites are present in the extracellular medium.

Keywords - PTMi

Glycation, Glycoprotein, Lipoprotein, Oxidation, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiP02647.
PaxDbiP02647.
PeptideAtlasiP02647.
PRIDEiP02647.

2D gel databases

DOSAC-COBS-2DPAGEP02647.
OGPiP02647.
REPRODUCTION-2DPAGEIPI00021841.
P02647.
SWISS-2DPAGEP02647.
UCD-2DPAGEP02647.

PTM databases

PhosphoSiteiP02647.

Miscellaneous databases

PMAP-CutDBP02647.

Expressioni

Tissue specificityi

Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease.1 Publication

Gene expression databases

ArrayExpressiP02647.
BgeeiP02647.
CleanExiHS_APOA1.
GenevestigatoriP02647.

Organism-specific databases

HPAiCAB016778.
HPA046715.

Interactioni

Subunit structurei

Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin. Interacts with NDRG1.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself12EBI-701692,EBI-701692
ABCA1O954774EBI-701692,EBI-784112
APPP050675EBI-701692,EBI-77613
HPP007383EBI-701692,EBI-1220767

Protein-protein interaction databases

BioGridi106832. 73 interactions.
DIPiDIP-29619N.
IntActiP02647. 62 interactions.
MINTiMINT-5000866.
STRINGi9606.ENSP00000236850.

Structurei

Secondary structure

1
267
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi33 – 4210
Helixi45 – 5915
Helixi61 – 655
Beta strandi69 – 735
Helixi80 – 889
Helixi93 – 15866
Turni159 – 1646
Helixi166 – 20338
Turni212 – 2143
Beta strandi215 – 2173
Helixi220 – 23718
Beta strandi238 – 2403
Helixi243 – 26624

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AV1X-ray4.00A/B/C/D68-267[»]
1GW3NMR-A166-211[»]
1GW4NMR-A166-211[»]
1ODPNMR-A190-209[»]
1ODQNMR-A190-209[»]
1ODRNMR-A190-209[»]
2A01X-ray2.40A/B/C25-267[»]
3J00electron microscopy-0/168-267[»]
3K2SX-ray-A/B25-267[»]
3R2PX-ray2.20A25-208[»]
DisProtiDP00386.
ProteinModelPortaliP02647.
SMRiP02647. Positions 26-267.

Miscellaneous databases

EvolutionaryTraceiP02647.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati68 – 89221Add
BLAST
Repeati90 – 111222Add
BLAST
Repeati112 – 122113; half-lengthAdd
BLAST
Repeati123 – 144224Add
BLAST
Repeati145 – 166225Add
BLAST
Repeati167 – 188226Add
BLAST
Repeati189 – 210227Add
BLAST
Repeati211 – 232228Add
BLAST
Repeati233 – 243119; half-lengthAdd
BLAST
Repeati244 – 2672410Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni68 – 26720010 X approximate tandem repeatsAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiNOG39720.
HOGENOMiHOG000033998.
HOVERGENiHBG105708.
InParanoidiP02647.
KOiK08757.
OMAiYRQKVAP.
OrthoDBiEOG7TBC3N.
PhylomeDBiP02647.
TreeFamiTF334458.

Family and domain databases

InterProiIPR000074. ApoA1_A4_E.
[Graphical view]
PfamiPF01442. Apolipoprotein. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02647-1 [UniParc]FASTAAdd to Basket

« Hide

MKAAVLTLAV LFLTGSQARH FWQQDEPPQS PWDRVKDLAT VYVDVLKDSG    50
RDYVSQFEGS ALGKQLNLKL LDNWDSVTST FSKLREQLGP VTQEFWDNLE 100
KETEGLRQEM SKDLEEVKAK VQPYLDDFQK KWQEEMELYR QKVEPLRAEL 150
QEGARQKLHE LQEKLSPLGE EMRDRARAHV DALRTHLAPY SDELRQRLAA 200
RLEALKENGG ARLAEYHAKA TEHLSTLSEK AKPALEDLRQ GLLPVLESFK 250
VSFLSALEEY TKKLNTQ 267
Length:267
Mass (Da):30,778
Last modified:July 21, 1986 - v1
Checksum:i1A28B8366E620310
GO

