Reviewed, UniProtKB/Swiss-Prot P02631 (ONCO_RAT)

Names and origin

Protein names

Recommended name:
    Oncomodulin
      Short name=OM
Alternative name(s):
    Parvalbumin beta

Gene names

Name:

Ocm

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	109 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions.
Tissue specificity	Found in tumor tissues and not detected in normal tissues.
Sequence similarities	Belongs to the parvalbumin family. Contains 2 EF-hand domains.

Ontologies

Keywords
Domain	Repeat
Ligand	Calcium
PTM	Acetylation
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed Ref.3

Chain

2 – 109

108

Oncomodulin

PRO_0000073584

Regions

Domain

39 – 74

36

EF-hand 1

Domain

78 – 109

32

EF-hand 2

Calcium binding

52 – 63

12

1 Ref.4

Calcium binding

91 – 102

12

2 Ref.4

Amino acid modifications

Modified residue

2

1

N-acetylserine Ref.3

Experimental info

Sequence conflict

26

1

E → Q AA sequence Ref.3

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

109

Helix Strand Turn

Details...

Helix

3 – 5

3

Helix

9 – 18

10

Helix

27 – 34

8

Helix

36 – 38

3

Helix

41 – 51

11

Beta strand

56 – 59

4

Helix

62 – 65

4

Helix

67 – 70

4

Helix

80 – 90

11

Beta strand

93 – 99

7

Helix

100 – 107

8

Sequences

	Sequence		Length	Mass (Da)
	P02631-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 89A168BD30748514	FASTA	109	12,188
	10 20 30 40 50 60 MSITDILSAE DIAAALQECQ DPDTFEPQKF FQTSGLSKMS ASQVKDIFRF IDNDQSGYLD 70 80 90 100 GDELKYFLQK FQSDARELTE SETKSLMDAA DNDGDGKIGA DEFQEMVHS

References

[1]	"A complete complementary DNA for the oncodevelopmental calcium-binding protein, oncomodulin." Gillen M.F., Banville D., Rutledge R.G., Narang S., Seligy V.L., Whitfield J.F., McManus J.P. J. Biol. Chem. 262:5308-5312(1987) [PubMed: 3558395] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Retroviral long terminal repeat is the promoter of the gene encoding the tumor-associated calcium-binding protein oncomodulin in the rat." Banville D., Boie Y. J. Mol. Biol. 207:481-490(1989) [PubMed: 2474657] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Buffalo.
[3]	"The complete amino acid sequence of oncomodulin -- a parvalbumin-like calcium-binding protein from Morris hepatoma 5123tc." McManus J.P., Watson D.C., Yaguchi M. Eur. J. Biochem. 136:9-17(1983) [PubMed: 6617664] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-109, ACETYLATION AT SER-2.
[4]	"Oncomodulin. 1H NMR and optical stopped-flow spectroscopic studies of its solution conformation and metal-binding properties." Williams T.C., Corson D.C., Sykes B.D., McManus J.P. J. Biol. Chem. 262:6248-6256(1987) [PubMed: 3571255] [Abstract] Cited for: CALCIUM-BINDING DATA.
[5]	"Structure of oncomodulin refined at 1.85-A resolution. An example of extensive molecular aggregation via Ca2+." Ahmed F.R., Przybylska M., Rose D.R., Birnbaum G.I., Pippy M.E., McManus J.P. J. Mol. Biol. 216:127-140(1990) [PubMed: 2231727] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBLGenBankDDBJ

J02705 mRNA. Translation: AAA41756.1.
X15836, X15837, X15838 Genomic DNA. Translation: CAA33840.1.

IPI

IPI00363600.

PIR

PVRTO. S04616.

RefSeq

NP_037127.1.

UniGene

Rn.9719

3D structure databases

PDBPDBe

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1OMD	X-ray	1.85	A	2-109	[»]
1RRO	X-ray	1.30	A	2-108	[»]
2NLN	NMR	-	A	2-108	[»]

ModBase

Search...

Genome annotation databases

Ensembl

ENSRNOG00000001031. Rattus norvegicus. [Contig view]

GeneID

25503.

KEGG

rno:25503.

Organism-specific databases

RGD

3222. Ocm.

Phylogenomic databases

HOVERGEN

P02631.

OMA

P02631. KDIFRFI.

Gene expression databases

ArrayExpress

P02631.

GermOnline

ENSRNOG00000001031. Rattus norvegicus.

Family and domain databases

InterPro

IPR011992. EF-Hand_type.
IPR018248. EF_hand.
IPR018247. EF_HAND_1.
IPR018249. EF_HAND_2.
IPR002048. EF_hand_Ca_bd.
IPR008080. Parvalbumin.
[Graphical view]

Gene3D

G3DSA:1.10.238.10. EF-Hand_type. 1 hit.

Pfam

PF00036. efhand. 2 hits.
[Graphical view]

PRINTS

PR01697. PARVALBUMIN.

ProDom

PD000012. EF-hand. 1 hit.
[Graphical view] [Entries sharing at least one domain]

SMART

SM00054. EFh. 2 hits.
[Graphical view]

PROSITE

PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

606913.

Entry information

Entry name

ONCO_RAT

Accession

Primary (citable) accession number: P02631

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 80 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)