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P02535 (K1C10_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Keratin, type I cytoskeletal 10
Alternative name(s):
56 kDa cytokeratin
Cytokeratin-10
Short name=CK-10
Keratin, type I cytoskeletal 59 kDa
Keratin-10
Short name=K10
Gene names
Name:Krt10
Synonyms:Krt1-10
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length570 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Heterotetramer of two type I and two type II keratins. keratin-10 is generally associated with keratin-1.

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Sequence similarities

Belongs to the intermediate filament family.

Sequence caution

The sequence BAB29296.1 differs from that shown. Reason: Frameshift at positions 96 and 122.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ChukQ60680-16EBI-646288,EBI-646260

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P02535-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P02535-2)

The sequence of this isoform differs from the canonical sequence as follows:
     97-106: YGGSSFGGAG → S
     144-145: GR → EK
Note: No experimental confirmation available.
Isoform 3 (identifier: P02535-3)

The sequence of this isoform differs from the canonical sequence as follows:
     97-106: YGGSSFGGAG → S
     144-145: GR → EK
     465-471: RGGSGGG → PRRQPRR
     472-570: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 570570Keratin, type I cytoskeletal 10
PRO_0000063643

Regions

Region1 – 143143Head
Region144 – 454311Rod
Region144 – 17936Coil 1A
Region180 – 20021Linker 1
Region201 – 29292Coil 1B
Region293 – 31523Linker 12
Region316 – 454139Coil 2
Region455 – 570116Tail
Compositional bias453 – 565113Gly/Ser-rich

Sites

Site3961Stutter

Amino acid modifications

Modified residue171Phosphoserine By similarity
Modified residue341Phosphoserine By similarity

Natural variations

Alternative sequence97 – 10610YGGSSFGGAG → S in isoform 2 and isoform 3.
VSP_021100
Alternative sequence144 – 1452GR → EK in isoform 2 and isoform 3.
VSP_021101
Alternative sequence465 – 4717RGGSGGG → PRRQPRR in isoform 3.
VSP_021102
Alternative sequence472 – 57099Missing in isoform 3.
VSP_021103

Experimental info

Sequence conflict41L → R in AAF65456. Ref.4
Sequence conflict61S → C in CAA24214. Ref.2
Sequence conflict231G → GGG Ref.4
Sequence conflict251S → F in CAA24214. Ref.2
Sequence conflict291S → F in CAA24214. Ref.2
Sequence conflict391Y → L in CAA24214. Ref.2
Sequence conflict421G → E in AAA39391. Ref.1
Sequence conflict461G → R in BAB29296. Ref.3
Sequence conflict941G → V in BAB29296. Ref.3
Sequence conflict105 – 1062AG → GS in CAA24214. Ref.2
Sequence conflict1111Missing Ref.2
Sequence conflict122 – 1232SY → GC in CAA24214. Ref.2
Sequence conflict1381S → G in CAA24214. Ref.2
Sequence conflict1491Q → R in CAA24214. Ref.2
Sequence conflict179 – 18810WYEKHGNSSQ → VVREARQLKP in CAA24214. Ref.2
Sequence conflict264 – 2696KSDLEM → QSVLEL in CAA24214. Ref.2
Sequence conflict2771E → G in BAC38210. Ref.3
Sequence conflict2851H → L in CAA24214. Ref.2
Sequence conflict3541E → A in CAA24214. Ref.2
Sequence conflict395 – 4006EGRYCV → VESLLR in CAA24214. Ref.2
Sequence conflict4651R → G in BAB29296. Ref.3
Sequence conflict4651R → G in BAC36371. Ref.3
Sequence conflict4651R → G in BAC38210. Ref.3
Sequence conflict466 – 4672GG → AD in BAB29296. Ref.3
Sequence conflict4691G → H in BAB29296. Ref.3
Sequence conflict4691G → H in BAC36371. Ref.3
Sequence conflict4691G → H in BAC38210. Ref.3
Sequence conflict509 – 5157GGSHGGS → CGGRGGG in CAA24214. Ref.2
Sequence conflict5241S → G in CAA24214. Ref.2
Sequence conflict5321H → R in CAA24214. Ref.2
Sequence conflict5351S → G in CAA24214. Ref.2
Sequence conflict5441S → G in CAA24214. Ref.2
Sequence conflict548 – 5492GQ → RR in CAA24214. Ref.2
Sequence conflict556 – 5572KS → SGT in CAA24214. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: EE60EA87DE7770E0

FASTA57057,770
        10         20         30         40         50         60 
MSVLYSSSSK QFSSSRSGGG GGGGSVRVSS TRGSLGGGYS SGGFSGGSFS RGSSGGGCFG 

