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Protein

Myosin light polypeptide 6

Gene

MYL6

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory light chain of myosin. Does not bind calcium.

GO - Molecular functioni

GO - Biological processi

  • actomyosin structure organization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin light polypeptide 6
Alternative name(s):
G2 catalytic
LC17-GI
LC17-NM
Myosin light chain alkali smooth-muscle/non-muscle isoforms
Gene namesi
Name:MYL6
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • actomyosin Source: UniProtKB
  • cytosol Source: Reactome
  • myosin II complex Source: UniProtKB
  • myosin II filament Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001986942 – 151Myosin light polypeptide 6Add BLAST150

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylcysteine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP02607.

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains.

Binary interactionsi

WithEntry#Exp.IntActNotes
MYH11P105872EBI-1027073,EBI-1027098

Protein-protein interaction databases

IntActiP02607. 2 interactors.

Structurei

Secondary structure

1151
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 17Combined sources12
Beta strandi21 – 25Combined sources5
Turni29 – 31Combined sources3
Helixi32 – 38Combined sources7
Helixi45 – 49Combined sources5
Helixi50 – 52Combined sources3
Helixi57 – 60Combined sources4
Helixi67 – 78Combined sources12
Helixi86 – 93Combined sources8
Helixi94 – 96Combined sources3
Beta strandi100 – 102Combined sources3
Helixi108 – 112Combined sources5
Turni113 – 115Combined sources3
Beta strandi116 – 118Combined sources3
Helixi122 – 129Combined sources8
Beta strandi137 – 139Combined sources3
Helixi141 – 150Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BR1X-ray3.50B/D/F/H2-151[»]
1BR4X-ray3.62B/D/F/H2-151[»]
1I84electron microscopy20.00T/W2-151[»]
3DTPelectron microscopy20.00C/D2-151[»]
3J04electron microscopy-C/F4-151[»]
ProteinModelPortaliP02607.
SMRiP02607.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02607.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 42EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini84 – 119EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini119 – 151EF-hand 3PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Contains 3 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG012180.
InParanoidiP02607.
PhylomeDBiP02607.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P02607-1) [UniParc]FASTAAdd to basket
Also known as: Smooth muscle, MLC3sm

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCDFSEEQTA EFKEAFQLFD RTGDGKILYS QCGDVMRALG QNPTNAEVMK
60 70 80 90 100
VLGNPKSDEM NLKTLKFEQF LPMMQTIAKN KDQGCFEDYV EGLRVFDKEG
110 120 130 140 150
NGTVMGAEIR HVLVTLGEKM TEEEVEQLVA GHEDSNGCIN YEELVRMVLS

G
Length:151
Mass (Da):16,987
Last modified:January 23, 2007 - v3
Checksum:i40A6916EC1E90C41
GO
Isoform 2 (identifier: P02607-2) [UniParc] [UniParc]FASTAAdd to basket
Also known as: Non-muscle, MLC3nm

The sequence of this isoform differs from the canonical sequence as follows:
     143-151: ELVRMVLSG → AFVRHILSG

Show »
Length:151
Mass (Da):16,983
Checksum:iC7B2917C56990C4F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66K → N AA sequence (PubMed:7319048).Curated1
Sequence conflicti66K → N AA sequence (PubMed:6870825).Curated1
Sequence conflicti101N → D AA sequence (PubMed:6870825).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_017063143 – 151ELVRMVLSG → AFVRHILSG in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15645 mRNA. Translation: AAA48978.1.
M15646 mRNA. Translation: AAA48979.1.
PIRiA28488. MOCHG2.
B28488. MOCH6N.
UniGeneiGga.840.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15645 mRNA. Translation: AAA48978.1.
M15646 mRNA. Translation: AAA48979.1.
PIRiA28488. MOCHG2.
B28488. MOCH6N.
UniGeneiGga.840.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BR1X-ray3.50B/D/F/H2-151[»]
1BR4X-ray3.62B/D/F/H2-151[»]
1I84electron microscopy20.00T/W2-151[»]
3DTPelectron microscopy20.00C/D2-151[»]
3J04electron microscopy-C/F4-151[»]
ProteinModelPortaliP02607.
SMRiP02607.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP02607. 2 interactors.

Proteomic databases

PRIDEiP02607.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG012180.
InParanoidiP02607.
PhylomeDBiP02607.

Miscellaneous databases

EvolutionaryTraceiP02607.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYL6_CHICK
AccessioniPrimary (citable) accession number: P02607
Secondary accession number(s): P08296
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 124 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.