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Protein

Myosin light chain 3, skeletal muscle isoform

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionMotor protein, Muscle protein, Myosin

Enzyme and pathway databases

ReactomeiR-GGA-390522. Striated Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin light chain 3, skeletal muscle isoform
Alternative name(s):
Alkali myosin light chain 3
Short name:
MLC-3
Myosin light chain 3f
Myosin light chain alkali 2
Short name:
Myosin light chain A2
Skeletal-muscle myosin L-4 light chain
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 7

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001987052 – 150Myosin light chain 3, skeletal muscle isoformAdd BLAST149

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2Blocked amino end (Ser)1

Post-translational modificationi

The N-terminus is blocked.

Proteomic databases

PaxDbiP02605.
PRIDEiP02605.

Expressioni

Gene expression databases

BgeeiENSGALG00000002907.
ExpressionAtlasiP02605. baseline.

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains.

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039262.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MVWelectron microscopy70.00C/F/I/L/O/R10-150[»]
1O18electron microscopy70.00F/I/L/O/R10-150[»]
1O19electron microscopy70.00C/F/I/L/O/U10-150[»]
1O1Aelectron microscopy70.00C/F/I/L/O/R10-150[»]
1O1Belectron microscopy70.00C/F/I/L10-150[»]
1O1Celectron microscopy70.00C/F/I/L/R10-150[»]
1O1Delectron microscopy70.00C/F/I/L/O/R10-150[»]
1O1Eelectron microscopy70.00C/F/I/L/O/R10-150[»]
1O1Felectron microscopy70.00C/F/I/L10-150[»]
1O1Gelectron microscopy70.00C/F/I/L/O/R10-150[»]
2W4Aelectron microscopy35.00C6-150[»]
2W4Gelectron microscopy35.00C6-150[»]
2W4Helectron microscopy35.00C6-150[»]
ProteinModelPortaliP02605.
SMRiP02605.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02605.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 41EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini44 – 79EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini83 – 118EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini118 – 150EF-hand 4PROSITE-ProRule annotationAdd BLAST33

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0030. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00590000082921.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
KOiK05738.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
SMARTiView protein in SMART
SM00054. EFh. 3 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS50222. EF_HAND_2. 4 hits.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform MLC3 (identifier: P02605-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSFSPDEIND FKEAFLLFDR TGDAKITLSQ VGDIVRALGQ NPTNAEINKI
60 70 80 90 100
LGNPSKEEMN AKKITFEEFL PMLQAAANNK DQGTFEDFVE GLRVFDKEGN
110 120 130 140 150
GTVMGAELRH VLATLGEKMT EEEVEELMKG QEDSNGCINY EAFVKHIMSV
Length:150
Mass (Da):16,710
Last modified:January 23, 2007 - v3
Checksum:i6F7BE6BA70055BE0
GO
Isoform MLC1 (identifier: P02604-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P02604.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:192
Mass (Da):20,899
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7 – 9EIN → QID AA sequence (PubMed:6783403).Curated3
Sequence conflicti74Q → QM in AAA48956 (PubMed:6709041).Curated1
Sequence conflicti104Missing in AAA48956 (PubMed:6709041).Curated1
Sequence conflicti128M → I in AAA48961 (PubMed:6709041).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00888 mRNA. Translation: AAA48961.1.
K02610, K02609 Genomic DNA. Translation: AAA48956.1.
PIRiI50384. MOCHA2.
RefSeqiNP_001038097.1. NM_001044632.1.
UniGeneiGga.4835.

Genome annotation databases

EnsembliENSGALT00000040054; ENSGALP00000039262; ENSGALG00000002907. [P02605-1]
GeneIDi396470.
KEGGigga:396470.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00888 mRNA. Translation: AAA48961.1.
K02610, K02609 Genomic DNA. Translation: AAA48956.1.
PIRiI50384. MOCHA2.
RefSeqiNP_001038097.1. NM_001044632.1.
UniGeneiGga.4835.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MVWelectron microscopy70.00C/F/I/L/O/R10-150[»]
1O18electron microscopy70.00F/I/L/O/R10-150[»]
1O19electron microscopy70.00C/F/I/L/O/U10-150[»]
1O1Aelectron microscopy70.00C/F/I/L/O/R10-150[»]
1O1Belectron microscopy70.00C/F/I/L10-150[»]
1O1Celectron microscopy70.00C/F/I/L/R10-150[»]
1O1Delectron microscopy70.00C/F/I/L/O/R10-150[»]
1O1Eelectron microscopy70.00C/F/I/L/O/R10-150[»]
1O1Felectron microscopy70.00C/F/I/L10-150[»]
1O1Gelectron microscopy70.00C/F/I/L/O/R10-150[»]
2W4Aelectron microscopy35.00C6-150[»]
2W4Gelectron microscopy35.00C6-150[»]
2W4Helectron microscopy35.00C6-150[»]
ProteinModelPortaliP02605.
SMRiP02605.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039262.

Proteomic databases

PaxDbiP02605.
PRIDEiP02605.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000040054; ENSGALP00000039262; ENSGALG00000002907. [P02605-1]
GeneIDi396470.
KEGGigga:396470.

Organism-specific databases

CTDi4632.

Phylogenomic databases

eggNOGiKOG0030. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00590000082921.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
KOiK05738.

Enzyme and pathway databases

ReactomeiR-GGA-390522. Striated Muscle Contraction.

Miscellaneous databases

EvolutionaryTraceiP02605.

Gene expression databases

BgeeiENSGALG00000002907.
ExpressionAtlasiP02605. baseline.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
SMARTiView protein in SMART
SM00054. EFh. 3 hits.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS50222. EF_HAND_2. 4 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiMLE3_CHICK
AccessioniPrimary (citable) accession number: P02605
Secondary accession number(s): Q90896
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: March 15, 2017
This is version 128 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.