ID MLE3_CHICK Reviewed; 150 AA. AC P02605; Q90896; DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot. DT 23-JAN-2007, sequence version 3. DT 27-MAR-2024, entry version 152. DE RecName: Full=Myosin light chain 3, skeletal muscle isoform; DE AltName: Full=Alkali myosin light chain 3; DE Short=MLC-3; DE AltName: Full=Myosin light chain 3f; DE AltName: Full=Myosin light chain alkali 2; DE Short=Myosin light chain A2; DE AltName: Full=Skeletal-muscle myosin L-4 light chain; OS Gallus gallus (Chicken). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; OC Phasianinae; Gallus. OX NCBI_TaxID=9031; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=6128725; DOI=10.1093/nar/10.19.6099; RA Nabeshima Y., Fujii-Kuriyama Y., Muramatsu M., Ogata K.; RT "Molecular cloning and nucleotide sequences of the complementary DNAs to RT chicken skeletal muscle myosin two alkali light chain mRNAs."; RL Nucleic Acids Res. 10:6099-6110(1982). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC TISSUE=Skeletal muscle; RX PubMed=6709041; DOI=10.1038/308333a0; RA Nabeshima Y., Fujii-Kuriyama Y., Muramatsu M., Ogata K.; RT "Alternative transcription and two modes of splicing results in two myosin RT light chains from one gene."; RL Nature 308:333-338(1984). RN [3] RP PROTEIN SEQUENCE OF 2-150, AND BLOCKAGE OF N-TERMINUS. RC TISSUE=Skeletal muscle; RX PubMed=6783403; DOI=10.1111/j.1432-1033.1981.tb06169.x; RA Maita T., Umegane T., Matsuda G.; RT "Amino-acid sequence of the L-4 light chain of chicken skeletal-muscle RT myosin."; RL Eur. J. Biochem. 114:45-49(1981). CC -!- SUBUNIT: Myosin is a hexamer of 2 heavy chains and 4 light chains. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=MLC3; CC IsoId=P02605-1; Sequence=Displayed; CC Name=MLC1; CC IsoId=P02604-1; Sequence=External; CC -!- PTM: The N-terminus is blocked. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; J00888; AAA48961.1; -; mRNA. DR EMBL; K02610; AAA48956.1; -; Genomic_DNA. DR EMBL; K02609; AAA48956.1; JOINED; Genomic_DNA. DR PIR; I50384; MOCHA2. DR RefSeq; NP_001038097.1; NM_001044632.1. [P02605-1] DR PDB; 1MVW; EM; 70.00 A; C/F/I/L/O/R=10-150. DR PDB; 1O18; EM; 70.00 A; F/I/L/O/R=10-150. DR PDB; 1O19; EM; 70.00 A; C/F/I/L/O/U=10-150. DR PDB; 1O1A; EM; 70.00 A; C/F/I/L/O/R=10-150. DR PDB; 1O1B; EM; 70.00 A; C/F/I/L=10-150. DR PDB; 1O1C; EM; 70.00 A; C/F/I/L/R=10-150. DR PDB; 1O1D; EM; 70.00 A; C/F/I/L/O/R=10-150. DR PDB; 1O1E; EM; 70.00 A; C/F/I/L/O/R=10-150. DR PDB; 1O1F; EM; 70.00 A; C/F/I/L=10-150. DR PDB; 1O1G; EM; 70.00 A; C/F/I/L/O/R=10-150. DR PDB; 2W4A; EM; 35.00 A; C=6-150. DR PDB; 2W4G; EM; 35.00 A; C=6-150. DR PDB; 2W4H; EM; 35.00 A; C=6-150. DR PDBsum; 1MVW; -. DR PDBsum; 1O18; -. DR PDBsum; 1O19; -. DR PDBsum; 1O1A; -. DR PDBsum; 1O1B; -. DR PDBsum; 1O1C; -. DR PDBsum; 1O1D; -. DR PDBsum; 1O1E; -. DR PDBsum; 1O1F; -. DR PDBsum; 1O1G; -. DR PDBsum; 2W4A; -. DR PDBsum; 2W4G; -. DR PDBsum; 2W4H; -. DR AlphaFoldDB; P02605; -. DR SMR; P02605; -. DR GeneID; 396470; -. DR KEGG; gga:396470; -. DR CTD; 4632; -. DR VEuPathDB; HostDB:geneid_396470; -. DR HOGENOM; CLU_061288_13_0_1; -. DR InParanoid; P02605; -. DR Reactome; R-GGA-390522; Striated Muscle Contraction. DR EvolutionaryTrace; P02605; -. DR Proteomes; UP000000539; Chromosome 7. DR Bgee; ENSGALG00000002907; Expressed in muscle tissue and 6 other cell types or tissues. DR ExpressionAtlas; P02605; baseline and differential. DR GO; GO:0043292; C:contractile fiber; IBA:GO_Central. DR GO; GO:0016460; C:myosin II complex; IBA:GO_Central. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR Gene3D; 1.10.238.10; EF-hand; 2. DR InterPro; IPR011992; EF-hand-dom_pair. DR InterPro; IPR002048; EF_hand_dom. DR PANTHER; PTHR23048; MYOSIN LIGHT CHAIN 1, 3; 1. DR PANTHER; PTHR23048:SF3; MYOSIN LIGHT CHAIN 1_3, SKELETAL MUSCLE ISOFORM; 1. DR SMART; SM00054; EFh; 3. DR SUPFAM; SSF47473; EF-hand; 1. DR PROSITE; PS50222; EF_HAND_2; 4. PE 1: Evidence at protein level; KW 3D-structure; Alternative splicing; Direct protein sequencing; KW Motor protein; Muscle protein; Myosin; Reference proteome; Repeat. FT INIT_MET 1 FT /note="Removed" FT /evidence="ECO:0000269|PubMed:6783403" FT CHAIN 2..150 FT /note="Myosin light chain 3, skeletal muscle isoform" FT /id="PRO_0000198705" FT DOMAIN 6..41 FT /note="EF-hand 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT DOMAIN 44..79 FT /note="EF-hand 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT DOMAIN 83..118 FT /note="EF-hand 3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT DOMAIN 118..150 FT /note="EF-hand 4" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT MOD_RES 2 FT /note="Blocked amino end (Ser)" FT CONFLICT 7..9 FT /note="EIN -> QID (in Ref. 3; AA sequence)" FT /evidence="ECO:0000305" FT CONFLICT 74 FT /note="Q -> QM (in Ref. 2; AAA48956)" FT /evidence="ECO:0000305" FT CONFLICT 104 FT /note="Missing (in Ref. 2; AAA48956)" FT /evidence="ECO:0000305" FT CONFLICT 128 FT /note="M -> I (in Ref. 2; AAA48961)" FT /evidence="ECO:0000305" SQ SEQUENCE 150 AA; 16710 MW; 6F7BE6BA70055BE0 CRC64; MSFSPDEIND FKEAFLLFDR TGDAKITLSQ VGDIVRALGQ NPTNAEINKI LGNPSKEEMN AKKITFEEFL PMLQAAANNK DQGTFEDFVE GLRVFDKEGN GTVMGAELRH VLATLGEKMT EEEVEELMKG QEDSNGCINY EAFVKHIMSV //