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Protein

Parvalbumin alpha

Gene
N/A
Organism
Esox lucius (Northern pike)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

Miscellaneous

This is the major component, having an isoelectric point of 5.0.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi50 – 611PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi89 – 1002PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: CAFA

Keywordsi

Molecular functionMuscle protein
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Parvalbumin alpha
Alternative name(s):
Parvalbumin III
Parvalbumin pI 5.0
Parvalbumin-3
OrganismiEsox lucius (Northern pike)
Taxonomic identifieri8010 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiEsociformesEsocidaeEsox

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000735951 – 108Parvalbumin alphaAdd BLAST108

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylalanine1

Keywords - PTMi

Acetylation

Structurei

Secondary structure

1108
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1 – 4Combined sources4
Helixi7 – 16Combined sources10
Turni18 – 21Combined sources4
Helixi25 – 31Combined sources7
Turni33 – 36Combined sources4
Helixi39 – 49Combined sources11
Beta strandi54 – 57Combined sources4
Helixi59 – 63Combined sources5
Helixi65 – 68Combined sources4
Helixi78 – 88Combined sources11
Beta strandi93 – 96Combined sources4
Helixi98 – 106Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PVAX-ray1.65A/B1-108[»]
2PASNMR-A1-108[»]
3PATNMR-A1-108[»]
DisProtiDP00550.
ProteinModelPortaliP02628.
SMRiP02628.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02628.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 72EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini76 – 108EF-hand 2PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the parvalbumin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG107490.

Family and domain databases

InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiView protein in Pfam
PF13499. EF-hand_7. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 2 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.

Sequencei

Sequence statusi: Complete.

P02628-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AKDLLKADDI KKALDAVKAE GSFNHKKFFA LVGLKAMSAN DVKKVFKAID
60 70 80 90 100
ADASGFIEEE ELKFVLKSFA ADGRDLTDAE TKAFLKAADK DGDGKIGIDE

FETLVHEA
Length:108
Mass (Da):11,707
Last modified:July 21, 1986 - v1
Checksum:i8737BD351BA4ABC3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti11K → KL in alpha-2. 1 Publication1
Natural varianti27K → A in alpha-2. 1 Publication1
Natural varianti31L → K in alpha-2. 1 Publication1

Sequence databases

PIRiA67143. PVPK.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPRVA_ESOLU
AccessioniPrimary (citable) accession number: P02628
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: August 30, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

This protein is more closely related to beta-type parvalbumins then to alpha-type.Curated

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families