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Protein

Parvalbumin alpha

Gene
N/A
Organism
Esox lucius (Northern pike)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi50 – 611PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi89 – 1002PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Parvalbumin alpha
Alternative name(s):
Parvalbumin III
Parvalbumin pI 5.0
Parvalbumin-3
OrganismiEsox lucius (Northern pike)
Taxonomic identifieri8010 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiEsociformesEsocidaeEsox

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000735951 – 108Parvalbumin alphaAdd BLAST108

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylalanine1

Keywords - PTMi

Acetylation

Structurei

Secondary structure

1108
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1 – 4Combined sources4
Helixi7 – 16Combined sources10
Turni18 – 21Combined sources4
Helixi25 – 31Combined sources7
Turni33 – 36Combined sources4
Helixi39 – 49Combined sources11
Beta strandi54 – 57Combined sources4
Helixi59 – 63Combined sources5
Helixi65 – 68Combined sources4
Helixi78 – 88Combined sources11
Beta strandi93 – 96Combined sources4
Helixi98 – 106Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PVAX-ray1.65A/B1-108[»]
2PASNMR-A1-108[»]
3PATNMR-A1-108[»]
DisProtiDP00550.
ProteinModelPortaliP02628.
SMRiP02628.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02628.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 72EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini76 – 108EF-hand 2PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the parvalbumin family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG107490.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P02628-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AKDLLKADDI KKALDAVKAE GSFNHKKFFA LVGLKAMSAN DVKKVFKAID
60 70 80 90 100
ADASGFIEEE ELKFVLKSFA ADGRDLTDAE TKAFLKAADK DGDGKIGIDE

FETLVHEA
Length:108
Mass (Da):11,707
Last modified:July 21, 1986 - v1
Checksum:i8737BD351BA4ABC3
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti11K → KL in alpha-2. 1 Publication1
Natural varianti27K → A in alpha-2. 1 Publication1
Natural varianti31L → K in alpha-2. 1 Publication1

Sequence databases

PIRiA67143. PVPK.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

PIRiA67143. PVPK.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1PVAX-ray1.65A/B1-108[»]
2PASNMR-A1-108[»]
3PATNMR-A1-108[»]
DisProtiDP00550.
ProteinModelPortaliP02628.
SMRiP02628.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG107490.

Miscellaneous databases

EvolutionaryTraceiP02628.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRVA_ESOLU
AccessioniPrimary (citable) accession number: P02628
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 30, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This is the major component, having an isoelectric point of 5.0.

Caution

This protein is more closely related to beta-type parvalbumins then to alpha-type.Curated

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.