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Protein

Myosin-1

Gene

myo-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Muscle contraction.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi177 – 1848ATPBy similarity

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • motor activity Source: InterPro
  • structural constituent of muscle Source: WormBase

GO - Biological processi

  • inositol lipid-mediated signaling Source: WormBase
  • muscle contraction Source: WormBase
  • pharyngeal pumping Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-1Imported
Alternative name(s):
Myosin heavy chain D1 Publication
Short name:
MHC D1 Publication
Gene namesi
Name:myo-1Imported
ORF Names:R06C7.10Imported
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome I

Organism-specific databases

WormBaseiR06C7.10; CE06253; WBGene00002348; myo-1.

Subcellular locationi

GO - Cellular componenti

  • striated muscle myosin thick filament Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Thick filament

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19381938Myosin-1PRO_0000123380Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei128 – 1281N6,N6,N6-trimethyllysineSequence analysis

Keywords - PTMi

Methylation

Proteomic databases

EPDiP02567.
PaxDbiP02567.
PRIDEiP02567.

PTM databases

iPTMnetiP02567.

Expressioni

Tissue specificityi

Found exclusively in the pharyngeal muscle.

Interactioni

Subunit structurei

Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with itr-1 (via c-terminal coiled coil domain).1 Publication

Protein-protein interaction databases

BioGridi37913. 1 interaction.
DIPiDIP-24827N.
MINTiMINT-1102984.
STRINGi6239.R06C7.10.1.

Structurei

3D structure databases

ProteinModelPortaliP02567.
SMRiP02567. Positions 4-802.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini84 – 785702Myosin motorAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni660 – 68223Actin-bindingAdd
BLAST
Regioni764 – 77815Actin-bindingAdd
BLAST
Regioni846 – 19381093Rodlike tail (S2 and LMM domains)Add
BLAST
Regioni846 – 1170325Alpha-helical tailpiece (short S2)Add
BLAST
Regioni1171 – 1938768Light meromyosin (LMM)Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili846 – 19381093Sequence analysisAdd
BLAST

Domaini

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.
Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).Curated

