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Protein

Gamma-crystallin C

Gene

Crygc

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Crystallins are the dominant structural components of the vertebrate eye lens.

GO - Molecular functioni

  • structural constituent of eye lens Source: RGD

GO - Biological processi

  • lens development in camera-type eye Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Eye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-crystallin C
Alternative name(s):
Gamma-C-crystallin
Gamma-crystallin 2-1
Gene namesi
Name:Crygc
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2421. Crygc.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 174173Gamma-crystallin CPRO_0000057591Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231S-methylcysteineBy similarity

Keywords - PTMi

Methylation

Proteomic databases

PRIDEiP02529.

PTM databases

iPTMnetiP02529.
PhosphoSiteiP02529.

Structurei

3D structure databases

ProteinModelPortaliP02529.
SMRiP02529. Positions 2-174.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 4039Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd
BLAST
Domaini41 – 8343Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd
BLAST
Domaini88 – 12841Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd
BLAST
Domaini129 – 17143Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni84 – 874Connecting peptide

Domaini

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated
Contains 4 beta/gamma crystallin 'Greek key' domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

HOGENOMiHOG000234389.
HOVERGENiHBG003364.
InParanoidiP02529.
PhylomeDBiP02529.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR033483. CRYGC.
IPR011024. G_crystallin-rel.
[Graphical view]
PANTHERiPTHR11818:SF32. PTHR11818:SF32. 1 hit.
PfamiPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02529-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKITFYEDR GFQGRCYECS SDCPNLQTYF SRCNSIRVDS GCWMLYERPN
60 70 80 90 100
YQGHQYFLRR GDYPDYQQWM GFSDSIRSCR LIPHTGSHRM RLYEKEDHKG
110 120 130 140 150
VMMELSEDCS CIQDRFHLSE VRSLHVLEGC WVLYEMPNYR GRQYLLRPQE
160 170
YRRYHDWGAV DAKAGSLRRV VDLY
Length:174
Mass (Da):20,951
Last modified:January 23, 2007 - v4
Checksum:iADB5D16DF57BC13B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti16 – 161C → S no nucleotide entry (PubMed:3783678).Curated
Sequence conflicti16 – 161C → S in AAA40986 (PubMed:6294661).Curated
Sequence conflicti36 – 361I → V no nucleotide entry (PubMed:3783678).Curated
Sequence conflicti36 – 361I → V in AAA40986 (PubMed:6294661).Curated
Sequence conflicti84 – 841H → R in AAA40986 (PubMed:6294661).Curated
Sequence conflicti88 – 881H → Q in AAA40986 (PubMed:6294661).Curated
Sequence conflicti169 – 1702RV → SA in AAA40986 (PubMed:6294661).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19359 Genomic DNA. Translation: AAA40983.1.
J00717 mRNA. Translation: AAA40986.1.
PIRiA02934. CYRTG2.
C24060.
I83432.
RefSeqiNP_001075129.1. NM_001081660.1.
UniGeneiRn.81172.

Genome annotation databases

GeneIDi24277.
KEGGirno:24277.
UCSCiRGD:2421. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M19359 Genomic DNA. Translation: AAA40983.1.
J00717 mRNA. Translation: AAA40986.1.
PIRiA02934. CYRTG2.
C24060.
I83432.
RefSeqiNP_001075129.1. NM_001081660.1.
UniGeneiRn.81172.

3D structure databases

ProteinModelPortaliP02529.
SMRiP02529. Positions 2-174.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiP02529.
PhosphoSiteiP02529.

Proteomic databases

PRIDEiP02529.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24277.
KEGGirno:24277.
UCSCiRGD:2421. rat.

Organism-specific databases

CTDi1420.
RGDi2421. Crygc.

Phylogenomic databases

HOGENOMiHOG000234389.
HOVERGENiHBG003364.
InParanoidiP02529.
PhylomeDBiP02529.

Miscellaneous databases

PROiP02529.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR033483. CRYGC.
IPR011024. G_crystallin-rel.
[Graphical view]
PANTHERiPTHR11818:SF32. PTHR11818:SF32. 1 hit.
PfamiPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Concerted and divergent evolution within the rat gamma-crystallin gene family."
    den Dunnen J.T., Moormann R.J.M., Lubsen N.H., Schoenmakers J.G.G.
    J. Mol. Biol. 189:37-46(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Nucleotide sequence of the rat gamma-crystallin gene region and comparison with an orthologous human region."
    den Dunnen J.T., van Neck J.W., Cremers F.P.M., Lubsen N.H., Schoenmakers J.G.G.
    Gene 78:201-213(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Extensive intragenic sequence homology in two distinct rat lens gamma-crystallin cDNAs suggests duplications of a primordial gene."
    Moormann R.J.M., den Dunnen J.T., Bloemendal H., Schoenmakers J.G.G.
    Proc. Natl. Acad. Sci. U.S.A. 79:6876-6880(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-174.

Entry informationi

Entry nameiCRGC_RAT
AccessioniPrimary (citable) accession number: P02529
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 122 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are six different gamma crystallins identified in rat lens.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.