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Protein

Parvalbumin beta

Gene
N/A
Organism
Gadus morhua subsp. callarias (Baltic cod) (Gadus callarias)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi51 – 511Calcium 1By similarity
Metal bindingi53 – 531Calcium 1By similarity
Metal bindingi57 – 571Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi59 – 591Calcium 1By similarity
Metal bindingi62 – 621Calcium 1By similarity
Metal bindingi90 – 901Calcium 2By similarity
Metal bindingi92 – 921Calcium 2By similarity
Metal bindingi94 – 941Calcium 2By similarity
Metal bindingi101 – 1011Calcium 2By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi51 – 62121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi90 – 101122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Parvalbumin beta
Alternative name(s):
Allergen Gad c I
Allergen M
Allergen: Gad c 1
OrganismiGadus morhua subsp. callarias (Baltic cod) (Gadus callarias)
Taxonomic identifieri8053 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataZeiogadariaGadariaeGadiformesGadoideiGadidaeGadus

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei3290. Gad c 1.0101.
357. Gad c 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 113113Parvalbumin betaPRO_0000073608Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylalanine1 Publication
Glycosylationi18 – 181S-linked (Glc)Curated

Keywords - PTMi

Acetylation, Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP02622.
SMRiP02622. Positions 1-106.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 7336EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini77 – 11236EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the parvalbumin family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG107490.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P02622-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AFKGILSNAD IKAAEAACFK EGSFDEDGFY AKVGLDAFSA DELKKLFKIA
60 70 80 90 100
DEDKEGFIEE DELKLFLIAF AADLRALTDA ETKAFLKAGD SDGDGKIGVD
110
EFGALVDKWG AKG
Length:113
Mass (Da):12,108
Last modified:July 21, 1986 - v1
Checksum:i4CD4E3DC5CCAE94F
GO

Sequence databases

PIRiA94236. PVCD.

Cross-referencesi

Sequence databases

PIRiA94236. PVCD.

3D structure databases

ProteinModelPortaliP02622.
SMRiP02622. Positions 1-106.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei3290. Gad c 1.0101.
357. Gad c 1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG107490.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The primary structure of allergen M from cod."
    Elsayed S., Bennich H.
    Scand. J. Immunol. 4:203-208(1975) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-75, ACETYLATION AT ALA-1.
  2. "The primary structure of fragment TM2 of allergen M from cod."
    Elsayed S., von Bahr-Lindstroem H., Bennich H.
    Scand. J. Immunol. 3:683-686(1974) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 76-113.
  3. "Stopped-flow kinetic studies of Ca(II) and Mg(II) dissociation in cod parvalbumin and bovine alpha-lactalbumin."
    Permyakov E.A., Ostrovsky A.V., Kalinichenko L.P.
    Biophys. Chem. 28:225-233(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: CALCIUM-BINDING.

Entry informationi

Entry nameiPRVB_GADMC
AccessioniPrimary (citable) accession number: P02622
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: March 16, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This parvalbumin has an isoelectric point of 4.40.

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.