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Protein

Actin, larval muscle

Gene

Act79B

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction.

Miscellaneous

In Drosophila there are 6 closely related actin genes.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • structural constituent of cytoskeleton Source: FlyBase

GO - Biological processi

  • cytoskeleton organization Source: FlyBase

Keywordsi

Molecular functionMuscle protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiP02574

Names & Taxonomyi

Protein namesi
Recommended name:
Actin, larval muscle
Alternative name(s):
Actin-79B
Gene namesi
Name:Act79B
ORF Names:CG7478
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0000045 Act79B

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000006621 – 2Removed in mature formBy similarity2
ChainiPRO_00000006633 – 376Actin, larval muscleAdd BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3N-acetylaspartateBy similarity1
Modified residuei45Methionine sulfoxide1 Publication1
Modified residuei48Methionine sulfoxide1 Publication1

Post-translational modificationi

Oxidation of Met-45 by Mical to form methionine sulfoxide promotes actin filament depolymerization. Methionine sulfoxide is produced stereospecifically, but it is not known whether the (S)-S-oxide or the (R)-S-oxide is produced.1 Publication

Keywords - PTMi

Acetylation, Oxidation

Proteomic databases

PaxDbiP02574
PRIDEiP02574

Expressioni

Developmental stagei

Expressed during larval stages and at a lower level in pupae.1 Publication

Gene expression databases

BgeeiFBgn0000045
ExpressionAtlasiP02574 baseline and differential
GenevisibleiP02574 DM

Interactioni

Protein-protein interaction databases

BioGridi65684, 33 interactors
DIPiDIP-23587N
IntActiP02574, 4 interactors
STRINGi7227.FBpp0078131

Structurei

3D structure databases

ProteinModelPortaliP02574
SMRiP02574
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiKOG0676 Eukaryota
COG5277 LUCA
GeneTreeiENSGT00760000118957
InParanoidiP02574
KOiK05692
OMAiTFQQART
OrthoDBiEOG091G08LD
PhylomeDBiP02574

Family and domain databases

InterProiView protein in InterPro
IPR004000 Actin
IPR020902 Actin/actin-like_CS
IPR004001 Actin_CS
PANTHERiPTHR11937 PTHR11937, 1 hit
PfamiView protein in Pfam
PF00022 Actin, 1 hit
PRINTSiPR00190 ACTIN
SMARTiView protein in SMART
SM00268 ACTIN, 1 hit
PROSITEiView protein in PROSITE
PS00406 ACTINS_1, 1 hit
PS00432 ACTINS_2, 1 hit
PS01132 ACTINS_ACT_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02574-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDEEASALV VDNGSGMCKA GFAGDDAPRA VFPSIVGRPR HQGVMVGMGQ
60 70 80 90 100
KDCYVGDEAQ SKRGILSLKY PIEHGIITNW DDMEKVWHHT FYNELRVAPE
110 120 130 140 150
EHPVLLTEAP LNPKANREKM TQIMFETFNS PAMYVAIQAV LSLYASGRTT
160 170 180 190 200
GIVLDSGDGV SHTVPIYEGY ALPHAILRLD LAGRDLTDYL MKILTERGYS
210 220 230 240 250
FTTTAEREIV RDIKEKLCYV ALDFEQEMAT AAASTSLEKS YELPDGQVIT
260 270 280 290 300
IGNERFRTPE ALFQPSFLGM ESCGIHETVY QSIMKCDVDI RKDLYANNVL
310 320 330 340 350
SGGTTMYPGI ADRMQKEITA LAPSTIKIKI IAPPERKYSV WIGGSILASL
360 370
STFQQMWISK QEYDESGPGI VHRKCF
Length:376
Mass (Da):41,787
Last modified:February 21, 2001 - v2
Checksum:iD08BB1B42DE86B94
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti185D → H in AAA28318 (PubMed:6405041).Curated1
Sequence conflicti326I → M in AAA28317 (PubMed:6405041).Curated1
Sequence conflicti326I → M in AAA28318 (PubMed:6405041).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18827, M18828 Genomic DNA Translation: AAA28317.1
M18829 Genomic DNA Translation: AAA28318.1
AE014296 Genomic DNA Translation: AAF51800.1
AY118735 mRNA Translation: AAM50595.1
PIRiA03002 ATFF7
RefSeqiNP_001262200.1, NM_001275271.1
NP_524210.1, NM_079486.4
UniGeneiDm.5748

Genome annotation databases

EnsemblMetazoaiFBtr0078478; FBpp0078131; FBgn0000045
FBtr0334090; FBpp0306215; FBgn0000045
GeneIDi40444
KEGGidme:Dmel_CG7478

Similar proteinsi

Entry informationi

Entry nameiACT4_DROME
AccessioniPrimary (citable) accession number: P02574
Secondary accession number(s): Q540X7, Q9VNW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 21, 2001
Last modified: May 23, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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