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Protein

Protein S100-G

Gene

S100g

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi18 – 31141; low affinityAdd
BLAST
Calcium bindingi58 – 69122; high affinityAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding, Vitamin D

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-G
Alternative name(s):
9 kDa CaBP
Calbindin-D9k
Cholecalcin
S100 calcium-binding protein G
Vitamin D-dependent calcium-binding protein, intestinal
Short name:
CABP
Gene namesi
Name:S100g
Synonyms:Calb3, S100d
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi2253. S100g.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 7978Protein S100-GPRO_0000144030Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication
Modified residuei42 – 421PhosphoserineCombined sources
Modified residuei47 – 471PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP02634.
PRIDEiP02634.

Expressioni

Gene expression databases

GenevisibleiP02634. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005622.

Structurei

3D structure databases

ProteinModelPortaliP02634.
SMRiP02634. Positions 2-79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 4836EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini45 – 7935EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J1CR. Eukaryota.
ENOG4111C34. LUCA.
GeneTreeiENSGT00530000064238.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP02634.
KOiK14734.
OMAiLLIQTEF.
OrthoDBiEOG7Z3F78.
PhylomeDBiP02634.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028489. S100G.
[Graphical view]
PANTHERiPTHR11639:SF73. PTHR11639:SF73. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02634-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAKKSPEEM KSIFQKYAAK EGDPNQLSKE ELKLLIQSEF PSLLKASSTL
60 70
DNLFKELDKN GDGEVSYEEF EVFFKKLSQ
Length:79
Mass (Da):9,038
Last modified:January 23, 2007 - v3
Checksum:i3566BD81668704C6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 32SA → AS AA sequence (PubMed:3741407).Curated
Sequence conflicti42 – 421S → N in AAA40843 (PubMed:6315698).Curated
Sequence conflicti45 – 451K → KQ in AAA40853 (PubMed:3194402).Curated
Sequence conflicti55 – 551K → E in AAA40843 (PubMed:6315698).Curated
Sequence conflicti60 – 601N → D AA sequence (PubMed:3741407).Curated
Sequence conflicti61 – 611G → D in AAA40843 (PubMed:6315698).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16635 Genomic DNA. Translation: CAA34627.1.
K00994 mRNA. Translation: AAA40843.1.
J02954 mRNA. Translation: AAA42333.1.
BC059153 mRNA. Translation: AAH59153.1.
J04133 Genomic DNA. Translation: AAA40853.1.
S78183 mRNA. Translation: AAD14276.1.
PIRiA31258. KLRTI.
RefSeqiNP_036653.1. NM_012521.2.
XP_006256950.1. XM_006256888.2.
UniGeneiRn.9974.

Genome annotation databases

EnsembliENSRNOT00000005622; ENSRNOP00000005622; ENSRNOG00000004222.
GeneIDi24249.
KEGGirno:24249.
UCSCiRGD:2253. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16635 Genomic DNA. Translation: CAA34627.1.
K00994 mRNA. Translation: AAA40843.1.
J02954 mRNA. Translation: AAA42333.1.
BC059153 mRNA. Translation: AAH59153.1.
J04133 Genomic DNA. Translation: AAA40853.1.
S78183 mRNA. Translation: AAD14276.1.
PIRiA31258. KLRTI.
RefSeqiNP_036653.1. NM_012521.2.
XP_006256950.1. XM_006256888.2.
UniGeneiRn.9974.

3D structure databases

ProteinModelPortaliP02634.
SMRiP02634. Positions 2-79.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005622.

Proteomic databases

PaxDbiP02634.
PRIDEiP02634.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000005622; ENSRNOP00000005622; ENSRNOG00000004222.
GeneIDi24249.
KEGGirno:24249.
UCSCiRGD:2253. rat.

Organism-specific databases

CTDi795.
RGDi2253. S100g.

Phylogenomic databases

eggNOGiENOG410J1CR. Eukaryota.
ENOG4111C34. LUCA.
GeneTreeiENSGT00530000064238.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP02634.
KOiK14734.
OMAiLLIQTEF.
OrthoDBiEOG7Z3F78.
PhylomeDBiP02634.

Miscellaneous databases

NextBioi602757.
PROiP02634.

Gene expression databases

GenevisibleiP02634. RN.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028489. S100G.
[Graphical view]
PANTHERiPTHR11639:SF73. PTHR11639:SF73. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The rat vitamin-D-dependent calcium-binding protein (9-kDa CaBP) gene. Complete nucleotide sequence and structural organization."
    Perret C., Lomri N., Gouhier N., Auffray C., Thomasset M.
    Eur. J. Biochem. 172:43-51(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Molecular cloning of the cDNA and chromosomal gene for vitamin D-dependent calcium-binding protein of rat intestine."
    Darwish H.M., Krisinger J., Strom M., Deluca H.F.
    Proc. Natl. Acad. Sci. U.S.A. 84:6108-6111(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Structure and nucleotide sequence of the rat intestinal vitamin D-dependent calcium binding protein gene."
    Krisinger J., Darwish H., Maeda N., Deluca H.F.
    Proc. Natl. Acad. Sci. U.S.A. 85:8988-8992(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.
  5. "The purification and complete amino acid sequence of the 9000-Mr Ca2+-binding protein from rat placenta. Identity with the vitamin D-dependent intestinal Ca2+-binding protein."
    McManus J.P., Watson D.C., Yaguchi M.
    Biochem. J. 235:585-595(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-79, ACETYLATION AT SER-2.
  6. "Sequence of rat intestinal vitamin D-dependent calcium-binding protein derived from a cDNA clone. Evolutionary implications."
    Desplan C., Heidmann O., Lillie J.W., Auffray C., Thomasset M.
    J. Biol. Chem. 258:13502-13505(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-79.
  7. "cDNA sequence identity of a vitamin D-dependent calcium-binding protein in the chick to calbindin D-9K."
    Zanello S.B., Boland R.L., Norman A.W.
    Endocrinology 136:2784-2787(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-71.
  8. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-42 AND SER-47, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiS100G_RAT
AccessioniPrimary (citable) accession number: P02634
Secondary accession number(s): P51964
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: December 9, 2015
This is version 123 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The synthesis of this protein in the absorptive cells of the rat duodenum is vitamin D3-dependent.

Caution

Was originally thought to originate from chick.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.