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P02647

- APOA1_HUMAN

UniProt

P02647 - APOA1_HUMAN

Protein

Apolipoprotein A-I

Gene

APOA1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 196 (01 Oct 2014)
      Sequence version 1 (21 Jul 1986)
      Previous versions | rss
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    Functioni

    Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.1 Publication

    GO - Molecular functioni

    1. apolipoprotein A-I receptor binding Source: BHF-UCL
    2. apolipoprotein receptor binding Source: BHF-UCL
    3. beta-amyloid binding Source: BHF-UCL
    4. cholesterol binding Source: BHF-UCL
    5. cholesterol transporter activity Source: BHF-UCL
    6. enzyme binding Source: BHF-UCL
    7. high-density lipoprotein particle binding Source: Ensembl
    8. high-density lipoprotein particle receptor binding Source: BHF-UCL
    9. identical protein binding Source: IntAct
    10. lipase inhibitor activity Source: Ensembl
    11. phosphatidylcholine-sterol O-acyltransferase activator activity Source: BHF-UCL
    12. phospholipid binding Source: BHF-UCL
    13. phospholipid transporter activity Source: Ensembl
    14. protein binding Source: UniProtKB

    GO - Biological processi

    1. adrenal gland development Source: Ensembl
    2. blood coagulation Source: Reactome
    3. blood vessel endothelial cell migration Source: Ensembl
    4. cellular lipid metabolic process Source: Reactome
    5. cholesterol biosynthetic process Source: Ensembl
    6. cholesterol efflux Source: BHF-UCL
    7. cholesterol homeostasis Source: BHF-UCL
    8. cholesterol import Source: BHF-UCL
    9. cholesterol metabolic process Source: BHF-UCL
    10. cholesterol transport Source: MGI
    11. endothelial cell proliferation Source: Ensembl
    12. glucocorticoid metabolic process Source: Ensembl
    13. G-protein coupled receptor signaling pathway Source: BHF-UCL
    14. high-density lipoprotein particle assembly Source: BHF-UCL
    15. high-density lipoprotein particle clearance Source: BHF-UCL
    16. high-density lipoprotein particle remodeling Source: BHF-UCL
    17. lipid storage Source: Ensembl
    18. lipoprotein biosynthetic process Source: Ensembl
    19. lipoprotein metabolic process Source: Reactome
    20. negative regulation of cell adhesion molecule production Source: BHF-UCL
    21. negative regulation of cytokine secretion involved in immune response Source: BHF-UCL
    22. negative regulation of heterotypic cell-cell adhesion Source: BHF-UCL
    23. negative regulation of inflammatory response Source: BHF-UCL
    24. negative regulation of interleukin-1 beta secretion Source: BHF-UCL
    25. negative regulation of lipase activity Source: Ensembl
    26. negative regulation of response to cytokine stimulus Source: BHF-UCL
    27. negative regulation of tumor necrosis factor-mediated signaling pathway Source: BHF-UCL
    28. negative regulation of very-low-density lipoprotein particle remodeling Source: BHF-UCL
    29. organ regeneration Source: Ensembl
    30. peptidyl-methionine modification Source: UniProtKB
    31. peripheral nervous system axon regeneration Source: Ensembl
    32. phosphatidylcholine biosynthetic process Source: BHF-UCL
    33. phospholipid efflux Source: BHF-UCL
    34. phospholipid homeostasis Source: BHF-UCL
    35. phototransduction, visible light Source: Reactome
    36. platelet activation Source: Reactome
    37. platelet degranulation Source: Reactome
    38. positive regulation of cholesterol esterification Source: BHF-UCL
    39. positive regulation of hydrolase activity Source: BHF-UCL
    40. positive regulation of transferase activity Source: Ensembl
    41. protein oxidation Source: UniProtKB
    42. protein stabilization Source: BHF-UCL
    43. regulation of Cdc42 protein signal transduction Source: BHF-UCL
    44. regulation of intestinal cholesterol absorption Source: Ensembl
    45. regulation of protein phosphorylation Source: Ensembl
    46. response to drug Source: Ensembl
    47. response to estrogen Source: Ensembl
    48. response to nutrient Source: Ensembl
    49. retinoid metabolic process Source: Reactome
    50. reverse cholesterol transport Source: BHF-UCL
    51. small molecule metabolic process Source: Reactome
    52. transmembrane transport Source: Reactome
    53. triglyceride homeostasis Source: BHF-UCL

    Keywords - Biological processi

    Cholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

    Enzyme and pathway databases

    ReactomeiREACT_111158. ABCA transporters in lipid homeostasis.
    REACT_116145. PPARA activates gene expression.
    REACT_13621. HDL-mediated lipid transport.
    REACT_160163. Scavenging of heme from plasma.
    REACT_163679. Scavenging by Class B Receptors.
    REACT_163699. Scavenging by Class A Receptors.
    REACT_24968. Retinoid metabolism and transport.
    REACT_6841. Chylomicron-mediated lipid transport.
    REACT_75925. Amyloids.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Apolipoprotein A-I
    Short name:
    Apo-AI
    Short name:
    ApoA-I
    Alternative name(s):
    Apolipoprotein A1
    Cleaved into the following 2 chains:
    Proapolipoprotein A-I
    Short name:
    ProapoA-I
    Alternative name(s):
    Apolipoprotein A-I(1-242)
    Gene namesi
    Name:APOA1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:600. APOA1.

