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Protein

Oncomodulin

Gene

Ocm

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi52 – 521Calcium 1By similarity
Metal bindingi56 – 561Calcium 1By similarity
Metal bindingi58 – 581Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi63 – 631Calcium 1By similarity
Metal bindingi91 – 911Calcium 1By similarity
Metal bindingi93 – 931Calcium 2By similarity
Metal bindingi95 – 951Calcium 2By similarity
Metal bindingi97 – 971Calcium 2; via carbonyl oxygenBy similarity
Metal bindingi102 – 1021Calcium 2By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi52 – 63121Add
BLAST
Calcium bindingi91 – 102122Add
BLAST

GO - Molecular functioni

  • calcium ion binding Source: RGD
  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: RGD

GO - Biological processi

  • regulation of cytosolic calcium ion concentration Source: RGD
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Oncomodulin
Short name:
OM
Alternative name(s):
Parvalbumin beta
Gene namesi
Name:Ocm
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi3222. Ocm.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • nucleus Source: RGD
  • protein complex Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 109108OncomodulinPRO_0000073584Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP02631.
PRIDEiP02631.

Expressioni

Tissue specificityi

Found in tumor tissues and not detected in normal tissues.

Gene expression databases

BgeeiENSRNOG00000001031.
GenevisibleiP02631. RN.

Interactioni

GO - Molecular functioni

  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040755.

Structurei

Secondary structure

1
109
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 53Combined sources
Helixi9 – 1810Combined sources
Helixi27 – 348Combined sources
Helixi36 – 383Combined sources
Helixi41 – 5111Combined sources
Beta strandi56 – 594Combined sources
Helixi62 – 654Combined sources
Helixi67 – 704Combined sources
Helixi80 – 9011Combined sources
Beta strandi93 – 997Combined sources
Helixi100 – 1078Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OMDX-ray1.85A2-109[»]
1RROX-ray1.30A2-109[»]
2NLNNMR-A2-109[»]
DisProtiDP00730.
ProteinModelPortaliP02631.
SMRiP02631. Positions 2-109.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02631.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 7436EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini78 – 10932EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the parvalbumin family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000008690.
HOGENOMiHOG000037438.
HOVERGENiHBG107490.
InParanoidiP02631.
OMAiKFFETSG.
OrthoDBiEOG091G0XK0.
PhylomeDBiP02631.
TreeFamiTF332342.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02631-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSITDILSAE DIAAALQECQ DPDTFEPQKF FQTSGLSKMS ASQVKDIFRF
60 70 80 90 100
IDNDQSGYLD GDELKYFLQK FQSDARELTE SETKSLMDAA DNDGDGKIGA

DEFQEMVHS
Length:109
Mass (Da):12,188
Last modified:January 23, 2007 - v2
Checksum:i89A168BD30748514
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261E → Q AA sequence (PubMed:6617664).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02705 mRNA. Translation: AAA41756.1.
X15836, X15837, X15838 Genomic DNA. Translation: CAA33840.1.
PIRiS04616. PVRTO.
RefSeqiNP_037127.1. NM_012995.1.
UniGeneiRn.9719.

Genome annotation databases

EnsembliENSRNOT00000043439; ENSRNOP00000040755; ENSRNOG00000001031.
ENSRNOT00000092601; ENSRNOP00000075788; ENSRNOG00000001031.
GeneIDi25503.
KEGGirno:25503.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02705 mRNA. Translation: AAA41756.1.
X15836, X15837, X15838 Genomic DNA. Translation: CAA33840.1.
PIRiS04616. PVRTO.
RefSeqiNP_037127.1. NM_012995.1.
UniGeneiRn.9719.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OMDX-ray1.85A2-109[»]
1RROX-ray1.30A2-109[»]
2NLNNMR-A2-109[»]
DisProtiDP00730.
ProteinModelPortaliP02631.
SMRiP02631. Positions 2-109.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040755.

Proteomic databases

PaxDbiP02631.
PRIDEiP02631.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000043439; ENSRNOP00000040755; ENSRNOG00000001031.
ENSRNOT00000092601; ENSRNOP00000075788; ENSRNOG00000001031.
GeneIDi25503.
KEGGirno:25503.

Organism-specific databases

CTDi4951.
RGDi3222. Ocm.

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000008690.
HOGENOMiHOG000037438.
HOVERGENiHBG107490.
InParanoidiP02631.
OMAiKFFETSG.
OrthoDBiEOG091G0XK0.
PhylomeDBiP02631.
TreeFamiTF332342.

Miscellaneous databases

EvolutionaryTraceiP02631.
PROiP02631.

Gene expression databases

BgeeiENSRNOG00000001031.
GenevisibleiP02631. RN.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiONCO_RAT
AccessioniPrimary (citable) accession number: P02631
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.