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P02605

- MLE3_CHICK

UniProt

P02605 - MLE3_CHICK

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Protein

Myosin light chain 3, skeletal muscle isoform

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin light chain 3, skeletal muscle isoform
Alternative name(s):
Alkali myosin light chain 3
Short name:
MLC-3
Myosin light chain 3f
Myosin light chain alkali 2
Short name:
Myosin light chain A2
Skeletal-muscle myosin L-4 light chain
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. myosin complex Source: UniProtKB-KW
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 150149Myosin light chain 3, skeletal muscle isoformPRO_0000198705Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21Blocked amino end (Ser)

Post-translational modificationi

The N-terminus is blocked.

Proteomic databases

PRIDEiP02605.

Expressioni

Gene expression databases

ExpressionAtlasiP02605. baseline.

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains.

Structurei

Secondary structure

1
150
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi9 – 179
Beta strandi21 – 233
Helixi27 – 3610
Helixi43 – 519
Turni52 – 543
Beta strandi57 – 593
Helixi65 – 7511
Helixi76 – 816
Helixi84 – 9411
Beta strandi97 – 993
Beta strandi101 – 1033
Helixi104 – 11310
Beta strandi114 – 1163
Helixi120 – 1278
Beta strandi135 – 1384
Helixi139 – 1468

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1MVWelectron microscopy70.00C/F/I/L/O/R10-150[»]
1O18electron microscopy70.00F/I/L/O/R10-150[»]
1O19electron microscopy70.00C/F/I/L/O/U10-150[»]
1O1Aelectron microscopy70.00C/F/I/L/O/R10-150[»]
1O1Belectron microscopy70.00C/F/I/L10-150[»]
1O1Celectron microscopy70.00C/F/I/L/R10-150[»]
1O1Delectron microscopy70.00C/F/I/L/O/R10-150[»]
1O1Eelectron microscopy70.00C/F/I/L/O/R10-150[»]
1O1Felectron microscopy70.00C/F/I/L10-150[»]
1O1Gelectron microscopy70.00C/F/I/L/O/R10-150[»]
2W4Aelectron microscopy35.00C6-150[»]
2W4Gelectron microscopy35.00C6-150[»]
2W4Helectron microscopy35.00C6-150[»]
ProteinModelPortaliP02605.
SMRiP02605. Positions 3-149.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02605.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini6 – 4136EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini44 – 7936EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini83 – 11836EF-hand 3PROSITE-ProRule annotationAdd
BLAST
Domaini118 – 15033EF-hand 4PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000233018.
HOVERGENiHBG012180.
KOiK05738.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
PROSITEiPS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform MLC3 (identifier: P02605-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFSPDEIND FKEAFLLFDR TGDAKITLSQ VGDIVRALGQ NPTNAEINKI
60 70 80 90 100
LGNPSKEEMN AKKITFEEFL PMLQAAANNK DQGTFEDFVE GLRVFDKEGN
110 120 130 140 150
GTVMGAELRH VLATLGEKMT EEEVEELMKG QEDSNGCINY EAFVKHIMSV
Length:150
Mass (Da):16,710
Last modified:January 23, 2007 - v3
Checksum:i6F7BE6BA70055BE0
GO
Isoform MLC1 (identifier: P02604-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform can be found in the external entry P02604.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:192
Mass (Da):20,899
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti7 – 93EIN → QID AA sequence (PubMed:6783403)Curated
Sequence conflicti74 – 741Q → QM in AAA48956. (PubMed:6709041)Curated
Sequence conflicti104 – 1041Missing in AAA48956. (PubMed:6709041)Curated
Sequence conflicti128 – 1281M → I in AAA48961. (PubMed:6709041)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J00888 mRNA. Translation: AAA48961.1.
K02610, K02609 Genomic DNA. Translation: AAA48956.1.
PIRiI50384. MOCHA2.
RefSeqiNP_001038097.1. NM_001044632.1.
UniGeneiGga.4835.

Genome annotation databases

GeneIDi396470.
KEGGigga:396470.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J00888 mRNA. Translation: AAA48961.1 .
K02610 , K02609 Genomic DNA. Translation: AAA48956.1 .
PIRi I50384. MOCHA2.
RefSeqi NP_001038097.1. NM_001044632.1.
UniGenei Gga.4835.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1MVW electron microscopy 70.00 C/F/I/L/O/R 10-150 [» ]
1O18 electron microscopy 70.00 F/I/L/O/R 10-150 [» ]
1O19 electron microscopy 70.00 C/F/I/L/O/U 10-150 [» ]
1O1A electron microscopy 70.00 C/F/I/L/O/R 10-150 [» ]
1O1B electron microscopy 70.00 C/F/I/L 10-150 [» ]
1O1C electron microscopy 70.00 C/F/I/L/R 10-150 [» ]
1O1D electron microscopy 70.00 C/F/I/L/O/R 10-150 [» ]
1O1E electron microscopy 70.00 C/F/I/L/O/R 10-150 [» ]
1O1F electron microscopy 70.00 C/F/I/L 10-150 [» ]
1O1G electron microscopy 70.00 C/F/I/L/O/R 10-150 [» ]
2W4A electron microscopy 35.00 C 6-150 [» ]
2W4G electron microscopy 35.00 C 6-150 [» ]
2W4H electron microscopy 35.00 C 6-150 [» ]
ProteinModelPortali P02605.
SMRi P02605. Positions 3-149.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P02605.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 396470.
KEGGi gga:396470.

Organism-specific databases

CTDi 4632.

Phylogenomic databases

HOGENOMi HOG000233018.
HOVERGENi HBG012180.
KOi K05738.

Miscellaneous databases

EvolutionaryTracei P02605.
NextBioi 20816509.

Gene expression databases

ExpressionAtlasi P02605. baseline.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
InterProi IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view ]
Pfami PF13405. EF-hand_6. 1 hit.
PF13499. EF-hand_7. 1 hit.
[Graphical view ]
SMARTi SM00054. EFh. 3 hits.
[Graphical view ]
PROSITEi PS50222. EF_HAND_2. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and nucleotide sequences of the complementary DNAs to chicken skeletal muscle myosin two alkali light chain mRNAs."
    Nabeshima Y., Fujii-Kuriyama Y., Muramatsu M., Ogata K.
    Nucleic Acids Res. 10:6099-6110(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Alternative transcription and two modes of splicing results in two myosin light chains from one gene."
    Nabeshima Y., Fujii-Kuriyama Y., Muramatsu M., Ogata K.
    Nature 308:333-338(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Skeletal muscle.
  3. "Amino-acid sequence of the L-4 light chain of chicken skeletal-muscle myosin."
    Maita T., Umegane T., Matsuda G.
    Eur. J. Biochem. 114:45-49(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-150, BLOCKAGE OF N-TERMINUS.
    Tissue: Skeletal muscle.

Entry informationi

Entry nameiMLE3_CHICK
AccessioniPrimary (citable) accession number: P02605
Secondary accession number(s): Q90896
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3