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Protein

Keratin, type I cytoskeletal 10

Gene

Krt10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei396Stutter1

GO - Molecular functioni

  • cytoskeletal protein binding Source: MGI
  • structural molecule activity Source: InterPro

GO - Biological processi

  • cellular response to calcium ion Source: MGI
  • epidermis development Source: MGI
  • epithelial cell differentiation Source: MGI
  • intermediate filament organization Source: MGI
  • keratinocyte development Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 10
Alternative name(s):
56 kDa cytokeratin
Cytokeratin-10
Short name:
CK-10
Keratin, type I cytoskeletal 59 kDa
Keratin-10
Short name:
K10
Gene namesi
Name:Krt10
Synonyms:Krt1-10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:96685. Krt10.

Subcellular locationi

GO - Cellular componenti

  • keratin filament Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636431 – 570Keratin, type I cytoskeletal 10Add BLAST570

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15PhosphoserineBy similarity1
Modified residuei17PhosphoserineBy similarity1
Modified residuei32Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei32Omega-N-methylarginine; alternateCombined sources1
Modified residuei34PhosphoserineCombined sources1
Modified residuei45PhosphoserineBy similarity1
Modified residuei48PhosphoserineCombined sources1
Modified residuei168PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PRIDEiP02535.

PTM databases

iPTMnetiP02535.
PhosphoSitePlusiP02535.

Expressioni

Gene expression databases

CleanExiMM_KRT10.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. keratin-10 is generally associated with keratin-1.

Binary interactionsi

WithEntry#Exp.IntActNotes
ChukQ60680-16EBI-646288,EBI-646260

GO - Molecular functioni

  • cytoskeletal protein binding Source: MGI

Protein-protein interaction databases

BioGridi201017. 8 interactors.
IntActiP02535. 2 interactors.
MINTiMINT-1859130.

Structurei

3D structure databases

ProteinModelPortaliP02535.
SMRiP02535.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 143HeadAdd BLAST143
Regioni144 – 454RodAdd BLAST311
Regioni144 – 179Coil 1AAdd BLAST36
Regioni180 – 200Linker 1Add BLAST21
Regioni201 – 292Coil 1BAdd BLAST92
Regioni293 – 315Linker 12Add BLAST23
Regioni316 – 454Coil 2Add BLAST139
Regioni455 – 570TailAdd BLAST116

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi453 – 565Gly/Ser-richAdd BLAST113

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

HOVERGENiHBG013015.
InParanoidiP02535.
KOiK07604.
PhylomeDBiP02535.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P02535-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSVLYSSSSK QFSSSRSGGG GGGGSVRVSS TRGSLGGGYS SGGFSGGSFS
60 70 80 90 100
RGSSGGGCFG GSSGGYGGFG GGGSFGGGYG GSSFGGGYGG SSFGGGYGGS
110 120 130 140 150
SFGGAGFGGG GSFGGGSFGG GSYGGGFGGG GFGGDGGSLL SGNGRVTMQN
160 170 180 190 200
LNDRLASYMD KVRALEESNY ELEGKIKEWY EKHGNSSQRE PRDYSKYYKT
210 220 230 240 250
IEDLKGQILT LTTDNANVLL QIDNARLAAD DFRLKYENEV TLRQSVEADI
260 270 280 290 300
NGLRRVLDEL TLSKSDLEMQ IESLNEELAY LKKNHEEEMR DLQNVSTGDV
310 320 330 340 350
NVEMNAAPGV DLTQLLNNMR NQYEQLAEKN RKDAEEWFNQ KSKELTTEID
360 370 380 390 400
SNIEQMSSHK SEITELRRTV QGLEIELQSQ LALKQSLEAS LAETEGRYCV
410 420 430 440 450
QLSQIQSQIS ALEEQLQQIR AETECQNAEY QQLLDIKTRL ENEIQTYRSL
460 470 480 490 500
LEGEGSSSGG GGGRRGGSGG GSYGGSSGGG SYGGSSGGGG SYGGSSGGGG
510 520 530 540 550
SYGGGSSGGG SHGGSSGGGY GGGSSSGGAG GHGGSSGGGY GGGSSSGGQG
560 570
GSGGFKSSGG GDQSSKGPRY
Length:570
Mass (Da):57,770
Last modified:January 23, 2007 - v3
Checksum:iEE60EA87DE7770E0
GO
Isoform 2 (identifier: P02535-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     97-106: YGGSSFGGAG → S
     144-145: GR → EK

Note: No experimental confirmation available.
Show »
Length:561
Mass (Da):57,060
Checksum:i8EEF036A0FA03831
GO
Isoform 3 (identifier: P02535-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     97-106: YGGSSFGGAG → S
     144-145: GR → EK
     465-471: RGGSGGG → PRRQPRR
     472-570: Missing.

