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P02621 (PRVB_MERMR) Reviewed, UniProtKB/Swiss-Prot

Last modified November 30, 2010. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Parvalbumin beta
OrganismMerlangius merlangus (Whiting)
Taxonomic identifier8058 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Euteleostei › Neoteleostei › Acanthomorpha › Paracanthopterygii › Gadiformes › Gadidae › Merlangius

Protein attributes

Sequence length108 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions.

Miscellaneous

This parvalbumin has an isoelectric point of 4.50.

Sequence similarities

Belongs to the parvalbumin family.

Contains 2 EF-hand domains.

Ontologies

Keywords
   DomainRepeat
   LigandCalcium
Metal-binding
   Molecular functionMuscle protein
   PTMAcetylation
Disulfide bond
   Technical term3D-structure
Direct protein sequencing
Gene Ontology (GO)
   Molecular functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 108108Parvalbumin beta
PRO_0000073615

Regions

Domain38 – 7336EF-hand 1
Domain77 – 10832EF-hand 2
Calcium binding51 – 62121 By similarity
Calcium binding90 – 101122 By similarity

Amino acid modifications

Modified residue11N-acetylalanine
Disulfide bond11 ↔ 33

Secondary structure

1 .................. 108
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P02621 [UniParc].

Last modified July 15, 1998. Version 2.
Checksum: 4AA2ACDD29334FB2

FASTA10811,323
        10         20         30         40         50         60 
AFAGILADAD CAAAVKACEA ADSFSYKAFF AKCGLSGKSA DDIKKAFVFI DQDKSGFIEE 

        70         80         90        100 
DELKLFLQVF KAGARALTDA ETKAFLKAGD SDGDGAIGVE EWVALVKA

« Hide

References

[1]"The amino acid sequence of the major parvalbumin of the whiting (Gadus merlangus)."
Joassin L., Gerday C.
Comp. Biochem. Physiol. 57B:159-161(1977) [PubMed: 318435] [Abstract]
Cited for: PROTEIN SEQUENCE.
Tissue: Muscle.
[2]"Fluorescence studies of the calcium binding to whiting (Gadus merlangus) parvalbumin."
Permyakov E.A., Yarmolenko V.V., Emelyanenko V.I., Burstein E.A., Closset J., Gerday C.
Eur. J. Biochem. 109:307-315(1980) [PubMed: 6773772] [Abstract]
Cited for: CALCIUM-BINDING.
[3]"Kinetic mechanism of calcium binding to whiting parvalbumin."
White H.D.
Biochemistry 27:3357-3365(1988) [PubMed: 3390436] [Abstract]
Cited for: CALCIUM-BINDING DATA.
[4]Declercq J.P., Baneres J.L., Rambaud J., Parello J.
Submitted (MAR-1998) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS), SEQUENCE REVISION TO 11-12.
Tissue: Muscle.
+Additional computationally mapped references.

Cross-references

Sequence databases

PIRPVWI. A03056.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1A75X-ray1.90A/B1-108[»]
ProteinModelPortalP02621.
SMRP02621. Positions 1-108.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG107490.

Family and domain databases

InterProIPR011992. EF-hand-like_dom.
IPR018247. EF_Hand_1_Ca_BS.
IPR018249. EF_HAND_2.
IPR002048. EF_hand_Ca-bd.
IPR008080. Parvalbumin.
[Graphical view]
Gene3DG3DSA:1.10.238.10. EF-Hand_type. 1 hit.
PRINTSPR01697. PARVALBUMIN.
SMARTSM00054. EFh. 2 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePRVB_MERMR
AccessionPrimary (citable) accession number: P02621
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 15, 1998
Last modified: November 30, 2010
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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