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P02634 (S100G_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein S100-G
Alternative name(s):
9 kDa CaBP
Calbindin-D9k
Cholecalcin
S100 calcium-binding protein G
Vitamin D-dependent calcium-binding protein, intestinal
Short name=CABP
Gene names
Name:S100g
Synonyms:Calb3, S100d
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length79 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Miscellaneous

The synthesis of this protein in the absorptive cells of the rat duodenum is vitamin D3-dependent.

Sequence similarities

Belongs to the S-101 family.

Contains 2 EF-hand domains.

Caution

Was originally thought to originate from chick (Ref.7).

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.5
Chain2 – 7978Protein S100-G
PRO_0000144030

Regions

Domain13 – 4836EF-hand 1
Domain45 – 7935EF-hand 2
Calcium binding18 – 31141; low affinity
Calcium binding58 – 69122; high affinity

Amino acid modifications

Modified residue21N-acetylserine Ref.5

Experimental info

Sequence conflict2 – 32SA → AS AA sequence Ref.5
Sequence conflict421S → N in AAA40843. Ref.6
Sequence conflict451K → KQ in AAA40853. Ref.3
Sequence conflict551K → E in AAA40843. Ref.6
Sequence conflict601N → D AA sequence Ref.5
Sequence conflict611G → D in AAA40843. Ref.6

Sequences

Sequence LengthMass (Da)Tools
P02634 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 3566BD81668704C6

FASTA799,038
        10         20         30         40         50         60 
MSAKKSPEEM KSIFQKYAAK EGDPNQLSKE ELKLLIQSEF PSLLKASSTL DNLFKELDKN 

        70 
GDGEVSYEEF EVFFKKLSQ 

« Hide

References

« Hide 'large scale' references
[1]"The rat vitamin-D-dependent calcium-binding protein (9-kDa CaBP) gene. Complete nucleotide sequence and structural organization."
Perret C., Lomri N., Gouhier N., Auffray C., Thomasset M.
Eur. J. Biochem. 172:43-51(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Molecular cloning of the cDNA and chromosomal gene for vitamin D-dependent calcium-binding protein of rat intestine."
Darwish H.M., Krisinger J., Strom M., Deluca H.F.
Proc. Natl. Acad. Sci. U.S.A. 84:6108-6111(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Structure and nucleotide sequence of the rat intestinal vitamin D-dependent calcium binding protein gene."
Krisinger J., Darwish H., Maeda N., Deluca H.F.
Proc. Natl. Acad. Sci. U.S.A. 85:8988-8992(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pituitary.
[5]"The purification and complete amino acid sequence of the 9000-Mr Ca2+-binding protein from rat placenta. Identity with the vitamin D-dependent intestinal Ca2+-binding protein."
McManus J.P., Watson D.C., Yaguchi M.
Biochem. J. 235:585-595(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-79, ACETYLATION AT SER-2.
[6]"Sequence of rat intestinal vitamin D-dependent calcium-binding protein derived from a cDNA clone. Evolutionary implications."
Desplan C., Heidmann O., Lillie J.W., Auffray C., Thomasset M.
J. Biol. Chem. 258:13502-13505(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-79.
[7]"cDNA sequence identity of a vitamin D-dependent calcium-binding protein in the chick to calbindin D-9K."
Zanello S.B., Boland R.L., Norman A.W.
Endocrinology 136:2784-2787(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-71.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X16635 Genomic DNA. Translation: CAA34627.1.
K00994 mRNA. Translation: AAA40843.1.
J02954 mRNA. Translation: AAA42333.1.
BC059153 mRNA. Translation: AAH59153.1.
J04133 Genomic DNA. Translation: AAA40853.1.
S78183 mRNA. Translation: AAD14276.1.
PIRKLRTI. A31258.
RefSeqNP_036653.1. NM_012521.2.
XP_006256950.1. XM_006256888.1.
UniGeneRn.9974.

3D structure databases

ProteinModelPortalP02634.
SMRP02634. Positions 2-79.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000005622.

Proteomic databases

PRIDEP02634.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000005622; ENSRNOP00000005622; ENSRNOG00000004222.
GeneID24249.
KEGGrno:24249.
UCSCRGD:2253. rat.

Organism-specific databases

CTD795.
RGD2253. S100g.

Phylogenomic databases

eggNOGNOG39449.
GeneTreeENSGT00530000064238.
HOGENOMHOG000246968.
HOVERGENHBG001479.
InParanoidP02634.
KOK14734.
OMAKGPSTLD.
OrthoDBEOG7Z3F78.
PhylomeDBP02634.

Gene expression databases

GenevestigatorP02634.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028489. S100G.
[Graphical view]
PANTHERPTHR11639:SF6. PTHR11639:SF6. 1 hit.
PfamPF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio602757.
PROP02634.

Entry information

Entry nameS100G_RAT
AccessionPrimary (citable) accession number: P02634
Secondary accession number(s): P51964
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families