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P02634

- S100G_RAT

UniProt

P02634 - S100G_RAT

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Protein

Protein S100-G

Gene
S100g, Calb3, S100d
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi18 – 31141; low affinityAdd
BLAST
Calcium bindingi58 – 69122; high affinityAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. vitamin D binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding, Vitamin D

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-G
Alternative name(s):
9 kDa CaBP
Calbindin-D9k
Cholecalcin
S100 calcium-binding protein G
Vitamin D-dependent calcium-binding protein, intestinal
Short name:
CABP
Gene namesi
Name:S100g
Synonyms:Calb3, S100d
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome X

Organism-specific databases

RGDi2253. S100g.

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: Ensembl
  2. basolateral plasma membrane Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 7978Protein S100-GPRO_0000144030Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP02634.

Expressioni

Gene expression databases

GenevestigatoriP02634.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005622.

Structurei

3D structure databases

ProteinModelPortaliP02634.
SMRiP02634. Positions 2-79.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 4836EF-hand 1Add
BLAST
Domaini45 – 7935EF-hand 2Add
BLAST

Sequence similaritiesi

Belongs to the S-101 family.
Contains 2 EF-hand domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG39449.
GeneTreeiENSGT00530000064238.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP02634.
KOiK14734.
OMAiQIHIENE.
OrthoDBiEOG7Z3F78.
PhylomeDBiP02634.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028489. S100G.
[Graphical view]
PANTHERiPTHR11639:SF67. PTHR11639:SF67. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02634-1 [UniParc]FASTAAdd to Basket

« Hide

MSAKKSPEEM KSIFQKYAAK EGDPNQLSKE ELKLLIQSEF PSLLKASSTL   50
DNLFKELDKN GDGEVSYEEF EVFFKKLSQ 79
Length:79
Mass (Da):9,038
Last modified:January 23, 2007 - v3
Checksum:i3566BD81668704C6
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 32SA → AS AA sequence 1 Publication
Sequence conflicti42 – 421S → N in AAA40843. 1 Publication
Sequence conflicti45 – 451K → KQ in AAA40853. 1 Publication
Sequence conflicti55 – 551K → E in AAA40843. 1 Publication
Sequence conflicti60 – 601N → D AA sequence 1 Publication
Sequence conflicti61 – 611G → D in AAA40843. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X16635 Genomic DNA. Translation: CAA34627.1.
K00994 mRNA. Translation: AAA40843.1.
J02954 mRNA. Translation: AAA42333.1.
BC059153 mRNA. Translation: AAH59153.1.
J04133 Genomic DNA. Translation: AAA40853.1.
S78183 mRNA. Translation: AAD14276.1.
PIRiA31258. KLRTI.
RefSeqiNP_036653.1. NM_012521.2.
XP_006256950.1. XM_006256888.1.
UniGeneiRn.9974.

Genome annotation databases

EnsembliENSRNOT00000005622; ENSRNOP00000005622; ENSRNOG00000004222.
GeneIDi24249.
KEGGirno:24249.
UCSCiRGD:2253. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X16635 Genomic DNA. Translation: CAA34627.1 .
K00994 mRNA. Translation: AAA40843.1 .
J02954 mRNA. Translation: AAA42333.1 .
BC059153 mRNA. Translation: AAH59153.1 .
J04133 Genomic DNA. Translation: AAA40853.1 .
S78183 mRNA. Translation: AAD14276.1 .
PIRi A31258. KLRTI.
RefSeqi NP_036653.1. NM_012521.2.
XP_006256950.1. XM_006256888.1.
UniGenei Rn.9974.

3D structure databases

ProteinModelPortali P02634.
SMRi P02634. Positions 2-79.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000005622.

Proteomic databases

PRIDEi P02634.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000005622 ; ENSRNOP00000005622 ; ENSRNOG00000004222 .
GeneIDi 24249.
KEGGi rno:24249.
UCSCi RGD:2253. rat.

Organism-specific databases

CTDi 795.
RGDi 2253. S100g.

Phylogenomic databases

eggNOGi NOG39449.
GeneTreei ENSGT00530000064238.
HOGENOMi HOG000246968.
HOVERGENi HBG001479.
InParanoidi P02634.
KOi K14734.
OMAi QIHIENE.
OrthoDBi EOG7Z3F78.
PhylomeDBi P02634.

Miscellaneous databases

NextBioi 602757.
PROi P02634.

Gene expression databases

Genevestigatori P02634.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028489. S100G.
[Graphical view ]
PANTHERi PTHR11639:SF67. PTHR11639:SF67. 1 hit.
Pfami PF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The rat vitamin-D-dependent calcium-binding protein (9-kDa CaBP) gene. Complete nucleotide sequence and structural organization."
    Perret C., Lomri N., Gouhier N., Auffray C., Thomasset M.
    Eur. J. Biochem. 172:43-51(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Molecular cloning of the cDNA and chromosomal gene for vitamin D-dependent calcium-binding protein of rat intestine."
    Darwish H.M., Krisinger J., Strom M., Deluca H.F.
    Proc. Natl. Acad. Sci. U.S.A. 84:6108-6111(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Structure and nucleotide sequence of the rat intestinal vitamin D-dependent calcium binding protein gene."
    Krisinger J., Darwish H., Maeda N., Deluca H.F.
    Proc. Natl. Acad. Sci. U.S.A. 85:8988-8992(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.
  5. "The purification and complete amino acid sequence of the 9000-Mr Ca2+-binding protein from rat placenta. Identity with the vitamin D-dependent intestinal Ca2+-binding protein."
    McManus J.P., Watson D.C., Yaguchi M.
    Biochem. J. 235:585-595(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-79, ACETYLATION AT SER-2.
  6. "Sequence of rat intestinal vitamin D-dependent calcium-binding protein derived from a cDNA clone. Evolutionary implications."
    Desplan C., Heidmann O., Lillie J.W., Auffray C., Thomasset M.
    J. Biol. Chem. 258:13502-13505(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-79.
  7. "cDNA sequence identity of a vitamin D-dependent calcium-binding protein in the chick to calbindin D-9K."
    Zanello S.B., Boland R.L., Norman A.W.
    Endocrinology 136:2784-2787(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-71.

Entry informationi

Entry nameiS100G_RAT
AccessioniPrimary (citable) accession number: P02634
Secondary accession number(s): P51964
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 115 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The synthesis of this protein in the absorptive cells of the rat duodenum is vitamin D3-dependent.

Caution

Was originally thought to originate from chick (1 Publication).

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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