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Protein

Apolipoprotein A-I

Gene

APOA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.1 Publication

GO - Molecular functioni

  • apolipoprotein A-I receptor binding Source: BHF-UCL
  • apolipoprotein receptor binding Source: BHF-UCL
  • beta-amyloid binding Source: BHF-UCL
  • chemorepellent activity Source: UniProtKB
  • cholesterol binding Source: BHF-UCL
  • cholesterol transporter activity Source: BHF-UCL
  • enzyme binding Source: BHF-UCL
  • high-density lipoprotein particle binding Source: Ensembl
  • high-density lipoprotein particle receptor binding Source: BHF-UCL
  • identical protein binding Source: IntAct
  • lipase inhibitor activity Source: Ensembl
  • phosphatidylcholine binding Source: GO_Central
  • phosphatidylcholine-sterol O-acyltransferase activator activity Source: BHF-UCL
  • phospholipid binding Source: BHF-UCL
  • phospholipid transporter activity Source: Ensembl

GO - Biological processi

  • adrenal gland development Source: Ensembl
  • animal organ regeneration Source: Ensembl
  • blood vessel endothelial cell migration Source: Ensembl
  • cellular protein metabolic process Source: Reactome
  • cholesterol biosynthetic process Source: GO_Central
  • cholesterol efflux Source: BHF-UCL
  • cholesterol homeostasis Source: BHF-UCL
  • cholesterol import Source: BHF-UCL
  • cholesterol metabolic process Source: BHF-UCL
  • cholesterol transport Source: MGI
  • endothelial cell proliferation Source: Ensembl
  • glucocorticoid metabolic process Source: Ensembl
  • G-protein coupled receptor signaling pathway Source: BHF-UCL
  • high-density lipoprotein particle assembly Source: BHF-UCL
  • high-density lipoprotein particle clearance Source: BHF-UCL
  • high-density lipoprotein particle remodeling Source: BHF-UCL
  • integrin-mediated signaling pathway Source: UniProtKB
  • lipid storage Source: Ensembl
  • lipoprotein biosynthetic process Source: Reactome
  • lipoprotein metabolic process Source: GO_Central
  • negative chemotaxis Source: UniProtKB
  • negative regulation of cell adhesion molecule production Source: BHF-UCL
  • negative regulation of cytokine secretion involved in immune response Source: BHF-UCL
  • negative regulation of heterotypic cell-cell adhesion Source: BHF-UCL
  • negative regulation of inflammatory response Source: BHF-UCL
  • negative regulation of interleukin-1 beta secretion Source: BHF-UCL
  • negative regulation of lipase activity Source: Ensembl
  • negative regulation of response to cytokine stimulus Source: BHF-UCL
  • negative regulation of tumor necrosis factor-mediated signaling pathway Source: BHF-UCL
  • negative regulation of very-low-density lipoprotein particle remodeling Source: BHF-UCL
  • neuron projection regeneration Source: GO_Central
  • peptidyl-methionine modification Source: UniProtKB
  • peripheral nervous system axon regeneration Source: Ensembl
  • phosphatidylcholine biosynthetic process Source: BHF-UCL
  • phospholipid efflux Source: BHF-UCL
  • phospholipid homeostasis Source: BHF-UCL
  • platelet degranulation Source: Reactome
  • positive regulation of cholesterol esterification Source: BHF-UCL
  • positive regulation of fatty acid biosynthetic process Source: GO_Central
  • positive regulation of hydrolase activity Source: BHF-UCL
  • positive regulation of lipoprotein lipase activity Source: GO_Central
  • positive regulation of Rho protein signal transduction Source: UniProtKB
  • positive regulation of stress fiber assembly Source: UniProtKB
  • positive regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
  • positive regulation of triglyceride catabolic process Source: GO_Central
  • protein oxidation Source: UniProtKB
  • protein stabilization Source: BHF-UCL
  • receptor-mediated endocytosis Source: Reactome
  • regulation of Cdc42 protein signal transduction Source: BHF-UCL
  • regulation of intestinal cholesterol absorption Source: GO_Central
  • regulation of protein phosphorylation Source: Ensembl
  • response to drug Source: Ensembl
  • response to estrogen Source: Ensembl
  • response to nutrient Source: Ensembl
  • retinoid metabolic process Source: Reactome
  • reverse cholesterol transport Source: BHF-UCL
  • transmembrane transport Source: Reactome
  • triglyceride catabolic process Source: GO_Central
  • triglyceride homeostasis Source: BHF-UCL
  • vitamin transport Source: AgBase

