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P02634

- S100G_RAT

UniProt

P02634 - S100G_RAT

Protein

Protein S100-G

Gene

S100g

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi18 – 31141; low affinityAdd
    BLAST
    Calcium bindingi58 – 69122; high affinityAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. vitamin D binding Source: UniProtKB-KW

    Keywords - Ligandi

    Calcium, Metal-binding, Vitamin D

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein S100-G
    Alternative name(s):
    9 kDa CaBP
    Calbindin-D9k
    Cholecalcin
    S100 calcium-binding protein G
    Vitamin D-dependent calcium-binding protein, intestinal
    Short name:
    CABP
    Gene namesi
    Name:S100g
    Synonyms:Calb3, S100d
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome X

    Organism-specific databases

    RGDi2253. S100g.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: Ensembl
    2. basolateral plasma membrane Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 7978Protein S100-GPRO_0000144030Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiP02634.

    Expressioni

    Gene expression databases

    GenevestigatoriP02634.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000005622.

    Structurei

    3D structure databases

    ProteinModelPortaliP02634.
    SMRiP02634. Positions 2-79.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini13 – 4836EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini45 – 7935EF-hand 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the S-101 family.Curated
    Contains 2 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG39449.
    GeneTreeiENSGT00530000064238.
    HOGENOMiHOG000246968.
    HOVERGENiHBG001479.
    InParanoidiP02634.
    KOiK14734.
    OMAiQIHIENE.
    OrthoDBiEOG7Z3F78.
    PhylomeDBiP02634.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR001751. S100/CaBP-9k_CS.
    IPR013787. S100_Ca-bd_sub.
    IPR028489. S100G.
    [Graphical view]
    PANTHERiPTHR11639:SF67. PTHR11639:SF67. 1 hit.
    PfamiPF00036. EF-hand_1. 1 hit.
    PF01023. S_100. 1 hit.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 1 hit.
    PS00303. S100_CABP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P02634-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAKKSPEEM KSIFQKYAAK EGDPNQLSKE ELKLLIQSEF PSLLKASSTL   50
    DNLFKELDKN GDGEVSYEEF EVFFKKLSQ 79
    Length:79
    Mass (Da):9,038
    Last modified:January 23, 2007 - v3
    Checksum:i3566BD81668704C6
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 32SA → AS AA sequence (PubMed:3741407)Curated
    Sequence conflicti42 – 421S → N in AAA40843. (PubMed:6315698)Curated
    Sequence conflicti45 – 451K → KQ in AAA40853. (PubMed:3194402)Curated
    Sequence conflicti55 – 551K → E in AAA40843. (PubMed:6315698)Curated
    Sequence conflicti60 – 601N → D AA sequence (PubMed:3741407)Curated
    Sequence conflicti61 – 611G → D in AAA40843. (PubMed:6315698)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16635 Genomic DNA. Translation: CAA34627.1.
    K00994 mRNA. Translation: AAA40843.1.
    J02954 mRNA. Translation: AAA42333.1.
    BC059153 mRNA. Translation: AAH59153.1.
    J04133 Genomic DNA. Translation: AAA40853.1.
    S78183 mRNA. Translation: AAD14276.1.
    PIRiA31258. KLRTI.
    RefSeqiNP_036653.1. NM_012521.2.
    XP_006256950.1. XM_006256888.1.
    UniGeneiRn.9974.

    Genome annotation databases

    EnsembliENSRNOT00000005622; ENSRNOP00000005622; ENSRNOG00000004222.
    GeneIDi24249.
    KEGGirno:24249.
    UCSCiRGD:2253. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16635 Genomic DNA. Translation: CAA34627.1 .
    K00994 mRNA. Translation: AAA40843.1 .
    J02954 mRNA. Translation: AAA42333.1 .
    BC059153 mRNA. Translation: AAH59153.1 .
    J04133 Genomic DNA. Translation: AAA40853.1 .
    S78183 mRNA. Translation: AAD14276.1 .
    PIRi A31258. KLRTI.
    RefSeqi NP_036653.1. NM_012521.2.
    XP_006256950.1. XM_006256888.1.
    UniGenei Rn.9974.

    3D structure databases

    ProteinModelPortali P02634.
    SMRi P02634. Positions 2-79.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000005622.

    Proteomic databases

    PRIDEi P02634.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000005622 ; ENSRNOP00000005622 ; ENSRNOG00000004222 .
    GeneIDi 24249.
    KEGGi rno:24249.
    UCSCi RGD:2253. rat.

    Organism-specific databases

    CTDi 795.
    RGDi 2253. S100g.

    Phylogenomic databases

    eggNOGi NOG39449.
    GeneTreei ENSGT00530000064238.
    HOGENOMi HOG000246968.
    HOVERGENi HBG001479.
    InParanoidi P02634.
    KOi K14734.
    OMAi QIHIENE.
    OrthoDBi EOG7Z3F78.
    PhylomeDBi P02634.

    Miscellaneous databases

    NextBioi 602757.
    PROi P02634.

    Gene expression databases

    Genevestigatori P02634.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR001751. S100/CaBP-9k_CS.
    IPR013787. S100_Ca-bd_sub.
    IPR028489. S100G.
    [Graphical view ]
    PANTHERi PTHR11639:SF67. PTHR11639:SF67. 1 hit.
    Pfami PF00036. EF-hand_1. 1 hit.
    PF01023. S_100. 1 hit.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 1 hit.
    PS00303. S100_CABP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The rat vitamin-D-dependent calcium-binding protein (9-kDa CaBP) gene. Complete nucleotide sequence and structural organization."
      Perret C., Lomri N., Gouhier N., Auffray C., Thomasset M.
      Eur. J. Biochem. 172:43-51(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Molecular cloning of the cDNA and chromosomal gene for vitamin D-dependent calcium-binding protein of rat intestine."
      Darwish H.M., Krisinger J., Strom M., Deluca H.F.
      Proc. Natl. Acad. Sci. U.S.A. 84:6108-6111(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Structure and nucleotide sequence of the rat intestinal vitamin D-dependent calcium binding protein gene."
      Krisinger J., Darwish H., Maeda N., Deluca H.F.
      Proc. Natl. Acad. Sci. U.S.A. 85:8988-8992(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pituitary.
    5. "The purification and complete amino acid sequence of the 9000-Mr Ca2+-binding protein from rat placenta. Identity with the vitamin D-dependent intestinal Ca2+-binding protein."
      McManus J.P., Watson D.C., Yaguchi M.
      Biochem. J. 235:585-595(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-79, ACETYLATION AT SER-2.
    6. "Sequence of rat intestinal vitamin D-dependent calcium-binding protein derived from a cDNA clone. Evolutionary implications."
      Desplan C., Heidmann O., Lillie J.W., Auffray C., Thomasset M.
      J. Biol. Chem. 258:13502-13505(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-79.
    7. "cDNA sequence identity of a vitamin D-dependent calcium-binding protein in the chick to calbindin D-9K."
      Zanello S.B., Boland R.L., Norman A.W.
      Endocrinology 136:2784-2787(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-71.

    Entry informationi

    Entry nameiS100G_RAT
    AccessioniPrimary (citable) accession number: P02634
    Secondary accession number(s): P51964
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 116 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The synthesis of this protein in the absorptive cells of the rat duodenum is vitamin D3-dependent.

    Caution

    Was originally thought to originate from chick.1 Publication

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3