Sequence similaritiesi

Contains 1 myosin motor domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0161. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00760000118919.
HOGENOMiHOG000173959.
InParanoidiP02567.
KOiK10352.
OMAiVAHIEDL.
OrthoDBiEOG7RBZ7G.
PhylomeDBiP02567.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P02567-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLEHEKDPG WQYLKRSREQ QLADQSRPYD SKKNVWIPDA EEGYIEGVIK
60 70 80 90 100
GPGPKADTVI VTAGGKDVTL KKDIVQEVNP PKFEKTEDMS NLTFLNDASV
110 120 130 140 150
LWNLRSRYAA MLIYTYSGLF CVVINPYKRL PIYTDSVARM FMGKRRTEMP
160 170 180 190 200
PHLFAVSDQA YRYMLQDHEN QSMLITGESG AGKTENTKKV ICYFATVGAS
210 220 230 240 250
QKAALKEGEK EVTLEDQIVQ TNPVLEAFGN AKTVRNNNSS RFGKFIRIHF
260 270 280 290 300
NKHGTLASCD IEHYLLEKSR VIRQAPGERC YHIFYQIYSD FKPQLRDELL
310 320 330 340 350
LNHPISNYWF VAQAELLIDG IDDTEEFQLT DEAFDVLKFS PTEKMDCYRL
360 370 380 390 400
MSAHMHMGNM KFKQRPREEQ AEPDGQDEAE RACNMYGIDV DQFLKALVSP
410 420 430 440 450
RVKVGTEWVS KGQNVDQVHW AIGAMAKGLY ARVFHWLVKK CNLTLDQKGI
460 470 480 490 500
DRDYFIGVLD IAGFEIFDFN SFEQLWINFV NEKLQQFFNH HMFVLEQEEY
510 520 530 540 550
AREGIQWTFI DFGLDLQACI ELIEKPLGII SMLDEECIVP KATDMTLAQK
560 570 580 590 600
LTDQHLGKHP NFEKPKPPKG KQGEAHFAMR HYAGTVRYNV LNWLEKNKDP
610 620 630 640 650
LNDTVVSVMK ASKKNDLLVE IWQDYTTQEE AAAAAKAGGG RKGGKSGSFM
660 670 680 690 700
TVSMMYRESL NKLMTMLHKT HPHFIRCIIP NEKKQSGMID AALVLNQLTC
710 720 730 740 750
NGVLEGIRIC RKGFPNRTQH PDFVQRYAIL AAKEAKSSDD MKTCAGAILQ
760 770 780 790 800
ALINQKQLND EQFRIGHTKV FFKAGVVAHI EDLRDDKLNQ IITGFQSAIR
810 820 830 840 850
WYTATADAGA RRKQLNSYII LQRNIRSWCV LRTWDWFLLF GKLRPQLKCG
860 870 880 890 900
KMAEEMIKMA EEQKVLEAEA KKAESARKSQ EEAYAKLSAE RSKLLEALEL
910 920 930 940 950
TQGGSAAIEE KLTRLNSARQ EVEKSLNDAN DRLSEHEEKN ADLEKQRRKA
960 970 980 990 1000
QQEVENLKKS IEAVDGNLAK SLEEKAAKEN QIHSLQDEMN SQDETIGKIN
1010 1020 1030 1040 1050
KEKKLLEENN RQLVDDLQAE EAKQAQANRL RGKLEQTLDE MEEAVEREKR
1060 1070 1080 1090 1100
IRAETEKSKR KVEGELKGAQ ETIDELSAIK LETDASLKKK EADIHALGVR
1110 1120 1130 1140 1150
IEDEQALANR LTRQSKENAQ RIIEIEDELE HERQSRSKAD RARAELQREL
1160 1170 1180 1190 1200
DELNERLDEQ NKQLEIQQDN NKKKDSEIIK FRRDLDEKNM ANEDQMAMIR
1210 1220 1230 1240 1250
RKNNDQISAL TNTLDALQKS KAKIEKEKGV LQKELDDINA QVDQETKSRV
1260 1270 1280 1290 1300
EQERLAKQYE IQVAELQQKV DEQSRQIGEY TSTKGRLSND NSDLARQVEE
1310 1320 1330 1340 1350
LEIHLATINR AKTAFSSQLV EAKKAAEDEL HERQEFHAAC KNLEHELDQC
1360 1370 1380 1390 1400
HELLEEQING KDDIQRQLSR INSEISQWKA RYEGEGLVGS EELEELKRKQ
1410 1420 1430 1440 1450
MNRVMDLQEA LSAAQNKVIS LEKAKGKLLA ETEDARSDVD RHLTVIASLE
1460 1470 1480 1490 1500
KKQRAFDKIV DDWKRKVDDI QKEIDATTRD SRNTSTEVFK LRSSMDNLSE
1510 1520 1530 1540 1550
QIETLRRENK IFSQEIRDIN EQITQGGRTY QEVHKSVRRL EQEKDELQHA
1560 1570 1580 1590 1600
LDEAEAALEA EESKVLRLQI EVQQIRSEIE KRIQEKEEEF ENTRKNHQRA
1610 1620 1630 1640 1650
LESIQASLET EAKSKAELAR AKKKLETDIN QLEIALDHAN KANVDAQKNL
1660 1670 1680 1690 1700
KKLFDQVKEL QGQVDDEQRR REEIRENYLA AEKRLAIALS ESEDLAHRIE
1710 1720 1730 1740 1750
ASDKHKKQLE IEQAELKSSN TELIGNNAAL SAMKRKVENE VQIARNELDE
1760 1770 1780 1790 1800
YLNELKASEE RARKAAADAD RLAEEVRQEQ EHAVHVDRQR KSLELNAKEL
1810 1820 1830 1840 1850
QAKIDDAERA MIQFGAKALA KVEDRVRSLE AELHSEQRRH QESIKGYTKQ
1860 1870 1880 1890 1900
ERRARELQFQ VEEDKKAFDR LQENVEKLQQ KIRVQKRQIE EAEEVATQNL
1910 1920 1930
SKFRQIQLAL ENAEERAEVA ENSLVRMRGQ VVRSATNK
Length:1,938
Mass (Da):223,323
Last modified:July 22, 2008 - v3
Checksum:i2569618A19034E4C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti94 – 941F → E no nucleotide entry (PubMed:6576334).Curated
Sequence conflicti98 – 981A → R no nucleotide entry (PubMed:6576334).Curated
Sequence conflicti377 – 3771D → V in CAA30854 (PubMed:2926820).Curated
Sequence conflicti389 – 3902DV → GD no nucleotide entry (PubMed:6576334).Curated
Sequence conflicti391 – 3911D → V in CAA30854 (PubMed:2926820).Curated
Sequence conflicti408 – 4081W → N no nucleotide entry (PubMed:6576334).Curated
Sequence conflicti474 – 4741Q → G no nucleotide entry (PubMed:6576334).Curated
Sequence conflicti577 – 5771F → L in CAA30854 (PubMed:2926820).Curated
Sequence conflicti681 – 6811N → I in CAA30854 (PubMed:2926820).Curated
Sequence conflicti1373 – 13731S → D no nucleotide entry (PubMed:6576334).Curated
Sequence conflicti1659 – 16591E → Q in AAA28120 (PubMed:3888374).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X08065 Genomic DNA. Translation: CAA30854.1.
Z71266, Z71261 Genomic DNA. Translation: CAA95848.1.
M37232 Genomic DNA. Translation: AAA28119.1.
M37234 Genomic DNA. Translation: AAA28120.1.
PIRiT21193. MWKW1.
RefSeqiNP_492053.1. NM_059652.4.
UniGeneiCel.17836.

