P02622 (PRVB_GADCA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Parvalbumin beta Alternative name(s): Allergen Gad c I Allergen M Allergen=Gad c 1
Organism	Gadus callarias (Baltic cod)
Taxonomic identifier	8053 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Paracanthopterygii › Gadiformes › Gadidae › Gadus

Protein attributes

Sequence length	113 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.
Allergenic properties	Causes an allergic reaction in human.
Miscellaneous	This parvalbumin has an isoelectric point of 4.40.
Sequence similarities	Belongs to the parvalbumin family. Contains 2 EF-hand domains.

Ontologies

Keywords
Disease	Allergen
Domain	Repeat
Ligand	Calcium Metal-binding
Molecular function	Muscle protein
PTM	Acetylation Glycoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Molecular function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 113	113	Parvalbumin beta		PRO_0000073608
Regions
	Domain	38 – 73	36	EF-hand 1
	Domain	77 – 112	36	EF-hand 2
	Calcium binding	51 – 62	12	1 By similarity
	Calcium binding	90 – 101	12	2 By similarity
Amino acid modifications
	Modified residue	1	1	N-acetylalanine Ref.1
	Glycosylation	18	1	S-linked (Glc) Probable

Sequences

	Sequence		Length	Mass (Da)
	P02622 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 4CD4E3DC5CCAE94F	FASTA	113	12,108
	10 20 30 40 50 60 AFKGILSNAD IKAAEAACFK EGSFDEDGFY AKVGLDAFSA DELKKLFKIA DEDKEGFIEE 70 80 90 100 110 DELKLFLIAF AADLRALTDA ETKAFLKAGD SDGDGKIGVD EFGALVDKWG AKG

References

[1]	"The primary structure of allergen M from cod." Elsayed S., Bennich H. Scand. J. Immunol. 4:203-208(1975) [PubMed: 1145128] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-75.
[2]	"The primary structure of fragment TM2 of allergen M from cod." Elsayed S., von Bahr-Lindstroem H., Bennich H. Scand. J. Immunol. 3:683-686(1974) [PubMed: 4423465] [Abstract] Cited for: PROTEIN SEQUENCE OF 76-113.
[3]	"Stopped-flow kinetic studies of Ca(II) and Mg(II) dissociation in cod parvalbumin and bovine alpha-lactalbumin." Permyakov E.A., Ostrovsky A.V., Kalinichenko L.P. Biophys. Chem. 28:225-233(1987) [PubMed: 3440123] [Abstract] Cited for: CALCIUM-BINDING.
+	Additional computationally mapped references.

Cross-references

Sequence databases
PIR	PVCD. A94236.
3D structure databases
ProteinModelPortal	P02622.
SMR	P02622. Positions 1-106.
ModBase	Search...
Protein family/group databases
Allergome	3290. Gad c 1.0101. 357. Gad c 1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG107490.
Family and domain databases
InterPro	IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR018249. EF_HAND_2. IPR002048. EF_hand_Ca-bd. IPR008080. Parvalbumin. [Graphical view]
Gene3D	G3DSA:1.10.238.10. EF-Hand_type. 1 hit.
PRINTS	PR01697. PARVALBUMIN.
SMART	SM00054. EFh. 2 hits. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 2 hits. PS50222. EF_HAND_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PRVB_GADCA

Accession

Primary (citable) accession number: P02622

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	January 11, 2011
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program