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Protein

Troponin C, skeletal muscle

Gene

TNNC2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi31 – 421Add BLAST12
Calcium bindingi67 – 782Add BLAST12
Calcium bindingi107 – 1183Add BLAST12
Calcium bindingi143 – 1544Add BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-GGA-390522. Striated Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin C, skeletal muscle
Gene namesi
Name:TNNC2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 20

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi131T → I: Decreases calcium affinity. 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000737072 – 163Troponin C, skeletal muscleAdd BLAST162

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2Blocked amino end (Ala)1

Proteomic databases

PaxDbiP02588.
PRIDEiP02588.

Expressioni

Gene expression databases

BgeeiENSGALG00000006835.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP02588. 2 interactors.
MINTiMINT-252237.
STRINGi9031.ENSGALP00000011046.

Structurei

Secondary structure

1163
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 14Combined sources4
Helixi17 – 30Combined sources14
Beta strandi31 – 34Combined sources4
Beta strandi35 – 38Combined sources4
Helixi40 – 49Combined sources10
Helixi56 – 66Combined sources11
Beta strandi68 – 70Combined sources3
Beta strandi72 – 75Combined sources4
Helixi76 – 87Combined sources12
Helixi89 – 92Combined sources4
Helixi97 – 106Combined sources10
Beta strandi111 – 114Combined sources4
Helixi116 – 124Combined sources9
Turni125 – 127Combined sources3
Helixi132 – 142Combined sources11
Beta strandi144 – 146Combined sources3
Beta strandi147 – 150Combined sources4
Helixi152 – 160Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AVSX-ray1.75A/B2-91[»]
1BLQNMR-A2-91[»]
1CTANMR-A/B94-127[»]
1CTDNMR-A/B94-127[»]
1EW7model-C3-162[»]
1JC2NMR-A89-163[»]
1NCXX-ray1.80A2-163[»]
1NCYX-ray2.10A2-163[»]
1NCZX-ray1.80A2-163[»]
1NPQNMR-A2-91[»]
1PONNMR-A94-127[»]
B130-163[»]
1SKTNMR-A2-91[»]
1SMGNMR-A2-91[»]
1TNPNMR-A2-91[»]
1TNQNMR-A2-91[»]
1TNWNMR-A2-163[»]
1TNXNMR-A2-163[»]
1TOPX-ray1.78A2-163[»]
1YTZX-ray3.00C2-163[»]
1YV0X-ray7.00C2-163[»]
1ZACNMR-A2-91[»]
2W49electron microscopy35.000/3/6/95-163[»]
2W4Uelectron microscopy35.000/3/6/95-163[»]
4TNCX-ray2.00A3-163[»]
ProteinModelPortaliP02588.
SMRiP02588.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02588.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 53EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini54 – 89EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini94 – 129EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini130 – 163EF-hand 4PROSITE-ProRule annotationAdd BLAST34

Sequence similaritiesi

Belongs to the troponin C family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118901.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiP02588.
KOiK12042.
OMAiVETWEVD.
OrthoDBiEOG091G0QHM.
PhylomeDBiP02588.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02588-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASMTDQQAE ARAFLSEEMI AEFKAAFDMF DADGGGDIST KELGTVMRML
60 70 80 90 100
GQNPTKEELD AIIEEVDEDG SGTIDFEEFL VMMVRQMKED AKGKSEEELA
110 120 130 140 150
NCFRIFDKNA DGFIDIEELG EILRATGEHV TEEDIEDLMK DSDKNNDGRI
160
DFDEFLKMME GVQ
Length:163
Mass (Da):18,375
Last modified:January 23, 2007 - v3
Checksum:iC4E1D9F40FFED3BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19027 mRNA. Translation: AAA49097.1. Sequence problems.
PIRiA03015. TPCHCS.
RefSeqiNP_990781.1. NM_205450.2.
UniGeneiGga.823.

Genome annotation databases

EnsembliENSGALT00000011060; ENSGALP00000011046; ENSGALG00000006835.
GeneIDi396434.
KEGGigga:396434.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19027 mRNA. Translation: AAA49097.1. Sequence problems.
PIRiA03015. TPCHCS.
RefSeqiNP_990781.1. NM_205450.2.
UniGeneiGga.823.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AVSX-ray1.75A/B2-91[»]
1BLQNMR-A2-91[»]
1CTANMR-A/B94-127[»]
1CTDNMR-A/B94-127[»]
1EW7model-C3-162[»]
1JC2NMR-A89-163[»]
1NCXX-ray1.80A2-163[»]
1NCYX-ray2.10A2-163[»]
1NCZX-ray1.80A2-163[»]
1NPQNMR-A2-91[»]
1PONNMR-A94-127[»]
B130-163[»]
1SKTNMR-A2-91[»]
1SMGNMR-A2-91[»]
1TNPNMR-A2-91[»]
1TNQNMR-A2-91[»]
1TNWNMR-A2-163[»]
1TNXNMR-A2-163[»]
1TOPX-ray1.78A2-163[»]
1YTZX-ray3.00C2-163[»]
1YV0X-ray7.00C2-163[»]
1ZACNMR-A2-91[»]
2W49electron microscopy35.000/3/6/95-163[»]
2W4Uelectron microscopy35.000/3/6/95-163[»]
4TNCX-ray2.00A3-163[»]
ProteinModelPortaliP02588.
SMRiP02588.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP02588. 2 interactors.
MINTiMINT-252237.
STRINGi9031.ENSGALP00000011046.

Proteomic databases

PaxDbiP02588.
PRIDEiP02588.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000011060; ENSGALP00000011046; ENSGALG00000006835.
GeneIDi396434.
KEGGigga:396434.

Organism-specific databases

CTDi7125.

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118901.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiP02588.
KOiK12042.
OMAiVETWEVD.
OrthoDBiEOG091G0QHM.
PhylomeDBiP02588.

Enzyme and pathway databases

ReactomeiR-GGA-390522. Striated Muscle Contraction.

Miscellaneous databases

EvolutionaryTraceiP02588.
PROiP02588.

Gene expression databases

BgeeiENSGALG00000006835.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNNC2_CHICK
AccessioniPrimary (citable) accession number: P02588
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 151 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Skeletal muscle troponin C binds four calcium ions.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.