Keywordsi

Biological processCholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Enzyme and pathway databases

ReactomeiR-HSA-114608. Platelet degranulation.
R-HSA-1369062. ABC transporters in lipid homeostasis.
R-HSA-174800. Chylomicron-mediated lipid transport.
R-HSA-194223. HDL-mediated lipid transport.
R-HSA-1989781. PPARA activates gene expression.
R-HSA-2168880. Scavenging of heme from plasma.
R-HSA-3000471. Scavenging by Class B Receptors.
R-HSA-3000480. Scavenging by Class A Receptors.
R-HSA-975634. Retinoid metabolism and transport.
R-HSA-977225. Amyloid fiber formation.

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein A-I
Short name:
Apo-AI
Short name:
ApoA-I
Alternative name(s):
Apolipoprotein A1
Cleaved into the following 2 chains:
Proapolipoprotein A-I
Short name:
ProapoA-I
Alternative name(s):
Apolipoprotein A-I(1-242)
Gene namesi
Name:APOA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:600. APOA1.

Subcellular locationi

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • cell surface Source: Ensembl
  • chylomicron Source: GO_Central
  • cytoplasmic vesicle Source: BHF-UCL
  • cytosol Source: Reactome
  • discoidal high-density lipoprotein particle Source: Ensembl
  • early endosome Source: Reactome
  • endocytic vesicle Source: BHF-UCL
  • endocytic vesicle lumen Source: Reactome
  • endoplasmic reticulum lumen Source: Reactome
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • extracellular space Source: UniProtKB
  • extracellular vesicle Source: UniProtKB
  • high-density lipoprotein particle Source: BHF-UCL
  • nucleus Source: Ensembl
  • plasma membrane Source: Reactome
  • secretory granule lumen Source: Reactome
  • spherical high-density lipoprotein particle Source: BHF-UCL
  • very-low-density lipoprotein particle Source: BHF-UCL

Keywords - Cellular componenti

Amyloid, HDL, Secreted

Pathology & Biotechi

Involvement in diseasei

High density lipoprotein deficiency 2 (HDLD2)
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionInherited as autosomal dominant trait. It is characterized by moderately low HDL cholesterol, predilection toward premature coronary artery disease (CAD) and a reduction in cellular cholesterol efflux.
See also OMIM:604091
High density lipoprotein deficiency 1 (HDLD1)
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionRecessive disorder characterized by absence of high density lipoprotein (HDL) cholesterol from plasma, accumulation of cholesteryl esters, premature coronary artery disease (CAD), hepatosplenomegaly, recurrent peripheral neuropathy and progressive muscle wasting and weakness.
See also OMIM:205400
APOA1 mutations may be involved in the pathogenesis of amyloid polyneuropathy-nephropathy Iowa type, also known as amyloidosis van Allen type or familial amyloid polyneuropathy type III (PubMed:3142462 and PubMed:2123470). The clinical picture is dominated by neuropathy in the early stages of the disease and nephropathy late in the course. Death is due in most cases to renal amyloidosis.
Amyloidosis 8 (AMYL8)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of hereditary generalized amyloidosis. Clinical features include extensive visceral amyloid deposits, renal amyloidosis resulting in nephrotic syndrome, arterial hypertension, hepatosplenomegaly, cholestasis, petechial skin rash. There is no involvement of the nervous system.
See also OMIM:105200
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00060950G → R in AMYL8; also found in a family with amyloid polyneuropathy-nephropathy Iowa. 3 PublicationsCorresponds to variant dbSNP:rs28931574Ensembl.1
Natural variantiVAR_00061084L → R in AMYL8. 1 PublicationCorresponds to variant dbSNP:rs121912724Ensembl.1

Keywords - Diseasei

Amyloidosis, Atherosclerosis, Disease mutation, Neuropathy

Organism-specific databases

DisGeNETi335.
MalaCardsiAPOA1.
MIMi105200. phenotype.
107680. gene+phenotype.
205400. phenotype.
604091. phenotype.
OpenTargetsiENSG00000118137.
Orphaneti425. Apolipoprotein A-I deficiency.
93560. Familial renal amyloidosis due to Apolipoprotein AI variant.
314701. Primary systemic amyloidosis.
PharmGKBiPA49.

Chemistry databases

ChEMBLiCHEMBL5984.

