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Protein

Oncomodulin

Gene

Ocm

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi52Calcium 1By similarity1
Metal bindingi56Calcium 1By similarity1
Metal bindingi58Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi63Calcium 1By similarity1
Metal bindingi91Calcium 1By similarity1
Metal bindingi93Calcium 2By similarity1
Metal bindingi95Calcium 2By similarity1
Metal bindingi97Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi102Calcium 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi52 – 631Add BLAST12
Calcium bindingi91 – 1022Add BLAST12

GO - Molecular functioni

  • calcium ion binding Source: RGD
  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: RGD

GO - Biological processi

  • regulation of cytosolic calcium ion concentration Source: RGD
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Oncomodulin
Short name:
OM
Alternative name(s):
Parvalbumin beta
Gene namesi
Name:Ocm
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi3222. Ocm.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • nucleus Source: RGD
  • protein complex Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000735842 – 109OncomodulinAdd BLAST108

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP02631.
PRIDEiP02631.

Expressioni

Tissue specificityi

Found in tumor tissues and not detected in normal tissues.

Gene expression databases

BgeeiENSRNOG00000001031.
GenevisibleiP02631. RN.

Interactioni

GO - Molecular functioni

  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040755.

Structurei

Secondary structure

1109
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 5Combined sources3
Helixi9 – 18Combined sources10
Helixi27 – 34Combined sources8
Helixi36 – 38Combined sources3
Helixi41 – 51Combined sources11
Beta strandi56 – 59Combined sources4
Helixi62 – 65Combined sources4
Helixi67 – 70Combined sources4
Helixi80 – 90Combined sources11
Beta strandi93 – 99Combined sources7
Helixi100 – 107Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OMDX-ray1.85A2-109[»]
1RROX-ray1.30A2-109[»]
2NLNNMR-A2-109[»]
DisProtiDP00730.
ProteinModelPortaliP02631.
SMRiP02631.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02631.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 74EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini78 – 109EF-hand 2PROSITE-ProRule annotationAdd BLAST32

Sequence similaritiesi

Belongs to the parvalbumin family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000008690.
HOGENOMiHOG000037438.
HOVERGENiHBG107490.
InParanoidiP02631.
OMAiKFFETSG.
OrthoDBiEOG091G0XK0.
PhylomeDBiP02631.
TreeFamiTF332342.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02631-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSITDILSAE DIAAALQECQ DPDTFEPQKF FQTSGLSKMS ASQVKDIFRF
60 70 80 90 100
IDNDQSGYLD GDELKYFLQK FQSDARELTE SETKSLMDAA DNDGDGKIGA

DEFQEMVHS
Length:109
Mass (Da):12,188
Last modified:January 23, 2007 - v2
Checksum:i89A168BD30748514
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26E → Q AA sequence (PubMed:6617664).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02705 mRNA. Translation: AAA41756.1.
X15836, X15837, X15838 Genomic DNA. Translation: CAA33840.1.
PIRiS04616. PVRTO.
RefSeqiNP_037127.1. NM_012995.1.
UniGeneiRn.9719.

Genome annotation databases

EnsembliENSRNOT00000043439; ENSRNOP00000040755; ENSRNOG00000001031.
ENSRNOT00000092601; ENSRNOP00000075788; ENSRNOG00000001031.
GeneIDi25503.
KEGGirno:25503.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02705 mRNA. Translation: AAA41756.1.
X15836, X15837, X15838 Genomic DNA. Translation: CAA33840.1.
PIRiS04616. PVRTO.
RefSeqiNP_037127.1. NM_012995.1.
UniGeneiRn.9719.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OMDX-ray1.85A2-109[»]
1RROX-ray1.30A2-109[»]
2NLNNMR-A2-109[»]
DisProtiDP00730.
ProteinModelPortaliP02631.
SMRiP02631.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000040755.

Proteomic databases

PaxDbiP02631.
PRIDEiP02631.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000043439; ENSRNOP00000040755; ENSRNOG00000001031.
ENSRNOT00000092601; ENSRNOP00000075788; ENSRNOG00000001031.
GeneIDi25503.
KEGGirno:25503.

Organism-specific databases

CTDi4951.
RGDi3222. Ocm.

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000008690.
HOGENOMiHOG000037438.
HOVERGENiHBG107490.
InParanoidiP02631.
OMAiKFFETSG.
OrthoDBiEOG091G0XK0.
PhylomeDBiP02631.
TreeFamiTF332342.

Miscellaneous databases

EvolutionaryTraceiP02631.
PROiP02631.

Gene expression databases

BgeeiENSRNOG00000001031.
GenevisibleiP02631. RN.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiONCO_RAT
AccessioniPrimary (citable) accession number: P02631
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.