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Protein

Protein S100-A1

Gene

S100A1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably acts as a Ca2+ signal transducer. In response to an increase in intracellular Ca2+ levels, binds calcium which triggers a conformational change. This conformational change allows interaction of S1001A with specific target proteins, such as TPR-containing proteins, and the modulation of their activity.By similarity

Miscellaneous

Able to bind zinc in vitro; the binding sites are different from the calcium binding sites. The physiological relevance of zinc binding is unclear. Physiological concentrations of potassium antagonize the binding of both divalent cations, especially affecting the high-affinity calcium-binding sites.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi20 – 331; low affinityBy similarityAdd BLAST14
Calcium bindingi63 – 742; high affinityBy similarityAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-BTA-5686938. Regulation of TLR by endogenous ligand.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A1
Alternative name(s):
S-100 protein alpha chain
S-100 protein subunit alpha
S100 calcium-binding protein A1
Gene namesi
Name:S100A1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001439602 – 94Protein S100-A1Add BLAST93

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2Blocked amino end (Gly)1 Publication1
Modified residuei86S-nitrosocysteineBy similarity1

Keywords - PTMi

S-nitrosylation

Proteomic databases

PaxDbiP02639.
PRIDEiP02639.

Expressioni

Tissue specificityi

Although predominant among the water-soluble brain proteins, S100 is also found in a variety of other tissues.1 Publication

Gene expression databases

BgeeiENSBTAG00000005163.
ExpressionAtlasiP02639. baseline and differential.

Interactioni

Subunit structurei

Dimer of either two alpha chains, or two beta chains, or one alpha and one beta chain. Also forms heterodimers with S100P. Interacts with AGER. Interacts with CAPZA1. Interacts with FKBP4. Interacts with RYR1 and RYR2. Interacts with CACYBP in a calcium-dependent manner. Interacts with PPP5C (via TPR repeats); the interaction is calcium-dependent and modulates PPP5C activity.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiP02639. 6 interactors.
STRINGi9913.ENSBTAP00000044226.

Structurei

Secondary structure

194
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 18Combined sources15
Helixi31 – 42Combined sources12
Turni43 – 45Combined sources3
Helixi46 – 49Combined sources4
Helixi54 – 64Combined sources11
Helixi75 – 90Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JPTNMR-A/B2-94[»]
ProteinModelPortaliP02639.
SMRiP02639.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02639.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 48EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini50 – 85EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IXZ2. Eukaryota.
ENOG4111987. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP02639.

Family and domain databases

CDDicd05025. S-100A1. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028486. S100-A1.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
PANTHERiPTHR11639:SF86. PTHR11639:SF86. 1 hit.
PfamiView protein in Pfam
PF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02639-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSELETAME TLINVFHAHS GKEGDKYKLS KKELKELLQT ELSGFLDAQK
60 70 80 90
DADAVDKVMK ELDENGDGEV DFQEYVVLVA ALTVACNNFF WENS
Length:94
Mass (Da):10,518
Last modified:January 23, 2007 - v2
Checksum:iAD5E400DB85025D2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti65N → D AA sequence (PubMed:7250124).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC141991 mRNA. Translation: AAI41992.1.
BC148019 mRNA. Translation: AAI48020.1.
PIRiA24156. BCBOIA.
RefSeqiNP_001092512.1. NM_001099042.2.
XP_005203778.1. XM_005203721.3.
XP_010801217.1. XM_010802915.2.
UniGeneiBt.35032.

Genome annotation databases

EnsembliENSBTAT00000006806; ENSBTAP00000006806; ENSBTAG00000005163.
GeneIDi528735.
KEGGibta:528735.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC141991 mRNA. Translation: AAI41992.1.
BC148019 mRNA. Translation: AAI48020.1.
PIRiA24156. BCBOIA.
RefSeqiNP_001092512.1. NM_001099042.2.
XP_005203778.1. XM_005203721.3.
XP_010801217.1. XM_010802915.2.
UniGeneiBt.35032.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2JPTNMR-A/B2-94[»]
ProteinModelPortaliP02639.
SMRiP02639.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP02639. 6 interactors.
STRINGi9913.ENSBTAP00000044226.

Proteomic databases

PaxDbiP02639.
PRIDEiP02639.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000006806; ENSBTAP00000006806; ENSBTAG00000005163.
GeneIDi528735.
KEGGibta:528735.

Organism-specific databases

CTDi6271.

Phylogenomic databases

eggNOGiENOG410IXZ2. Eukaryota.
ENOG4111987. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP02639.

Enzyme and pathway databases

ReactomeiR-BTA-5686938. Regulation of TLR by endogenous ligand.

Miscellaneous databases

EvolutionaryTraceiP02639.

Gene expression databases

BgeeiENSBTAG00000005163.
ExpressionAtlasiP02639. baseline and differential.

Family and domain databases

CDDicd05025. S-100A1. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028486. S100-A1.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
PANTHERiPTHR11639:SF86. PTHR11639:SF86. 1 hit.
PfamiView protein in Pfam
PF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiS10A1_BOVIN
AccessioniPrimary (citable) accession number: P02639
Secondary accession number(s): A5PJ73
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: June 7, 2017
This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.