    Subcellular locationi

    GO - Cellular componenti

    1. blood microparticle Source: UniProt
    2. cytoplasmic vesicle Source: BHF-UCL
    3. cytosol Source: Reactome
    4. early endosome Source: Reactome
    5. endocytic vesicle Source: BHF-UCL
    6. endocytic vesicle lumen Source: Reactome
    7. endoplasmic reticulum lumen Source: Reactome
    8. extracellular region Source: Reactome
    9. extracellular space Source: BHF-UCL
    10. extracellular vesicular exosome Source: UniProt
    11. high-density lipoprotein particle Source: BHF-UCL
    12. nucleus Source: Ensembl
    13. plasma membrane Source: Reactome
    14. secretory granule lumen Source: Reactome
    15. spherical high-density lipoprotein particle Source: BHF-UCL
    16. very-low-density lipoprotein particle Source: BHF-UCL

    Keywords - Cellular componenti

    Amyloid, HDL, Secreted

    Pathology & Biotechi

    Involvement in diseasei

    High density lipoprotein deficiency 2 (HDLD2) [MIM:604091]: Inherited as autosomal dominant trait. It is characterized by moderately low HDL cholesterol, predilection toward premature coronary artery disease (CAD) and a reduction in cellular cholesterol efflux.
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    High density lipoprotein deficiency 1 (HDLD1) [MIM:205400]: Recessive disorder characterized by absence of high density lipoprotein (HDL) cholesterol from plasma, accumulation of cholesteryl esters, premature coronary artery disease (CAD), hepatosplenomegaly, recurrent peripheral neuropathy and progressive muscle wasting and weakness.
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    APOA1 mutations may be involved in the pathogenesis of amyloid polyneuropathy-nephropathy Iowa type, also known as amyloidosis van Allen type or familial amyloid polyneuropathy type III (PubMed:3142462 and PubMed:2123470). The clinical picture is dominated by neuropathy in the early stages of the disease and nephropathy late in the course. Death is due in most cases to renal amyloidosis.
    Amyloidosis 8 (AMYL8) [MIM:105200]: A hereditary generalized amyloidosis due to deposition of apolipoprotein A1, fibrinogen and lysozyme amyloids. Viscera are particularly affected. There is no involvement of the nervous system. Clinical features include renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash.4 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti50 – 501G → R in AMYL8; also found in a family with amyloid polyneuropathy-nephropathy Iowa. 3 Publications
    Corresponds to variant rs28931574 [ dbSNP | Ensembl ].
    VAR_000609
    Natural varianti84 – 841L → R in AMYL8. 1 Publication
    VAR_000610

    Keywords - Diseasei

    Amyloidosis, Atherosclerosis, Disease mutation, Neuropathy

    Organism-specific databases

    MIMi105200. phenotype.
    107680. gene+phenotype.
    205400. phenotype.
    604091. phenotype.
    Orphaneti425. Apolipoprotein A-I deficiency.
    93560. Familial renal amyloidosis due to Apolipoprotein AI variant.
    314701. Primary systemic amyloidosis.
    PharmGKBiPA49.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 18182 PublicationsAdd
    BLAST
    Chaini19 – 267249Proapolipoprotein A-IPRO_0000425323Add
    BLAST
    Chaini25 – 267243Apolipoprotein A-IPRO_0000001939Add
    BLAST
    Chaini25 – 266242Truncated apolipoprotein A-IPRO_0000001940Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei110 – 1101Methionine sulfoxide1 Publication
    Modified residuei136 – 1361Methionine sulfoxide1 Publication
    Glycosylationi263 – 2631N-linked (Glc) (glycation)

    Post-translational modificationi

    Glycosylated.By similarity
    Palmitoylated.1 Publication
    Phosphorylation sites are present in the extracellular medium.

    Keywords - PTMi

    Glycation, Glycoprotein, Lipoprotein, Oxidation, Palmitate, Phosphoprotein

    Proteomic databases

    MaxQBiP02647.
    PaxDbiP02647.
    PeptideAtlasiP02647.
    PRIDEiP02647.

    2D gel databases

    DOSAC-COBS-2DPAGEP02647.
    OGPiP02647.
    REPRODUCTION-2DPAGEIPI00021841.
    P02647.
    SWISS-2DPAGEP02647.
    UCD-2DPAGEP02647.

    PTM databases

    PhosphoSiteiP02647.

    Miscellaneous databases

    PMAP-CutDBP02647.

