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Protein

Troponin I, fast skeletal muscle

Gene

TNNI2

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi105 – 11612By similarityAdd
BLAST

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • troponin T binding Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Actin-binding, Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin I, fast skeletal muscle
Alternative name(s):
Troponin I, fast-twitch isoform
Gene namesi
Name:TNNI2
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 182181Troponin I, fast skeletal musclePRO_0000186145Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylglycine1 Publication
Modified residuei12 – 121Phosphothreonine; by PHK2 Publications
Modified residuei118 – 1181Phosphoserine; by PKA2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

PTM databases

iPTMnetiP02643.

Interactioni

Subunit structurei

Binds to actin and tropomyosin.1 Publication

GO - Molecular functioni

  • troponin T binding Source: UniProtKB

Protein-protein interaction databases

BioGridi1172600. 5 interactions.
IntActiP02643. 1 interaction.

Structurei

Secondary structure

1
182
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 3227Combined sources
Helixi120 – 1267Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A2XX-ray2.30B2-48[»]
1EW7model-I4-137[»]
1NPQNMR-B116-132[»]
ProteinModelPortaliP02643.
SMRiP02643. Positions 4-180.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02643.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 4847Involved in binding TNCAdd
BLAST
Regioni97 – 11721Involved in binding TNC and actinAdd
BLAST

Sequence similaritiesi

Belongs to the troponin I family.Curated

Phylogenomic databases

HOVERGENiHBG052737.
InParanoidiP02643.
KOiK12043.

Family and domain databases

InterProiIPR001978. Troponin.
[Graphical view]
PfamiPF00992. Troponin. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02643-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDEEKRNRA ITARRQHLKS VMLQIAATEL EKEEGRREAE KQNYLAEHCP
60 70 80 90 100
PLSLPGSMAE VQELCKQLHA KIDAAEEEKY DMEIKVQKSS KELEDMNQKL
110 120 130 140 150
FDLRGKFKRP PLRRVRMSAD AMLKALLGSK HKVCMDLRAN LKQVKKEDTE
160 170 180
KERDLRDVGD WRKNIEEKSG MEGRKKMFES ES
Length:182
Mass (Da):21,214
Last modified:January 23, 2007 - v3
Checksum:i5BE12DBB6C90FFCF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti154 – 1563Missing AA sequence (PubMed:1180911).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04347 mRNA. Translation: AAA31490.1.
X14190 mRNA. Translation: CAA32392.1.
S61403 mRNA. Translation: AAB26824.1.
V00897 mRNA. Translation: CAA24262.1.
V00898 mRNA. Translation: CAA24263.1.
PIRiA45060. TPRBIS.
I46513.
RefSeqiNP_001076252.1. NM_001082783.1.
UniGeneiOcu.6670.

Genome annotation databases

GeneIDi100009581.
KEGGiocu:100009581.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L04347 mRNA. Translation: AAA31490.1.
X14190 mRNA. Translation: CAA32392.1.
S61403 mRNA. Translation: AAB26824.1.
V00897 mRNA. Translation: CAA24262.1.
V00898 mRNA. Translation: CAA24263.1.
PIRiA45060. TPRBIS.
I46513.
RefSeqiNP_001076252.1. NM_001082783.1.
UniGeneiOcu.6670.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A2XX-ray2.30B2-48[»]
1EW7model-I4-137[»]
1NPQNMR-B116-132[»]
ProteinModelPortaliP02643.
SMRiP02643. Positions 4-180.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi1172600. 5 interactions.
IntActiP02643. 1 interaction.

PTM databases

iPTMnetiP02643.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009581.
KEGGiocu:100009581.

Organism-specific databases

CTDi7136.

Phylogenomic databases

HOVERGENiHBG052737.
InParanoidiP02643.
KOiK12043.

Miscellaneous databases

EvolutionaryTraceiP02643.

Family and domain databases

InterProiIPR001978. Troponin.
[Graphical view]
PfamiPF00992. Troponin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNNI2_RABIT
AccessioniPrimary (citable) accession number: P02643
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 107 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.