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P02561 (TPM4_HORSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tropomyosin alpha-4 chain
Alternative name(s):
Platelet beta tropomyosin
Tropomyosin-4
Gene names
Name:TPM4
OrganismEquus caballus (Horse) [Reference proteome]
Taxonomic identifier9796 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus

Protein attributes

Sequence length248 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. Binds calcium.

Subunit structure

Heterodimer of an alpha and a beta chain.

Subcellular location

Cytoplasmcytoskeleton.

Domain

The molecule is in a coiled coil structure that is formed by 2 polypeptide chains. The sequence exhibits a prominent seven-residues periodicity.

Miscellaneous

This protein can span only six actin monomers.

Sequence similarities

Belongs to the tropomyosin family.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
   DomainCoiled coil
   LigandActin-binding
Calcium
Metal-binding
   Molecular functionMuscle protein
   PTMAcetylation
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-KW

cytoskeleton

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.1
Chain2 – 248247Tropomyosin alpha-4 chain
PRO_0000205634

Regions

Coiled coil2 – 248247 By similarity

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue1771N6-acetyllysine By similarity
Modified residue2151N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P02561 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 5D5CDF6BF76BB2A8

FASTA24828,523
        10         20         30         40         50         60 
MAGLNSLEAV KRKIQALQQQ ADEAEDRAQG LQRELDGERE RREKAEGDVA ALNRRIQLVE 

        70         80         90        100        110        120 
EELDRAQERL ATALQKLEEA EKAADESERG MKVIENRAMK DEEKMEIQEM QLKEAKHIAE 

       130        140        150        160        170        180 
EADRKYEEVA RKLVILEGEL ERAEERAEVS ELKCGDLEEE LKNVTNNLKS LEAASEKYSE 

       190        200        210        220        230        240 
KEDKYEEEIK LLSDKLKEAE TRAEFAERTV AKLEKTIDDL EEKLAQAKEE NVGLHQTLDQ 


TLDELNCI 

« Hide

References

[1]"Amino acid sequence of equine platelet tropomyosin. Correlation with interaction properties."
Lewis W.G., Cote G.P., Mak A.S., Smillie L.B.
FEBS Lett. 156:269-273(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-248.

Cross-references

Sequence databases

PIRTMHOBP. A02984.

3D structure databases

ProteinModelPortalP02561.
SMRP02561. Positions 5-248.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9796.ENSECAP00000019820.

Proteomic databases

PRIDEP02561.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG304012.
HOGENOMHOG000231522.
HOVERGENHBG107404.
InParanoidP02561.

Family and domain databases

InterProIPR000533. Tropomyosin.
[Graphical view]
PfamPF00261. Tropomyosin. 1 hit.
[Graphical view]
PRINTSPR00194. TROPOMYOSIN.
PROSITEPS00326. TROPOMYOSIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTPM4_HORSE
AccessionPrimary (citable) accession number: P02561
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 13, 2013
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families