    Expressioni

    Tissue specificityi

    Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease.1 Publication

    Gene expression databases

    ArrayExpressiP02647.
    BgeeiP02647.
    CleanExiHS_APOA1.
    GenevestigatoriP02647.

    Organism-specific databases

    HPAiCAB016778.
    HPA046715.

    Interactioni

    Subunit structurei

    Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin. Interacts with NDRG1.4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself12EBI-701692,EBI-701692
    ABCA1O954774EBI-701692,EBI-784112
    APPP050675EBI-701692,EBI-77613
    FGAP026712EBI-701692,EBI-348571
    HPP007383EBI-701692,EBI-1220767

    Protein-protein interaction databases

    BioGridi106832. 73 interactions.
    DIPiDIP-29619N.
    IntActiP02647. 65 interactions.
    MINTiMINT-5000866.
    STRINGi9606.ENSP00000236850.

    Structurei

    Secondary structure

    1
    267
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi33 – 4210
    Helixi45 – 5915
    Helixi61 – 655
    Beta strandi69 – 735
    Helixi80 – 889
    Helixi93 – 15866
    Turni159 – 1646
    Helixi166 – 20338
    Turni212 – 2143
    Beta strandi215 – 2173
    Helixi220 – 23718
    Beta strandi238 – 2403
    Helixi243 – 26624

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1AV1X-ray4.00A/B/C/D68-267[»]
    1GW3NMR-A166-211[»]
    1GW4NMR-A166-211[»]
    1ODPNMR-A190-209[»]
    1ODQNMR-A190-209[»]
    1ODRNMR-A190-209[»]
    2A01X-ray2.40A/B/C25-267[»]
    3J00electron microscopy-0/168-267[»]
    3K2SX-ray-A/B25-267[»]
    3R2PX-ray2.20A25-208[»]
    DisProtiDP00386.
    ProteinModelPortaliP02647.
    SMRiP02647. Positions 26-267.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP02647.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati68 – 89221Add
    BLAST
    Repeati90 – 111222Add
    BLAST
    Repeati112 – 122113; half-lengthAdd
    BLAST
    Repeati123 – 144224Add
    BLAST
    Repeati145 – 166225Add
    BLAST
    Repeati167 – 188226Add
    BLAST
    Repeati189 – 210227Add
    BLAST
    Repeati211 – 232228Add
    BLAST
    Repeati233 – 243119; half-lengthAdd
    BLAST
    Repeati244 – 2672410Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni68 – 26720010 X approximate tandem repeatsAdd
    BLAST

    Sequence similaritiesi

    Belongs to the apolipoprotein A1/A4/E family.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG39720.
    HOGENOMiHOG000033998.
    HOVERGENiHBG105708.
    InParanoidiP02647.
    KOiK08757.
    OMAiYRQKVAP.
    OrthoDBiEOG7TBC3N.
    PhylomeDBiP02647.
    TreeFamiTF334458.

    Family and domain databases

    InterProiIPR000074. ApoA1_A4_E.
    [Graphical view]
    PfamiPF01442. Apolipoprotein. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P02647-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKAAVLTLAV LFLTGSQARH FWQQDEPPQS PWDRVKDLAT VYVDVLKDSG    50
    RDYVSQFEGS ALGKQLNLKL LDNWDSVTST FSKLREQLGP VTQEFWDNLE 100
    KETEGLRQEM SKDLEEVKAK VQPYLDDFQK KWQEEMELYR QKVEPLRAEL 150
    QEGARQKLHE LQEKLSPLGE EMRDRARAHV DALRTHLAPY SDELRQRLAA 200
    RLEALKENGG ARLAEYHAKA TEHLSTLSEK AKPALEDLRQ GLLPVLESFK 250
    VSFLSALEEY TKKLNTQ 267
    Length:267
    Mass (Da):30,778
    Last modified:July 21, 1986 - v1
    Checksum:i1A28B8366E620310
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti32 – 321W → P AA sequence (PubMed:1742316)Curated

    Mass spectrometryi

    Molecular mass is 28081 Da from positions 25 - 267. Determined by ESI. Without methionine sulfoxide.1 Publication
    Molecular mass is 28098 Da from positions 25 - 267. Determined by ESI. With 1 methionine sulfoxide, oxidation at Met-110.1 Publication
    Molecular mass is 28095 Da from positions 25 - 267. Determined by ESI. With 1 methionine sulfoxide, oxidation at Met-136.1 Publication
    Molecular mass is 28114 Da from positions 25 - 267. Determined by ESI. With 2 methionine sulfoxides, oxidation at Met-110 and Met-136.1 Publication

    Polymorphismi

    Genetic variations in APOA1 can result in APOA1 deficiency and are associated with low levels of HDL cholesterol [MIMi:107680].