Mass spectrometryi

Molecular mass is 28081 Da from positions 25 - 267. Determined by ESI. Without methionine sulfoxide.1 Publication
Molecular mass is 28098 Da from positions 25 - 267. Determined by ESI. With 1 methionine sulfoxide, oxidation at Met-110.1 Publication
Molecular mass is 28095 Da from positions 25 - 267. Determined by ESI. With 1 methionine sulfoxide, oxidation at Met-136.1 Publication
Molecular mass is 28114 Da from positions 25 - 267. Determined by ESI. With 2 methionine sulfoxides, oxidation at Met-110 and Met-136.1 Publication

Polymorphismi

Genetic variations in APOA1 can result in APOA1 deficiency and are associated with low levels of HDL cholesterol [MIMi:107680].

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti27 – 271P → H in Munster-3C.
Corresponds to variant rs121912720 [ dbSNP | Ensembl ].
VAR_000605
Natural varianti27 – 271P → R.1 Publication
Corresponds to variant rs121912720 [ dbSNP | Ensembl ].
VAR_000606
Natural varianti28 – 281P → R in Munster-3B. 1 Publication
VAR_000607
Natural varianti34 – 341R → L in Baltimore. 1 Publication
Corresponds to variant rs28929476 [ dbSNP | Ensembl ].
VAR_000608
Natural varianti50 – 501G → R in AMYL8; also found in a family with amyloid polyneuropathy-nephropathy Iowa. 3 Publications
Corresponds to variant rs28931574 [ dbSNP | Ensembl ].
VAR_000609
Natural varianti61 – 611A → T.1 Publication
Corresponds to variant rs12718465 [ dbSNP | Ensembl ].
VAR_025445
Natural varianti84 – 841L → R in AMYL8. 1 Publication
VAR_000610
Natural varianti92 – 921T → I Polymorphism confirmed at protein level. 2 Publications
VAR_017017
Natural varianti113 – 1131D → E.1 Publication
VAR_000611
Natural varianti119 – 1191A → D in Hita.
VAR_000612
Natural varianti126 – 1261D → H.
Corresponds to variant rs5077 [ dbSNP | Ensembl ].
VAR_016189
Natural varianti127 – 1271D → N in Munster-3A.
VAR_000613
Natural varianti131 – 1311K → M.1 Publication
Corresponds to variant rs4882 [ dbSNP | Ensembl ].
VAR_000615
Natural varianti131 – 1311Missing in Marburg/Munster-2.
VAR_000614
Natural varianti132 – 1321W → R in Tsushima.
VAR_000616
Natural varianti134 – 1341E → K in Fukuoka. 1 Publication
VAR_000617
Natural varianti160 – 1601E → K in Norway. 1 Publication
VAR_000618
Natural varianti163 – 1631E → G.1 Publication
VAR_000619
Natural varianti167 – 1671P → R in Giessen. 1 Publication
VAR_000620
Natural varianti168 – 1681L → R in Zaragoza. 1 Publication
VAR_000621
Natural varianti171 – 1711E → V.1 Publication
VAR_000622
Natural varianti180 – 1801V → E in Oita; 60% of normal apoA-I and normal HDL cholesterol levels. Rapidly cleared from plasma. 1 Publication
VAR_021362
Natural varianti184 – 1841R → P.
Corresponds to variant rs5078 [ dbSNP | Ensembl ].
VAR_014609
Natural varianti189 – 1891P → R.1 Publication
VAR_000623
Natural varianti197 – 1971R → C in Milano; associated with decreased HDL levels and moderate increases in triglycerides; no evidence of association with premature vascular disease. 1 Publication
Corresponds to variant rs28931573 [ dbSNP | Ensembl ].
VAR_000624
Natural varianti222 – 2221E → K in Munster-4. 1 Publication
VAR_000625

