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P02585

- TNNC2_HUMAN

UniProt

P02585 - TNNC2_HUMAN

Protein

Troponin C, skeletal muscle

Gene

TNNC2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi28 – 39121Add
    BLAST
    Calcium bindingi64 – 75122Add
    BLAST
    Calcium bindingi104 – 115123Add
    BLAST
    Calcium bindingi140 – 151124Add
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. muscle filament sliding Source: Reactome
    2. regulation of muscle contraction Source: ProtInc
    3. skeletal muscle contraction Source: UniProtKB

    Keywords - Molecular functioni

    Muscle protein

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_16969. Striated Muscle Contraction.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Troponin C, skeletal muscle
    Gene namesi
    Name:TNNC2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:11944. TNNC2.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. troponin complex Source: UniProtKB

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36633.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 160159Troponin C, skeletal musclePRO_0000073703Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylthreonine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiP02585.
    PRIDEiP02585.

    PTM databases

    PhosphoSiteiP02585.

    Expressioni

    Gene expression databases

    ArrayExpressiP02585.
    BgeeiP02585.
    CleanExiHS_TNNC2.
    GenevestigatoriP02585.

    Organism-specific databases

    HPAiHPA043174.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000361636.

    Structurei

    3D structure databases

    ProteinModelPortaliP02585.
    SMRiP02585. Positions 3-160.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini15 – 5036EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini51 – 8636EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini91 – 12636EF-hand 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini127 – 16034EF-hand 4PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the troponin C family.Curated
    Contains 4 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5126.
    HOGENOMiHOG000233018.
    HOVERGENiHBG012180.
    InParanoidiP02585.
    KOiK12042.
    OMAiMTDAQQE.
    OrthoDBiEOG76X61W.
    PhylomeDBiP02585.
    TreeFamiTF318191.

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view]
    PfamiPF13499. EF-hand_7. 1 hit.
    [Graphical view]
    SMARTiSM00054. EFh. 4 hits.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 4 hits.
    PS50222. EF_HAND_2. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P02585-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDQQAEARS YLSEEMIAEF KAAFDMFDAD GGGDISVKEL GTVMRMLGQT    50
    PTKEELDAII EEVDEDGSGT IDFEEFLVMM VRQMKEDAKG KSEEELAECF 100
    RIFDRNADGY IDPEELAEIF RASGEHVTDE EIESLMKDGD KNNDGRIDFD 150
    EFLKMMEGVQ 160
    Length:160
    Mass (Da):18,122
    Last modified:January 23, 2007 - v2
    Checksum:iEA93729732A0F916
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 32TD → DT AA sequence (PubMed:978749)Curated
    Sequence conflicti114 – 1141E → G in AAA91854. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07898 mRNA. Translation: CAA30737.1.
    M33772, M33771 Genomic DNA. Translation: AAA61197.1.
    M22307 mRNA. Translation: AAA91854.1.
    AK291323 mRNA. Translation: BAF84012.1.
    CR541864 mRNA. Translation: CAG46662.1.
    CR541884 mRNA. Translation: CAG46682.1.
    CH471077 Genomic DNA. Translation: EAW75803.1.
    AL050348 Genomic DNA. No translation available.
    BC005323 mRNA. Translation: AAH05323.1.
    CCDSiCCDS13375.1.
    PIRiA36574. TPHUCS.
    RefSeqiNP_003270.1. NM_003279.2.
    UniGeneiHs.182421.

    Genome annotation databases

    EnsembliENST00000372555; ENSP00000361636; ENSG00000101470.
    GeneIDi7125.
    KEGGihsa:7125.
    UCSCiuc002xpr.3. human.

    Polymorphism databases

    DMDMi136043.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07898 mRNA. Translation: CAA30737.1 .
    M33772 , M33771 Genomic DNA. Translation: AAA61197.1 .
    M22307 mRNA. Translation: AAA91854.1 .
    AK291323 mRNA. Translation: BAF84012.1 .
    CR541864 mRNA. Translation: CAG46662.1 .
    CR541884 mRNA. Translation: CAG46682.1 .
    CH471077 Genomic DNA. Translation: EAW75803.1 .
    AL050348 Genomic DNA. No translation available.
    BC005323 mRNA. Translation: AAH05323.1 .
    CCDSi CCDS13375.1.
    PIRi A36574. TPHUCS.
    RefSeqi NP_003270.1. NM_003279.2.
    UniGenei Hs.182421.

    3D structure databases

    ProteinModelPortali P02585.
    SMRi P02585. Positions 3-160.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000361636.

    PTM databases

    PhosphoSitei P02585.

    Polymorphism databases

    DMDMi 136043.

    Proteomic databases

    PaxDbi P02585.
    PRIDEi P02585.

    Protocols and materials databases

    DNASUi 7125.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000372555 ; ENSP00000361636 ; ENSG00000101470 .
    GeneIDi 7125.
    KEGGi hsa:7125.
    UCSCi uc002xpr.3. human.

    Organism-specific databases

    CTDi 7125.
    GeneCardsi GC20M044451.
    HGNCi HGNC:11944. TNNC2.
    HPAi HPA043174.
    MIMi 191039. gene.
    neXtProti NX_P02585.
    PharmGKBi PA36633.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5126.
    HOGENOMi HOG000233018.
    HOVERGENi HBG012180.
    InParanoidi P02585.
    KOi K12042.
    OMAi MTDAQQE.
    OrthoDBi EOG76X61W.
    PhylomeDBi P02585.
    TreeFami TF318191.

    Enzyme and pathway databases

    Reactomei REACT_16969. Striated Muscle Contraction.

    Miscellaneous databases

    ChiTaRSi TNNC2. human.
    GeneWikii TNNC2.
    GenomeRNAii 7125.
    NextBioi 27883.
    PROi P02585.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P02585.
    Bgeei P02585.
    CleanExi HS_TNNC2.
    Genevestigatori P02585.

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    [Graphical view ]
    Pfami PF13499. EF-hand_7. 1 hit.
    [Graphical view ]
    SMARTi SM00054. EFh. 4 hits.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 4 hits.
    PS50222. EF_HAND_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differential expression of slow and fast skeletal muscle troponin C. Slow skeletal muscle troponin C is expressed in human fibroblasts."
      Gahlmann R., Wade R., Gunning R., Kedes L.
      J. Mol. Biol. 201:379-391(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Cloning, structural analysis, and expression of the human fast twitch skeletal muscle troponin C gene."
      Gahlmann R., Kedes L.
      J. Biol. Chem. 265:12520-12528(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Wu Q.L.
      Submitted (MAR-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Muscle.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Tongue.
    5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.
    9. "Human skeletal muscle proteins. The primary structure of troponin C."
      Romero-Herrera A.E., Castillo O., Lehmann H.
      J. Mol. Evol. 8:251-270(1976) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-160, ACETYLATION AT THR-2.
      Tissue: Skeletal muscle.

    Entry informationi

    Entry nameiTNNC2_HUMAN
    AccessioniPrimary (citable) accession number: P02585
    Secondary accession number(s): Q6FH92
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 141 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Skeletal muscle troponin C binds four calcium ions.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3