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti27 – 271P → H in Munster-3C.
    Corresponds to variant rs121912720 [ dbSNP | Ensembl ].
    VAR_000605
    Natural varianti27 – 271P → R.1 Publication
    Corresponds to variant rs121912720 [ dbSNP | Ensembl ].
    VAR_000606
    Natural varianti28 – 281P → R in Munster-3B. 1 Publication
    VAR_000607
    Natural varianti34 – 341R → L in Baltimore. 1 Publication
    Corresponds to variant rs28929476 [ dbSNP | Ensembl ].
    VAR_000608
    Natural varianti50 – 501G → R in AMYL8; also found in a family with amyloid polyneuropathy-nephropathy Iowa. 3 Publications
    Corresponds to variant rs28931574 [ dbSNP | Ensembl ].
    VAR_000609
    Natural varianti61 – 611A → T.1 Publication
    Corresponds to variant rs12718465 [ dbSNP | Ensembl ].
    VAR_025445
    Natural varianti84 – 841L → R in AMYL8. 1 Publication
    VAR_000610
    Natural varianti92 – 921T → I Polymorphism confirmed at protein level. 2 Publications
    VAR_017017
    Natural varianti113 – 1131D → E.1 Publication
    VAR_000611
    Natural varianti119 – 1191A → D in Hita.
    VAR_000612
    Natural varianti126 – 1261D → H.
    Corresponds to variant rs5077 [ dbSNP | Ensembl ].
    VAR_016189
    Natural varianti127 – 1271D → N in Munster-3A.
    VAR_000613
    Natural varianti131 – 1311K → M.1 Publication
    Corresponds to variant rs4882 [ dbSNP | Ensembl ].
    VAR_000615
    Natural varianti131 – 1311Missing in Marburg/Munster-2.
    VAR_000614
    Natural varianti132 – 1321W → R in Tsushima.
    VAR_000616
    Natural varianti134 – 1341E → K in Fukuoka. 1 Publication
    VAR_000617
    Natural varianti160 – 1601E → K in Norway. 1 Publication
    VAR_000618
    Natural varianti163 – 1631E → G.1 Publication
    VAR_000619
    Natural varianti167 – 1671P → R in Giessen. 1 Publication
    VAR_000620
    Natural varianti168 – 1681L → R in Zaragoza. 1 Publication
    VAR_000621
    Natural varianti171 – 1711E → V.1 Publication
    VAR_000622
    Natural varianti180 – 1801V → E in Oita; 60% of normal apoA-I and normal HDL cholesterol levels. Rapidly cleared from plasma. 1 Publication
    VAR_021362
    Natural varianti184 – 1841R → P.
    Corresponds to variant rs5078 [ dbSNP | Ensembl ].
    VAR_014609
    Natural varianti189 – 1891P → R.1 Publication
    VAR_000623
    Natural varianti197 – 1971R → C in Milano; associated with decreased HDL levels and moderate increases in triglycerides; no evidence of association with premature vascular disease. 1 Publication
    Corresponds to variant rs28931573 [ dbSNP | Ensembl ].
    VAR_000624
    Natural varianti222 – 2221E → K in Munster-4. 1 Publication
    VAR_000625

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J00098 Genomic DNA. Translation: AAB59514.1.
    X01038 Genomic DNA. Translation: CAA25519.1.
    X02162 mRNA. Translation: CAA26097.1.
    X00566 mRNA. Translation: CAA25232.1.
    M11791 mRNA. Translation: AAA35545.1.
    X07496 Genomic DNA. Translation: CAA30377.1.
    M27875 mRNA. Translation: AAA62829.1.
    M29068 mRNA. Translation: AAA51747.1.
    AY422952 Genomic DNA. Translation: AAQ91811.1.
    AY555191 Genomic DNA. Translation: AAS68227.1.
    A14829 mRNA. Translation: CAA01198.1.
    AK292231 mRNA. Translation: BAF84920.1.
    EF444948 Genomic DNA. Translation: ACA05932.1.
    EF444948 Genomic DNA. Translation: ACA05933.1.
    EF444948 Genomic DNA. Translation: ACA05934.1.
    EF444948 Genomic DNA. Translation: ACA05935.1.
    EF444948 Genomic DNA. Translation: ACA05936.1.
    CH471065 Genomic DNA. Translation: EAW67274.1.
    BC005380 mRNA. Translation: AAH05380.1.
    BC110286 mRNA. Translation: AAI10287.1.
    CCDSiCCDS8378.1.
    PIRiA90947. LPHUA1.
    RefSeqiNP_000030.1. NM_000039.1.
    XP_005271596.1. XM_005271539.1.
    XP_005271597.1. XM_005271540.1.
    UniGeneiHs.93194.

    Genome annotation databases

    EnsembliENST00000236850; ENSP00000236850; ENSG00000118137.
    ENST00000359492; ENSP00000352471; ENSG00000118137.
    ENST00000375320; ENSP00000364469; ENSG00000118137.
    ENST00000375323; ENSP00000364472; ENSG00000118137.
    GeneIDi335.
    KEGGihsa:335.
    UCSCiuc001ppv.1. human.