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti32 – 321W → P AA sequence 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J00098 Genomic DNA. Translation: AAB59514.1.
X01038 Genomic DNA. Translation: CAA25519.1.
X02162 mRNA. Translation: CAA26097.1.
X00566 mRNA. Translation: CAA25232.1.
M11791 mRNA. Translation: AAA35545.1.
X07496 Genomic DNA. Translation: CAA30377.1.
M27875 mRNA. Translation: AAA62829.1.
M29068 mRNA. Translation: AAA51747.1.
AY422952 Genomic DNA. Translation: AAQ91811.1.
AY555191 Genomic DNA. Translation: AAS68227.1.
A14829 mRNA. Translation: CAA01198.1.
AK292231 mRNA. Translation: BAF84920.1.
EF444948 Genomic DNA. Translation: ACA05932.1.
EF444948 Genomic DNA. Translation: ACA05933.1.
EF444948 Genomic DNA. Translation: ACA05934.1.
EF444948 Genomic DNA. Translation: ACA05935.1.
EF444948 Genomic DNA. Translation: ACA05936.1.
CH471065 Genomic DNA. Translation: EAW67274.1.
BC005380 mRNA. Translation: AAH05380.1.
BC110286 mRNA. Translation: AAI10287.1.
CCDSiCCDS8378.1.
PIRiA90947. LPHUA1.
RefSeqiNP_000030.1. NM_000039.1.
XP_005271596.1. XM_005271539.1.
XP_005271597.1. XM_005271540.1.
UniGeneiHs.93194.

Genome annotation databases

EnsembliENST00000236850; ENSP00000236850; ENSG00000118137.
ENST00000359492; ENSP00000352471; ENSG00000118137.
ENST00000375320; ENSP00000364469; ENSG00000118137.
ENST00000375323; ENSP00000364472; ENSG00000118137.
GeneIDi335.
KEGGihsa:335.
UCSCiuc001ppv.1. human.

Polymorphism databases

DMDMi113992.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J00098 Genomic DNA. Translation: AAB59514.1 .
X01038 Genomic DNA. Translation: CAA25519.1 .
X02162 mRNA. Translation: CAA26097.1 .
X00566 mRNA. Translation: CAA25232.1 .
M11791 mRNA. Translation: AAA35545.1 .
X07496 Genomic DNA. Translation: CAA30377.1 .
M27875 mRNA. Translation: AAA62829.1 .
M29068 mRNA. Translation: AAA51747.1 .
AY422952 Genomic DNA. Translation: AAQ91811.1 .
AY555191 Genomic DNA. Translation: AAS68227.1 .
A14829 mRNA. Translation: CAA01198.1 .
AK292231 mRNA. Translation: BAF84920.1 .
EF444948 Genomic DNA. Translation: ACA05932.1 .
EF444948 Genomic DNA. Translation: ACA05933.1 .
EF444948 Genomic DNA. Translation: ACA05934.1 .
EF444948 Genomic DNA. Translation: ACA05935.1 .
EF444948 Genomic DNA. Translation: ACA05936.1 .
CH471065 Genomic DNA. Translation: EAW67274.1 .
BC005380 mRNA. Translation: AAH05380.1 .
BC110286 mRNA. Translation: AAI10287.1 .
CCDSi CCDS8378.1.
PIRi A90947. LPHUA1.
RefSeqi NP_000030.1. NM_000039.1.
XP_005271596.1. XM_005271539.1.
XP_005271597.1. XM_005271540.1.
UniGenei Hs.93194.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1AV1 X-ray 4.00 A/B/C/D 68-267 [» ]
1GW3 NMR - A 166-211 [» ]
1GW4 NMR - A 166-211 [» ]
1ODP NMR - A 190-209 [» ]
1ODQ NMR - A 190-209 [» ]
1ODR NMR - A 190-209 [» ]
2A01 X-ray 2.40 A/B/C 25-267 [» ]
3J00 electron microscopy - 0/1 68-267 [» ]
3K2S X-ray - A/B 25-267 [» ]
3R2P X-ray 2.20 A 25-208 [» ]
DisProti DP00386.
ProteinModelPortali P02647.
SMRi P02647. Positions 26-267.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106832. 73 interactions.
DIPi DIP-29619N.
IntActi P02647. 62 interactions.
MINTi MINT-5000866.
STRINGi 9606.ENSP00000236850.

Chemistry

ChEMBLi CHEMBL5984.

PTM databases

PhosphoSitei P02647.

Polymorphism databases

DMDMi 113992.

2D gel databases

DOSAC-COBS-2DPAGE P02647.
OGPi P02647.
REPRODUCTION-2DPAGE IPI00021841.
P02647.
SWISS-2DPAGE P02647.
UCD-2DPAGE P02647.

Proteomic databases

MaxQBi P02647.
PaxDbi P02647.
PeptideAtlasi P02647.
PRIDEi P02647.

Protocols and materials databases

DNASUi 335.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000236850 ; ENSP00000236850 ; ENSG00000118137 .
ENST00000359492 ; ENSP00000352471 ; ENSG00000118137 .
ENST00000375320 ; ENSP00000364469 ; ENSG00000118137 .
ENST00000375323 ; ENSP00000364472 ; ENSG00000118137 .
GeneIDi 335.
KEGGi hsa:335.
UCSCi uc001ppv.1. human.

Organism-specific databases

CTDi 335.
GeneCardsi GC11M116706.
HGNCi HGNC:600. APOA1.
HPAi CAB016778.
HPA046715.
MIMi 105200. phenotype.
107680. gene+phenotype.
205400. phenotype.
604091. phenotype.
neXtProti NX_P02647.
Orphaneti 425. Apolipoprotein A-I deficiency.
93560. Familial renal amyloidosis due to Apolipoprotein AI variant.
314701. Primary systemic amyloidosis.
PharmGKBi PA49.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG39720.
HOGENOMi HOG000033998.
HOVERGENi HBG105708.
InParanoidi P02647.
KOi K08757.
OMAi YRQKVAP.
OrthoDBi EOG7TBC3N.
PhylomeDBi P02647.
TreeFami TF334458.

Enzyme and pathway databases

Reactomei REACT_111158. ABCA transporters in lipid homeostasis.
REACT_116145. PPARA activates gene expression.
REACT_13621. HDL-mediated lipid transport.
REACT_160163. Scavenging of heme from plasma.
REACT_163679. Scavenging by Class B Receptors.
REACT_163699. Scavenging by Class A Receptors.
REACT_24968. Retinoid metabolism and transport.
REACT_6841. Chylomicron-mediated lipid transport.
REACT_75925. Amyloids.

Miscellaneous databases

ChiTaRSi APOA1. human.
EvolutionaryTracei P02647.
GeneWikii Apolipoprotein_A1.
GenomeRNAii 335.
NextBioi 1387.
PMAP-CutDB P02647.
PROi P02647.
SOURCEi Search...

Gene expression databases

ArrayExpressi P02647.
Bgeei P02647.
CleanExi HS_APOA1.
Genevestigatori P02647.

