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Protein

Parvalbumin alpha

Gene

Pvalb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi52 – 631Add BLAST12
Calcium bindingi91 – 1022Add BLAST12

GO - Molecular functioni

  • calcium ion binding Source: RGD
  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: RGD

GO - Biological processi

  • regulation of cytosolic calcium ion concentration Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Parvalbumin alpha
Gene namesi
Name:Pvalb
Synonyms:Pva
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi3457. Pvalb.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • extracellular exosome Source: Ensembl
  • neuronal cell body Source: RGD
  • nucleus Source: RGD
  • protein complex Source: RGD
  • terminal bouton Source: ParkinsonsUK-UCL
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved3 Publications
ChainiPRO_00000735922 – 110Parvalbumin alphaAdd BLAST109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine3 Publications1
Modified residuei2PhosphoserineCombined sources1
Modified residuei8PhosphoserineCombined sources1
Modified residuei24PhosphoserineCombined sources1
Modified residuei66PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP02625.
PRIDEiP02625.

PTM databases

iPTMnetiP02625.
PhosphoSitePlusiP02625.

Expressioni

Gene expression databases

BgeeiENSRNOG00000006471.
GenevisibleiP02625. RN.

Interactioni

GO - Molecular functioni

  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000058825.

Structurei

Secondary structure

1110
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 6Combined sources4
Helixi9 – 17Combined sources9
Helixi22 – 25Combined sources4
Helixi27 – 33Combined sources7
Helixi36 – 38Combined sources3
Helixi41 – 51Combined sources11
Beta strandi52 – 55Combined sources4
Beta strandi56 – 59Combined sources4
Helixi61 – 65Combined sources5
Helixi67 – 71Combined sources5
Helixi80 – 90Combined sources11
Turni91 – 94Combined sources4
Beta strandi95 – 99Combined sources5
Helixi100 – 108Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G33X-ray1.44A38-110[»]
1RTPX-ray2.001/2/32-110[»]
1RWYX-ray1.05A/B/C2-110[»]
1S3PX-ray2.00A2-110[»]
1XVJX-ray1.80A/B2-110[»]
2JWWNMR-A2-110[»]
3F45X-ray2.00A2-110[»]
ProteinModelPortaliP02625.
SMRiP02625.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02625.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 74EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini78 – 110EF-hand 2PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Belongs to the parvalbumin family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000008690.
HOGENOMiHOG000037438.
HOVERGENiHBG107490.
InParanoidiP02625.
OMAiAVDSFDH.
OrthoDBiEOG091G0ZAO.
PhylomeDBiP02625.
TreeFamiTF332342.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02625-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSMTDLLSAE DIKKAIGAFT AADSFDHKKF FQMVGLKKKS ADDVKKVFHI
60 70 80 90 100
LDKDKSGFIE EDELGSILKG FSSDARDLSA KETKTLMAAG DKDGDGKIGV
110
EEFSTLVAES
Length:110
Mass (Da):11,926
Last modified:January 23, 2007 - v2
Checksum:i6A1509AC8F012B3D
GO

Mass spectrometryi

Molecular mass is 11836.88±1.57 Da from positions 2 - 110. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12725 mRNA. Translation: AAA41799.1.
M15457
, M15453, M15454, M15455 Genomic DNA. Translation: AAA41800.1.
BC126090 mRNA. Translation: AAI26091.1.
M10764 mRNA. Translation: AAA41797.1.
M10765 mRNA. Translation: AAA41798.1.
PIRiA29308. PVRTA.
RefSeqiNP_071944.1. NM_022499.2.
XP_006241991.1. XM_006241929.3.
UniGeneiRn.2005.

Genome annotation databases

EnsembliENSRNOT00000067635; ENSRNOP00000058825; ENSRNOG00000006471.
GeneIDi25269.
KEGGirno:25269.
UCSCiRGD:3457. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M12725 mRNA. Translation: AAA41799.1.
M15457
, M15453, M15454, M15455 Genomic DNA. Translation: AAA41800.1.
BC126090 mRNA. Translation: AAI26091.1.
M10764 mRNA. Translation: AAA41797.1.
M10765 mRNA. Translation: AAA41798.1.
PIRiA29308. PVRTA.
RefSeqiNP_071944.1. NM_022499.2.
XP_006241991.1. XM_006241929.3.
UniGeneiRn.2005.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G33X-ray1.44A38-110[»]
1RTPX-ray2.001/2/32-110[»]
1RWYX-ray1.05A/B/C2-110[»]
1S3PX-ray2.00A2-110[»]
1XVJX-ray1.80A/B2-110[»]
2JWWNMR-A2-110[»]
3F45X-ray2.00A2-110[»]
ProteinModelPortaliP02625.
SMRiP02625.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000058825.

PTM databases

iPTMnetiP02625.
PhosphoSitePlusiP02625.

Proteomic databases

PaxDbiP02625.
PRIDEiP02625.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000067635; ENSRNOP00000058825; ENSRNOG00000006471.
GeneIDi25269.
KEGGirno:25269.
UCSCiRGD:3457. rat.

Organism-specific databases

CTDi5816.
RGDi3457. Pvalb.

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000008690.
HOGENOMiHOG000037438.
HOVERGENiHBG107490.
InParanoidiP02625.
OMAiAVDSFDH.
OrthoDBiEOG091G0ZAO.
PhylomeDBiP02625.
TreeFamiTF332342.

Miscellaneous databases

EvolutionaryTraceiP02625.
PROiP02625.

Gene expression databases

BgeeiENSRNOG00000006471.
GenevisibleiP02625. RN.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRVA_RAT
AccessioniPrimary (citable) accession number: P02625
Secondary accession number(s): A0JN21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 150 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.