    Polymorphism databases

    DMDMi113992.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    SHMPD

    The Singapore human mutation and polymorphism database

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J00098 Genomic DNA. Translation: AAB59514.1 .
    X01038 Genomic DNA. Translation: CAA25519.1 .
    X02162 mRNA. Translation: CAA26097.1 .
    X00566 mRNA. Translation: CAA25232.1 .
    M11791 mRNA. Translation: AAA35545.1 .
    X07496 Genomic DNA. Translation: CAA30377.1 .
    M27875 mRNA. Translation: AAA62829.1 .
    M29068 mRNA. Translation: AAA51747.1 .
    AY422952 Genomic DNA. Translation: AAQ91811.1 .
    AY555191 Genomic DNA. Translation: AAS68227.1 .
    A14829 mRNA. Translation: CAA01198.1 .
    AK292231 mRNA. Translation: BAF84920.1 .
    EF444948 Genomic DNA. Translation: ACA05932.1 .
    EF444948 Genomic DNA. Translation: ACA05933.1 .
    EF444948 Genomic DNA. Translation: ACA05934.1 .
    EF444948 Genomic DNA. Translation: ACA05935.1 .
    EF444948 Genomic DNA. Translation: ACA05936.1 .
    CH471065 Genomic DNA. Translation: EAW67274.1 .
    BC005380 mRNA. Translation: AAH05380.1 .
    BC110286 mRNA. Translation: AAI10287.1 .
    CCDSi CCDS8378.1.
    PIRi A90947. LPHUA1.
    RefSeqi NP_000030.1. NM_000039.1.
    XP_005271596.1. XM_005271539.1.
    XP_005271597.1. XM_005271540.1.
    UniGenei Hs.93194.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1AV1 X-ray 4.00 A/B/C/D 68-267 [» ]
    1GW3 NMR - A 166-211 [» ]
    1GW4 NMR - A 166-211 [» ]
    1ODP NMR - A 190-209 [» ]
    1ODQ NMR - A 190-209 [» ]
    1ODR NMR - A 190-209 [» ]
    2A01 X-ray 2.40 A/B/C 25-267 [» ]
    3J00 electron microscopy - 0/1 68-267 [» ]
    3K2S X-ray - A/B 25-267 [» ]
    3R2P X-ray 2.20 A 25-208 [» ]
    DisProti DP00386.
    ProteinModelPortali P02647.
    SMRi P02647. Positions 26-267.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106832. 73 interactions.
    DIPi DIP-29619N.
    IntActi P02647. 65 interactions.
    MINTi MINT-5000866.
    STRINGi 9606.ENSP00000236850.

    Chemistry

    ChEMBLi CHEMBL5984.

    PTM databases

    PhosphoSitei P02647.

    Polymorphism databases

    DMDMi 113992.

    2D gel databases

    DOSAC-COBS-2DPAGE P02647.
    OGPi P02647.
    REPRODUCTION-2DPAGE IPI00021841.
    P02647.
    SWISS-2DPAGE P02647.
    UCD-2DPAGE P02647.

    Proteomic databases

    MaxQBi P02647.
    PaxDbi P02647.
    PeptideAtlasi P02647.
    PRIDEi P02647.

    Protocols and materials databases

    DNASUi 335.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000236850 ; ENSP00000236850 ; ENSG00000118137 .
    ENST00000359492 ; ENSP00000352471 ; ENSG00000118137 .
    ENST00000375320 ; ENSP00000364469 ; ENSG00000118137 .
    ENST00000375323 ; ENSP00000364472 ; ENSG00000118137 .
    GeneIDi 335.
    KEGGi hsa:335.
    UCSCi uc001ppv.1. human.

    Organism-specific databases

    CTDi 335.
    GeneCardsi GC11M116706.
    HGNCi HGNC:600. APOA1.
    HPAi CAB016778.
    HPA046715.
    MIMi 105200. phenotype.
    107680. gene+phenotype.
    205400. phenotype.
    604091. phenotype.
    neXtProti NX_P02647.
    Orphaneti 425. Apolipoprotein A-I deficiency.
    93560. Familial renal amyloidosis due to Apolipoprotein AI variant.
    314701. Primary systemic amyloidosis.
    PharmGKBi PA49.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39720.
    HOGENOMi HOG000033998.
    HOVERGENi HBG105708.
    InParanoidi P02647.
    KOi K08757.
    OMAi YRQKVAP.
    OrthoDBi EOG7TBC3N.
    PhylomeDBi P02647.
    TreeFami TF334458.

    Enzyme and pathway databases

    Reactomei REACT_111158. ABCA transporters in lipid homeostasis.
    REACT_116145. PPARA activates gene expression.
    REACT_13621. HDL-mediated lipid transport.
    REACT_160163. Scavenging of heme from plasma.
    REACT_163679. Scavenging by Class B Receptors.
    REACT_163699. Scavenging by Class A Receptors.
    REACT_24968. Retinoid metabolism and transport.
    REACT_6841. Chylomicron-mediated lipid transport.
    REACT_75925. Amyloids.

