Rho crystallin - Rana temporaria (European common frog)

Preferred order of sections

Names and origin

Protein names	Recommended name: Rho crystallin
Organism	Rana temporaria (European common frog)
Taxonomic identifier	8407 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Neobatrachia › Ranoidea › Ranidae › Raninae › Rana › Rana

Protein attributes

Sequence length	324 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subunit structure	Monomer.
Sequence similarities	Belongs to the aldo/keto reductase family.
Caution	Was originally called epsilon crystallin.

Ontologies

Keywords
Molecular function	Eye lens protein
PTM	Acetylation
Technical term	3D-structure
Gene Ontology (GO)
Molecular function	oxidoreductase activity Inferred from electronic annotation. Source: InterPro structural constituent of eye lens Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

Removed By similarity

Chain

2 – 324

323

Rho crystallin

PRO_0000124614

Regions

Nucleotide binding

218 – 281

64

NADP By similarity

Amino acid modifications

Modified residue

2

1

N-acetylthreonine By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

P02532 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 19D72B345982869F
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FASTA

324

37,015

        10         20         30         40         50         60 
MTLTKETRVT LNDGNMMPIL GLGTYASPHV PKSLAEEAVK IAIDVGYRHI DCAFITGNEM 

        70         80         90        100        110        120 
HIGNGIRSKI SDGTVKREDI FYTGKLWCTY FSPEMVRKGL ERSLRDVGMD YLDLFLMHWP 

       130        140        150        160        170        180 
VSLKPSGASD PSDKDKPFIY DNVDLCATWE ALEARKDAGL VRSLGVSNFN RRQLERILNK 

       190        200        210        220        230        240 
PGLKYKPVCN QVECHVYLNQ NKLHSYCKSK DIVLVTYSVL GSHRDRNWVD LSLPVLLDDP 

       250        260        270        280        290        300 
ILNKVAAKYN RTSAEIAMRF ILQKGIVVLA KSFTPARIKQ NLGVFEFELK PEDMKSLESL 

       310        320 
DRNLHYGPFR EVKQHPEYPF HDEY

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References

[1]	"Rho-crystallins from frog eye lens: structure and expression." Dolgilevich S.M., Mikaelian A.S., Kniazeva M.V., Snegovaia I.Y., Simirskii V.N., Aleinikova K.S., Gause G.G. Jr. Dokl. Akad. Nauk 335:373-377(1994) [PubMed: 8186748] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lens.
[2]	"A novel type of crystallin in the frog eye lens. 35-kDa polypeptide is not homologous to any of the major classes of lens crystallins." Tomarev S.I., Zinovieva R.D., Dolgilevich S.M., Luchin S.V., Krayev A.S., Skryabin K.G., Gause G.G. Jr. FEBS Lett. 171:297-302(1984) [PubMed: 6609843] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 100-324. Tissue: Lens.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

S70451 mRNA. Translation: AAB30820.1.
X00659 mRNA. Translation: CAA25277.1. Sequence problems.

PIR

CYFGE. A02938.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2AR4	model	-	A	1-324	[»]

ProteinModelPortal

P02532.

SMR

P02532. Positions 5-324.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Phylogenomic databases

HOVERGEN

HBG000020.

Family and domain databases

InterPro

IPR001395. Aldo/ket_red.
IPR018170. Aldo/ket_reductase_CS.
IPR020471. Aldo/keto_reductase_subgr.
IPR023210. NADP_OxRdtase_dom.
[Graphical view]

Gene3D

G3DSA:3.20.20.100. Aldo/ket_red. 1 hit.

PANTHER

PTHR11732. Aldo/ket_red. 1 hit.

Pfam

PF00248. Aldo_ket_red. 1 hit.
[Graphical view]

PIRSF

PIRSF000097. AKR. 1 hit.

PRINTS

PR00069. ALDKETRDTASE.

SUPFAM

SSF51430. Aldo/ket_red. 1 hit.

PROSITE

PS00798. ALDOKETO_REDUCTASE_1. 1 hit.
PS00062. ALDOKETO_REDUCTASE_2. 1 hit.
PS00063. ALDOKETO_REDUCTASE_3. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

CRO_RANTE

Accession

Primary (citable) accession number: P02532

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	January 23, 2007
Last modified:	June 28, 2011
This is version 71 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families