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Protein

Protein S100-G

Gene

S100g

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi18 – 31141; low affinityAdd
BLAST
Calcium bindingi58 – 69122; high affinityAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding, Vitamin D

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-G
Alternative name(s):
9 kDa CaBP
Calbindin-D9k
Cholecalcin
S100 calcium-binding protein G
Vitamin D-dependent calcium-binding protein, intestinal
Short name:
CABP
Gene namesi
Name:S100g
Synonyms:Calb3, S100d
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi2253. S100g.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 7978Protein S100-GPRO_0000144030Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP02634.

Expressioni

Gene expression databases

GenevestigatoriP02634.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005622.

Structurei

3D structure databases

ProteinModelPortaliP02634.
SMRiP02634. Positions 2-79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 4836EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini45 – 7935EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG39449.
GeneTreeiENSGT00530000064238.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP02634.
KOiK14734.
OMAiLLIQTEF.
OrthoDBiEOG7Z3F78.
PhylomeDBiP02634.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028489. S100G.
[Graphical view]
PANTHERiPTHR11639:SF67. PTHR11639:SF67. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02634-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAKKSPEEM KSIFQKYAAK EGDPNQLSKE ELKLLIQSEF PSLLKASSTL
60 70
DNLFKELDKN GDGEVSYEEF EVFFKKLSQ
Length:79
Mass (Da):9,038
Last modified:January 23, 2007 - v3
Checksum:i3566BD81668704C6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 32SA → AS AA sequence (PubMed:3741407).Curated
Sequence conflicti42 – 421S → N in AAA40843 (PubMed:6315698).Curated
Sequence conflicti45 – 451K → KQ in AAA40853 (PubMed:3194402).Curated
Sequence conflicti55 – 551K → E in AAA40843 (PubMed:6315698).Curated
Sequence conflicti60 – 601N → D AA sequence (PubMed:3741407).Curated
Sequence conflicti61 – 611G → D in AAA40843 (PubMed:6315698).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16635 Genomic DNA. Translation: CAA34627.1.
K00994 mRNA. Translation: AAA40843.1.
J02954 mRNA. Translation: AAA42333.1.
BC059153 mRNA. Translation: AAH59153.1.
J04133 Genomic DNA. Translation: AAA40853.1.
S78183 mRNA. Translation: AAD14276.1.
PIRiA31258. KLRTI.
RefSeqiNP_036653.1. NM_012521.2.
XP_006256950.1. XM_006256888.2.
UniGeneiRn.9974.

Genome annotation databases

EnsembliENSRNOT00000005622; ENSRNOP00000005622; ENSRNOG00000004222.
GeneIDi24249.
KEGGirno:24249.
UCSCiRGD:2253. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16635 Genomic DNA. Translation: CAA34627.1.
K00994 mRNA. Translation: AAA40843.1.
J02954 mRNA. Translation: AAA42333.1.
BC059153 mRNA. Translation: AAH59153.1.
J04133 Genomic DNA. Translation: AAA40853.1.
S78183 mRNA. Translation: AAD14276.1.
PIRiA31258. KLRTI.
RefSeqiNP_036653.1. NM_012521.2.
XP_006256950.1. XM_006256888.2.
UniGeneiRn.9974.

3D structure databases

ProteinModelPortaliP02634.
SMRiP02634. Positions 2-79.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005622.

Proteomic databases

PRIDEiP02634.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005622; ENSRNOP00000005622; ENSRNOG00000004222.
GeneIDi24249.
KEGGirno:24249.
UCSCiRGD:2253. rat.

Organism-specific databases

CTDi795.
RGDi2253. S100g.

Phylogenomic databases

eggNOGiNOG39449.
GeneTreeiENSGT00530000064238.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP02634.
KOiK14734.
OMAiLLIQTEF.
OrthoDBiEOG7Z3F78.
PhylomeDBiP02634.

Miscellaneous databases

NextBioi602757.
PROiP02634.

Gene expression databases

GenevestigatoriP02634.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028489. S100G.
[Graphical view]
PANTHERiPTHR11639:SF67. PTHR11639:SF67. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The rat vitamin-D-dependent calcium-binding protein (9-kDa CaBP) gene. Complete nucleotide sequence and structural organization."
    Perret C., Lomri N., Gouhier N., Auffray C., Thomasset M.
    Eur. J. Biochem. 172:43-51(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Molecular cloning of the cDNA and chromosomal gene for vitamin D-dependent calcium-binding protein of rat intestine."
    Darwish H.M., Krisinger J., Strom M., Deluca H.F.
    Proc. Natl. Acad. Sci. U.S.A. 84:6108-6111(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Structure and nucleotide sequence of the rat intestinal vitamin D-dependent calcium binding protein gene."
    Krisinger J., Darwish H., Maeda N., Deluca H.F.
    Proc. Natl. Acad. Sci. U.S.A. 85:8988-8992(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.
  5. "The purification and complete amino acid sequence of the 9000-Mr Ca2+-binding protein from rat placenta. Identity with the vitamin D-dependent intestinal Ca2+-binding protein."
    McManus J.P., Watson D.C., Yaguchi M.
    Biochem. J. 235:585-595(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-79, ACETYLATION AT SER-2.
  6. "Sequence of rat intestinal vitamin D-dependent calcium-binding protein derived from a cDNA clone. Evolutionary implications."
    Desplan C., Heidmann O., Lillie J.W., Auffray C., Thomasset M.
    J. Biol. Chem. 258:13502-13505(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-79.
  7. "cDNA sequence identity of a vitamin D-dependent calcium-binding protein in the chick to calbindin D-9K."
    Zanello S.B., Boland R.L., Norman A.W.
    Endocrinology 136:2784-2787(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-71.

Entry informationi

Entry nameiS100G_RAT
AccessioniPrimary (citable) accession number: P02634
Secondary accession number(s): P51964
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: January 7, 2015
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The synthesis of this protein in the absorptive cells of the rat duodenum is vitamin D3-dependent.

Caution

Was originally thought to originate from chick.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.