    Miscellaneous databases

    ChiTaRSi APOA1. human.
    EvolutionaryTracei P02647.
    GeneWikii Apolipoprotein_A1.
    GenomeRNAii 335.
    NextBioi 1387.
    PMAP-CutDB P02647.
    PROi P02647.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P02647.
    Bgeei P02647.
    CleanExi HS_APOA1.
    Genevestigatori P02647.

    Family and domain databases

    InterProi IPR000074. ApoA1_A4_E.
    [Graphical view ]
    Pfami PF01442. Apolipoprotein. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Nucleotide sequence of cloned cDNA of human apolipoprotein A-I."
      Cheung P., Chan L.
      Nucleic Acids Res. 11:3703-3715(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Isolation and characterization of the human apolipoprotein A-I gene."
      Karathanasis S.K., Zannis V.I., Breslow J.L.
      Proc. Natl. Acad. Sci. U.S.A. 80:6147-6151(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Isolation and DNA sequence of full-length cDNA and of the entire gene for human apolipoprotein AI -- discovery of a new genetic polymorphism in the apo AI gene."
      Seilhamer J.J., Protter A.A., Frossard P., Levy-Wilson B.
      DNA 3:309-317(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance."
      Sharpe C.R., Sidoli A., Shelley C.S., Lucero M.A., Shoulders C.C., Baralle F.E.
      Nucleic Acids Res. 12:3917-3932(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "Nucleotide sequence and the encoded amino acids of human apolipoprotein A-I mRNA."
      Law S.W., Brewer H.B. Jr.
      Proc. Natl. Acad. Sci. U.S.A. 81:66-70(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    7. "Tangier disease. The complete mRNA sequence encoding for preproapo-A-I."
      Law S.W., Brewer H.B. Jr.
      J. Biol. Chem. 260:12810-12814(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (VARIANT TANGIER).
    9. "Production of human recombinant proapolipoprotein A-I in Escherichia coli: purification and biochemical characterization."
      Moguilevsky N., Roobol C., Loriau R., Guillaume J.P., Jacobs P., Cravador A., Herzog A., Brouwers L., Scarso A., Gilles P., Holmquist L., Carlson L.A., Bollen A.
      DNA 8:429-436(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    10. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-61.
    11. "Expression of human proapolipoprotein A-1."
      Bollen A., Gobert J., Wuelfert E.
      Patent number EP0293357, 30-NOV-1988
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    12. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    13. NHLBI resequencing and genotyping service (RS&G)
      Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    14. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    15. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Skeletal muscle.
    16. Cited for: PROTEIN SEQUENCE OF 19-27.
    17. "The primary structure of human plasma high density apolipoprotein glutamine I (ApoA-I). II. The amino acid sequence and alignment of cyanogen bromide fragments IV, III, and I."
      Baker H.N., Gotto A.M. Jr., Jackson R.L.
      J. Biol. Chem. 250:2725-2738(1975) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-267.
    18. "The amino acid sequence of human APOA-I, an apolipoprotein isolated from high density lipoproteins."
      Brewer H.B. Jr., Fairwell T., Larue A., Ronan R., Houser A., Bronzert T.J.
      Biochem. Biophys. Res. Commun. 80:623-630(1978) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-267.
    19. "Serum prostacyclin stabilizing factor is identical to apolipoprotein A-I (Apo A-I). A novel function of Apo A-I."
      Yui Y., Aoyama T., Morishita H., Takahashi M., Takatsu Y., Kawai C.
      J. Clin. Invest. 82:803-807(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-56.
    20. "Identification of apolipoprotein A1 and immunoglobulin as components of a serum complex that mediates activation of human sperm motility."
      Aakerloef E., Joernvall H., Slotte H., Pousette A.
      Biochemistry 30:8986-8990(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-50, FUNCTION, IDENTIFICATION IN THE SPAP COMPLEX.
      Tissue: Serum.
    21. "Apolipoprotein A-I binds to a family of bovine seminal plasma proteins."
      Manjunath P., Marcel Y.L., Uma J., Seidah N.G., Chretien M., Chapdelaine A.
      J. Biol. Chem. 264:16853-16857(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-48.
    22. "Similarity of cruzin, an inhibitor of Trypanosoma cruzi neuraminidase, to high-density lipoprotein."
      Prioli R.P., Ordovas J.M., Rosenberg I., Schaeffer E.J., Pereira M.E.A.
      Science 238:1417-1419(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-43.
    23. "The human myocardial two-dimensional gel protein database: update 1994."
      Corbett J.M., Wheeler C.H., Baker C.S., Yacoub M.H., Dunn M.J.
