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Protein

Protein S100-G

Gene

S100G

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi18 – 311; low affinityAdd BLAST14
Calcium bindingi58 – 692; high affinityAdd BLAST12

GO - Molecular functioni

Keywordsi

LigandCalcium, Metal-binding, Vitamin D

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-G
Alternative name(s):
Calbindin-D9k
S100 calcium-binding protein G
Vitamin D-dependent calcium-binding protein, intestinal
Short name:
CABP
Gene namesi
Name:S100G
Synonyms:CALB3, S100D
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome X

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00001440262 – 79Protein S100-GAdd BLAST78

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei42PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP02633.

Expressioni

Gene expression databases

BgeeiENSBTAG00000017020.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022630.

Structurei

Secondary structure

179
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 18Combined sources12
Beta strandi20 – 22Combined sources3
Beta strandi26 – 28Combined sources3
Helixi29 – 39Combined sources11
Helixi40 – 42Combined sources3
Beta strandi45 – 48Combined sources4
Helixi50 – 57Combined sources8
Beta strandi58 – 60Combined sources3
Beta strandi62 – 65Combined sources4
Helixi67 – 77Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B1GNMR-A5-79[»]
1BOCNMR-A5-79[»]
1BODNMR-A5-79[»]
1CDNNMR-A5-79[»]
1CLBNMR-A5-79[»]
1D1ONMR-A5-79[»]
1HT9X-ray1.76A/B5-79[»]
1IG5X-ray1.50A5-79[»]
1IGVX-ray1.85A5-79[»]
1KCYNMR-A5-79[»]
1KQVNMR-A1-79[»]
1KSMNMR-A1-79[»]
1N65NMR-A5-79[»]
1QX2X-ray1.44A/B5-79[»]
1RT0NMR-A58-69[»]
2BCANMR-A5-79[»]
2BCBNMR-A5-79[»]
2MAZNMR-A5-79[»]
3ICBX-ray2.30A5-79[»]
4ICBX-ray1.60A5-79[»]
ProteinModelPortaliP02633.
SMRiP02633.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02633.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 48EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini45 – 79EF-hand 2PROSITE-ProRule annotationAdd BLAST35

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J1CR. Eukaryota.
ENOG4111C34. LUCA.
GeneTreeiENSGT00530000064238.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP02633.
KOiK14734.
OMAiLLIQTEF.
OrthoDBiEOG091G137D.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028489. S100G.
PANTHERiPTHR11639:SF81. PTHR11639:SF81. 1 hit.
PfamiView protein in Pfam
PF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02633-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAKKSPEEL KGIFEKYAAK EGDPNQLSKE ELKLLLQTEF PSLLKGPSTL
60 70
DELFEELDKN GDGEVSFEEF QVLVKKISQ
Length:79
Mass (Da):8,918
Last modified:January 23, 2007 - v3
Checksum:i80A5B2AA11D4E74B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18344 mRNA. Translation: AAA30420.1.
BC118480 mRNA. Translation: AAI18481.1.
PIRiA40151. KLBOI.
RefSeqiNP_776682.1. NM_174257.3.
UniGeneiBt.390.

Genome annotation databases

EnsembliENSBTAT00000022630; ENSBTAP00000022630; ENSBTAG00000017020.
GeneIDi281658.
KEGGibta:281658.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18344 mRNA. Translation: AAA30420.1.
BC118480 mRNA. Translation: AAI18481.1.
PIRiA40151. KLBOI.
RefSeqiNP_776682.1. NM_174257.3.
UniGeneiBt.390.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B1GNMR-A5-79[»]
1BOCNMR-A5-79[»]
1BODNMR-A5-79[»]
1CDNNMR-A5-79[»]
1CLBNMR-A5-79[»]
1D1ONMR-A5-79[»]
1HT9X-ray1.76A/B5-79[»]
1IG5X-ray1.50A5-79[»]
1IGVX-ray1.85A5-79[»]
1KCYNMR-A5-79[»]
1KQVNMR-A1-79[»]
1KSMNMR-A1-79[»]
1N65NMR-A5-79[»]
1QX2X-ray1.44A/B5-79[»]
1RT0NMR-A58-69[»]
2BCANMR-A5-79[»]
2BCBNMR-A5-79[»]
2MAZNMR-A5-79[»]
3ICBX-ray2.30A5-79[»]
4ICBX-ray1.60A5-79[»]
ProteinModelPortaliP02633.
SMRiP02633.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022630.

Proteomic databases

PaxDbiP02633.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000022630; ENSBTAP00000022630; ENSBTAG00000017020.
GeneIDi281658.
KEGGibta:281658.

Organism-specific databases

CTDi795.

Phylogenomic databases

eggNOGiENOG410J1CR. Eukaryota.
ENOG4111C34. LUCA.
GeneTreeiENSGT00530000064238.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP02633.
KOiK14734.
OMAiLLIQTEF.
OrthoDBiEOG091G137D.
TreeFamiTF332727.

Miscellaneous databases

EvolutionaryTraceiP02633.

Gene expression databases

BgeeiENSBTAG00000017020.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028489. S100G.
PANTHERiPTHR11639:SF81. PTHR11639:SF81. 1 hit.
PfamiView protein in Pfam
PF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiS100G_BOVIN
AccessioniPrimary (citable) accession number: P02633
Secondary accession number(s): Q17Q94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: March 15, 2017
This is version 139 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.