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Protein

Troponin C, skeletal muscle

Gene

TNNC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi28 – 391Add BLAST12
Calcium bindingi64 – 752Add BLAST12
Calcium bindingi104 – 1153Add BLAST12
Calcium bindingi140 – 1514Add BLAST12

GO - Molecular functioni

GO - Biological processi

  • muscle filament sliding Source: Reactome
  • regulation of muscle contraction Source: ProtInc
  • skeletal muscle contraction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101470-MONOMER.
ReactomeiR-HSA-390522. Striated Muscle Contraction.
SIGNORiP02585.

Names & Taxonomyi

Protein namesi
Recommended name:
Troponin C, skeletal muscle
Gene namesi
Name:TNNC2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:11944. TNNC2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • troponin complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000101470.
PharmGKBiPA36633.

Chemistry databases

DrugBankiDB01023. Felodipine.

Polymorphism and mutation databases

BioMutaiTNNC2.
DMDMi136043.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000737032 – 160Troponin C, skeletal muscleAdd BLAST159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonine1 Publication1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP02585.
PeptideAtlasiP02585.
PRIDEiP02585.

PTM databases

PhosphoSitePlusiP02585.

Expressioni

Gene expression databases

BgeeiENSG00000101470.
CleanExiHS_TNNC2.
ExpressionAtlasiP02585. baseline and differential.
GenevisibleiP02585. HS.

Organism-specific databases

HPAiHPA043174.
HPA058481.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TNNI3Q6FGX23EBI-10249681,EBI-10249686

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112980. 4 interactors.
IntActiP02585. 4 interactors.
STRINGi9606.ENSP00000361636.

Structurei

3D structure databases

ProteinModelPortaliP02585.
SMRiP02585.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 50EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini51 – 86EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini91 – 126EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini127 – 160EF-hand 4PROSITE-ProRule annotationAdd BLAST34

Sequence similaritiesi

Belongs to the troponin C family.Curated
Contains 4 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118901.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiP02585.
KOiK12042.
OMAiVETWEVD.
OrthoDBiEOG091G0QHM.
PhylomeDBiP02585.
TreeFamiTF318191.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02585-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDQQAEARS YLSEEMIAEF KAAFDMFDAD GGGDISVKEL GTVMRMLGQT
60 70 80 90 100
PTKEELDAII EEVDEDGSGT IDFEEFLVMM VRQMKEDAKG KSEEELAECF
110 120 130 140 150
RIFDRNADGY IDPEELAEIF RASGEHVTDE EIESLMKDGD KNNDGRIDFD
160
EFLKMMEGVQ
Length:160
Mass (Da):18,122
Last modified:January 23, 2007 - v2
Checksum:iEA93729732A0F916
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2 – 3TD → DT AA sequence (PubMed:978749).Curated2
Sequence conflicti114E → G in AAA91854 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07898 mRNA. Translation: CAA30737.1.
M33772, M33771 Genomic DNA. Translation: AAA61197.1.
M22307 mRNA. Translation: AAA91854.1.
AK291323 mRNA. Translation: BAF84012.1.
CR541864 mRNA. Translation: CAG46662.1.
CR541884 mRNA. Translation: CAG46682.1.
CH471077 Genomic DNA. Translation: EAW75803.1.
AL050348 Genomic DNA. No translation available.
BC005323 mRNA. Translation: AAH05323.1.
CCDSiCCDS13375.1.
PIRiA36574. TPHUCS.
RefSeqiNP_003270.1. NM_003279.2.
UniGeneiHs.182421.

Genome annotation databases

EnsembliENST00000372555; ENSP00000361636; ENSG00000101470.
GeneIDi7125.
KEGGihsa:7125.
UCSCiuc002xpr.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07898 mRNA. Translation: CAA30737.1.
M33772, M33771 Genomic DNA. Translation: AAA61197.1.
M22307 mRNA. Translation: AAA91854.1.
AK291323 mRNA. Translation: BAF84012.1.
CR541864 mRNA. Translation: CAG46662.1.
CR541884 mRNA. Translation: CAG46682.1.
CH471077 Genomic DNA. Translation: EAW75803.1.
AL050348 Genomic DNA. No translation available.
BC005323 mRNA. Translation: AAH05323.1.
CCDSiCCDS13375.1.
PIRiA36574. TPHUCS.
RefSeqiNP_003270.1. NM_003279.2.
UniGeneiHs.182421.

3D structure databases

ProteinModelPortaliP02585.
SMRiP02585.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112980. 4 interactors.
IntActiP02585. 4 interactors.
STRINGi9606.ENSP00000361636.

Chemistry databases

DrugBankiDB01023. Felodipine.

PTM databases

PhosphoSitePlusiP02585.

Polymorphism and mutation databases

BioMutaiTNNC2.
DMDMi136043.

Proteomic databases

PaxDbiP02585.
PeptideAtlasiP02585.
PRIDEiP02585.

Protocols and materials databases

DNASUi7125.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000372555; ENSP00000361636; ENSG00000101470.
GeneIDi7125.
KEGGihsa:7125.
UCSCiuc002xpr.4. human.

Organism-specific databases

CTDi7125.
GeneCardsiTNNC2.
HGNCiHGNC:11944. TNNC2.
HPAiHPA043174.
HPA058481.
MIMi191039. gene.
neXtProtiNX_P02585.
OpenTargetsiENSG00000101470.
PharmGKBiPA36633.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00760000118901.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiP02585.
KOiK12042.
OMAiVETWEVD.
OrthoDBiEOG091G0QHM.
PhylomeDBiP02585.
TreeFamiTF318191.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000101470-MONOMER.
ReactomeiR-HSA-390522. Striated Muscle Contraction.
SIGNORiP02585.

Miscellaneous databases

ChiTaRSiTNNC2. human.
GeneWikiiTNNC2.
GenomeRNAii7125.
PROiP02585.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101470.
CleanExiHS_TNNC2.
ExpressionAtlasiP02585. baseline and differential.
GenevisibleiP02585. HS.

Family and domain databases

CDDicd00051. EFh. 2 hits.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
PF13833. EF-hand_8. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 4 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNNC2_HUMAN
AccessioniPrimary (citable) accession number: P02585
Secondary accession number(s): Q6FH92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 161 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Skeletal muscle troponin C binds four calcium ions.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.