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P02632 (S100G_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein S100-G
Alternative name(s):
Calbindin-D9k
S100 calcium-binding protein G
Vitamin D-dependent calcium-binding protein, intestinal
Short name=CABP

Cleaved into the following chain:

  1. Protein S100-G, minor isoform
Gene names
Name:S100G
Synonyms:CALB3, S100D
OrganismSus scrofa (Pig) [Complete proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length79 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the S-100 family.

Contains 2 EF-hand domains.

Ontologies

Keywords
   DomainRepeat
   LigandCalcium
Vitamin D
   PTMAcetylation
   Technical term3D-structure
Complete proteome
Direct protein sequencing
Gene Ontology (GO)
   Molecular functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

vitamin D binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2
Chain2 – 7978Protein S100-G
PRO_0000144029
Chain3 – 7977Protein S100-G, minor isoform
PRO_0000275899

Regions

Domain13 – 4836EF-hand 1
Domain45 – 7935EF-hand 2
Calcium binding18 – 31141; low affinity
Calcium binding58 – 69122; high affinity

Amino acid modifications

Modified residue21N-acetylserine
Modified residue31N-acetylalanine; in Protein S100-G, minor isoform

Experimental info

Sequence conflict621D → N AA sequence Ref.2

Secondary structure

1 ............ 79
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P02632 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: E8AB53BF23BD2D57

FASTA798,929
        10         20         30         40         50         60 
MSAQKSPAEL KSIFEKYAAK EGDPNQLSKE ELKQLIQAEF PSLLKGPRTL DDLFQELDKN 

        70 
GDGEVSFEEF QVLVKKISQ

« Hide

References

[1]"Cloning of the porcine calbindin-D9k complementary deoxyribonucleic acid by anchored polymerase chain reaction technique."
Jeung E.B., Krisinger J., Dann J.L., Leung P.C.
Biol. Reprod. 47:503-508(1992) [PubMed: 1391336] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Yorkshire.
Tissue: Duodenum.
[2]"The amino acid sequence of porcine intestinal calcium-binding protein."
Hofmann T., Kawakami M., Hitchman A.J.W., Harrison J.E., Dorrington K.J.
Can. J. Biochem. 57:737-748(1979) [PubMed: 476518] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-79.
[3]"1H NMR studies of porcine calbindin D9k in solution: sequential resonance assignment, secondary structure, and global fold."
Drakenberg T., Hofmann T., Chazin W.J.
Biochemistry 28:5946-5954(1989) [PubMed: 2775745] [Abstract]
Cited for: STRUCTURE BY NMR.
[4]"Three-dimensional solution structure of Ca(2+)-loaded porcine calbindin D9k determined by nuclear magnetic resonance spectroscopy."
Akke M., Drakenberg T., Chazin W.J.
Biochemistry 31:1011-1020(1992) [PubMed: 1734952] [Abstract]
Cited for: STRUCTURE BY NMR.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L13068 mRNA. Translation: AAA81524.1.
PIRKLPGI. A56802.
RefSeqNP_999305.1. NM_214140.2.
UniGeneSsc.429.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1CB1NMR-A2-79[»]
1RSWNMR-A58-69[»]
1RSXNMR-A58-69[»]
ProteinModelPortalP02632.
SMRP02632. Positions 2-79.
ModBaseSearch...

Protein-protein interaction databases

STRINGP02632.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID397265.
KEGGssc:397265.

Organism-specific databases

CTD795.

Phylogenomic databases

GeneTreeENSGT00530000064238.
HOVERGENHBG001479.
OrthoDBEOG4NP754.

Family and domain databases

InterProIPR018248. EF-hand.
IPR011992. EF-hand-like_dom.
IPR018247. EF_Hand_1_Ca_BS.
IPR018249. EF_HAND_2.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]
Gene3DG3DSA:1.10.238.10. EF-Hand_type. 1 hit.
KOK14734.
PfamPF00036. efhand. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameS100G_PIG
AccessionPrimary (citable) accession number: P02632
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 16, 2011
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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