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Protein

Protein S100-G

Gene

S100g

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi18 – 311; low affinityAdd BLAST14
Calcium bindingi58 – 692; high affinityAdd BLAST12

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding, Vitamin D

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-G
Alternative name(s):
9 kDa CaBP
Calbindin-D9k
Cholecalcin
S100 calcium-binding protein G
Vitamin D-dependent calcium-binding protein, intestinal
Short name:
CABP
Gene namesi
Name:S100g
Synonyms:Calb3, S100d
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi2253. S100g.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001440302 – 79Protein S100-GAdd BLAST78

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei42PhosphoserineCombined sources1
Modified residuei47PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP02634.
PRIDEiP02634.

PTM databases

iPTMnetiP02634.
PhosphoSitePlusiP02634.

Expressioni

Gene expression databases

BgeeiENSRNOG00000004222.
GenevisibleiP02634. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005622.

Structurei

3D structure databases

ProteinModelPortaliP02634.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 48EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini45 – 79EF-hand 2PROSITE-ProRule annotationAdd BLAST35

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J1CR. Eukaryota.
ENOG4111C34. LUCA.
GeneTreeiENSGT00530000064238.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP02634.
KOiK14734.
OMAiLLIQTEF.
OrthoDBiEOG091G137D.
PhylomeDBiP02634.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028489. S100G.
[Graphical view]
PANTHERiPTHR11639:SF73. PTHR11639:SF73. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02634-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAKKSPEEM KSIFQKYAAK EGDPNQLSKE ELKLLIQSEF PSLLKASSTL
60 70
DNLFKELDKN GDGEVSYEEF EVFFKKLSQ
Length:79
Mass (Da):9,038
Last modified:January 23, 2007 - v3
Checksum:i3566BD81668704C6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2 – 3SA → AS AA sequence (PubMed:3741407).Curated2
Sequence conflicti42S → N in AAA40843 (PubMed:6315698).Curated1
Sequence conflicti45K → KQ in AAA40853 (PubMed:3194402).Curated1
Sequence conflicti55K → E in AAA40843 (PubMed:6315698).Curated1
Sequence conflicti60N → D AA sequence (PubMed:3741407).Curated1
Sequence conflicti61G → D in AAA40843 (PubMed:6315698).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16635 Genomic DNA. Translation: CAA34627.1.
K00994 mRNA. Translation: AAA40843.1.
J02954 mRNA. Translation: AAA42333.1.
BC059153 mRNA. Translation: AAH59153.1.
J04133 Genomic DNA. Translation: AAA40853.1.
S78183 mRNA. Translation: AAD14276.1.
PIRiA31258. KLRTI.
RefSeqiNP_036653.1. NM_012521.2.
XP_006256950.1. XM_006256888.3.
UniGeneiRn.9974.

Genome annotation databases

EnsembliENSRNOT00000005622; ENSRNOP00000005622; ENSRNOG00000004222.
GeneIDi24249.
KEGGirno:24249.
UCSCiRGD:2253. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16635 Genomic DNA. Translation: CAA34627.1.
K00994 mRNA. Translation: AAA40843.1.
J02954 mRNA. Translation: AAA42333.1.
BC059153 mRNA. Translation: AAH59153.1.
J04133 Genomic DNA. Translation: AAA40853.1.
S78183 mRNA. Translation: AAD14276.1.
PIRiA31258. KLRTI.
RefSeqiNP_036653.1. NM_012521.2.
XP_006256950.1. XM_006256888.3.
UniGeneiRn.9974.

3D structure databases

ProteinModelPortaliP02634.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005622.

PTM databases

iPTMnetiP02634.
PhosphoSitePlusiP02634.

Proteomic databases

PaxDbiP02634.
PRIDEiP02634.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005622; ENSRNOP00000005622; ENSRNOG00000004222.
GeneIDi24249.
KEGGirno:24249.
UCSCiRGD:2253. rat.

Organism-specific databases

CTDi795.
RGDi2253. S100g.

Phylogenomic databases

eggNOGiENOG410J1CR. Eukaryota.
ENOG4111C34. LUCA.
GeneTreeiENSGT00530000064238.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP02634.
KOiK14734.
OMAiLLIQTEF.
OrthoDBiEOG091G137D.
PhylomeDBiP02634.

Miscellaneous databases

PROiP02634.

Gene expression databases

BgeeiENSRNOG00000004222.
GenevisibleiP02634. RN.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028489. S100G.
[Graphical view]
PANTHERiPTHR11639:SF73. PTHR11639:SF73. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS100G_RAT
AccessioniPrimary (citable) accession number: P02634
Secondary accession number(s): P51964
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The synthesis of this protein in the absorptive cells of the rat duodenum is vitamin D3-dependent.

Caution

Was originally thought to originate from chick.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.