      Electrophoresis 15:1459-1465(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-42.
      Tissue: Heart.
    24. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
      Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
      Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-34.
      Tissue: Platelet.
    25. "The apolipoprotein A-I binding protein of placenta and the SP-40,40 protein of human blood are different proteins which both bind to apolipoprotein A-I."
      Ehnholm C., Bozas S.E., Tenkanen H., Kirszbaum L., Metso J., Murphy B., Walker I.D.
      Biochim. Biophys. Acta 1086:255-260(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-33, INTERACTION WITH APOA1BP AND CLU.
    26. Lubec G., Vishwanath V., Chen W.-Q., Sun Y.
      Submitted (DEC-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 35-64; 70-101; 121-140; 165-173; 185-195 AND 240-263, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Brain, Cajal-Retzius cell and Fetal brain cortex.
    27. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 118-267.
    28. "Human apolipoprotein A-I. Post-translational modification by fatty acid acylation."
      Hoeg J.M., Meng M.S., Ronan R., Fairwell T., Brewer H.B. Jr.
      J. Biol. Chem. 261:3911-3914(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: PALMITOYLATION.
    29. "Intracellular and extracellular processing of human apolipoprotein A-I: secreted apolipoprotein A-I isoprotein 2 is a propeptide."
      Zannis V.I., Karathanasis S.K., Keutmann H.T., Goldberger G., Breslow J.L.
      Proc. Natl. Acad. Sci. U.S.A. 80:2574-2578(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEOLYTIC PROCESSING.
    30. "The preferential site of non-enzymatic glycation of human apolipoprotein A-I in vivo."
      Calvo C., Ulloa N., Campos M., Verdugo C., Ayrault-Jarrier M.
      Clin. Chim. Acta 217:193-198(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCATION AT LYS-263.
    31. "Cloning and characterization of a novel apolipoprotein A-I-binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I."
      Ritter M., Buechler C., Boettcher A., Barlage S., Schmitz-Madry A., Orso E., Bared S.M., Schmiedeknecht G., Baehr C.H., Fricker G., Schmitz G.
      Genomics 79:693-702(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH APOA1BP.
    32. "Characterization of specifically oxidized apolipoproteins in mildly oxidized high density lipoprotein."
      Pankhurst G., Wang X.L., Wilcken D.E., Baernthaler G., Panzenboeck U., Raftery M., Stocker R.
      J. Lipid Res. 44:349-355(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: MASS SPECTROMETRY, OXIDATION AT MET-110 AND MET-136, TISSUE SPECIFICITY.
    33. "Novel mass spectrometric immunoassays for the rapid structural characterization of plasma apolipoproteins."
      Niederkofler E.E., Tubbs K.A., Kiernan U.A., Nedelkov D., Nelson R.W.
      J. Lipid Res. 44:630-639(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY.
    34. "NDRG1 interacts with APO A-I and A-II and is a functional candidate for the HDL-C QTL on 8q24."
      Hunter M., Angelicheva D., Tournev I., Ingley E., Chan D.C., Watts G.F., Kremensky I., Kalaydjieva L.
      Biochem. Biophys. Res. Commun. 332:982-992(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NDRG1.
    35. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    36. "Conformation of human serum apolipoprotein A-I(166-185) in the presence of sodium dodecyl sulfate or dodecylphosphocholine by 1H-NMR and CD. Evidence for specific peptide-SDS interactions."
      Wang G., Treleaven W.D., Cushley R.J.
      Biochim. Biophys. Acta 1301:174-184(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 190-209.
    37. "Crystal structure of truncated human apolipoprotein A-I suggests a lipid-bound conformation."
      Borhani D.W., Rogers D.P., Engler J.A., Brouillette C.G.
      Proc. Natl. Acad. Sci. U.S.A. 94:12291-12296(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 67-267.
    38. "Autosomal dominant hypoalphalipoproteinemia due to a completely defective apolipoprotein A-I gene."
      Nakata K., Kobayashi K., Yanagi H., Shimakura Y., Tsuchiya S., Arinami T., Hamaguchi H.
      Biochem. Biophys. Res. Commun. 196:950-955(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISEASE.
    39. "Apolipoprotein A-I Q[-2]X causing isolated apolipoprotein A-I deficiency in a family with analphalipoproteinemia."
      Ng D.S., Leiter L.A., Vezina C., Connelly P.W., Hegele R.A.
      J. Clin. Invest. 93:223-229(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISEASE.
    40. "Apolipoprotein A-IMilano. Detection of normal A-I in affected subjects and evidence for a cysteine for arginine substitution in the variant A-I."
      Weisgraber K.H., Rall S.C. Jr., Bersot T.P., Mahley R.W., Franceschini G., Sirtori C.R.