Family and domain databases

InterProi IPR000074. ApoA1_A4_E.
[Graphical view ]
Pfami PF01442. Apolipoprotein. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Nucleotide sequence of cloned cDNA of human apolipoprotein A-I."
    Cheung P., Chan L.
    Nucleic Acids Res. 11:3703-3715(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Isolation and characterization of the human apolipoprotein A-I gene."
    Karathanasis S.K., Zannis V.I., Breslow J.L.
    Proc. Natl. Acad. Sci. U.S.A. 80:6147-6151(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Isolation and DNA sequence of full-length cDNA and of the entire gene for human apolipoprotein AI -- discovery of a new genetic polymorphism in the apo AI gene."
    Seilhamer J.J., Protter A.A., Frossard P., Levy-Wilson B.
    DNA 3:309-317(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance."
    Sharpe C.R., Sidoli A., Shelley C.S., Lucero M.A., Shoulders C.C., Baralle F.E.
    Nucleic Acids Res. 12:3917-3932(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. "Nucleotide sequence and the encoded amino acids of human apolipoprotein A-I mRNA."
    Law S.W., Brewer H.B. Jr.
    Proc. Natl. Acad. Sci. U.S.A. 81:66-70(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  7. "Tangier disease. The complete mRNA sequence encoding for preproapo-A-I."
    Law S.W., Brewer H.B. Jr.
    J. Biol. Chem. 260:12810-12814(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  8. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (VARIANT TANGIER).
  9. "Production of human recombinant proapolipoprotein A-I in Escherichia coli: purification and biochemical characterization."
    Moguilevsky N., Roobol C., Loriau R., Guillaume J.P., Jacobs P., Cravador A., Herzog A., Brouwers L., Scarso A., Gilles P., Holmquist L., Carlson L.A., Bollen A.
    DNA 8:429-436(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  10. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-61.
  11. "Expression of human proapolipoprotein A-1."
    Bollen A., Gobert J., Wuelfert E.
    Patent number EP0293357, 30-NOV-1988
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  12. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  13. NHLBI resequencing and genotyping service (RS&G)
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  14. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  15. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Skeletal muscle.
  16. Cited for: PROTEIN SEQUENCE OF 19-27.
  17. "The primary structure of human plasma high density apolipoprotein glutamine I (ApoA-I). II. The amino acid sequence and alignment of cyanogen bromide fragments IV, III, and I."
    Baker H.N., Gotto A.M. Jr., Jackson R.L.
    J. Biol. Chem. 250:2725-2738(1975) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-267.
  18. "The amino acid sequence of human APOA-I, an apolipoprotein isolated from high density lipoproteins."
    Brewer H.B. Jr., Fairwell T., Larue A., Ronan R., Houser A., Bronzert T.J.
    Biochem. Biophys. Res. Commun. 80:623-630(1978) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-267.
  19. "Serum prostacyclin stabilizing factor is identical to apolipoprotein A-I (Apo A-I). A novel function of Apo A-I."
    Yui Y., Aoyama T., Morishita H., Takahashi M., Takatsu Y., Kawai C.
    J. Clin. Invest. 82:803-807(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-56.
  20. "Identification of apolipoprotein A1 and immunoglobulin as components of a serum complex that mediates activation of human sperm motility."
    Aakerloef E., Joernvall H., Slotte H., Pousette A.
    Biochemistry 30:8986-8990(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-50, FUNCTION, IDENTIFICATION IN THE SPAP COMPLEX.
    Tissue: Serum.
  21. "Apolipoprotein A-I binds to a family of bovine seminal plasma proteins."
    Manjunath P., Marcel Y.L., Uma J., Seidah N.G., Chretien M., Chapdelaine A.
    J. Biol. Chem. 264:16853-16857(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-48.
  22. "Similarity of cruzin, an inhibitor of Trypanosoma cruzi neuraminidase, to high-density lipoprotein."
    Prioli R.P., Ordovas J.M., Rosenberg I., Schaeffer E.J., Pereira M.E.A.
    Science 238:1417-1419(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-43.
  23. "The human myocardial two-dimensional gel protein database: update 1994."
    Corbett J.M., Wheeler C.H., Baker C.S., Yacoub M.H., Dunn M.J.
    Electrophoresis 15:1459-1465(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-42.
    Tissue: Heart.
  24. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
    Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
    Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-34.
    Tissue: Platelet.
  25. "The apolipoprotein A-I binding protein of placenta and the SP-40,40 protein of human blood are different proteins which both bind to apolipoprotein A-I."
    Ehnholm C., Bozas S.E., Tenkanen H., Kirszbaum L., Metso J., Murphy B., Walker I.D.
    Biochim. Biophys. Acta 1086:255-260(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-33, INTERACTION WITH APOA1BP AND CLU.
  26. Lubec G., Vishwanath V., Chen W.-Q., Sun Y.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 35-64; 70-101; 121-140; 165-173; 185-195 AND 240-263, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Brain, Cajal-Retzius cell and Fetal brain cortex.
  27. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 118-267.
  28. "Human apolipoprotein A-I. Post-translational modification by fatty acid acylation."
    Hoeg J.M., Meng M.S., Ronan R., Fairwell T., Brewer H.B. Jr.
    J. Biol. Chem. 261:3911-3914(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PALMITOYLATION.
  29. "Intracellular and extracellular processing of human apolipoprotein A-I: secreted apolipoprotein A-I isoprotein 2 is a propeptide."
    Zannis V.I., Karathanasis S.K., Keutmann H.T., Goldberger G., Breslow J.L.
    Proc. Natl. Acad. Sci. U.S.A. 80:2574-2578(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEOLYTIC PROCESSING.
  30. "The preferential site of non-enzymatic glycation of human apolipoprotein A-I in vivo."
    Calvo C., Ulloa N., Campos M., Verdugo C., Ayrault-Jarrier M.
    Clin. Chim. Acta 217:193-198(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCATION AT LYS-263.
  31. "Cloning and characterization of a novel apolipoprotein A-I-binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I."
    Ritter M., Buechler C., Boettcher A., Barlage S., Schmitz-Madry A., Orso E., Bared S.M., Schmiedeknecht G., Baehr C.H., Fricker G., Schmitz G.
    Genomics 79:693-702(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH APOA1BP.
  32. "Characterization of specifically oxidized apolipoproteins in mildly oxidized high density lipoprotein."
    Pankhurst G., Wang X.L., Wilcken D.E., Baernthaler G., Panzenboeck U., Raftery M., Stocker R.
    J. Lipid Res. 44:349-355(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: MASS SPECTROMETRY, OXIDATION AT MET-110 AND MET-136 TO METHIONINE SULFOXIDES, TISSUE SPECIFICITY.
  33. "Novel mass spectrometric immunoassays for the rapid structural characterization of plasma apolipoproteins."
    Niederkofler E.E., Tubbs K.A., Kiernan U.A., Nedelkov D., Nelson R.W.
    J. Lipid Res. 44:630-639(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
  34. "NDRG1 interacts with APO A-I and A-II and is a functional candidate for the HDL-C QTL on 8q24."
    Hunter M., Angelicheva D., Tournev I., Ingley E., Chan D.C., Watts G.F., Kremensky I., Kalaydjieva L.
    Biochem. Biophys. Res. Commun. 332:982-992(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NDRG1.
  35. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  36. "Conformation of human serum apolipoprotein A-I(166-185) in the presence of sodium dodecyl sulfate or dodecylphosphocholine by 1H-NMR and CD. Evidence for specific peptide-SDS interactions."
    Wang G., Treleaven W.D., Cushley R.J.
    Biochim. Biophys. Acta 1301:174-184(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 190-209.
  37. "Crystal structure of truncated human apolipoprotein A-I suggests a lipid-bound conformation."
    Borhani D.W., Rogers D.P., Engler J.A., Brouillette C.G.
    Proc. Natl. Acad. Sci. U.S.A. 94:12291-12296(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 67-267.
  38. "Autosomal dominant hypoalphalipoproteinemia due to a completely defective apolipoprotein A-I gene."
    Nakata K., Kobayashi K., Yanagi H., Shimakura Y., Tsuchiya S., Arinami T., Hamaguchi H.
    Biochem. Biophys. Res. Commun. 196:950-955(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISEASE.
  39. "Apolipoprotein A-I Q[-2]X causing isolated apolipoprotein A-I deficiency in a family with analphalipoproteinemia."
    Ng D.S., Leiter L.A., Vezina C., Connelly P.W., Hegele R.A.
    J. Clin. Invest. 93:223-229(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISEASE.
  40. "Apolipoprotein A-IMilano. Detection of normal A-I in affected subjects and evidence for a cysteine for arginine substitution in the variant A-I."
    Weisgraber K.H., Rall S.C. Jr., Bersot T.P., Mahley R.W., Franceschini G., Sirtori C.R.
    J. Biol. Chem. 258:2508-2513(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT MILANO CYS-197.