Note: No experimental confirmation available.
Show »
Length:462
Mass (Da):49,501
Checksum:iD7A0BC767157B99D
GO

Sequence cautioni

The sequence BAB29296 differs from that shown. Reason: Frameshift at positions 96 and 122.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4L → R in AAF65456 (Ref. 4) Curated1
Sequence conflicti6S → C in CAA24214 (PubMed:6188955).Curated1
Sequence conflicti23G → GGG (Ref. 4) Curated1
Sequence conflicti25S → F in CAA24214 (PubMed:6188955).Curated1
Sequence conflicti29S → F in CAA24214 (PubMed:6188955).Curated1
Sequence conflicti39Y → L in CAA24214 (PubMed:6188955).Curated1
Sequence conflicti42G → E in AAA39391 (PubMed:2581944).Curated1
Sequence conflicti46G → R in BAB29296 (PubMed:16141072).Curated1
Sequence conflicti94G → V in BAB29296 (PubMed:16141072).Curated1
Sequence conflicti105 – 106AG → GS in CAA24214 (PubMed:6188955).Curated2
Sequence conflicti111Missing (PubMed:6188955).Curated1
Sequence conflicti122 – 123SY → GC in CAA24214 (PubMed:6188955).Curated2
Sequence conflicti138S → G in CAA24214 (PubMed:6188955).Curated1
Sequence conflicti149Q → R in CAA24214 (PubMed:6188955).Curated1
Sequence conflicti179 – 188WYEKHGNSSQ → VVREARQLKP in CAA24214 (PubMed:6188955).Curated10
Sequence conflicti264 – 269KSDLEM → QSVLEL in CAA24214 (PubMed:6188955).Curated6
Sequence conflicti277E → G in BAC38210 (PubMed:16141072).Curated1
Sequence conflicti285H → L in CAA24214 (PubMed:6188955).Curated1
Sequence conflicti354E → A in CAA24214 (PubMed:6188955).Curated1
Sequence conflicti395 – 400EGRYCV → VESLLR in CAA24214 (PubMed:6188955).Curated6
Sequence conflicti465R → G in BAB29296 (PubMed:16141072).Curated1
Sequence conflicti465R → G in BAC36371 (PubMed:16141072).Curated1
Sequence conflicti465R → G in BAC38210 (PubMed:16141072).Curated1
Sequence conflicti466 – 467GG → AD in BAB29296 (PubMed:16141072).Curated2
Sequence conflicti469G → H in BAB29296 (PubMed:16141072).Curated1
Sequence conflicti469G → H in BAC36371 (PubMed:16141072).Curated1
Sequence conflicti469G → H in BAC38210 (PubMed:16141072).Curated1
Sequence conflicti509 – 515GGSHGGS → CGGRGGG in CAA24214 (PubMed:6188955).Curated7
Sequence conflicti524S → G in CAA24214 (PubMed:6188955).Curated1
Sequence conflicti532H → R in CAA24214 (PubMed:6188955).Curated1
Sequence conflicti535S → G in CAA24214 (PubMed:6188955).Curated1
Sequence conflicti544S → G in CAA24214 (PubMed:6188955).Curated1
Sequence conflicti548 – 549GQ → RR in CAA24214 (PubMed:6188955).Curated2
Sequence conflicti556 – 557KS → SGT in CAA24214 (PubMed:6188955).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02110097 – 106YGGSSFGGAG → S in isoform 2 and isoform 3. 1 Publication10
Alternative sequenceiVSP_021101144 – 145GR → EK in isoform 2 and isoform 3. 1 Publication2
Alternative sequenceiVSP_021102465 – 471RGGSGGG → PRRQPRR in isoform 3. 1 Publication7
Alternative sequenceiVSP_021103472 – 570Missing in isoform 3. 1 PublicationAdd BLAST99

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00193, M10081 Genomic DNA. Translation: AAA39391.1.
V00830 mRNA. Translation: CAA24214.1.
AK014360 mRNA. Translation: BAB29296.1. Frameshift.
AK076508 mRNA. Translation: BAC36371.1.
AK081402 mRNA. Translation: BAC38210.1.
AK081914 mRNA. Translation: BAC38369.1.
AF245658 Genomic DNA. Translation: AAF65456.1.
CCDSiCCDS25380.1. [P02535-2]
PIRiA02940. KRMSE1.
S07330.
RefSeqiNP_034790.2. NM_010660.2.
UniGeneiMm.22662.

Genome annotation databases

GeneIDi16661.
KEGGimmu:16661.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00193, M10081 Genomic DNA. Translation: AAA39391.1.
V00830 mRNA. Translation: CAA24214.1.
AK014360 mRNA. Translation: BAB29296.1. Frameshift.
AK076508 mRNA. Translation: BAC36371.1.
AK081402 mRNA. Translation: BAC38210.1.
AK081914 mRNA. Translation: BAC38369.1.
AF245658 Genomic DNA. Translation: AAF65456.1.
CCDSiCCDS25380.1. [P02535-2]
PIRiA02940. KRMSE1.
S07330.
RefSeqiNP_034790.2. NM_010660.2.
UniGeneiMm.22662.

3D structure databases

ProteinModelPortaliP02535.
SMRiP02535.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201017. 8 interactors.
IntActiP02535. 2 interactors.
MINTiMINT-1859130.

PTM databases

iPTMnetiP02535.
PhosphoSitePlusiP02535.

Proteomic databases

PRIDEiP02535.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi16661.
KEGGimmu:16661.

Organism-specific databases

CTDi3858.
MGIiMGI:96685. Krt10.

Phylogenomic databases

HOVERGENiHBG013015.
InParanoidiP02535.
KOiK07604.
PhylomeDBiP02535.

Miscellaneous databases

ChiTaRSiKrt10. mouse.
PROiP02535.
SOURCEiSearch...

Gene expression databases

CleanExiMM_KRT10.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK1C10_MOUSE
AccessioniPrimary (citable) accession number: P02535
Secondary accession number(s): P08731
, Q8BUX3, Q8BV09, Q8BVU3, Q9CXH6, Q9JKB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 131 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.