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Protein

Protein S100-G

Gene

S100G

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi18 – 311; low affinityAdd BLAST14
Calcium bindingi58 – 692; high affinityAdd BLAST12

GO - Molecular functioni

Keywordsi

LigandCalcium, Metal-binding, Vitamin D

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-G
Alternative name(s):
Calbindin-D9k
S100 calcium-binding protein G
Vitamin D-dependent calcium-binding protein, intestinal
Short name:
CABP
Gene namesi
Name:S100G
Synonyms:CALB3, S100D
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome X

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00001440262 – 79Protein S100-GAdd BLAST78

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei42PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP02633.

Expressioni

Gene expression databases

BgeeiENSBTAG00000017020.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022630.

Structurei

Secondary structure

179
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 18Combined sources12
Beta strandi20 – 22Combined sources3
Beta strandi26 – 28Combined sources3
Helixi29 – 39Combined sources11
Helixi40 – 42Combined sources3
Beta strandi45 – 48Combined sources4
Helixi50 – 57Combined sources8
Beta strandi58 – 60Combined sources3
Beta strandi62 – 65Combined sources4
Helixi67 – 77Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B1GNMR-A5-79[»]
1BOCNMR-A5-79[»]
1BODNMR-A5-79[»]
1CDNNMR-A5-79[»]
1CLBNMR-A5-79[»]
1D1ONMR-A5-79[»]
1HT9X-ray1.76A/B5-79[»]
1IG5X-ray1.50A5-79[»]
1IGVX-ray1.85A5-79[»]
1KCYNMR-A5-79[»]
1KQVNMR-A1-79[»]
1KSMNMR-A1-79[»]
1N65NMR-A5-79[»]
1QX2X-ray1.44A/B5-79[»]
1RT0NMR-A58-69[»]
2BCANMR-A5-79[»]
2BCBNMR-A5-79[»]
2MAZNMR-A5-79[»]
3ICBX-ray2.30A5-79[»]
4ICBX-ray1.60A5-79[»]
ProteinModelPortaliP02633.
SMRiP02633.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02633.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 48EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini45 – 79EF-hand 2PROSITE-ProRule annotationAdd BLAST35

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J1CR. Eukaryota.
ENOG4111C34. LUCA.
GeneTreeiENSGT00530000064238.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP02633.
KOiK14734.
OMAiLLIQTEF.
OrthoDBiEOG091G137D.
TreeFamiTF332727.

Family and domain databases

InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028489. S100G.
PANTHERiPTHR11639:SF81. PTHR11639:SF81. 1 hit.
PfamiView protein in Pfam
PF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02633-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAKKSPEEL KGIFEKYAAK EGDPNQLSKE ELKLLLQTEF PSLLKGPSTL
60 70
DELFEELDKN GDGEVSFEEF QVLVKKISQ
Length:79
Mass (Da):8,918
Last modified:January 23, 2007 - v3
Checksum:i80A5B2AA11D4E74B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18344 mRNA. Translation: AAA30420.1.
BC118480 mRNA. Translation: AAI18481.1.
PIRiA40151. KLBOI.
RefSeqiNP_776682.1. NM_174257.3.
UniGeneiBt.390.

Genome annotation databases

EnsembliENSBTAT00000022630; ENSBTAP00000022630; ENSBTAG00000017020.
GeneIDi281658.
KEGGibta:281658.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18344 mRNA. Translation: AAA30420.1.
BC118480 mRNA. Translation: AAI18481.1.
PIRiA40151. KLBOI.
RefSeqiNP_776682.1. NM_174257.3.
UniGeneiBt.390.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1B1GNMR-A5-79[»]
1BOCNMR-A5-79[»]
1BODNMR-A5-79[»]
1CDNNMR-A5-79[»]
1CLBNMR-A5-79[»]
1D1ONMR-A5-79[»]
1HT9X-ray1.76A/B5-79[»]
1IG5X-ray1.50A5-79[»]
1IGVX-ray1.85A5-79[»]
1KCYNMR-A5-79[»]
1KQVNMR-A1-79[»]
1KSMNMR-A1-79[»]
1N65NMR-A5-79[»]
1QX2X-ray1.44A/B5-79[»]
1RT0NMR-A58-69[»]
2BCANMR-A5-79[»]
2BCBNMR-A5-79[»]
2MAZNMR-A5-79[»]
3ICBX-ray2.30A5-79[»]
4ICBX-ray1.60A5-79[»]
ProteinModelPortaliP02633.
SMRiP02633.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022630.

Proteomic databases

PaxDbiP02633.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000022630; ENSBTAP00000022630; ENSBTAG00000017020.
GeneIDi281658.
KEGGibta:281658.

Organism-specific databases

CTDi795.

Phylogenomic databases

eggNOGiENOG410J1CR. Eukaryota.
ENOG4111C34. LUCA.
GeneTreeiENSGT00530000064238.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP02633.
KOiK14734.
OMAiLLIQTEF.
OrthoDBiEOG091G137D.
TreeFamiTF332727.

Miscellaneous databases

EvolutionaryTraceiP02633.

Gene expression databases

BgeeiENSBTAG00000017020.

Family and domain databases

InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028489. S100G.
PANTHERiPTHR11639:SF81. PTHR11639:SF81. 1 hit.
PfamiView protein in Pfam
PF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiS100G_BOVIN
AccessioniPrimary (citable) accession number: P02633
Secondary accession number(s): Q17Q94
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: May 10, 2017
This is version 140 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.