        70         80         90        100        110        120 
GSSGGYGGFG GGGSFGGGYG GSSFGGGYGG SSFGGGYGGS SFGGAGFGGG GSFGGGSFGG 

       130        140        150        160        170        180 
GSYGGGFGGG GFGGDGGSLL SGNGRVTMQN LNDRLASYMD KVRALEESNY ELEGKIKEWY 

       190        200        210        220        230        240 
EKHGNSSQRE PRDYSKYYKT IEDLKGQILT LTTDNANVLL QIDNARLAAD DFRLKYENEV 

       250        260        270        280        290        300 
TLRQSVEADI NGLRRVLDEL TLSKSDLEMQ IESLNEELAY LKKNHEEEMR DLQNVSTGDV 

       310        320        330        340        350        360 
NVEMNAAPGV DLTQLLNNMR NQYEQLAEKN RKDAEEWFNQ KSKELTTEID SNIEQMSSHK 

       370        380        390        400        410        420 
SEITELRRTV QGLEIELQSQ LALKQSLEAS LAETEGRYCV QLSQIQSQIS ALEEQLQQIR 

       430        440        450        460        470        480 
AETECQNAEY QQLLDIKTRL ENEIQTYRSL LEGEGSSSGG GGGRRGGSGG GSYGGSSGGG 

       490        500        510        520        530        540 
SYGGSSGGGG SYGGSSGGGG SYGGGSSGGG SHGGSSGGGY GGGSSSGGAG GHGGSSGGGY 

       550        560        570 
GGGSSSGGQG GSGGFKSSGG GDQSSKGPRY 

« Hide

Isoform 2 [UniParc].

Checksum: 8EEF036A0FA03831
Show »

FASTA56157,060
Isoform 3 [UniParc].

Checksum: D7A0BC767157B99D
Show »

FASTA46249,501

References

« Hide 'large scale' references
[1]"Organization of a type I keratin gene. Evidence for evolution of intermediate filaments from a common ancestral gene."
Krieg T.M., Schafer M.P., Cheng C.K., Filpula D., Flaherty P., Steinert P.M., Roop D.R.
J. Biol. Chem. 260:5867-5870(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
[2]"Complete amino acid sequence of a mouse epidermal keratin subunit and implications for the structure of intermediate filaments."
Steinert P.M., Rice R.H., Roop D.R., Trus B.L., Steven A.C.
Nature 302:794-800(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
Strain: C57BL/6J.
Tissue: Head.
[4]Reichelt J., Magin T.M.
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-341 (ISOFORMS 2/3).
Strain: 129/SvJ.
Tissue: Liver.
[5]Lubec G., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 146-154; 164-175; 227-233; 244-254; 361-367; 385-397 AND 440-448, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: OF1.
Tissue: Hippocampus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L00193, M10081 Genomic DNA. Translation: AAA39391.1.
V00830 mRNA. Translation: CAA24214.1.
AK014360 mRNA. Translation: BAB29296.1. Frameshift.
AK076508 mRNA. Translation: BAC36371.1.
AK081402 mRNA. Translation: BAC38210.1.
AK081914 mRNA. Translation: BAC38369.1.
AF245658 Genomic DNA. Translation: AAF65456.1.
PIRKRMSE1. A02940.
S07330.
RefSeqNP_034790.2. NM_010660.2.
UniGeneMm.22662.

3D structure databases

ProteinModelPortalP02535.
SMRP02535. Positions 142-293, 311-453.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid201017. 7 interactions.
IntActP02535. 2 interactions.
MINTMINT-1859130.

PTM databases

PhosphoSiteP02535.

Proteomic databases

PaxDbP02535.
PRIDEP02535.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID16661.
KEGGmmu:16661.

Organism-specific databases

CTD3858.
MGIMGI:96685. Krt10.

Phylogenomic databases

eggNOGNOG147548.
HOVERGENHBG013015.
InParanoidP02535.
KOK07604.
PhylomeDBP02535.

Gene expression databases

CleanExMM_KRT10.
GenevestigatorP02535.

Family and domain databases

InterProIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERPTHR23239. PTHR23239. 1 hit.
PfamPF00038. Filament. 1 hit.
[Graphical view]
PRINTSPR01248. TYPE1KERATIN.
PROSITEPS00226. IF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSKRT10. mouse.
NextBio290363.
PROP02535.
SOURCESearch...

Entry information

Entry nameK1C10_MOUSE
AccessionPrimary (citable) accession number: P02535
Secondary accession number(s): P08731 expand/collapse secondary AC list , Q8BUX3, Q8BV09, Q8BVU3, Q9CXH6, Q9JKB4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot