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Protein

Oncomodulin

Gene

Ocm

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi52Calcium 1By similarity1
Metal bindingi56Calcium 1By similarity1
Metal bindingi58Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi63Calcium 1By similarity1
Metal bindingi91Calcium 1By similarity1
Metal bindingi93Calcium 2By similarity1
Metal bindingi95Calcium 2By similarity1
Metal bindingi97Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi102Calcium 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi52 – 631Add BLAST12
Calcium bindingi91 – 1022Add BLAST12

GO - Molecular functioni

  • calcium ion binding Source: CAFA
  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: CAFA

GO - Biological processi

  • positive regulation of axon extension involved in regeneration Source: CAFA
  • positive regulation of optical nerve axon regeneration Source: CAFA
  • positive regulation of retinal ganglion cell axon guidance Source: CAFA
  • protein homotetramerization Source: CAFA
  • protein homotrimerization Source: CAFA
  • regulation of cytosolic calcium ion concentration Source: RGD
  • response to wounding Source: CAFA

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Oncomodulin
Short name:
OM
Alternative name(s):
Parvalbumin beta
Gene namesi
Name:Ocm
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi3222. Ocm.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000735842 – 109OncomodulinAdd BLAST108

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP02631.
PRIDEiP02631.

Expressioni

Tissue specificityi

Found in tumor tissues and not detected in normal tissues.

Gene expression databases

BgeeiENSRNOG00000001031.
GenevisibleiP02631. RN.

Interactioni

GO - Molecular functioni

  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: CAFA

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040755.

Structurei

Secondary structure

1109
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 5Combined sources3
Helixi9 – 18Combined sources10
Helixi27 – 34Combined sources8
Helixi36 – 38Combined sources3
Helixi41 – 51Combined sources11
Beta strandi56 – 59Combined sources4
Helixi62 – 65Combined sources4
Helixi67 – 70Combined sources4
Helixi80 – 90Combined sources11
Beta strandi93 – 99Combined sources7
Helixi100 – 107Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OMDX-ray1.85A2-109[»]
1RROX-ray1.30A2-109[»]
2NLNNMR-A2-109[»]
DisProtiDP00730.
ProteinModelPortaliP02631.
SMRiP02631.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02631.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 74EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini78 – 109EF-hand 2PROSITE-ProRule annotationAdd BLAST32

Sequence similaritiesi

Belongs to the parvalbumin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000008690.
HOGENOMiHOG000037438.
HOVERGENiHBG107490.
InParanoidiP02631.
OMAiQVKDIFR.
OrthoDBiEOG091G0XK0.
PhylomeDBiP02631.
TreeFamiTF332342.

Family and domain databases

InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiView protein in Pfam
PF13499. EF-hand_7. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 2 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02631-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSITDILSAE DIAAALQECQ DPDTFEPQKF FQTSGLSKMS ASQVKDIFRF
60 70 80 90 100
IDNDQSGYLD GDELKYFLQK FQSDARELTE SETKSLMDAA DNDGDGKIGA

DEFQEMVHS
Length:109
Mass (Da):12,188
Last modified:January 23, 2007 - v2
Checksum:i89A168BD30748514
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26E → Q AA sequence (PubMed:6617664).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02705 mRNA. Translation: AAA41756.1.
X15836, X15837, X15838 Genomic DNA. Translation: CAA33840.1.
PIRiS04616. PVRTO.
RefSeqiNP_037127.1. NM_012995.1.
UniGeneiRn.9719.

Genome annotation databases

EnsembliENSRNOT00000043439; ENSRNOP00000040755; ENSRNOG00000001031.
ENSRNOT00000092601; ENSRNOP00000075788; ENSRNOG00000001031.
GeneIDi25503.
KEGGirno:25503.

Similar proteinsi

Entry informationi

Entry nameiONCO_RAT
AccessioniPrimary (citable) accession number: P02631
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families