Polymorphism and mutation databases

BioMutaiAPOA1.
DMDMi113992.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 182 PublicationsAdd BLAST18
ChainiPRO_000042532319 – 267Proapolipoprotein A-IAdd BLAST249
ChainiPRO_000000193925 – 267Apolipoprotein A-IAdd BLAST243
ChainiPRO_000000194025 – 266Truncated apolipoprotein A-IAdd BLAST242

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei110Methionine sulfoxide1 Publication1
Modified residuei136Methionine sulfoxide1 Publication1
Glycosylationi263N-linked (Glc) (glycation)1

Post-translational modificationi

Glycosylated.By similarity
Palmitoylated.1 Publication
Phosphorylation sites are present in the extracellular medium.

Keywords - PTMi

Glycation, Glycoprotein, Lipoprotein, Oxidation, Palmitate, Phosphoprotein

Proteomic databases

EPDiP02647.
MaxQBiP02647.
PaxDbiP02647.
PeptideAtlasiP02647.
PRIDEiP02647.

2D gel databases

DOSAC-COBS-2DPAGEiP02647.
OGPiP02647.
REPRODUCTION-2DPAGEiIPI00021841.
P02647.
SWISS-2DPAGEiP02647.
UCD-2DPAGEiP02647.

PTM databases

iPTMnetiP02647.
PhosphoSitePlusiP02647.

Miscellaneous databases

PMAP-CutDBiP02647.

Expressioni

Tissue specificityi

Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease.1 Publication

Gene expression databases

BgeeiENSG00000118137.
CleanExiHS_APOA1.
ExpressionAtlasiP02647. baseline and differential.
GenevisibleiP02647. HS.

Organism-specific databases

HPAiCAB016778.
HPA046715.

Interactioni

Subunit structurei

Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin. Interacts with NDRG1.4 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • apolipoprotein A-I receptor binding Source: BHF-UCL
  • apolipoprotein receptor binding Source: BHF-UCL
  • enzyme binding Source: BHF-UCL
  • high-density lipoprotein particle receptor binding Source: BHF-UCL
  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi106832. 90 interactors.
DIPiDIP-29619N.
IntActiP02647. 70 interactors.
MINTiMINT-5000866.
STRINGi9606.ENSP00000236850.

Structurei

Secondary structure

1267
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi33 – 42Combined sources10
Helixi45 – 59Combined sources15
Helixi61 – 65Combined sources5
Beta strandi69 – 73Combined sources5
Helixi80 – 88Combined sources9
Helixi93 – 158Combined sources66
Turni159 – 164Combined sources6
Helixi166 – 203Combined sources38
Turni212 – 214Combined sources3
Beta strandi215 – 217Combined sources3
Helixi220 – 237Combined sources18
Beta strandi238 – 240Combined sources3
Helixi243 – 266Combined sources24

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AV1X-ray4.00A/B/C/D68-267[»]
1GW3NMR-A166-211[»]
1GW4NMR-A166-211[»]
1ODPNMR-A190-209[»]
1ODQNMR-A190-209[»]
1ODRNMR-A190-209[»]
2A01X-ray2.40A/B/C25-267[»]
2MSCNMR-A/C68-265[»]
2MSDNMR-A/C68-265[»]
2MSENMR-A/C68-265[»]
2N5ENMR-A/B79-267[»]
3K2SX-ray-A/B25-267[»]
3R2PX-ray2.20A25-208[»]
4V6Melectron microscopy7.10A0/A168-267[»]
ProteinModelPortaliP02647.
SMRiP02647.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02647.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati68 – 891Add BLAST22
Repeati90 – 1112Add BLAST22
Repeati112 – 1223; half-lengthAdd BLAST11
Repeati123 – 1444Add BLAST22
Repeati145 – 1665Add BLAST22
Repeati167 – 1886Add BLAST22
Repeati189 – 2107Add BLAST22
Repeati211 – 2328Add BLAST22
Repeati233 – 2439; half-lengthAdd BLAST11
Repeati244 – 26710Add BLAST24

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni68 – 26710 X approximate tandem repeatsAdd BLAST200

Sequence similaritiesi

Belongs to the apolipoprotein A1/A4/E family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IWKR. Eukaryota.
ENOG410YGQ6. LUCA.
GeneTreeiENSGT00530000063081.
HOGENOMiHOG000033998.
HOVERGENiHBG105708.
InParanoidiP02647.
KOiK08757.
OMAiKDFATVY.
OrthoDBiEOG091G0IA5.
PhylomeDBiP02647.
TreeFamiTF334458.

