Reviewed, UniProtKB/Swiss-Prot P02621 (PRVB_MERMR)

Names and origin

Protein names	Recommended name:     Parvalbumin beta
Organism	Merlangius merlangus (Whiting)
Taxonomic identifier	8058 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Paracanthopterygii › Gadiformes › Gadidae › Merlangius

Protein attributes

Sequence length	108 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	In muscle, the calcium-binding protein parvalbumin is thought to be involved in muscle relaxation.
Miscellaneous	This parvalbumin has an isoelectric point of 4.50.
Sequence similarities	Belongs to the parvalbumin family. Contains 2 EF-hand domains.

Ontologies

Keywords
Domain	Repeat
Ligand	Calcium
Molecular function	Muscle protein
PTM	Acetylation Disulfide bond
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 108

108

Parvalbumin beta

PRO_0000073615

Regions

Domain

38 – 73

36

EF-hand 1

Domain

77 – 108

32

EF-hand 2

Calcium binding

51 – 62

12

1 By similarity

Calcium binding

90 – 101

12

2 By similarity

Amino acid modifications

Modified residue

1

1

N-acetylalanine

Disulfide bond

11 ↔ 33

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

108

Helix Strand Turn

Details...

Helix

9 – 17

9

Helix

26 – 32

7

Helix

40 – 50

11

Beta strand

55 – 59

5

Helix

60 – 63

4

Helix

66 – 70

5

Helix

79 – 89

11

Beta strand

94 – 97

4

Helix

99 – 106

8

Sequences

	Sequence		Length	Mass (Da)
	P02621-1 [UniParc]. Last modified July 15, 1998. Version 2. Checksum: 4AA2ACDD29334FB2	FASTA	108	11,323
	10 20 30 40 50 60 AFAGILADAD CAAAVKACEA ADSFSYKAFF AKCGLSGKSA DDIKKAFVFI DQDKSGFIEE 70 80 90 100 DELKLFLQVF KAGARALTDA ETKAFLKAGD SDGDGAIGVE EWVALVKA

References

[1]	"The amino acid sequence of the major parvalbumin of the whiting (Gadus merlangus)." Joassin L., Gerday C. Comp. Biochem. Physiol. 57B:159-161(1977) [PubMed: 318435] [Abstract] Cited for: PROTEIN SEQUENCE. Tissue: Muscle.
[2]	"Fluorescence studies of the calcium binding to whiting (Gadus merlangus) parvalbumin." Permyakov E.A., Yarmolenko V.V., Emelyanenko V.I., Burstein E.A., Closset J., Gerday C. Eur. J. Biochem. 109:307-315(1980) [PubMed: 6773772] [Abstract] Cited for: CALCIUM-BINDING.
[3]	"Kinetic mechanism of calcium binding to whiting parvalbumin." White H.D. Biochemistry 27:3357-3365(1988) [PubMed: 3390436] [Abstract] Cited for: CALCIUM-BINDING DATA.
[4]	Declercq J.P., Baneres J.L., Rambaud J., Parello J. Submitted (MAR-1998) to the PDB data bank Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS), SEQUENCE REVISION TO 11-12. Tissue: Muscle.

Cross-references

Sequence databases

PIR

PVWI. A03056.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1A75	X-ray	1.90	A/B	1-108	[»]

ModBase

Search...

Phylogenomic databases

HOVERGEN

P02621.

Family and domain databases

InterPro

IPR011992. EF-hand-like_dom.
IPR018247. EF_Hand_1_Ca_BS.
IPR018249. EF_HAND_2.
IPR002048. EF_hand_Ca_bd.
IPR008080. Parvalbumin.
[Graphical view]

Gene3D

G3DSA:1.10.238.10. EF-Hand_type. 1 hit.

PRINTS

PR01697. PARVALBUMIN.

SMART

SM00054. EFh. 2 hits.
[Graphical view]

PROSITE

PS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

PRVB_MERMR

Accession

Primary (citable) accession number: P02621

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 15, 1998
Last modified:	January 19, 2010
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)