Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Actin, larval muscle

Gene

Act79B

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Multiple isoforms are involved in various cellular functions such as cytoskeleton structure, cell mobility, chromosome movement and muscle contraction.

Miscellaneous

In Drosophila there are 6 closely related actin genes.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • structural constituent of cytoskeleton Source: FlyBase

GO - Biological processi

  • cytoskeleton organization Source: FlyBase

Keywordsi

Molecular functionMuscle protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-190873. Gap junction degradation.
R-DME-196025. Formation of annular gap junctions.
R-DME-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-DME-3928662. EPHB-mediated forward signaling.
R-DME-3928665. EPH-ephrin mediated repulsion of cells.
R-DME-437239. Recycling pathway of L1.
R-DME-4420097. VEGFA-VEGFR2 Pathway.
R-DME-5663213. RHO GTPases Activate WASPs and WAVEs.
R-DME-5689603. UCH proteinases.
R-DME-5696394. DNA Damage Recognition in GG-NER.
R-DME-8856828. Clathrin-mediated endocytosis.
SignaLinkiP02574.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin, larval muscle
Alternative name(s):
Actin-79B
Gene namesi
Name:Act79B
ORF Names:CG7478
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0000045. Act79B.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000006621 – 2Removed in mature formBy similarity2
ChainiPRO_00000006633 – 376Actin, larval muscleAdd BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3N-acetylaspartateBy similarity1
Modified residuei45Methionine sulfoxide1 Publication1
Modified residuei48Methionine sulfoxide1 Publication1

Post-translational modificationi

Oxidation of Met-45 by Mical to form methionine sulfoxide promotes actin filament depolymerization. Methionine sulfoxide is produced stereospecifically, but it is not known whether the (S)-S-oxide or the (R)-S-oxide is produced.1 Publication

Keywords - PTMi

Acetylation, Oxidation

Proteomic databases

PaxDbiP02574.
PRIDEiP02574.

Expressioni

Developmental stagei

Expressed during larval stages and at a lower level in pupae.1 Publication

Gene expression databases

BgeeiFBgn0000045.
ExpressionAtlasiP02574. differential.
GenevisibleiP02574. DM.

Interactioni

Protein-protein interaction databases

BioGridi65684. 32 interactors.
DIPiDIP-23587N.
IntActiP02574. 6 interactors.
MINTiMINT-773935.
STRINGi7227.FBpp0078131.

Structurei

3D structure databases

ProteinModelPortaliP02574.
SMRiP02574.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the actin family.Curated

Phylogenomic databases

eggNOGiKOG0676. Eukaryota.
COG5277. LUCA.
GeneTreeiENSGT00760000118957.
InParanoidiP02574.
KOiK05692.
OMAiMCDDEPS.
OrthoDBiEOG091G08LD.
PhylomeDBiP02574.

Family and domain databases

InterProiView protein in InterPro
IPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
PANTHERiPTHR11937. PTHR11937. 1 hit.
PfamiView protein in Pfam
PF00022. Actin. 1 hit.
PRINTSiPR00190. ACTIN.
SMARTiView protein in SMART
SM00268. ACTIN. 1 hit.
PROSITEiView protein in PROSITE
PS00406. ACTINS_1. 1 hit.
PS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02574-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCDEEASALV VDNGSGMCKA GFAGDDAPRA VFPSIVGRPR HQGVMVGMGQ
60 70 80 90 100
KDCYVGDEAQ SKRGILSLKY PIEHGIITNW DDMEKVWHHT FYNELRVAPE
110 120 130 140 150
EHPVLLTEAP LNPKANREKM TQIMFETFNS PAMYVAIQAV LSLYASGRTT
160 170 180 190 200
GIVLDSGDGV SHTVPIYEGY ALPHAILRLD LAGRDLTDYL MKILTERGYS
210 220 230 240 250
FTTTAEREIV RDIKEKLCYV ALDFEQEMAT AAASTSLEKS YELPDGQVIT
260 270 280 290 300
IGNERFRTPE ALFQPSFLGM ESCGIHETVY QSIMKCDVDI RKDLYANNVL
310 320 330 340 350
SGGTTMYPGI ADRMQKEITA LAPSTIKIKI IAPPERKYSV WIGGSILASL
360 370
STFQQMWISK QEYDESGPGI VHRKCF
Length:376
Mass (Da):41,787
Last modified:February 21, 2001 - v2
Checksum:iD08BB1B42DE86B94
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti185D → H in AAA28318 (PubMed:6405041).Curated1
Sequence conflicti326I → M in AAA28317 (PubMed:6405041).Curated1
Sequence conflicti326I → M in AAA28318 (PubMed:6405041).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18827, M18828 Genomic DNA. Translation: AAA28317.1.
M18829 Genomic DNA. Translation: AAA28318.1.
AE014296 Genomic DNA. Translation: AAF51800.1.
AY118735 mRNA. Translation: AAM50595.1.
PIRiA03002. ATFF7.
RefSeqiNP_001262200.1. NM_001275271.1.
NP_524210.1. NM_079486.4.
UniGeneiDm.5748.

Genome annotation databases

EnsemblMetazoaiFBtr0078478; FBpp0078131; FBgn0000045.
FBtr0334090; FBpp0306215; FBgn0000045.
GeneIDi40444.
KEGGidme:Dmel_CG7478.

Similar proteinsi

Entry informationi

Entry nameiACT4_DROME
AccessioniPrimary (citable) accession number: P02574
Secondary accession number(s): Q540X7, Q9VNW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: February 21, 2001
Last modified: September 27, 2017
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families