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Protein

Troponin C, skeletal muscle

Gene

TNNC2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

Miscellaneous

Skeletal muscle troponin C binds four calcium ions.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi31 – 421Add BLAST12
Calcium bindingi67 – 782Add BLAST12
Calcium bindingi107 – 1183Add BLAST12
Calcium bindingi143 – 1544Add BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMuscle protein
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-GGA-390522 Striated Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin C, skeletal muscle
Gene namesi
Name:TNNC2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 20

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi131T → I: Decreases calcium affinity. 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000737072 – 163Troponin C, skeletal muscleAdd BLAST162

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2Blocked amino end (Ala)1

Proteomic databases

PaxDbiP02588
PRIDEiP02588

Expressioni

Gene expression databases

BgeeiENSGALG00000006835

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP02588, 2 interactors
MINTiP02588
STRINGi9031.ENSGALP00000011046

Structurei

Secondary structure

1163
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 14Combined sources4
Helixi17 – 30Combined sources14
Beta strandi31 – 34Combined sources4
Beta strandi35 – 38Combined sources4
Helixi40 – 49Combined sources10
Helixi56 – 66Combined sources11
Beta strandi68 – 70Combined sources3
Beta strandi72 – 75Combined sources4
Helixi76 – 87Combined sources12
Helixi89 – 92Combined sources4
Helixi97 – 106Combined sources10
Beta strandi111 – 114Combined sources4
Helixi116 – 124Combined sources9
Turni125 – 127Combined sources3
Helixi132 – 142Combined sources11
Beta strandi144 – 146Combined sources3
Beta strandi147 – 150Combined sources4
Helixi152 – 160Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AVSX-ray1.75A/B2-91[»]
1BLQNMR-A2-91[»]
1CTANMR-A/B94-127[»]
1CTDNMR-A/B94-127[»]
1EW7model-C3-162[»]
1JC2NMR-A89-163[»]
1NCXX-ray1.80A2-163[»]
1NCYX-ray2.10A2-163[»]
1NCZX-ray1.80A2-163[»]
1NPQNMR-A2-91[»]
1PONNMR-A94-127[»]
B130-163[»]
1SKTNMR-A2-91[»]
1SMGNMR-A2-91[»]
1TNPNMR-A2-91[»]
1TNQNMR-A2-91[»]
1TNWNMR-A2-163[»]
1TNXNMR-A2-163[»]
1TOPX-ray1.78A2-163[»]
1YTZX-ray3.00C2-163[»]
1YV0X-ray7.00C2-163[»]
1ZACNMR-A2-91[»]
2W49electron microscopy35.000/3/6/95-163[»]
2W4Uelectron microscopy35.000/3/6/95-163[»]
4TNCX-ray2.00A3-163[»]
ProteinModelPortaliP02588
SMRiP02588
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02588

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 53EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini54 – 89EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini94 – 129EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini130 – 163EF-hand 4PROSITE-ProRule annotationAdd BLAST34

Sequence similaritiesi

Belongs to the troponin C family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00760000118901
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiP02588
KOiK12042
OMAiVETWEVD
OrthoDBiEOG091G0QHM
PhylomeDBiP02588

Family and domain databases

CDDicd00051 EFh, 2 hits
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
PF13833 EF-hand_8, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 4 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 4 hits
PS50222 EF_HAND_2, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02588-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASMTDQQAE ARAFLSEEMI AEFKAAFDMF DADGGGDIST KELGTVMRML
60 70 80 90 100
GQNPTKEELD AIIEEVDEDG SGTIDFEEFL VMMVRQMKED AKGKSEEELA
110 120 130 140 150
NCFRIFDKNA DGFIDIEELG EILRATGEHV TEEDIEDLMK DSDKNNDGRI
160
DFDEFLKMME GVQ
Length:163
Mass (Da):18,375
Last modified:January 23, 2007 - v3
Checksum:iC4E1D9F40FFED3BC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19027 mRNA Translation: AAA49097.1 Sequence problems.
PIRiA03015 TPCHCS
RefSeqiNP_990781.1, NM_205450.2
UniGeneiGga.823

Genome annotation databases

EnsembliENSGALT00000011060; ENSGALP00000011046; ENSGALG00000006835
GeneIDi396434
KEGGigga:396434

Similar proteinsi

Entry informationi

Entry nameiTNNC2_CHICK
AccessioniPrimary (citable) accession number: P02588
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 160 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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