Family and domain databases

InterProiView protein in InterPro
IPR000074. ApoA_E.
PfamiView protein in Pfam
PF01442. Apolipoprotein. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02647-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAAVLTLAV LFLTGSQARH FWQQDEPPQS PWDRVKDLAT VYVDVLKDSG
60 70 80 90 100
RDYVSQFEGS ALGKQLNLKL LDNWDSVTST FSKLREQLGP VTQEFWDNLE
110 120 130 140 150
KETEGLRQEM SKDLEEVKAK VQPYLDDFQK KWQEEMELYR QKVEPLRAEL
160 170 180 190 200
QEGARQKLHE LQEKLSPLGE EMRDRARAHV DALRTHLAPY SDELRQRLAA
210 220 230 240 250
RLEALKENGG ARLAEYHAKA TEHLSTLSEK AKPALEDLRQ GLLPVLESFK
260
VSFLSALEEY TKKLNTQ
Length:267
Mass (Da):30,778
Last modified:July 21, 1986 - v1
Checksum:i1A28B8366E620310
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti32W → P AA sequence (PubMed:1742316).Curated1

Mass spectrometryi

Molecular mass is 28081 Da from positions 25 - 267. Determined by ESI. Without methionine sulfoxide.1 Publication
Molecular mass is 28098 Da from positions 25 - 267. Determined by ESI. With 1 methionine sulfoxide, oxidation at Met-110.1 Publication
Molecular mass is 28095 Da from positions 25 - 267. Determined by ESI. With 1 methionine sulfoxide, oxidation at Met-136.1 Publication
Molecular mass is 28114 Da from positions 25 - 267. Determined by ESI. With 2 methionine sulfoxides, oxidation at Met-110 and Met-136.1 Publication

Polymorphismi

Genetic variations in APOA1 can result in APOA1 deficiency and are associated with low levels of HDL cholesterol [MIMi:107680].Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00060527P → H in Munster-3C. Corresponds to variant dbSNP:rs121912720Ensembl.1
Natural variantiVAR_00060627P → R1 PublicationCorresponds to variant dbSNP:rs121912720Ensembl.1
Natural variantiVAR_00060728P → R in Munster-3B. 1 PublicationCorresponds to variant dbSNP:rs121912721Ensembl.1
Natural variantiVAR_00060834R → L in Baltimore. 1 PublicationCorresponds to variant dbSNP:rs28929476Ensembl.1
Natural variantiVAR_00060950G → R in AMYL8; also found in a family with amyloid polyneuropathy-nephropathy Iowa. 3 PublicationsCorresponds to variant dbSNP:rs28931574Ensembl.1
Natural variantiVAR_02544561A → T1 PublicationCorresponds to variant dbSNP:rs12718465Ensembl.1
Natural variantiVAR_00061084L → R in AMYL8. 1 PublicationCorresponds to variant dbSNP:rs121912724Ensembl.1
Natural variantiVAR_01701792T → I Polymorphism; confirmed at protein level. 2 PublicationsCorresponds to variant dbSNP:rs766422306Ensembl.1
Natural variantiVAR_000611113D → E1 PublicationCorresponds to variant dbSNP:rs150243849Ensembl.1
Natural variantiVAR_000612119A → D in Hita. 1
Natural variantiVAR_016189126D → H. Corresponds to variant dbSNP:rs5077Ensembl.1
Natural variantiVAR_000613127D → N in Munster-3A. 1
Natural variantiVAR_000615131K → M1 PublicationCorresponds to variant dbSNP:rs4882Ensembl.1
Natural variantiVAR_000614131Missing in Marburg/Munster-2. 1
Natural variantiVAR_000616132W → R in Tsushima. 1
Natural variantiVAR_000617134E → K in Fukuoka. 1 Publication1
Natural variantiVAR_000618160E → K in Norway. 1 PublicationCorresponds to variant dbSNP:rs121912718Ensembl.1
Natural variantiVAR_000619163E → G1 PublicationCorresponds to variant dbSNP:rs758509542Ensembl.1
Natural variantiVAR_000620167P → R in Giessen. 1 PublicationCorresponds to variant dbSNP:rs121912719Ensembl.1
Natural variantiVAR_000621168L → R in Zaragoza. 1 Publication1
Natural variantiVAR_000622171E → V1 Publication1
Natural variantiVAR_074073173R → S in Boston; no evidence of association with premature coronary heart disease; associated with decreased levels of HDL cholesterol; associated with decreased serum cellular cholesterol efflux; associated with decreased lecithin-cholesterol acyltransferase (LCAT) activity. 1 Publication1
Natural variantiVAR_021362180V → E in Oita; 60% of normal apoA-I and normal HDL cholesterol levels; rapidly cleared from plasma. 1 PublicationCorresponds to variant dbSNP:rs121912727Ensembl.1
Natural variantiVAR_014609184R → P. Corresponds to variant dbSNP:rs5078Ensembl.1
Natural variantiVAR_000623189P → R1 PublicationCorresponds to variant dbSNP:rs121912722Ensembl.1
Natural variantiVAR_000624197R → C in Milano; no evidence of association with premature vascular disease; associated with decreased HDL levels and moderate increase in triglycerides; allows the formation of disulfide-linked homodimers via the introduced cysteine; assembles properly in HDL; alters protein structure; has no tendency to form fibrils and aggregates. 2 PublicationsCorresponds to variant dbSNP:rs28931573Ensembl.1
Natural variantiVAR_000625222E → K in Munster-4. 1 PublicationCorresponds to variant dbSNP:rs121912717Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00098 Genomic DNA. Translation: AAB59514.1.
X01038 Genomic DNA. Translation: CAA25519.1.
X02162 mRNA. Translation: CAA26097.1.
X00566 mRNA. Translation: CAA25232.1.
M11791 mRNA. Translation: AAA35545.1.
X07496 Genomic DNA. Translation: CAA30377.1.
M27875 mRNA. Translation: AAA62829.1.
M29068 mRNA. Translation: AAA51747.1.
AY422952 Genomic DNA. Translation: AAQ91811.1.
AY555191 Genomic DNA. Translation: AAS68227.1.
A14829 mRNA. Translation: CAA01198.1.
AK292231 mRNA. Translation: BAF84920.1.
EF444948 Genomic DNA. Translation: ACA05932.1.
EF444948 Genomic DNA. Translation: ACA05933.1.
EF444948 Genomic DNA. Translation: ACA05934.1.
EF444948 Genomic DNA. Translation: ACA05935.1.
EF444948 Genomic DNA. Translation: ACA05936.1.
CH471065 Genomic DNA. Translation: EAW67274.1.
BC005380 mRNA. Translation: AAH05380.1.
BC110286 mRNA. Translation: AAI10287.1.
CCDSiCCDS8378.1.
PIRiA90947. LPHUA1.
RefSeqiNP_000030.1. NM_000039.2.
NP_001304946.1. NM_001318017.1.
NP_001304947.1. NM_001318018.1.
NP_001304950.1. NM_001318021.1.
UniGeneiHs.93194.

