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Protein

Gamma-crystallin B

Gene

CRYGB

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Crystallins are the dominant structural components of the vertebrate eye lens.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Eye lens protein

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-crystallin B
Alternative name(s):
Gamma-B-crystallin
Gamma-crystallin II
Gene namesi
Name:CRYGB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00000575812 – 175Gamma-crystallin BAdd BLAST174

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (Glc) (glycation); in vitro1
Disulfide bondi19 ↔ 231 Publication

Keywords - PTMi

Disulfide bond, Glycation, Glycoprotein

Proteomic databases

PaxDbiP02526.
PRIDEiP02526.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009553.

Structurei

Secondary structure

1175
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 9Combined sources7
Helixi10 – 12Combined sources3
Beta strandi13 – 19Combined sources7
Turni27 – 29Combined sources3
Beta strandi34 – 41Combined sources8
Beta strandi43 – 48Combined sources6
Turni49 – 51Combined sources3
Beta strandi52 – 58Combined sources7
Beta strandi60 – 65Combined sources6
Helixi66 – 69Combined sources4
Beta strandi72 – 74Combined sources3
Beta strandi78 – 81Combined sources4
Beta strandi90 – 96Combined sources7
Turni97 – 99Combined sources3
Beta strandi100 – 106Combined sources7
Helixi113 – 117Combined sources5
Beta strandi124 – 130Combined sources7
Beta strandi132 – 137Combined sources6
Turni138 – 140Combined sources3
Beta strandi141 – 147Combined sources7
Beta strandi149 – 152Combined sources4
Helixi155 – 158Combined sources4
Beta strandi167 – 170Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AMMX-ray1.20A2-175[»]
1DSLX-ray1.55A88-175[»]
1GAMX-ray2.60A/B88-173[»]
1GCSX-ray2.00A2-175[»]
1I5IX-ray2.40A2-175[»]
4GCRX-ray1.47A2-175[»]
4W9AX-ray1.38A1-175[»]
4W9BX-ray1.28A1-175[»]
ProteinModelPortaliP02526.
SMRiP02526.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02526.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 40Beta/gamma crystallin 'Greek key' 1PROSITE-ProRule annotationAdd BLAST39
Domaini41 – 83Beta/gamma crystallin 'Greek key' 2PROSITE-ProRule annotationAdd BLAST43
Domaini89 – 129Beta/gamma crystallin 'Greek key' 3PROSITE-ProRule annotationAdd BLAST41
Domaini130 – 172Beta/gamma crystallin 'Greek key' 4PROSITE-ProRule annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni84 – 88Connecting peptide5

Domaini

Has a two-domain beta-structure, folded into four very similar Greek key motifs.

Sequence similaritiesi

Belongs to the beta/gamma-crystallin family.Curated
Contains 4 beta/gamma crystallin 'Greek key' domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IWCR. Eukaryota.
ENOG411298R. LUCA.
GeneTreeiENSGT00760000118812.
HOGENOMiHOG000234389.
HOVERGENiHBG003364.
InParanoidiP02526.
OMAiFRGQMSE.
OrthoDBiEOG091G0L2P.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
[Graphical view]
PfamiPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02526-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKITFYEDR GFQGHCYECS SDCPNLQPYF SRCNSIRVDS GCWMLYERPN
60 70 80 90 100
YQGHQYFLRR GDYPDYQQWM GFNDSIRSCR LIPQHTGTFR MRIYERDDFR
110 120 130 140 150
GQMSEITDDC PSLQDRFHLT EVHSLNVLEG SWVLYEMPSY RGRQYLLRPG
160 170
EYRRYLDWGA MNAKVGSLRR VMDFY
Length:175
Mass (Da):21,097
Last modified:January 23, 2007 - v2
Checksum:i0CF283DA837CC593
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120T → S in CAA25518 (PubMed:6092016).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01036 mRNA. Translation: CAA25518.1.
M16894 mRNA. Translation: AAA30476.1.
EF208024 mRNA. Translation: ABM97504.1.
PIRiA29655. CYBOG.
RefSeqiNP_001013612.1. NM_001013594.1.
UniGeneiBt.399.

Genome annotation databases

EnsembliENSBTAT00000009553; ENSBTAP00000009553; ENSBTAG00000021770.
GeneIDi281720.
KEGGibta:281720.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X01036 mRNA. Translation: CAA25518.1.
M16894 mRNA. Translation: AAA30476.1.
EF208024 mRNA. Translation: ABM97504.1.
PIRiA29655. CYBOG.
RefSeqiNP_001013612.1. NM_001013594.1.
UniGeneiBt.399.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AMMX-ray1.20A2-175[»]
1DSLX-ray1.55A88-175[»]
1GAMX-ray2.60A/B88-173[»]
1GCSX-ray2.00A2-175[»]
1I5IX-ray2.40A2-175[»]
4GCRX-ray1.47A2-175[»]
4W9AX-ray1.38A1-175[»]
4W9BX-ray1.28A1-175[»]
ProteinModelPortaliP02526.
SMRiP02526.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000009553.

Proteomic databases

PaxDbiP02526.
PRIDEiP02526.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000009553; ENSBTAP00000009553; ENSBTAG00000021770.
GeneIDi281720.
KEGGibta:281720.

Organism-specific databases

CTDi1419.

Phylogenomic databases

eggNOGiENOG410IWCR. Eukaryota.
ENOG411298R. LUCA.
GeneTreeiENSGT00760000118812.
HOGENOMiHOG000234389.
HOVERGENiHBG003364.
InParanoidiP02526.
OMAiFRGQMSE.
OrthoDBiEOG091G0L2P.

Miscellaneous databases

EvolutionaryTraceiP02526.

Family and domain databases

InterProiIPR001064. Beta/gamma_crystallin.
IPR011024. G_crystallin-rel.
[Graphical view]
PfamiPF00030. Crystall. 2 hits.
[Graphical view]
PRINTSiPR01367. BGCRYSTALLIN.
SMARTiSM00247. XTALbg. 2 hits.
[Graphical view]
SUPFAMiSSF49695. SSF49695. 1 hit.
PROSITEiPS50915. CRYSTALLIN_BETA_GAMMA. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRGB_BOVIN
AccessioniPrimary (citable) accession number: P02526
Secondary accession number(s): A2TJU8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.