  41. "Tangier disease: defective recombination of a specific Tangier apolipoprotein A-I isoform (pro-apo A-I) with high density lipoproteins."
    Schmitz G., Assmann G., Rall S.C. Jr., Mahley R.W.
    Proc. Natl. Acad. Sci. U.S.A. 80:6081-6085(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT TANGIER.
  42. "Apolipoprotein A-IGiessen (Pro143-->Arg). A mutant that is defective in activating lecithin:cholesterol acyltransferase."
    Utermann G., Haas J., Steinmetz A., Paetzold R., Rall S.C. Jr., Weisgraber K.H., Mahley R.W.
    Eur. J. Biochem. 144:325-331(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GIESSEN ARG-167.
  43. "Abnormal lecithin:cholesterol acyltransferase activation by a human apolipoprotein A-I variant in which a single lysine residue is deleted."
    Rall S.C. Jr., Weisgraber K.H., Mahley R.W., Ogawa Y., Fielding C.J., Utermann G., Haas J., Steinmetz A., Menzel H.J., Assmann G.
    J. Biol. Chem. 259:10063-10070(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT NORWAY LYS-160.
  44. "Variant apolipoprotein AI as a major constituent of a human hereditary amyloid."
    Nichols W.C., Dwulet F.E., Liepnieks J., Benson M.D.
    Biochem. Biophys. Res. Commun. 156:762-768(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-107, VARIANT AMYL8 ARG-50.
  45. "A mutation in apolipoprotein A-I in the Iowa type of familial amyloidotic polyneuropathy."
    Nichols W.C., Gregg R.E., Brewer H.B. Jr., Benson M.D.
    Genomics 8:318-323(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT AMYL8 ARG-50.
  46. "Isolation and characterization of human apolipoprotein A-I Fukuoka (110 Glu-->Lys). A novel apolipoprotein variant."
    Takada Y., Sasaki J., Ogata S., Nakanishi T., Ikehara Y., Arakawa K.
    Biochim. Biophys. Acta 1043:169-176(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-267, VARIANT FUKUOKA LYS-134.
  47. Cited for: PROTEIN SEQUENCE OF 25-112, VARIANT AMYL8 ARG-84.
  48. Cited for: VARIANT BALTIMORE LEU-34.
  49. "Apolipoprotein A-I variants. Naturally occurring substitutions of proline residues affect plasma concentration of apolipoprotein A-I."
    von Eckardstein A., Funke H., Henke A., Altland K., Benninghoven A., Assmann G., Welp S., Roetrige A., Kock R.
    J. Clin. Invest. 84:1722-1730(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS ARG-27; ARG-28 AND ARG-189.
  50. "Structural analysis of human apolipoprotein A-I variants. Amino acid substitutions are nonrandomly distributed throughout the apolipoprotein A-I primary structure."
    von Eckardstein A., Funke H., Walter M., Altland K., Benninghoven A., Assmann G.
    J. Biol. Chem. 265:8610-8617(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS GLU-113; MET-131; GLY-163; VAL-171 AND LYS-222.
  51. "Characterization of two new human apolipoprotein A-I variants: apolipoprotein A-I Tsushima (Trp-108-->Arg) and A-I Hita (Ala-95-->Asp)."
    Araki K., Sasaki J., Matsunaga A., Takada Y., Moriyama K., Hidaka K., Arakawa K.
    Biochim. Biophys. Acta 1214:272-278(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS HITA AND TSUSHIMA.
  52. "Familial nephropathic systemic amyloidosis caused by apolipoprotein AI variant Arg26."
    Vigushin D.M., Gough J., Allan D., Alguacil A., Penner B., Pettigrew N.M., Quinonez G., Bernstein K., Booth S.E., Booth D.R., Soutar A.K., Hawkins P.N., Pepys M.B.
    Q. J. Med. 87:149-154(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT AMYL8 ARG-50.
  53. Cited for: VARIANT AOITA GLU-180.
  54. "Apo A-I Zaragoza(L144R): a novel mutation in the apolipoprotein A-I gene associated with familial hypoalphalipoproteinemia."
    Recalde D., Cenarro A., Civeira F., Pocovi M.
    Hum. Mutat. 11:416-416(1998)
    Cited for: VARIANT ZARAGOZA ARG-168.
  55. "Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors."
    Morabia A., Cayanis E., Costanza M.C., Ross B.M., Flaherty M.S., Alvin G.B., Das K., Gilliam T.C.
    Hum. Mol. Genet. 12:2733-2743(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ILE-92.
  56. "Quantitative detection of single amino acid polymorphisms by targeted proteomics."
    Su Z.D., Sun L., Yu D.X., Li R.X., Li H.X., Yu Z.J., Sheng Q.H., Lin X., Zeng R., Wu J.R.
    J. Mol. Cell Biol. 3:309-315(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ILE-92, IDENTIFICATION BY MASS SPECTROMETRY.

Entry informationi

Entry nameiAPOA1_HUMAN
AccessioniPrimary (citable) accession number: P02647
Secondary accession number(s): A8K866
, Q6LDN9, Q6Q785, Q9UCS8, Q9UCT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: September 3, 2014
This is version 195 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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