      J. Biol. Chem. 258:2508-2513(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT MILANO CYS-197.
    41. "Tangier disease: defective recombination of a specific Tangier apolipoprotein A-I isoform (pro-apo A-I) with high density lipoproteins."
      Schmitz G., Assmann G., Rall S.C. Jr., Mahley R.W.
      Proc. Natl. Acad. Sci. U.S.A. 80:6081-6085(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT TANGIER.
    42. "Apolipoprotein A-IGiessen (Pro143-->Arg). A mutant that is defective in activating lecithin:cholesterol acyltransferase."
      Utermann G., Haas J., Steinmetz A., Paetzold R., Rall S.C. Jr., Weisgraber K.H., Mahley R.W.
      Eur. J. Biochem. 144:325-331(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT GIESSEN ARG-167.
    43. "Abnormal lecithin:cholesterol acyltransferase activation by a human apolipoprotein A-I variant in which a single lysine residue is deleted."
      Rall S.C. Jr., Weisgraber K.H., Mahley R.W., Ogawa Y., Fielding C.J., Utermann G., Haas J., Steinmetz A., Menzel H.J., Assmann G.
      J. Biol. Chem. 259:10063-10070(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT NORWAY LYS-160.
    44. "Variant apolipoprotein AI as a major constituent of a human hereditary amyloid."
      Nichols W.C., Dwulet F.E., Liepnieks J., Benson M.D.
      Biochem. Biophys. Res. Commun. 156:762-768(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-107, VARIANT AMYL8 ARG-50.
    45. "A mutation in apolipoprotein A-I in the Iowa type of familial amyloidotic polyneuropathy."
      Nichols W.C., Gregg R.E., Brewer H.B. Jr., Benson M.D.
      Genomics 8:318-323(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT AMYL8 ARG-50.
    46. "Isolation and characterization of human apolipoprotein A-I Fukuoka (110 Glu-->Lys). A novel apolipoprotein variant."
      Takada Y., Sasaki J., Ogata S., Nakanishi T., Ikehara Y., Arakawa K.
      Biochim. Biophys. Acta 1043:169-176(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-267, VARIANT FUKUOKA LYS-134.
    47. Cited for: PROTEIN SEQUENCE OF 25-112, VARIANT AMYL8 ARG-84.
    48. Cited for: VARIANT BALTIMORE LEU-34.
    49. "Apolipoprotein A-I variants. Naturally occurring substitutions of proline residues affect plasma concentration of apolipoprotein A-I."
      von Eckardstein A., Funke H., Henke A., Altland K., Benninghoven A., Assmann G., Welp S., Roetrige A., Kock R.
      J. Clin. Invest. 84:1722-1730(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ARG-27; ARG-28 AND ARG-189.
    50. "Structural analysis of human apolipoprotein A-I variants. Amino acid substitutions are nonrandomly distributed throughout the apolipoprotein A-I primary structure."
      von Eckardstein A., Funke H., Walter M., Altland K., Benninghoven A., Assmann G.
      J. Biol. Chem. 265:8610-8617(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS GLU-113; MET-131; GLY-163; VAL-171 AND LYS-222.
    51. "Characterization of two new human apolipoprotein A-I variants: apolipoprotein A-I Tsushima (Trp-108-->Arg) and A-I Hita (Ala-95-->Asp)."
      Araki K., Sasaki J., Matsunaga A., Takada Y., Moriyama K., Hidaka K., Arakawa K.
      Biochim. Biophys. Acta 1214:272-278(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS HITA AND TSUSHIMA.
    52. "Familial nephropathic systemic amyloidosis caused by apolipoprotein AI variant Arg26."
      Vigushin D.M., Gough J., Allan D., Alguacil A., Penner B., Pettigrew N.M., Quinonez G., Bernstein K., Booth S.E., Booth D.R., Soutar A.K., Hawkins P.N., Pepys M.B.
      Q. J. Med. 87:149-154(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT AMYL8 ARG-50.
    53. Cited for: VARIANT AOITA GLU-180.
    54. "Apo A-I Zaragoza(L144R): a novel mutation in the apolipoprotein A-I gene associated with familial hypoalphalipoproteinemia."
      Recalde D., Cenarro A., Civeira F., Pocovi M.
      Hum. Mutat. 11:416-416(1998)
      Cited for: VARIANT ZARAGOZA ARG-168.
    55. "Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors."
      Morabia A., Cayanis E., Costanza M.C., Ross B.M., Flaherty M.S., Alvin G.B., Das K., Gilliam T.C.
      Hum. Mol. Genet. 12:2733-2743(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT ILE-92.
    56. "Quantitative detection of single amino acid polymorphisms by targeted proteomics."
      Su Z.D., Sun L., Yu D.X., Li R.X., Li H.X., Yu Z.J., Sheng Q.H., Lin X., Zeng R., Wu J.R.
      J. Mol. Cell Biol. 3:309-315(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT ILE-92, IDENTIFICATION BY MASS SPECTROMETRY.

    Entry informationi

    Entry nameiAPOA1_HUMAN
    AccessioniPrimary (citable) accession number: P02647
    Secondary accession number(s): A8K866
    , Q6LDN9, Q6Q785, Q9UCS8, Q9UCT8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 196 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3