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Protein

Troponin T, fast skeletal muscle

Gene

TNNT3

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

GO - Biological processi

Keywordsi

Molecular functionMuscle protein

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin T, fast skeletal muscle
Short name:
TnTf
Alternative name(s):
Fast skeletal muscle troponin T
Short name:
fTnT
Gene namesi
Name:TNNT3
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00001861802 – 279Troponin T, fast skeletal muscleAdd BLAST278

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei2PhosphoserineBy similarity1
Modified residuei98PhosphoserineBy similarity1
Modified residuei169PhosphoserineBy similarity1
Modified residuei176PhosphoserineBy similarity1
Modified residuei177PhosphoserineBy similarity1
Modified residuei213PhosphoserineBy similarity1
Modified residuei229PhosphotyrosineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

PTM databases

iPTMnetiP02641.

Interactioni

Protein-protein interaction databases

CORUMiP02641.
STRINGi9986.ENSOCUP00000022512.

Structurei

3D structure databases

ProteinModelPortaliP02641.
SMRiP02641.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the troponin T family.Curated

Phylogenomic databases

eggNOGiKOG3634. Eukaryota.
ENOG410XS6A. LUCA.
HOGENOMiHOG000231049.
HOVERGENiHBG052790.
InParanoidiP02641.

Family and domain databases

InterProiView protein in InterPro
IPR027707. TNNT.
IPR027708. Tnnt3.
IPR001978. Troponin.
PANTHERiPTHR11521. PTHR11521. 1 hit.
PTHR11521:SF18. PTHR11521:SF18. 1 hit.
PfamiView protein in Pfam
PF00992. Troponin. 1 hit.

Sequences (9)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 9 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform TnT1 (identifier: P02641-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDEEVEHVE EQYEEEEEAQ EEAPSPAEVH EPAPEVHVPE EVHEDALEDM
60 70 80 90 100
REEEEEEEKP RPKLTAPKIP EGEKVDFDDI QKKRQNKDLM ELQALIDSHF
110 120 130 140 150
EARKKEEEEL VALKERIEKR RAERAEQQRI RAEKERERQN RLAEEKARRE
160 170 180 190 200
EEDAKRRAEE DLKKKKALSS MGANYSSYLA KADQKRGKKQ TAREMKKKIL
210 220 230 240 250
AERRKPLNID HLSDEKLRDK AKELWDTLYQ LETDKFEFGE KLKRQKYDIM
260 270
NVRARVEMLA KFSKKAGTTA KGKVGGRWK
Length:279
Mass (Da):33,034
Last modified:January 23, 2007 - v4
Checksum:i1CF35712F2EE5281
GO
Isoform TnT1F (identifier: P02641-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     45-56: Missing.

Show »
Length:267
Mass (Da):31,558
Checksum:i93062FDF9B9E9788
GO
Isoform TnT2 (identifier: P02641-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     33-39: Missing.

Show »
Length:272
Mass (Da):32,304
Checksum:i58DC0B4D3B056450
GO
Isoform TnT2F (identifier: P02641-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-17: Missing.
     45-56: Missing.

Show »
Length:261
Mass (Da):30,750
Checksum:i66C6C865952E546F
GO
Isoform TnT2FA (identifier: P02641-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     33-39: Missing.
     45-56: Missing.

Show »
Length:260
Mass (Da):30,828
Checksum:i84BCA5FA9FA8AA66
GO
Isoform TnT2.5F (identifier: P02641-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-17: Missing.
     33-39: Missing.
     45-56: Missing.

Show »
Length:254
Mass (Da):30,020
Checksum:i730C371C8E65DB31
GO
Isoform TnT3 (identifier: P02641-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-39: Missing.

Show »
Length:262
Mass (Da):31,289
Checksum:iFD052B1246631107
GO
Isoform TnT3F (identifier: P02641-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     23-39: Missing.
     45-56: Missing.

Show »
Length:250
Mass (Da):29,813
Checksum:iBB0EBF385076ADCB
GO
Isoform TnT4F (identifier: P02641-9) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-17: Missing.
     23-39: Missing.
     45-56: Missing.

Show »
Length:244
Mass (Da):29,005
Checksum:i934314CF18FD0556
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20Q → E AA sequence (PubMed:320204).Curated1
Sequence conflicti36 – 37VH → HV AA sequence (PubMed:320204).Curated2
Sequence conflicti36 – 37VH → HV AA sequence (PubMed:2704041).Curated2
Sequence conflicti62Missing AA sequence (PubMed:320204).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00665312 – 17Missing in isoform TnT2F, isoform TnT2.5F and isoform TnT4F. Curated6
Alternative sequenceiVSP_00665423 – 39Missing in isoform TnT3, isoform TnT3F and isoform TnT4F. CuratedAdd BLAST17
Alternative sequenceiVSP_00665533 – 39Missing in isoform TnT2, isoform TnT2FA and isoform TnT2.5F. Curated7
Alternative sequenceiVSP_00665645 – 56Missing in isoform TnT1F, isoform TnT2F, isoform TnT2FA, isoform TnT2.5F, isoform TnT3F and isoform TnT4F. CuratedAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U04970 mRNA. Translation: AAA16023.1.
U04971 mRNA. Translation: AAA16024.1.
U04972 mRNA. Translation: AAA16025.1.
U04973 mRNA. Translation: AAA16026.1.
U04974 mRNA. Translation: AAA16027.1.
U04975 mRNA. Translation: AAA16028.1.
U04976 mRNA. Translation: AAA16029.1.
U04977 mRNA. Translation: AAA16030.1.
U04978 mRNA. Translation: AAA16031.1.
UniGeneiOcu.1806.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTNNT3_RABIT
AccessioniPrimary (citable) accession number: P02641
Secondary accession number(s): P19349, P19350
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: September 27, 2017
This is version 101 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families