Genome annotation databases

EnsembliENST00000236850; ENSP00000236850; ENSG00000118137.
ENST00000359492; ENSP00000352471; ENSG00000118137.
ENST00000375320; ENSP00000364469; ENSG00000118137.
ENST00000375323; ENSP00000364472; ENSG00000118137.
GeneIDi335.
KEGGihsa:335.
UCSCiuc001ppv.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00098 Genomic DNA. Translation: AAB59514.1.
X01038 Genomic DNA. Translation: CAA25519.1.
X02162 mRNA. Translation: CAA26097.1.
X00566 mRNA. Translation: CAA25232.1.
M11791 mRNA. Translation: AAA35545.1.
X07496 Genomic DNA. Translation: CAA30377.1.
M27875 mRNA. Translation: AAA62829.1.
M29068 mRNA. Translation: AAA51747.1.
AY422952 Genomic DNA. Translation: AAQ91811.1.
AY555191 Genomic DNA. Translation: AAS68227.1.
A14829 mRNA. Translation: CAA01198.1.
AK292231 mRNA. Translation: BAF84920.1.
EF444948 Genomic DNA. Translation: ACA05932.1.
EF444948 Genomic DNA. Translation: ACA05933.1.
EF444948 Genomic DNA. Translation: ACA05934.1.
EF444948 Genomic DNA. Translation: ACA05935.1.
EF444948 Genomic DNA. Translation: ACA05936.1.
CH471065 Genomic DNA. Translation: EAW67274.1.
BC005380 mRNA. Translation: AAH05380.1.
BC110286 mRNA. Translation: AAI10287.1.
CCDSiCCDS8378.1.
PIRiA90947. LPHUA1.
RefSeqiNP_000030.1. NM_000039.2.
NP_001304946.1. NM_001318017.1.
NP_001304947.1. NM_001318018.1.
NP_001304950.1. NM_001318021.1.
UniGeneiHs.93194.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AV1X-ray4.00A/B/C/D68-267[»]
1GW3NMR-A166-211[»]
1GW4NMR-A166-211[»]
1ODPNMR-A190-209[»]
1ODQNMR-A190-209[»]
1ODRNMR-A190-209[»]
2A01X-ray2.40A/B/C25-267[»]
2MSCNMR-A/C68-265[»]
2MSDNMR-A/C68-265[»]
2MSENMR-A/C68-265[»]
2N5ENMR-A/B79-267[»]
3K2SX-ray-A/B25-267[»]
3R2PX-ray2.20A25-208[»]
4V6Melectron microscopy7.10A0/A168-267[»]
ProteinModelPortaliP02647.
SMRiP02647.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106832. 90 interactors.
DIPiDIP-29619N.
IntActiP02647. 70 interactors.
MINTiMINT-5000866.
STRINGi9606.ENSP00000236850.