Genome annotation databases

EnsemblMetazoaiR06C7.10.1; R06C7.10.1; WBGene00002348.
R06C7.10.2; R06C7.10.2; WBGene00002348.
GeneIDi172471.
KEGGicel:CELE_R06C7.10.
UCSCiR06C7.10.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X08065 Genomic DNA. Translation: CAA30854.1.
Z71266, Z71261 Genomic DNA. Translation: CAA95848.1.
M37232 Genomic DNA. Translation: AAA28119.1.
M37234 Genomic DNA. Translation: AAA28120.1.
PIRiT21193. MWKW1.
RefSeqiNP_492053.1. NM_059652.4.
UniGeneiCel.17836.

3D structure databases

ProteinModelPortaliP02567.
SMRiP02567. Positions 4-802.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi37913. 1 interaction.
DIPiDIP-24827N.
MINTiMINT-1102984.
STRINGi6239.R06C7.10.1.

PTM databases

iPTMnetiP02567.

Proteomic databases

EPDiP02567.
PaxDbiP02567.
PRIDEiP02567.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiR06C7.10.1; R06C7.10.1; WBGene00002348.
R06C7.10.2; R06C7.10.2; WBGene00002348.
GeneIDi172471.
KEGGicel:CELE_R06C7.10.
UCSCiR06C7.10.1. c. elegans.

Organism-specific databases

CTDi172471.
WormBaseiR06C7.10; CE06253; WBGene00002348; myo-1.

Phylogenomic databases

eggNOGiKOG0161. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00760000118919.
HOGENOMiHOG000173959.
InParanoidiP02567.
KOiK10352.
OMAiVAHIEDL.
OrthoDBiEOG7RBZ7G.
PhylomeDBiP02567.

Miscellaneous databases

NextBioi875649.
PROiP02567.

Family and domain databases

Gene3Di4.10.270.10. 1 hit.
InterProiIPR027401. Myosin-like_IQ_dom.
IPR001609. Myosin_head_motor_dom.
IPR004009. Myosin_N.
IPR002928. Myosin_tail.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF02736. Myosin_N. 1 hit.
PF01576. Myosin_tail_1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51456. MYOSIN_MOTOR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of the complete Caenorhabditis elegans myosin heavy chain gene family."
    Dibb N.J., Maruyama I.N., Krause M., Karn J.
    J. Mol. Biol. 205:603-613(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Bristol N2.
  2. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  3. "Protein structural domains in the Caenorhabditis elegans unc-54 myosin heavy chain gene are not separated by introns."
    Karn J., Brenner S., Barnett L.
    Proc. Natl. Acad. Sci. U.S.A. 80:4253-4257(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-1795.
  4. "Cloning nematode myosin genes."
    Karn J., Dibb N.J., Miller D.M.
    Cell Muscle Motil. 6:185-237(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 115-365 AND 1492-1763.
  5. "A direct interaction between IP(3) receptors and myosin II regulates IP(3) signaling in C. elegans."
    Walker D.S., Ly S., Lockwood K.C., Baylis H.A.
    Curr. Biol. 12:951-956(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ITR-1.

Entry informationi

Entry nameiMYO1_CAEEL
AccessioniPrimary (citable) accession number: P02567
Secondary accession number(s): Q19674
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 22, 2008
Last modified: May 11, 2016
This is version 144 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Miscellaneous

There are four different myosin heavy chains in C.elegans.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.