Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein S100-G

Gene

S100g

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Miscellaneous

The synthesis of this protein in the absorptive cells of the rat duodenum is vitamin D3-dependent.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi18 – 311; low affinityAdd BLAST14
Calcium bindingi58 – 692; high affinityAdd BLAST12

GO - Molecular functioni

Keywordsi

LigandCalcium, Metal-binding, Vitamin D

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-G
Alternative name(s):
9 kDa CaBP
Calbindin-D9k
Cholecalcin
S100 calcium-binding protein G
Vitamin D-dependent calcium-binding protein, intestinal
Short name:
CABP
Gene namesi
Name:S100g
Synonyms:Calb3, S100d
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi2253. S100g.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001440302 – 79Protein S100-GAdd BLAST78

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei42PhosphoserineCombined sources1
Modified residuei47PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP02634.
PRIDEiP02634.

PTM databases

iPTMnetiP02634.
PhosphoSitePlusiP02634.

Expressioni

Gene expression databases

BgeeiENSRNOG00000004222.
GenevisibleiP02634. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000005622.

Structurei

3D structure databases

ProteinModelPortaliP02634.
SMRiP02634.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 48EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini45 – 79EF-hand 2PROSITE-ProRule annotationAdd BLAST35

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J1CR. Eukaryota.
ENOG4111C34. LUCA.
GeneTreeiENSGT00530000064238.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP02634.
KOiK14734.
OMAiLLIQTEF.
OrthoDBiEOG091G137D.
PhylomeDBiP02634.

Family and domain databases

CDDicd00213. S-100. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR034325. S-100_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028489. S100G.
PANTHERiPTHR11639:SF81. PTHR11639:SF81. 1 hit.
PfamiView protein in Pfam
PF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02634-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAKKSPEEM KSIFQKYAAK EGDPNQLSKE ELKLLIQSEF PSLLKASSTL
60 70
DNLFKELDKN GDGEVSYEEF EVFFKKLSQ
Length:79
Mass (Da):9,038
Last modified:January 23, 2007 - v3
Checksum:i3566BD81668704C6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2 – 3SA → AS AA sequence (PubMed:3741407).Curated2
Sequence conflicti42S → N in AAA40843 (PubMed:6315698).Curated1
Sequence conflicti45K → KQ in AAA40853 (PubMed:3194402).Curated1
Sequence conflicti55K → E in AAA40843 (PubMed:6315698).Curated1
Sequence conflicti60N → D AA sequence (PubMed:3741407).Curated1
Sequence conflicti61G → D in AAA40843 (PubMed:6315698).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16635 Genomic DNA. Translation: CAA34627.1.
K00994 mRNA. Translation: AAA40843.1.
J02954 mRNA. Translation: AAA42333.1.
BC059153 mRNA. Translation: AAH59153.1.
J04133 Genomic DNA. Translation: AAA40853.1.
S78183 mRNA. Translation: AAD14276.1.
PIRiA31258. KLRTI.
RefSeqiNP_036653.1. NM_012521.2.
XP_006256950.1. XM_006256888.3.
UniGeneiRn.9974.

Genome annotation databases

EnsembliENSRNOT00000005622; ENSRNOP00000005622; ENSRNOG00000004222.
GeneIDi24249.
KEGGirno:24249.
UCSCiRGD:2253. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiS100G_RAT
AccessioniPrimary (citable) accession number: P02634
Secondary accession number(s): P51964
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: May 10, 2017
This is version 132 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was originally thought to originate from chick.1 Publication

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families