Chemistry databases

ChEMBLiCHEMBL5984.

PTM databases

iPTMnetiP02647.
PhosphoSitePlusiP02647.

Polymorphism and mutation databases

BioMutaiAPOA1.
DMDMi113992.

2D gel databases

DOSAC-COBS-2DPAGEiP02647.
OGPiP02647.
REPRODUCTION-2DPAGEiIPI00021841.
P02647.
SWISS-2DPAGEiP02647.
UCD-2DPAGEiP02647.

Proteomic databases

EPDiP02647.
MaxQBiP02647.
PaxDbiP02647.
PeptideAtlasiP02647.
PRIDEiP02647.

Protocols and materials databases

DNASUi335.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000236850; ENSP00000236850; ENSG00000118137.
ENST00000359492; ENSP00000352471; ENSG00000118137.
ENST00000375320; ENSP00000364469; ENSG00000118137.
ENST00000375323; ENSP00000364472; ENSG00000118137.
GeneIDi335.
KEGGihsa:335.
UCSCiuc001ppv.2. human.

Organism-specific databases

CTDi335.
DisGeNETi335.
GeneCardsiAPOA1.
HGNCiHGNC:600. APOA1.
HPAiCAB016778.
HPA046715.
MalaCardsiAPOA1.
MIMi105200. phenotype.
107680. gene+phenotype.
205400. phenotype.
604091. phenotype.
neXtProtiNX_P02647.
OpenTargetsiENSG00000118137.
Orphaneti425. Apolipoprotein A-I deficiency.
93560. Familial renal amyloidosis due to Apolipoprotein AI variant.
314701. Primary systemic amyloidosis.
PharmGKBiPA49.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWKR. Eukaryota.
ENOG410YGQ6. LUCA.
GeneTreeiENSGT00530000063081.
HOGENOMiHOG000033998.
HOVERGENiHBG105708.
InParanoidiP02647.
KOiK08757.
OMAiKDFATVY.
OrthoDBiEOG091G0IA5.
PhylomeDBiP02647.
TreeFamiTF334458.

Enzyme and pathway databases

ReactomeiR-HSA-114608. Platelet degranulation.
R-HSA-1369062. ABC transporters in lipid homeostasis.
R-HSA-174800. Chylomicron-mediated lipid transport.
R-HSA-194223. HDL-mediated lipid transport.
R-HSA-1989781. PPARA activates gene expression.
R-HSA-2168880. Scavenging of heme from plasma.
R-HSA-3000471. Scavenging by Class B Receptors.
R-HSA-3000480. Scavenging by Class A Receptors.
R-HSA-975634. Retinoid metabolism and transport.
R-HSA-977225. Amyloid fiber formation.

Miscellaneous databases

ChiTaRSiAPOA1. human.
EvolutionaryTraceiP02647.
GeneWikiiApolipoprotein_A1.
GenomeRNAii335.
PMAP-CutDBiP02647.
PROiPR:P02647.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000118137.
CleanExiHS_APOA1.
ExpressionAtlasiP02647. baseline and differential.
GenevisibleiP02647. HS.

Family and domain databases

InterProiView protein in InterPro
IPR000074. ApoA_E.
PfamiView protein in Pfam
PF01442. Apolipoprotein. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAPOA1_HUMAN
AccessioniPrimary (citable) accession number: P02647
Secondary accession number(s): A8K866
, Q6LDN9, Q6Q785, Q9UCS8, Q9UCT8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: March 15, 2017
This is version 223 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.