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Protein

Myosin light polypeptide 6

Gene

MYL6

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory light chain of myosin. Does not bind calcium.

GO - Molecular functioni

  • actin-dependent ATPase activity Source: HGNC
  • ADP binding Source: CAFA
  • ATPase activity Source: UniProtKB
  • calcium ion binding Source: InterPro
  • magnesium ion binding Source: CAFA
  • myosin heavy chain binding Source: CAFA
  • myosin II binding Source: CAFA
  • protein heterodimerization activity Source: CAFA
  • structural constituent of muscle Source: CAFA

GO - Biological processi

  • actomyosin structure organization Source: UniProtKB
  • myofibril assembly Source: CAFA

Keywordsi

Molecular functionMotor protein, Muscle protein, Myosin

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin light polypeptide 6
Alternative name(s):
G2 catalytic
LC17-GI
LC17-NM
Myosin light chain alkali smooth-muscle/non-muscle isoforms
Gene namesi
Name:MYL6
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001986942 – 151Myosin light polypeptide 6Add BLAST150

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylcysteine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP02607

PTM databases

iPTMnetiP02607

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains.

Binary interactionsi

WithEntry#Exp.IntActNotes
MYH11P105872EBI-1027073,EBI-1027098

GO - Molecular functioni

  • myosin heavy chain binding Source: CAFA
  • myosin II binding Source: CAFA
  • protein heterodimerization activity Source: CAFA

Protein-protein interaction databases

IntActiP02607, 2 interactors

Structurei

Secondary structure

1151
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 17Combined sources12
Beta strandi21 – 25Combined sources5
Turni29 – 31Combined sources3
Helixi32 – 38Combined sources7
Helixi45 – 49Combined sources5
Helixi50 – 52Combined sources3
Helixi57 – 60Combined sources4
Helixi67 – 78Combined sources12
Helixi86 – 93Combined sources8
Helixi94 – 96Combined sources3
Beta strandi100 – 102Combined sources3
Helixi108 – 112Combined sources5
Turni113 – 115Combined sources3
Beta strandi116 – 118Combined sources3
Helixi122 – 129Combined sources8
Beta strandi137 – 139Combined sources3
Helixi141 – 150Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BR1X-ray3.50B/D/F/H2-151[»]
1BR4X-ray3.62B/D/F/H2-151[»]
1I84electron microscopy20.00T/W2-151[»]
3DTPelectron microscopy20.00C/D2-151[»]
3J04electron microscopy-C/F4-151[»]
ProteinModelPortaliP02607
SMRiP02607
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02607

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 42EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini84 – 119EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini119 – 151EF-hand 3PROSITE-ProRule annotationAdd BLAST33

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG012180
InParanoidiP02607
PhylomeDBiP02607

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13405 EF-hand_6, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 3 hits

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P02607-1) [UniParc]FASTAAdd to basket
Also known as: Smooth muscle, MLC3sm

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCDFSEEQTA EFKEAFQLFD RTGDGKILYS QCGDVMRALG QNPTNAEVMK
60 70 80 90 100
VLGNPKSDEM NLKTLKFEQF LPMMQTIAKN KDQGCFEDYV EGLRVFDKEG
110 120 130 140 150
NGTVMGAEIR HVLVTLGEKM TEEEVEQLVA GHEDSNGCIN YEELVRMVLS

G
Length:151
Mass (Da):16,987
Last modified:January 23, 2007 - v3
Checksum:i40A6916EC1E90C41
GO
Isoform 2 (identifier: P02607-2) [UniParc] [UniParc]FASTAAdd to basket
Also known as: Non-muscle, MLC3nm

The sequence of this isoform differs from the canonical sequence as follows:
     143-151: ELVRMVLSG → AFVRHILSG

Show »
Length:151
Mass (Da):16,983
Checksum:iC7B2917C56990C4F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66K → N AA sequence (PubMed:7319048).Curated1
Sequence conflicti66K → N AA sequence (PubMed:6870825).Curated1
Sequence conflicti101N → D AA sequence (PubMed:6870825).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017063143 – 151ELVRMVLSG → AFVRHILSG in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15645 mRNA Translation: AAA48978.1
M15646 mRNA Translation: AAA48979.1
PIRiA28488 MOCHG2
B28488 MOCH6N
UniGeneiGga.840

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMYL6_CHICK
AccessioniPrimary (citable) accession number: P02607
Secondary accession number(s): P08296
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: March 28, 2018
This is version 129 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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