Reviewed, UniProtKB/Swiss-Prot P02527 (CRGA_BOVIN)

Names and origin

Protein names

Recommended name:
    Gamma-crystallin A
Alternative name(s):
    Gamma-A-crystallin
    Gamma-crystallin IVB

Gene names

Name:

CRYGA

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	175 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Crystallins are the dominant structural components of the vertebrate eye lens.
Domain	Has a two-domain beta-structure, folded into four very similar Greek key motifs.
Sequence similarities	Belongs to the beta/gamma-crystallin family. Contains 4 beta/gamma crystallin 'Greek key' domains.

Ontologies

Keywords
Cellular component	Eye lens protein
Domain	Repeat
Technical term	Direct protein sequencing
Gene Ontology (GO)
Molecular function	structural constituent of eye lens Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.1
	Chain	2 – 175	174	Gamma-crystallin A		PRO_0000057580
Regions
	Domain	2 – 40	39	Beta/gamma crystallin 'Greek key' 1
	Domain	41 – 83	43	Beta/gamma crystallin 'Greek key' 2
	Domain	89 – 129	41	Beta/gamma crystallin 'Greek key' 3
	Domain	130 – 172	43	Beta/gamma crystallin 'Greek key' 4
	Region	84 – 88	5	Connecting peptide

Sequences

	Sequence		Length	Mass (Da)
	P02527-1 [UniParc]. Last modified April 17, 2007. Version 2. Checksum: 612258034CBF5BDF	FASTA	175	21,135
	10 20 30 40 50 60 MGKITFYEDR GFQGHCYQCS SNNCLQQPYF SRCNSIRVDV HSWFVYQRPD YRGHQYMLQR 70 80 90 100 110 120 GNYPQYGQWM GFDDSIRSCR LIPQHTGTFR MRIYERDDFR GQMSEITDDC PSLQDRFHLT 130 140 150 160 170 EVNSVRVLEG SWVIYEMPSY RGRQYLLRPG EYRRYLDWGA MNAKVGSLRR VMDFY

References

[1]	"The amino acid sequence of gamma-crystallin (fraction II) from calf lens." Croft L.R. Biochem. J. 128:961-970(1972) [PubMed: 4674126] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-175.

Cross-references

Sequence databases
IPI	IPI00691511.
3D structure databases
HSSP	HSSP built from PDB template 1DSL based on UniProtKB P02526.
SMR	P02527. Positions 2-175.
ModBase	Search...
Phylogenomic databases
HOVERGEN	P02527.
Family and domain databases
InterPro	IPR001064. Crystallin. [Graphical view]
Gene3D	G3DSA:2.60.20.10. Crystallin. 2 hits.
Pfam	PF00030. Crystall. 2 hits. [Graphical view]
PRINTS	PR01367. BGCRYSTALLIN.
SMART	SM00247. XTALbg. 2 hits. [Graphical view]
PROSITE	PS50915. CRYSTALLIN_BETA_GAMMA. 4 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CRGA_BOVIN

Accession

Primary (citable) accession number: P02527

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	April 17, 2007
Last modified:	February 10, 2009
This is version 57 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)