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Protein

Parvalbumin alpha

Gene

Pvalb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi52 – 631Add BLAST12
Calcium bindingi91 – 1022Add BLAST12

GO - Molecular functioni

  • calcium ion binding Source: RGD
  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: RGD

GO - Biological processi

  • regulation of cytosolic calcium ion concentration Source: RGD

Keywordsi

Molecular functionMuscle protein
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Parvalbumin alpha
Gene namesi
Name:Pvalb
Synonyms:Pva
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi3457. Pvalb.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • extracellular exosome Source: Ensembl
  • neuronal cell body Source: RGD
  • nucleus Source: RGD
  • protein complex Source: RGD
  • terminal bouton Source: ParkinsonsUK-UCL

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved3 Publications
ChainiPRO_00000735922 – 110Parvalbumin alphaAdd BLAST109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine3 Publications1
Modified residuei2PhosphoserineCombined sources1
Modified residuei8PhosphoserineCombined sources1
Modified residuei24PhosphoserineCombined sources1
Modified residuei66PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP02625.
PRIDEiP02625.

PTM databases

iPTMnetiP02625.
PhosphoSitePlusiP02625.

Expressioni

Gene expression databases

BgeeiENSRNOG00000006471.
GenevisibleiP02625. RN.

Interactioni

GO - Molecular functioni

  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000058825.

Structurei

Secondary structure

1110
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 6Combined sources4
Helixi9 – 17Combined sources9
Helixi22 – 25Combined sources4
Helixi27 – 33Combined sources7
Helixi36 – 38Combined sources3
Helixi41 – 51Combined sources11
Beta strandi52 – 55Combined sources4
Beta strandi56 – 59Combined sources4
Helixi61 – 65Combined sources5
Helixi67 – 71Combined sources5
Helixi80 – 90Combined sources11
Turni91 – 94Combined sources4
Beta strandi95 – 99Combined sources5
Helixi100 – 108Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G33X-ray1.44A38-110[»]
1RTPX-ray2.001/2/32-110[»]
1RWYX-ray1.05A/B/C2-110[»]
1S3PX-ray2.00A2-110[»]
1XVJX-ray1.80A/B2-110[»]
2JWWNMR-A2-110[»]
3F45X-ray2.00A2-110[»]
ProteinModelPortaliP02625.
SMRiP02625.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02625.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 74EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini78 – 110EF-hand 2PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the parvalbumin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000008690.
HOGENOMiHOG000037438.
HOVERGENiHBG107490.
InParanoidiP02625.
OMAiAVDSFDH.
OrthoDBiEOG091G0ZAO.
PhylomeDBiP02625.
TreeFamiTF332342.

Family and domain databases

CDDicd00051. EFh. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiView protein in Pfam
PF13499. EF-hand_7. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 2 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02625-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMTDLLSAE DIKKAIGAFT AADSFDHKKF FQMVGLKKKS ADDVKKVFHI
60 70 80 90 100
LDKDKSGFIE EDELGSILKG FSSDARDLSA KETKTLMAAG DKDGDGKIGV
110
EEFSTLVAES
Length:110
Mass (Da):11,926
Last modified:January 23, 2007 - v2
Checksum:i6A1509AC8F012B3D
GO

Mass spectrometryi

Molecular mass is 11836.88±1.57 Da from positions 2 - 110. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12725 mRNA. Translation: AAA41799.1.
M15457
, M15453, M15454, M15455 Genomic DNA. Translation: AAA41800.1.
BC126090 mRNA. Translation: AAI26091.1.
M10764 mRNA. Translation: AAA41797.1.
M10765 mRNA. Translation: AAA41798.1.
PIRiA29308. PVRTA.
RefSeqiNP_071944.1. NM_022499.2.
XP_006241991.1. XM_006241929.3.
UniGeneiRn.2005.

Genome annotation databases

EnsembliENSRNOT00000067635; ENSRNOP00000058825; ENSRNOG00000006471.
GeneIDi25269.
KEGGirno:25269.
UCSCiRGD:3457. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPRVA_RAT
AccessioniPrimary (citable) accession number: P02625
Secondary accession number(s): A0JN21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: May 10, 2017
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families